Mass Spectrometry Analysis of Protonated Marine Natural Product Seriniquinone

Detalhes bibliográficos
Autor(a) principal: Silva, Rodrigo Moreira da
Data de Publicação: 2018
Outros Autores: Guaratini, Thais, Jimenez, Paula Christine [UNIFESP], Fenical, William, Costa-Lotufo, Leticia Veras, Vessecchi, Ricardo, Lopes, Norberto Peporine
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: https://dx.doi.org/10.21577/0103-5053.20180037
https://repositorio.unifesp.br/handle/11600/55616
Resumo: Seriniquinone is a natural quinone isolated from a rare marine bacterium of the genus Serinicoccus. This secondary metabolite has been shown to have anticancer properties, which has raised attention of the scientific community. In this short report, we present the first investigation of the gas-phase chemistry fragmentation reactions of seriniquinone in electrospray ionization tandem mass spectrometry (ESI-MS/MS), to be further applied in pharmacokinetics and metabolism studies. All the proposals herein were supported by computational chemistry.
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spelling Mass Spectrometry Analysis of Protonated Marine Natural Product SeriniquinoneSerinicoccusSeriniquinoneElectrospray ionization mass spectrometryQuinonesComputational chemistrySeriniquinone is a natural quinone isolated from a rare marine bacterium of the genus Serinicoccus. This secondary metabolite has been shown to have anticancer properties, which has raised attention of the scientific community. In this short report, we present the first investigation of the gas-phase chemistry fragmentation reactions of seriniquinone in electrospray ionization tandem mass spectrometry (ESI-MS/MS), to be further applied in pharmacokinetics and metabolism studies. All the proposals herein were supported by computational chemistry.Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, NPPNS, BR-14040903 Ribeirao Preto, SP, BrazilLychnoflora Pesquisa & Desenvolvimento Prod Nat L, Campus USP, Ribeirao Preto, SP, BrazilUniv Fed Sao Paulo, Dept Ciencias Mar, BR-11070100 Santos, SP, BrazilUniv Calif San Diego, Scripps Inst Oceanog, CMBB, 9500 Gilman Dr 0204, La Jolla, CA 92093 USAUniv Sao Paulo, Dept Farmacol, Inst Ciencias Biomed, BR-05508900 Sao Paulo, SP, BrazilUniv Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, Dept Quim, BR-14040901 Ribeirao Preto, SP, BrazilUniv Fed Sao Paulo, Dept Ciencias Mar, BR-11070100 Santos, SP, BrazilWeb of ScienceFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)FAPESP: 2014/50265-3Soc Brasileira QuimicaUniversidade Federal de São Paulo (UNIFESP)Silva, Rodrigo Moreira daGuaratini, ThaisJimenez, Paula Christine [UNIFESP]Fenical, WilliamCosta-Lotufo, Leticia VerasVessecchi, RicardoLopes, Norberto Peporine2020-07-20T16:30:58Z2020-07-20T16:30:58Z2018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion1162-1166application/pdfhttps://dx.doi.org/10.21577/0103-5053.20180037Journal Of The Brazilian Chemical Society. Sao Paulo, v. 29, n. 5, p. 1162-1166, 2018.10.21577/0103-5053.20180037S0103-50532018000501162.pdf0103-5053S0103-50532018000501162https://repositorio.unifesp.br/handle/11600/55616WOS:000427641700024engJournal Of The Brazilian Chemical SocietySao Pauloinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-11T07:50:27Zoai:repositorio.unifesp.br/:11600/55616Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-11T07:50:27Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Mass Spectrometry Analysis of Protonated Marine Natural Product Seriniquinone
title Mass Spectrometry Analysis of Protonated Marine Natural Product Seriniquinone
spellingShingle Mass Spectrometry Analysis of Protonated Marine Natural Product Seriniquinone
Silva, Rodrigo Moreira da
Serinicoccus
Seriniquinone
Electrospray ionization mass spectrometry
Quinones
Computational chemistry
title_short Mass Spectrometry Analysis of Protonated Marine Natural Product Seriniquinone
title_full Mass Spectrometry Analysis of Protonated Marine Natural Product Seriniquinone
title_fullStr Mass Spectrometry Analysis of Protonated Marine Natural Product Seriniquinone
title_full_unstemmed Mass Spectrometry Analysis of Protonated Marine Natural Product Seriniquinone
title_sort Mass Spectrometry Analysis of Protonated Marine Natural Product Seriniquinone
author Silva, Rodrigo Moreira da
author_facet Silva, Rodrigo Moreira da
Guaratini, Thais
Jimenez, Paula Christine [UNIFESP]
Fenical, William
Costa-Lotufo, Leticia Veras
Vessecchi, Ricardo
Lopes, Norberto Peporine
author_role author
author2 Guaratini, Thais
Jimenez, Paula Christine [UNIFESP]
Fenical, William
Costa-Lotufo, Leticia Veras
Vessecchi, Ricardo
Lopes, Norberto Peporine
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Silva, Rodrigo Moreira da
Guaratini, Thais
Jimenez, Paula Christine [UNIFESP]
Fenical, William
Costa-Lotufo, Leticia Veras
Vessecchi, Ricardo
Lopes, Norberto Peporine
dc.subject.por.fl_str_mv Serinicoccus
Seriniquinone
Electrospray ionization mass spectrometry
Quinones
Computational chemistry
topic Serinicoccus
Seriniquinone
Electrospray ionization mass spectrometry
Quinones
Computational chemistry
description Seriniquinone is a natural quinone isolated from a rare marine bacterium of the genus Serinicoccus. This secondary metabolite has been shown to have anticancer properties, which has raised attention of the scientific community. In this short report, we present the first investigation of the gas-phase chemistry fragmentation reactions of seriniquinone in electrospray ionization tandem mass spectrometry (ESI-MS/MS), to be further applied in pharmacokinetics and metabolism studies. All the proposals herein were supported by computational chemistry.
publishDate 2018
dc.date.none.fl_str_mv 2018
2020-07-20T16:30:58Z
2020-07-20T16:30:58Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://dx.doi.org/10.21577/0103-5053.20180037
Journal Of The Brazilian Chemical Society. Sao Paulo, v. 29, n. 5, p. 1162-1166, 2018.
10.21577/0103-5053.20180037
S0103-50532018000501162.pdf
0103-5053
S0103-50532018000501162
https://repositorio.unifesp.br/handle/11600/55616
WOS:000427641700024
url https://dx.doi.org/10.21577/0103-5053.20180037
https://repositorio.unifesp.br/handle/11600/55616
identifier_str_mv Journal Of The Brazilian Chemical Society. Sao Paulo, v. 29, n. 5, p. 1162-1166, 2018.
10.21577/0103-5053.20180037
S0103-50532018000501162.pdf
0103-5053
S0103-50532018000501162
WOS:000427641700024
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal Of The Brazilian Chemical Society
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1162-1166
application/pdf
dc.coverage.none.fl_str_mv Sao Paulo
dc.publisher.none.fl_str_mv Soc Brasileira Quimica
publisher.none.fl_str_mv Soc Brasileira Quimica
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
_version_ 1814268435533660160

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