Human tissue kallikreins 3 and 5 can act as plasminogen activator releasing active plasmin

Detalhes bibliográficos
Autor(a) principal: Souza, Lucas R. de
Data de Publicação: 2013
Outros Autores: Melo, Pollyana Maria Saud [UNIFESP], Paschoalin, Thaysa [UNIFESP], Carmona, Adriana Karaoglanovic [UNIFESP], Kondo, Marcia Yuri [UNIFESP], Hirata, Izaura Yoshico [UNIFESP], Blaber, Michael, Tersariol, Ivarne Luis dos Santos [UNIFESP], Takatsuka, Joyce, Juliano, Maria Aparecida [UNIFESP], Juliano, Luiz [UNIFESP], Gomes, Roseli A., Puzer, Luciano
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1016/j.bbrc.2013.03.001
http://repositorio.unifesp.br/handle/11600/36204
Resumo: Human tissue kallikreins (KLKs) are a group of serine proteases found in many tissues and biological fluids and are differentially expressed in several specific pathologies. Here, we present evidences of the ability of these enzymes to activate plasminogen. Kallikreins 3 and 5 were able to induce plasmin activity after hydrolyzing plasminogen, and we also verified that plasminogen activation was potentiated in the presence of glycosaminoglycans compared with plasminogen activation by tPA. This finding can shed new light on the plasminogen/plasmin system and its involvement in tumor metastasis, in which kallikreins appear to be upregulated. (C) 2013 Elsevier Inc. All rights reserved.
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spelling Human tissue kallikreins 3 and 5 can act as plasminogen activator releasing active plasminPlasminogenPlasminKallikreinProteaseHuman tissue kallikreins (KLKs) are a group of serine proteases found in many tissues and biological fluids and are differentially expressed in several specific pathologies. Here, we present evidences of the ability of these enzymes to activate plasminogen. Kallikreins 3 and 5 were able to induce plasmin activity after hydrolyzing plasminogen, and we also verified that plasminogen activation was potentiated in the presence of glycosaminoglycans compared with plasminogen activation by tPA. This finding can shed new light on the plasminogen/plasmin system and its involvement in tumor metastasis, in which kallikreins appear to be upregulated. (C) 2013 Elsevier Inc. All rights reserved.Univ Fed ABC, Ctr Ciencias Nat & Humanas, Santo Andre, SP, BrazilUniversidade Federal de São Paulo, Dept Biofis, Sao Carlos, SP, BrazilFlorida State Univ, Coll Med, Dept Biomed Sci, Tallahassee, FL 32306 USAUniv Mogi das Cruzes, Ctr Interdisciplinar Invest Bioquim, São Paulo, BrazilUniv Fed Triangulo Mineiro, Inst Ciencias Biol & Nat, Uberaba, MG, BrazilUniversidade Federal de São Paulo, Dept Biofis, Sao Carlos, SP, BrazilWeb of ScienceFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)FAPESP: Proc 2011/51297-8CNPq: 312701/2009-8Elsevier B.V.Universidade Federal do ABC (UFABC)Universidade Federal de São Paulo (UNIFESP)Florida State UnivUniv Mogi das CruzesUniv Fed Triangulo MineiroSouza, Lucas R. deMelo, Pollyana Maria Saud [UNIFESP]Paschoalin, Thaysa [UNIFESP]Carmona, Adriana Karaoglanovic [UNIFESP]Kondo, Marcia Yuri [UNIFESP]Hirata, Izaura Yoshico [UNIFESP]Blaber, MichaelTersariol, Ivarne Luis dos Santos [UNIFESP]Takatsuka, JoyceJuliano, Maria Aparecida [UNIFESP]Juliano, Luiz [UNIFESP]Gomes, Roseli A.Puzer, Luciano2016-01-24T14:31:34Z2016-01-24T14:31:34Z2013-04-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion333-337application/pdfhttp://dx.doi.org/10.1016/j.bbrc.2013.03.001Biochemical and Biophysical Research Communications. San Diego: Academic Press Inc Elsevier Science, v. 433, n. 3, p. 333-337, 2013.10.1016/j.bbrc.2013.03.001WOS000318190400012.pdf0006-291Xhttp://repositorio.unifesp.br/handle/11600/36204WOS:000318190400012engBiochemical and Biophysical Research Communicationsinfo:eu-repo/semantics/openAccesshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policyreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-06T20:38:48Zoai:repositorio.unifesp.br/:11600/36204Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-06T20:38:48Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Human tissue kallikreins 3 and 5 can act as plasminogen activator releasing active plasmin
title Human tissue kallikreins 3 and 5 can act as plasminogen activator releasing active plasmin
spellingShingle Human tissue kallikreins 3 and 5 can act as plasminogen activator releasing active plasmin
Souza, Lucas R. de
Plasminogen
Plasmin
Kallikrein
Protease
title_short Human tissue kallikreins 3 and 5 can act as plasminogen activator releasing active plasmin
title_full Human tissue kallikreins 3 and 5 can act as plasminogen activator releasing active plasmin
title_fullStr Human tissue kallikreins 3 and 5 can act as plasminogen activator releasing active plasmin
title_full_unstemmed Human tissue kallikreins 3 and 5 can act as plasminogen activator releasing active plasmin
title_sort Human tissue kallikreins 3 and 5 can act as plasminogen activator releasing active plasmin
author Souza, Lucas R. de
author_facet Souza, Lucas R. de
Melo, Pollyana Maria Saud [UNIFESP]
Paschoalin, Thaysa [UNIFESP]
Carmona, Adriana Karaoglanovic [UNIFESP]
Kondo, Marcia Yuri [UNIFESP]
Hirata, Izaura Yoshico [UNIFESP]
Blaber, Michael
Tersariol, Ivarne Luis dos Santos [UNIFESP]
Takatsuka, Joyce
Juliano, Maria Aparecida [UNIFESP]
Juliano, Luiz [UNIFESP]
Gomes, Roseli A.
Puzer, Luciano
author_role author
author2 Melo, Pollyana Maria Saud [UNIFESP]
Paschoalin, Thaysa [UNIFESP]
Carmona, Adriana Karaoglanovic [UNIFESP]
Kondo, Marcia Yuri [UNIFESP]
Hirata, Izaura Yoshico [UNIFESP]
Blaber, Michael
Tersariol, Ivarne Luis dos Santos [UNIFESP]
Takatsuka, Joyce
Juliano, Maria Aparecida [UNIFESP]
Juliano, Luiz [UNIFESP]
Gomes, Roseli A.
Puzer, Luciano
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal do ABC (UFABC)
Universidade Federal de São Paulo (UNIFESP)
Florida State Univ
Univ Mogi das Cruzes
Univ Fed Triangulo Mineiro
dc.contributor.author.fl_str_mv Souza, Lucas R. de
Melo, Pollyana Maria Saud [UNIFESP]
Paschoalin, Thaysa [UNIFESP]
Carmona, Adriana Karaoglanovic [UNIFESP]
Kondo, Marcia Yuri [UNIFESP]
Hirata, Izaura Yoshico [UNIFESP]
Blaber, Michael
Tersariol, Ivarne Luis dos Santos [UNIFESP]
Takatsuka, Joyce
Juliano, Maria Aparecida [UNIFESP]
Juliano, Luiz [UNIFESP]
Gomes, Roseli A.
Puzer, Luciano
dc.subject.por.fl_str_mv Plasminogen
Plasmin
Kallikrein
Protease
topic Plasminogen
Plasmin
Kallikrein
Protease
description Human tissue kallikreins (KLKs) are a group of serine proteases found in many tissues and biological fluids and are differentially expressed in several specific pathologies. Here, we present evidences of the ability of these enzymes to activate plasminogen. Kallikreins 3 and 5 were able to induce plasmin activity after hydrolyzing plasminogen, and we also verified that plasminogen activation was potentiated in the presence of glycosaminoglycans compared with plasminogen activation by tPA. This finding can shed new light on the plasminogen/plasmin system and its involvement in tumor metastasis, in which kallikreins appear to be upregulated. (C) 2013 Elsevier Inc. All rights reserved.
publishDate 2013
dc.date.none.fl_str_mv 2013-04-12
2016-01-24T14:31:34Z
2016-01-24T14:31:34Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.bbrc.2013.03.001
Biochemical and Biophysical Research Communications. San Diego: Academic Press Inc Elsevier Science, v. 433, n. 3, p. 333-337, 2013.
10.1016/j.bbrc.2013.03.001
WOS000318190400012.pdf
0006-291X
http://repositorio.unifesp.br/handle/11600/36204
WOS:000318190400012
url http://dx.doi.org/10.1016/j.bbrc.2013.03.001
http://repositorio.unifesp.br/handle/11600/36204
identifier_str_mv Biochemical and Biophysical Research Communications. San Diego: Academic Press Inc Elsevier Science, v. 433, n. 3, p. 333-337, 2013.
10.1016/j.bbrc.2013.03.001
WOS000318190400012.pdf
0006-291X
WOS:000318190400012
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Biochemical and Biophysical Research Communications
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
eu_rights_str_mv openAccess
rights_invalid_str_mv http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.format.none.fl_str_mv 333-337
application/pdf
dc.publisher.none.fl_str_mv Elsevier B.V.
publisher.none.fl_str_mv Elsevier B.V.
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
_version_ 1814268289123090432

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