Efeitos do exercício físico prévio sobre a função renal, disfunção autonômica e atividade nervosa simpática renal no diabetes mellitus experimental, em ratos

• Autor(a) principal: Silva, Kleiton Augusto dos Santos [UNIFESP]
• Data de Publicação: 2011
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://repositorio.unifesp.br/handle/11600/9421
• topic: Diabetes Mellitus; Diabetes Mellitus/psycological; Rim/Fisiologia; Exercício; Exercise

Background: The exercise training (ET) has been recognized as an important therapeutic intervention for the chronic degenerative diseases such as Diabetes Mellitus (DM) that cause renal and cardiovascular complications. However, little is known if previous ET intervention modulates the physiological and medical impact caused by these dysfunctions. We investigated the effects of previous ET on renal sympathetic nerve activity (RSNA), cardiovascular autonomic control and renal function in rats with experimental diabetes. Methods: Male Wistar rats were divided in five groups: control (C, n= 8), diabetic (D, n= 8), trained control (TC, n= 8) or diabetic (TD, n= 8) and previous trained diabetic (PTD, n= 8). TC and TD were submitted to 10 wks and PTD to 14 wks of ET. Renal function, proteinuria, RSNA and autonomic modulation and baroreflex sensitivity (BRS) were evaluated. Results: Previous ET reduced proteinuria in PTD group (36.9±10.2 mg/24 h) as compared to D group (90.6±5.7 mg/24 h, p<0.05) and attenuated in relation to TD group (46.8±4.1 mg/24 h), fractional excretion of sodium in PTD group (0.72±0.06 %) as compared to D group (2.40±0.30 %, p<0.05) and attenuated in relation to TD group (0.99±0.02 %). Moreover, previous ET normalizes RSNA in PTD when compared to D group (23.6±0.6 mV/cycle vs. 18.1±1.7 mV/cycle, p<0.05), respectively and improve heart rate variability as well as BRS compared to D group. Conclusion: This study demonstrates that the previous ET is an important therapeutical tool in order to increase the safety and bring greater healthy benefits, with respect to cardiovascular and kidney alterations due to DM. Thus, these data indicates a necessity to performe ET in patients with high risk of DM in order to minimize future impact on cardiovascular and renal function induced DM.