Verbal ability impairment in juvenile systemic lupus erythematosus
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/11600/45408 http://dx.doi.org/10.1590/S0482-50042010000400003 |
Resumo: | Introduction/Objective: Evaluate the frequency of verbal ability impairment and associated factors in patients with juvenile systemic lupus erythematosus (JSLE). Patients and Methods: Cross sectional study of 36 children and adolescents with JSLE of a group of 57 patients at the Clinic of Rheumatology, Department of Pediatrics and Medical Clinic of Santa Casa de Misericordia de Sao Paulo. At the time of diagnosis and study, we analyzed the following epidemiological features: clinical, socioeconomic, and educational level. Patients underwent cognitive and laboratory tests and we assessed disease activity (SLEDAI), cumulative damage (SLICC-DI), and treatment with corticosteroids. The patients underwent cognitive tests (Wechsler Intelligence Scales: WISC III and Waiss III), and the results were evaluated according to epidemiological, clinical, laboratory and treatment features. Results: The mean age at diagnosis was 11.2 +/- 2 years and at the time of the study the mean age was 15.4 +/- 4.7 years. There was predominance of women (89%) and of socioeconomic class C patients (61.1%). The cognitive impairment found in these patients was frequent (58.3%), affecting more often the verbal ability. We found association of verbal ability impairment with low socioeconomic status and cumulative damage (P < 0.05), but not with disease activity, presence of autoantibodies, and dose of corticosteroids (P > 0.05). Conclusions: Change in verbal ability is frequent in JSLE and is associated with socioeconomic status and cumulative damage, and should be suspected and investigated, particularly in pediatric patients to avoid quality of life impairment in adulthood. As it is not related with disease activity or presence of autoantibodies, it should always be assessed in the presence or absence of these factors. Likewise, the doses of corticosteroids should be independently evaluated. |
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Santos, Maria Carolina dosOkuda, Eunice MitikoRonchezel, Marcos Vinicius [UNIFESP]Leon, Elaine PiresTrindade, Vilma dos Santos [UNIFESP]Bastos, Wanda AlvesSacchetti, Silvana BrasiliaUniversidade Federal de São Paulo (UNIFESP)2018-06-18T11:48:18Z2018-06-18T11:48:18Z2010-07-01Revista Brasileira De Reumatologia. New York: Elsevier Science Inc, v. 50, n. 4, p. 362-374, 2010.0482-5004http://repositorio.unifesp.br/11600/45408http://dx.doi.org/10.1590/S0482-50042010000400003S0482-50042010000400003-pt.pdfS0482-50042010000400003-en.pdfS0482-5004201000040000310.1590/S0482-50042010000400003WOS:000208389400003Introduction/Objective: Evaluate the frequency of verbal ability impairment and associated factors in patients with juvenile systemic lupus erythematosus (JSLE). Patients and Methods: Cross sectional study of 36 children and adolescents with JSLE of a group of 57 patients at the Clinic of Rheumatology, Department of Pediatrics and Medical Clinic of Santa Casa de Misericordia de Sao Paulo. At the time of diagnosis and study, we analyzed the following epidemiological features: clinical, socioeconomic, and educational level. Patients underwent cognitive and laboratory tests and we assessed disease activity (SLEDAI), cumulative damage (SLICC-DI), and treatment with corticosteroids. The patients underwent cognitive tests (Wechsler Intelligence Scales: WISC III and Waiss III), and the results were evaluated according to epidemiological, clinical, laboratory and treatment features. Results: The mean age at diagnosis was 11.2 +/- 2 years and at the time of the study the mean age was 15.4 +/- 4.7 years. There was predominance of women (89%) and of socioeconomic class C patients (61.1%). The cognitive impairment found in these patients was frequent (58.3%), affecting more often the verbal ability. We found association of verbal ability impairment with low socioeconomic status and cumulative damage (P < 0.05), but not with disease activity, presence of autoantibodies, and dose of corticosteroids (P > 0.05). Conclusions: Change in verbal ability is frequent in JSLE and is associated with socioeconomic status and cumulative damage, and should be suspected and investigated, particularly in pediatric patients to avoid quality of life impairment in adulthood. As it is not related with disease activity or presence of autoantibodies, it should always be assessed in the presence or absence of these factors. Likewise, the doses of corticosteroids should be independently evaluated.Irmandade Santa Casa Misericordia Sao Paulo, Dept Pediat, Disciplina Reumatol, Sao Paulo, BrazilWeb of Science362-374porElsevier B.V.Revista Brasileira De Reumatologiahttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policyinfo:eu-repo/semantics/openAccesssystemic lupus erythematosuscognitionchildadolescentcognitive testsVerbal ability impairment in juvenile systemic lupus erythematosusComprometimento da habilidade verbal no lúpus eritematoso sistêmico juvenilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlereponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALS0482-50042010000400003-en.pdfapplication/pdf288775${dspace.ui.url}/bitstream/11600/45408/1/S0482-50042010000400003-en.pdf2910ed8eae6b64176eceae94c92f2553MD51open accessS0482-50042010000400003-pt.pdfapplication/pdf474821${dspace.ui.url}/bitstream/11600/45408/2/S0482-50042010000400003-pt.pdf495e2427ef38380ae02c847ff97be8edMD52open accessTEXTS0482-50042010000400003-en.pdf.txtS0482-50042010000400003-en.pdf.txtExtracted texttext/plain31503${dspace.ui.url}/bitstream/11600/45408/3/S0482-50042010000400003-en.pdf.txt2b88d4e2ea76c34006901a774eb67274MD53open accessS0482-50042010000400003-pt.pdf.txtS0482-50042010000400003-pt.pdf.txtExtracted texttext/plain34494${dspace.ui.url}/bitstream/11600/45408/6/S0482-50042010000400003-pt.pdf.txt33abd74cc87c55be219df062aceb5194MD56open accessTHUMBNAILS0482-50042010000400003-en.pdf.jpgS0482-50042010000400003-en.pdf.jpgIM Thumbnailimage/jpeg5887${dspace.ui.url}/bitstream/11600/45408/5/S0482-50042010000400003-en.pdf.jpgd7ca861e861646c984cd16c99d860376MD55open accessS0482-50042010000400003-pt.pdf.jpgS0482-50042010000400003-pt.pdf.jpgIM Thumbnailimage/jpeg5969${dspace.ui.url}/bitstream/11600/45408/8/S0482-50042010000400003-pt.pdf.jpg19c796ef1a320bdadad117ea1c456599MD58open access11600/454082022-08-02 13:02:02.944open accessoai:repositorio.unifesp.br:11600/45408Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:13:14.674942Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Verbal ability impairment in juvenile systemic lupus erythematosus |
dc.title.pt.fl_str_mv |
Comprometimento da habilidade verbal no lúpus eritematoso sistêmico juvenil |
title |
Verbal ability impairment in juvenile systemic lupus erythematosus |
spellingShingle |
Verbal ability impairment in juvenile systemic lupus erythematosus Santos, Maria Carolina dos systemic lupus erythematosus cognition child adolescent cognitive tests |
title_short |
Verbal ability impairment in juvenile systemic lupus erythematosus |
title_full |
Verbal ability impairment in juvenile systemic lupus erythematosus |
title_fullStr |
Verbal ability impairment in juvenile systemic lupus erythematosus |
title_full_unstemmed |
Verbal ability impairment in juvenile systemic lupus erythematosus |
title_sort |
Verbal ability impairment in juvenile systemic lupus erythematosus |
author |
Santos, Maria Carolina dos |
author_facet |
Santos, Maria Carolina dos Okuda, Eunice Mitiko Ronchezel, Marcos Vinicius [UNIFESP] Leon, Elaine Pires Trindade, Vilma dos Santos [UNIFESP] Bastos, Wanda Alves Sacchetti, Silvana Brasilia |
author_role |
author |
author2 |
Okuda, Eunice Mitiko Ronchezel, Marcos Vinicius [UNIFESP] Leon, Elaine Pires Trindade, Vilma dos Santos [UNIFESP] Bastos, Wanda Alves Sacchetti, Silvana Brasilia |
author2_role |
author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Santos, Maria Carolina dos Okuda, Eunice Mitiko Ronchezel, Marcos Vinicius [UNIFESP] Leon, Elaine Pires Trindade, Vilma dos Santos [UNIFESP] Bastos, Wanda Alves Sacchetti, Silvana Brasilia |
dc.subject.eng.fl_str_mv |
systemic lupus erythematosus cognition child adolescent cognitive tests |
topic |
systemic lupus erythematosus cognition child adolescent cognitive tests |
description |
Introduction/Objective: Evaluate the frequency of verbal ability impairment and associated factors in patients with juvenile systemic lupus erythematosus (JSLE). Patients and Methods: Cross sectional study of 36 children and adolescents with JSLE of a group of 57 patients at the Clinic of Rheumatology, Department of Pediatrics and Medical Clinic of Santa Casa de Misericordia de Sao Paulo. At the time of diagnosis and study, we analyzed the following epidemiological features: clinical, socioeconomic, and educational level. Patients underwent cognitive and laboratory tests and we assessed disease activity (SLEDAI), cumulative damage (SLICC-DI), and treatment with corticosteroids. The patients underwent cognitive tests (Wechsler Intelligence Scales: WISC III and Waiss III), and the results were evaluated according to epidemiological, clinical, laboratory and treatment features. Results: The mean age at diagnosis was 11.2 +/- 2 years and at the time of the study the mean age was 15.4 +/- 4.7 years. There was predominance of women (89%) and of socioeconomic class C patients (61.1%). The cognitive impairment found in these patients was frequent (58.3%), affecting more often the verbal ability. We found association of verbal ability impairment with low socioeconomic status and cumulative damage (P < 0.05), but not with disease activity, presence of autoantibodies, and dose of corticosteroids (P > 0.05). Conclusions: Change in verbal ability is frequent in JSLE and is associated with socioeconomic status and cumulative damage, and should be suspected and investigated, particularly in pediatric patients to avoid quality of life impairment in adulthood. As it is not related with disease activity or presence of autoantibodies, it should always be assessed in the presence or absence of these factors. Likewise, the doses of corticosteroids should be independently evaluated. |
publishDate |
2010 |
dc.date.issued.fl_str_mv |
2010-07-01 |
dc.date.accessioned.fl_str_mv |
2018-06-18T11:48:18Z |
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2018-06-18T11:48:18Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Revista Brasileira De Reumatologia. New York: Elsevier Science Inc, v. 50, n. 4, p. 362-374, 2010. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/11600/45408 http://dx.doi.org/10.1590/S0482-50042010000400003 |
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0482-5004 |
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10.1590/S0482-50042010000400003 |
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WOS:000208389400003 |
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Revista Brasileira De Reumatologia. New York: Elsevier Science Inc, v. 50, n. 4, p. 362-374, 2010. 0482-5004 S0482-50042010000400003-pt.pdf S0482-50042010000400003-en.pdf S0482-50042010000400003 10.1590/S0482-50042010000400003 WOS:000208389400003 |
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http://repositorio.unifesp.br/11600/45408 http://dx.doi.org/10.1590/S0482-50042010000400003 |
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por |
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por |
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Revista Brasileira De Reumatologia |
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http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy |
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362-374 |
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Elsevier B.V. |
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Elsevier B.V. |
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