The influence of nutritional status and disease on adiponectin and TNF-alpha levels in colorectal cancer patients

• Autor(a) principal: Vicente, Mariana Abe [UNIFESP]
• Data de Publicação: 2014
• Outros Autores: Silva, Tiago Donizetti [UNIFESP], Barao, Katia [UNIFESP], Felipe, Aledson Vitor [UNIFESP], Oyama, Lila Missae [UNIFESP], Forones, Nora Manoukian [UNIFESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: https://dx.doi.org/10.3305/nh.2014.30.1.7132; https://repositorio.unifesp.br/handle/11600/37908
• topic: Adipocytokines; Colorectal Cancer; Nutrition Assessment

Background: the aim of this study was to evaluate the association between adiponectin and tumor necrosis factor-a (TNF-alpha) serum levels in colorectal cancer (CRC) patients and compare these levels to clinical stage and nutritional status.Methods: A total of 79 patients were enrolled in the study (39 with CRC and 40 in the control). Nutritional status was assessed by Patient-Generated Subjective Global Assessment (PG-SGA), body mass index (BMI), and phase angle (PhA). Adiponectin and TNF-alpha serum concentrations were determined using an enzyme-linked immunosorbent assay.Results: Serum adiponectin levels were higher among CRC patients (p = 0.001). TNF-alpha serum levels were not significantly different between the groups, but patients with stage III or IV CRC had higher levels of TNF-alpha than those with lower stage disease (p = 0.037). the three tools used for the assessment of nutritional status (BMI, PhA, and PG-SGA) demonstrated that patients with a more severe nutritional deficit had higher adipocytokine levels, although these differences were significant only to TNF-alpha, when distributed PhA in tertiles.Conclusions: Adiponectin levels were higher among CRC patients. Although TNF-alpha serum levels from CRC patients did not differ significantly to the control group, CRC patients with stage III or IV had higher levels compared to those with stage I and II tumors. Nutritional status, as determined by BMI, PhA, and PG-SGA, demonstrated that patients with a greatest nutritional deficit, had higher levels of adipocytokines; however, these differences were significant only for TNF-alpha, when distributed PhA in tertiles.