Innate Sensing of the Gut Microbiota: Modulation of Inflammatory and Autoimmune Diseases

Detalhes bibliográficos
Autor(a) principal: Ignacio, Aline
Data de Publicação: 2016
Outros Autores: Morales, Camila Ideli, Saraiva Camara, Niels Olsen [UNIFESP], Almeida, Rafael Ribeiro
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.3389/fimmu.2016.00054
https://repositorio.unifesp.br/handle/11600/57966
Resumo: The mammalian gastrointestinal tract harbors a diverse microbial community with which dynamic interactions have been established over millennia of coevolution. Commensal bacteria and their products are sensed by innate receptors expressed in gut epithelia and in gut-associated immune cells, thereby promoting the proper development of mucosal immune system and host homeostasis. Many studies have demonstrated that host-microbiota interactions play a key role during local and systemic immunity. Therefore, this review will focus on how innate sensing of the gut microbiota and their metabolites through inflammasome and toll-like receptors impact the modulation of a distinct set of inflammatory and autoimmune diseases. We believe that a better understanding of the fine-tuning that governs host-microbiota interactions will further improve common prophylactic and therapeutic applications.
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spelling Innate Sensing of the Gut Microbiota: Modulation of Inflammatory and Autoimmune Diseasesmicrobiotatoll-like receptorsinflammasomeautoimmunityinflammatory diseasesThe mammalian gastrointestinal tract harbors a diverse microbial community with which dynamic interactions have been established over millennia of coevolution. Commensal bacteria and their products are sensed by innate receptors expressed in gut epithelia and in gut-associated immune cells, thereby promoting the proper development of mucosal immune system and host homeostasis. Many studies have demonstrated that host-microbiota interactions play a key role during local and systemic immunity. Therefore, this review will focus on how innate sensing of the gut microbiota and their metabolites through inflammasome and toll-like receptors impact the modulation of a distinct set of inflammatory and autoimmune diseases. We believe that a better understanding of the fine-tuning that governs host-microbiota interactions will further improve common prophylactic and therapeutic applications.Univ Sao Paulo, Inst Biomed Sci, Dept Immunol, Lab Transplantat Immunobiol, Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Med, Div Nephrol, Sao Paulo, BrazilUniv Sao Paulo, Renal Pathophysiol Lab, Dept Clin Med, Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Med, Div Nephrol, Sao Paulo, BrazilWeb of ScienceCNPqSao Paulo State Research Funding Agency (FAPESP)FAPESP fellowshipsFAPESP: 12/02270-2Frontiers Media Sa2020-08-21T17:00:22Z2020-08-21T17:00:22Z2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion-application/pdfhttp://dx.doi.org/10.3389/fimmu.2016.00054Frontiers In Immunology. Lausanne, v. 7, p. -, 2016.10.3389/fimmu.2016.00054WOS000370412500001.pdf1664-3224https://repositorio.unifesp.br/handle/11600/57966WOS:000370412500001engFrontiers In ImmunologyLausanneinfo:eu-repo/semantics/openAccessIgnacio, AlineMorales, Camila IdeliSaraiva Camara, Niels Olsen [UNIFESP]Almeida, Rafael Ribeiroreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-01T19:53:23Zoai:repositorio.unifesp.br/:11600/57966Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-01T19:53:23Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Innate Sensing of the Gut Microbiota: Modulation of Inflammatory and Autoimmune Diseases
title Innate Sensing of the Gut Microbiota: Modulation of Inflammatory and Autoimmune Diseases
spellingShingle Innate Sensing of the Gut Microbiota: Modulation of Inflammatory and Autoimmune Diseases
Ignacio, Aline
microbiota
toll-like receptors
inflammasome
autoimmunity
inflammatory diseases
title_short Innate Sensing of the Gut Microbiota: Modulation of Inflammatory and Autoimmune Diseases
title_full Innate Sensing of the Gut Microbiota: Modulation of Inflammatory and Autoimmune Diseases
title_fullStr Innate Sensing of the Gut Microbiota: Modulation of Inflammatory and Autoimmune Diseases
title_full_unstemmed Innate Sensing of the Gut Microbiota: Modulation of Inflammatory and Autoimmune Diseases
title_sort Innate Sensing of the Gut Microbiota: Modulation of Inflammatory and Autoimmune Diseases
author Ignacio, Aline
author_facet Ignacio, Aline
Morales, Camila Ideli
Saraiva Camara, Niels Olsen [UNIFESP]
Almeida, Rafael Ribeiro
author_role author
author2 Morales, Camila Ideli
Saraiva Camara, Niels Olsen [UNIFESP]
Almeida, Rafael Ribeiro
author2_role author
author
author
dc.contributor.author.fl_str_mv Ignacio, Aline
Morales, Camila Ideli
Saraiva Camara, Niels Olsen [UNIFESP]
Almeida, Rafael Ribeiro
dc.subject.por.fl_str_mv microbiota
toll-like receptors
inflammasome
autoimmunity
inflammatory diseases
topic microbiota
toll-like receptors
inflammasome
autoimmunity
inflammatory diseases
description The mammalian gastrointestinal tract harbors a diverse microbial community with which dynamic interactions have been established over millennia of coevolution. Commensal bacteria and their products are sensed by innate receptors expressed in gut epithelia and in gut-associated immune cells, thereby promoting the proper development of mucosal immune system and host homeostasis. Many studies have demonstrated that host-microbiota interactions play a key role during local and systemic immunity. Therefore, this review will focus on how innate sensing of the gut microbiota and their metabolites through inflammasome and toll-like receptors impact the modulation of a distinct set of inflammatory and autoimmune diseases. We believe that a better understanding of the fine-tuning that governs host-microbiota interactions will further improve common prophylactic and therapeutic applications.
publishDate 2016
dc.date.none.fl_str_mv 2016
2020-08-21T17:00:22Z
2020-08-21T17:00:22Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.3389/fimmu.2016.00054
Frontiers In Immunology. Lausanne, v. 7, p. -, 2016.
10.3389/fimmu.2016.00054
WOS000370412500001.pdf
1664-3224
https://repositorio.unifesp.br/handle/11600/57966
WOS:000370412500001
url http://dx.doi.org/10.3389/fimmu.2016.00054
https://repositorio.unifesp.br/handle/11600/57966
identifier_str_mv Frontiers In Immunology. Lausanne, v. 7, p. -, 2016.
10.3389/fimmu.2016.00054
WOS000370412500001.pdf
1664-3224
WOS:000370412500001
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Frontiers In Immunology
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv -
application/pdf
dc.coverage.none.fl_str_mv Lausanne
dc.publisher.none.fl_str_mv Frontiers Media Sa
publisher.none.fl_str_mv Frontiers Media Sa
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
_version_ 1814268279783424000

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