NMDA and AMPA/Kainate Glutamatergic Receptors in the Prelimbic Medial Prefrontal Cortex Modulate the Elaborated Defensive Behavior and Innate Fear-Induced Antinociception Elicited by GABA(A) Receptor Blockade in the Medial Hypothalamus
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/37792 http://dx.doi.org/10.1093/cercor/bht001 |
Resumo: | The aim of the present study was to investigate the involvement of N-methyl-d-aspartate (NMDA) and amino-3-hydroxy-5-methyl-isoxazole-4-proprionate (AMPA)/kainate receptors of the prelimbic (PL) division of the medial prefrontal cortex (MPFC) on the panic attack-like reactions evoked by gamma-aminobutyric acid-A receptor blockade in the medial hypothalamus (MH). Rats were pretreated with NaCl 0.9%, LY235959 (NMDA receptor antagonist), and NBQX (AMPA/kainate receptor antagonist) in the PL at 3 different concentrations. Ten minutes later, the MH was treated with bicuculline, and the defensive responses were recorded for 10 min. the antagonism of NMDA receptors in the PL decreased the frequency and duration of all defensive behaviors evoked by the stimulation of the MH and reduced the innate fear-induced antinociception. However, the pretreatment of the PL cortex with NBQX was able to decrease only part of defensive responses and innate fear-induced antinociception. the present findings suggest that the NMDA-glutamatergic system of the PL is critically involved in panic-like responses and innate fear-induced antinociception and those AMPA/kainate receptors are also recruited during the elaboration of fear-induced antinociception and in panic attack-related response. the activation of the glutamatergic neurotransmission of PL division of the MPFC during the elaboration of oriented behavioral reactions elicited by the chemical stimulation of the MH recruits mainly NMDA receptors in comparison with AMPA/kainate receptors. |
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Freitas, Renato Leonardo deSalgado-Rohner, Carlos JoseBiagioni, Audrey FranciscoMedeiros, Priscila [UNIFESP]Cecilio Hallak, Jaime EduardoCrippa, Jose Alexandre S.Coimbra, Norberto CysneUniversidade de São Paulo (USP)Universidade Federal de São Paulo (UNIFESP)Univ Fed Rio Grande do Sul2016-01-24T14:37:19Z2016-01-24T14:37:19Z2014-06-01Cerebral Cortex. Cary: Oxford Univ Press Inc, v. 24, n. 6, p. 1518-1528, 2014.1047-3211http://repositorio.unifesp.br/handle/11600/37792http://dx.doi.org/10.1093/cercor/bht00110.1093/cercor/bht001WOS:000336529700010The aim of the present study was to investigate the involvement of N-methyl-d-aspartate (NMDA) and amino-3-hydroxy-5-methyl-isoxazole-4-proprionate (AMPA)/kainate receptors of the prelimbic (PL) division of the medial prefrontal cortex (MPFC) on the panic attack-like reactions evoked by gamma-aminobutyric acid-A receptor blockade in the medial hypothalamus (MH). Rats were pretreated with NaCl 0.9%, LY235959 (NMDA receptor antagonist), and NBQX (AMPA/kainate receptor antagonist) in the PL at 3 different concentrations. Ten minutes later, the MH was treated with bicuculline, and the defensive responses were recorded for 10 min. the antagonism of NMDA receptors in the PL decreased the frequency and duration of all defensive behaviors evoked by the stimulation of the MH and reduced the innate fear-induced antinociception. However, the pretreatment of the PL cortex with NBQX was able to decrease only part of defensive responses and innate fear-induced antinociception. the present findings suggest that the NMDA-glutamatergic system of the PL is critically involved in panic-like responses and innate fear-induced antinociception and those AMPA/kainate receptors are also recruited during the elaboration of fear-induced antinociception and in panic attack-related response. the activation of the glutamatergic neurotransmission of PL division of the MPFC during the elaboration of oriented behavioral reactions elicited by the chemical stimulation of the MH recruits mainly NMDA receptors in comparison with AMPA/kainate receptors.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)FAEPAFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Magister Scientiae (M.Sc.) fellowshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Univ São Paulo, Fac Med Ribeirao Preto, Dept Farmacol, Lab Neuroanat & Neuropsicobiol, BR-14049900 Ribeirao Preto, SP, BrazilUniv São Paulo, Fac Med Ribeirao Preto, Dept Neurociencias & Ciencias Comportament, Setor Psiquiatria, BR-14049900 Ribeirao Preto, SP, BrazilUniv São Paulo, Fac Med Ribeirao Preto, Dept Farmacol, NAP USP Neurobiol Emocoes NuPNE, BR-14049900 Ribeirao Preto, SP, BrazilUniversidade Federal de São Paulo UNIFESP, Dept Biociencias, BR-1060001 Santos, SP, BrazilUniv Fed Rio Grande do Sul, CNPq, Natl Inst Sci & Translat Technol Med INCT TM, Porto Alegre, RS, BrazilUniv São Paulo, Inst Neurociencias & Comportamento INeC, BR-14040901 Ribeirao Preto, SP, BrazilUniversidade Federal de São Paulo UNIFESP, Dept Biociencias, BR-1060001 Santos, SP, BrazilCNPq: 483763/2010-1CNPq: 135930/2009-0CNPq: 301905/2010-0FAEPA: 345/2009FAPESP: 01/03752-6FAPESP: 2009/17258-5FAPESP: 2008/08955-1FAPESP: 2010/15140-4FAPESP: 2010/14446-2Magister Scientiae (M.Sc.) fellowship: 03/05256-1Web of Science1518-1528engOxford Univ Press IncCerebral Cortexhttp://www.oxfordjournals.org/access_purchase/self-archiving_policyb.htmlinfo:eu-repo/semantics/openAccessamino-3-hydroxy-5-methyl-isoxazole-4-proprionatekainate receptorsgamma-aminobutyric acid-A receptorsdorsomedial hypothalamusinnate fear-induced antinociceptionN-methyl-d-aspartate receptorspanic-like behaviorprelimbic medial prefrontal cortexNMDA and AMPA/Kainate Glutamatergic Receptors in the Prelimbic Medial Prefrontal Cortex Modulate the Elaborated Defensive Behavior and Innate Fear-Induced Antinociception Elicited by GABA(A) Receptor Blockade in the Medial Hypothalamusinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlereponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/377922023-02-15 10:56:36.096metadata only accessoai:repositorio.unifesp.br:11600/37792Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-02-15T13:56:36Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
NMDA and AMPA/Kainate Glutamatergic Receptors in the Prelimbic Medial Prefrontal Cortex Modulate the Elaborated Defensive Behavior and Innate Fear-Induced Antinociception Elicited by GABA(A) Receptor Blockade in the Medial Hypothalamus |
title |
NMDA and AMPA/Kainate Glutamatergic Receptors in the Prelimbic Medial Prefrontal Cortex Modulate the Elaborated Defensive Behavior and Innate Fear-Induced Antinociception Elicited by GABA(A) Receptor Blockade in the Medial Hypothalamus |
spellingShingle |
NMDA and AMPA/Kainate Glutamatergic Receptors in the Prelimbic Medial Prefrontal Cortex Modulate the Elaborated Defensive Behavior and Innate Fear-Induced Antinociception Elicited by GABA(A) Receptor Blockade in the Medial Hypothalamus Freitas, Renato Leonardo de amino-3-hydroxy-5-methyl-isoxazole-4-proprionate kainate receptors gamma-aminobutyric acid-A receptors dorsomedial hypothalamus innate fear-induced antinociception N-methyl-d-aspartate receptors panic-like behavior prelimbic medial prefrontal cortex |
title_short |
NMDA and AMPA/Kainate Glutamatergic Receptors in the Prelimbic Medial Prefrontal Cortex Modulate the Elaborated Defensive Behavior and Innate Fear-Induced Antinociception Elicited by GABA(A) Receptor Blockade in the Medial Hypothalamus |
title_full |
NMDA and AMPA/Kainate Glutamatergic Receptors in the Prelimbic Medial Prefrontal Cortex Modulate the Elaborated Defensive Behavior and Innate Fear-Induced Antinociception Elicited by GABA(A) Receptor Blockade in the Medial Hypothalamus |
title_fullStr |
NMDA and AMPA/Kainate Glutamatergic Receptors in the Prelimbic Medial Prefrontal Cortex Modulate the Elaborated Defensive Behavior and Innate Fear-Induced Antinociception Elicited by GABA(A) Receptor Blockade in the Medial Hypothalamus |
title_full_unstemmed |
NMDA and AMPA/Kainate Glutamatergic Receptors in the Prelimbic Medial Prefrontal Cortex Modulate the Elaborated Defensive Behavior and Innate Fear-Induced Antinociception Elicited by GABA(A) Receptor Blockade in the Medial Hypothalamus |
title_sort |
NMDA and AMPA/Kainate Glutamatergic Receptors in the Prelimbic Medial Prefrontal Cortex Modulate the Elaborated Defensive Behavior and Innate Fear-Induced Antinociception Elicited by GABA(A) Receptor Blockade in the Medial Hypothalamus |
author |
Freitas, Renato Leonardo de |
author_facet |
Freitas, Renato Leonardo de Salgado-Rohner, Carlos Jose Biagioni, Audrey Francisco Medeiros, Priscila [UNIFESP] Cecilio Hallak, Jaime Eduardo Crippa, Jose Alexandre S. Coimbra, Norberto Cysne |
author_role |
author |
author2 |
Salgado-Rohner, Carlos Jose Biagioni, Audrey Francisco Medeiros, Priscila [UNIFESP] Cecilio Hallak, Jaime Eduardo Crippa, Jose Alexandre S. Coimbra, Norberto Cysne |
author2_role |
author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Federal de São Paulo (UNIFESP) Univ Fed Rio Grande do Sul |
dc.contributor.author.fl_str_mv |
Freitas, Renato Leonardo de Salgado-Rohner, Carlos Jose Biagioni, Audrey Francisco Medeiros, Priscila [UNIFESP] Cecilio Hallak, Jaime Eduardo Crippa, Jose Alexandre S. Coimbra, Norberto Cysne |
dc.subject.eng.fl_str_mv |
amino-3-hydroxy-5-methyl-isoxazole-4-proprionate kainate receptors gamma-aminobutyric acid-A receptors dorsomedial hypothalamus innate fear-induced antinociception N-methyl-d-aspartate receptors panic-like behavior prelimbic medial prefrontal cortex |
topic |
amino-3-hydroxy-5-methyl-isoxazole-4-proprionate kainate receptors gamma-aminobutyric acid-A receptors dorsomedial hypothalamus innate fear-induced antinociception N-methyl-d-aspartate receptors panic-like behavior prelimbic medial prefrontal cortex |
description |
The aim of the present study was to investigate the involvement of N-methyl-d-aspartate (NMDA) and amino-3-hydroxy-5-methyl-isoxazole-4-proprionate (AMPA)/kainate receptors of the prelimbic (PL) division of the medial prefrontal cortex (MPFC) on the panic attack-like reactions evoked by gamma-aminobutyric acid-A receptor blockade in the medial hypothalamus (MH). Rats were pretreated with NaCl 0.9%, LY235959 (NMDA receptor antagonist), and NBQX (AMPA/kainate receptor antagonist) in the PL at 3 different concentrations. Ten minutes later, the MH was treated with bicuculline, and the defensive responses were recorded for 10 min. the antagonism of NMDA receptors in the PL decreased the frequency and duration of all defensive behaviors evoked by the stimulation of the MH and reduced the innate fear-induced antinociception. However, the pretreatment of the PL cortex with NBQX was able to decrease only part of defensive responses and innate fear-induced antinociception. the present findings suggest that the NMDA-glutamatergic system of the PL is critically involved in panic-like responses and innate fear-induced antinociception and those AMPA/kainate receptors are also recruited during the elaboration of fear-induced antinociception and in panic attack-related response. the activation of the glutamatergic neurotransmission of PL division of the MPFC during the elaboration of oriented behavioral reactions elicited by the chemical stimulation of the MH recruits mainly NMDA receptors in comparison with AMPA/kainate receptors. |
publishDate |
2014 |
dc.date.issued.fl_str_mv |
2014-06-01 |
dc.date.accessioned.fl_str_mv |
2016-01-24T14:37:19Z |
dc.date.available.fl_str_mv |
2016-01-24T14:37:19Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Cerebral Cortex. Cary: Oxford Univ Press Inc, v. 24, n. 6, p. 1518-1528, 2014. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/37792 http://dx.doi.org/10.1093/cercor/bht001 |
dc.identifier.issn.none.fl_str_mv |
1047-3211 |
dc.identifier.doi.none.fl_str_mv |
10.1093/cercor/bht001 |
dc.identifier.wos.none.fl_str_mv |
WOS:000336529700010 |
identifier_str_mv |
Cerebral Cortex. Cary: Oxford Univ Press Inc, v. 24, n. 6, p. 1518-1528, 2014. 1047-3211 10.1093/cercor/bht001 WOS:000336529700010 |
url |
http://repositorio.unifesp.br/handle/11600/37792 http://dx.doi.org/10.1093/cercor/bht001 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Cerebral Cortex |
dc.rights.driver.fl_str_mv |
http://www.oxfordjournals.org/access_purchase/self-archiving_policyb.html info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
http://www.oxfordjournals.org/access_purchase/self-archiving_policyb.html |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1518-1528 |
dc.publisher.none.fl_str_mv |
Oxford Univ Press Inc |
publisher.none.fl_str_mv |
Oxford Univ Press Inc |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
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1802764194778447872 |