Evaluation of survival of patients with hepatocellular carcinoma: A comparative analysis of prognostic systems

• Autor(a) principal: Tannus, Roberta Kazan [UNIFESP]
• Data de Publicação: 2018
• Outros Autores: Almeida-Carvalho, S. R. [UNIFESP], Matos, Carla Adriana Loureiro de [UNIFESP], Gonzalez, Adriano Miziara [UNIFESP], Salzedas-Netto, Alcides Augusto [UNIFESP], Szejnfeld, Denis [UNIFESP], D'Ippolito, Giuseppe [UNIFESP], Lanzoni, Valeria Pereira [UNIFESP], Souza-Silva, I. [UNIFESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: https://repositorio.unifesp.br/handle/11600/55645; http://dx.doi.org/10.1371/journal.pone.0194922

Background and aim There are several prognostic systems that address different aspects of the patient and the tumour and can guide the management of patients with hepatocellular carcinoma (HCC). This study aimed to evaluate and compare the eight staging systems for a group of patients in a public service in Brazil. Methods Patients with HCC were retrospectively analysed between 2000 and 2012. The prognostic systems Okuda, The Cancer of the Liver Italian Program (CLIP), the Chinese University Prognostic Index (CUPI), Groupe d'Etude et de Traitement du Carcinome Hepatocellulaire (GRETCH), the modified TNM-based Japan Integrated Score (JIS) combined with alpha-fetoprotein and Child-Turcotte-Pugh (CTP), the TNM system, and the Barcelona Clinic Liver Cancer Classification (BCLC) were applied to these patients and compared through model fit measurements, likelihood scores, and the Akaike Information Criterion (AIC). Results A total of 247 patients were studied. The average survival time was 60 months. The TNM, Okuda, CLIP, GRETCH, modified JIS, and BCLC systems were well correlated with one another and individually important to the prediction of survival among the patients studied. However, in the statistical analysis, the CUPI delivered the best predictive performance (AIC = 566