Effects of isoflavone on the learning and memory of women in menopause: a double-blind placebo-controlled study

Detalhes bibliográficos
Autor(a) principal: Santos-Galduróz, Ruth Ferreira
Data de Publicação: 2010
Outros Autores: Galduróz, José Carlos Fernandes [UNIFESP], Facco, R.L., Hachul, Helena [UNIFESP], Tufik, Sergio [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/S0100-879X2010007500104
http://repositorio.unifesp.br/handle/11600/6006
Resumo: Hormone decline is common to all women during aging and, associated with other factors, leads to cognitive impairment. Its replacement enhances cognitive performance, but not all women present a clinical and family or personal history that justifies its use, mainly women with a history of cancer. The aim of this study was to determine whether a daily oral dose of 80 mg of isoflavone extract for 4 months can produce benefits in women with low hormone levels, contributing to improvement in cognitive aspects. The sample comprised 50- to 65-year-old women whose menstruation had ceased at least 1 year before and who had not undergone hormone replacement. The volunteers were allocated to two groups of 19 individuals each, i.e., isoflavone and placebo. There was a weak correlation between menopause duration and low performance in the capacity to manipulate information (central executive). We observed an increase in the capacity to integrate information in the group treated with isoflavone, but no improvement in the capacity to form new memories. We did not observe differences between groups in terms of signs and symptoms suggestive of depression according to the Geriatric Depression Scale. Our results point to a possible beneficial effect of isoflavone on some abilities of the central executive. These effects could also contribute to minimizing the impact of memory impairment. Further research based on controlled clinical trials is necessary to reach consistent conclusions.
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spelling Effects of isoflavone on the learning and memory of women in menopause: a double-blind placebo-controlled studyIsoflavoneCognitive disordersAgingInformation integrationMemoryMenopauseHormone decline is common to all women during aging and, associated with other factors, leads to cognitive impairment. Its replacement enhances cognitive performance, but not all women present a clinical and family or personal history that justifies its use, mainly women with a history of cancer. The aim of this study was to determine whether a daily oral dose of 80 mg of isoflavone extract for 4 months can produce benefits in women with low hormone levels, contributing to improvement in cognitive aspects. The sample comprised 50- to 65-year-old women whose menstruation had ceased at least 1 year before and who had not undergone hormone replacement. The volunteers were allocated to two groups of 19 individuals each, i.e., isoflavone and placebo. There was a weak correlation between menopause duration and low performance in the capacity to manipulate information (central executive). We observed an increase in the capacity to integrate information in the group treated with isoflavone, but no improvement in the capacity to form new memories. We did not observe differences between groups in terms of signs and symptoms suggestive of depression according to the Geriatric Depression Scale. Our results point to a possible beneficial effect of isoflavone on some abilities of the central executive. These effects could also contribute to minimizing the impact of memory impairment. Further research based on controlled clinical trials is necessary to reach consistent conclusions.Universidade Estadual Paulista Departamento de BiociênciasUniversidade Federal do ABC Centro de Matemática, Computação e CogniçãoUniversidade Federal de São Paulo (UNIFESP) Departamento de PsicobiologiaIndependent researcher in private practice Departamento de PsicobiologiaUNIFESP, Depto. de PsicobiologiaSciELOConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Associação Fundo de Incentivo à Pesquisa (AFIP)Associação Brasileira de Divulgação CientíficaUniversidade Estadual Paulista (UNESP)Universidade Federal do ABC Centro de Matemática, Computação e CogniçãoUniversidade Federal de São Paulo (UNIFESP)Independent researcher in private practice Departamento de PsicobiologiaSantos-Galduróz, Ruth FerreiraGalduróz, José Carlos Fernandes [UNIFESP]Facco, R.L.Hachul, Helena [UNIFESP]Tufik, Sergio [UNIFESP]2015-06-14T13:41:57Z2015-06-14T13:41:57Z2010-11-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion1123-1126application/pdfhttp://dx.doi.org/10.1590/S0100-879X2010007500104Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 43, n. 11, p. 1123-1126, 2010.10.1590/S0100-879X2010007500104S0100-879X2010001100016.pdf0100-879XS0100-879X2010001100016http://repositorio.unifesp.br/handle/11600/6006WOS:000284591800016engBrazilian Journal of Medical and Biological Researchinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-05T23:41:53Zoai:repositorio.unifesp.br/:11600/6006Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-05T23:41:53Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Effects of isoflavone on the learning and memory of women in menopause: a double-blind placebo-controlled study
title Effects of isoflavone on the learning and memory of women in menopause: a double-blind placebo-controlled study
spellingShingle Effects of isoflavone on the learning and memory of women in menopause: a double-blind placebo-controlled study
Santos-Galduróz, Ruth Ferreira
Isoflavone
Cognitive disorders
Aging
Information integration
Memory
Menopause
title_short Effects of isoflavone on the learning and memory of women in menopause: a double-blind placebo-controlled study
title_full Effects of isoflavone on the learning and memory of women in menopause: a double-blind placebo-controlled study
title_fullStr Effects of isoflavone on the learning and memory of women in menopause: a double-blind placebo-controlled study
title_full_unstemmed Effects of isoflavone on the learning and memory of women in menopause: a double-blind placebo-controlled study
title_sort Effects of isoflavone on the learning and memory of women in menopause: a double-blind placebo-controlled study
author Santos-Galduróz, Ruth Ferreira
author_facet Santos-Galduróz, Ruth Ferreira
Galduróz, José Carlos Fernandes [UNIFESP]
Facco, R.L.
Hachul, Helena [UNIFESP]
Tufik, Sergio [UNIFESP]
author_role author
author2 Galduróz, José Carlos Fernandes [UNIFESP]
Facco, R.L.
Hachul, Helena [UNIFESP]
Tufik, Sergio [UNIFESP]
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (UNESP)
Universidade Federal do ABC Centro de Matemática, Computação e Cognição
Universidade Federal de São Paulo (UNIFESP)
Independent researcher in private practice Departamento de Psicobiologia
dc.contributor.author.fl_str_mv Santos-Galduróz, Ruth Ferreira
Galduróz, José Carlos Fernandes [UNIFESP]
Facco, R.L.
Hachul, Helena [UNIFESP]
Tufik, Sergio [UNIFESP]
dc.subject.por.fl_str_mv Isoflavone
Cognitive disorders
Aging
Information integration
Memory
Menopause
topic Isoflavone
Cognitive disorders
Aging
Information integration
Memory
Menopause
description Hormone decline is common to all women during aging and, associated with other factors, leads to cognitive impairment. Its replacement enhances cognitive performance, but not all women present a clinical and family or personal history that justifies its use, mainly women with a history of cancer. The aim of this study was to determine whether a daily oral dose of 80 mg of isoflavone extract for 4 months can produce benefits in women with low hormone levels, contributing to improvement in cognitive aspects. The sample comprised 50- to 65-year-old women whose menstruation had ceased at least 1 year before and who had not undergone hormone replacement. The volunteers were allocated to two groups of 19 individuals each, i.e., isoflavone and placebo. There was a weak correlation between menopause duration and low performance in the capacity to manipulate information (central executive). We observed an increase in the capacity to integrate information in the group treated with isoflavone, but no improvement in the capacity to form new memories. We did not observe differences between groups in terms of signs and symptoms suggestive of depression according to the Geriatric Depression Scale. Our results point to a possible beneficial effect of isoflavone on some abilities of the central executive. These effects could also contribute to minimizing the impact of memory impairment. Further research based on controlled clinical trials is necessary to reach consistent conclusions.
publishDate 2010
dc.date.none.fl_str_mv 2010-11-01
2015-06-14T13:41:57Z
2015-06-14T13:41:57Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0100-879X2010007500104
Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 43, n. 11, p. 1123-1126, 2010.
10.1590/S0100-879X2010007500104
S0100-879X2010001100016.pdf
0100-879X
S0100-879X2010001100016
http://repositorio.unifesp.br/handle/11600/6006
WOS:000284591800016
url http://dx.doi.org/10.1590/S0100-879X2010007500104
http://repositorio.unifesp.br/handle/11600/6006
identifier_str_mv Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 43, n. 11, p. 1123-1126, 2010.
10.1590/S0100-879X2010007500104
S0100-879X2010001100016.pdf
0100-879X
S0100-879X2010001100016
WOS:000284591800016
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Brazilian Journal of Medical and Biological Research
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1123-1126
application/pdf
dc.publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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