Use of single photon emission computed tomography and magnetic resonance to evaluate central nervous system involvement in patients with juvenile systemic lupus erythematosus
Autor(a) principal: | |
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Data de Publicação: | 2002 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/1477 http://dx.doi.org/10.1590/S0100-879X2002000700007 |
Resumo: | The objective of the present study was to identify the single photon emission computed tomography (SPECT) and magnetic resonance (MR) findings in juvenile systemic lupus erythematosus (JSLE) patients with CNS involvement and to try to correlate them with neurological clinical history data and neurological clinical examination. Nineteen patients with JSLE (16 girls and 3 boys, mean age at onset 9.2 years) were submitted to neurological examination, electroencephalography, cerebrospinal fluid analysis, SPECT and MR. All the evaluations were made separately within a period of 15 days. SPECT and MR findings were analyzed independently by two radiologists. Electroencephalography and cerebrospinal fluid analysis revealed no relevant alterations. Ten of 19 patients (53%) presented neurological abnormalities including present or past neurological clinical history (8/19, 42%), abnormal neurological clinical examination (5/19, 26%), and abnormal SPECT or MR (8/19, 42% and 3/19, 16%, respectively). The most common changes in SPECT were cerebral hypoperfusion and heterogeneous distribution of blood flow. The most common abnormalities in MR were leukomalacia and diffuse alterations of white matter. There was a correlation between SPECT and MR (P<0.05). We conclude that SPECT and MR are complementary and useful exams in the evaluation of neurological involvement of lupus. |
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Prismich, Glaucia [UNIFESP]Hilário, Maria Odete Esteves [UNIFESP]Len, Claudio Arnaldo [UNIFESP]Terreri, Maria Teresa Ramos Ascensão [UNIFESP]Quaresma, Marina Rodrigues [UNIFESP]Alonso, Gilberto [UNIFESP]Sevillano, Marta Maite [UNIFESP]Lederman, Henrique Manoel [UNIFESP]Universidade Federal de São Paulo (UNIFESP)2015-06-14T13:29:45Z2015-06-14T13:29:45Z2002-07-01Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 35, n. 7, p. 805-810, 2002.0100-879Xhttp://repositorio.unifesp.br/handle/11600/1477http://dx.doi.org/10.1590/S0100-879X2002000700007S0100-879X2002000700007.pdfS0100-879X200200070000710.1590/S0100-879X2002000700007WOS:000177456600007The objective of the present study was to identify the single photon emission computed tomography (SPECT) and magnetic resonance (MR) findings in juvenile systemic lupus erythematosus (JSLE) patients with CNS involvement and to try to correlate them with neurological clinical history data and neurological clinical examination. Nineteen patients with JSLE (16 girls and 3 boys, mean age at onset 9.2 years) were submitted to neurological examination, electroencephalography, cerebrospinal fluid analysis, SPECT and MR. All the evaluations were made separately within a period of 15 days. SPECT and MR findings were analyzed independently by two radiologists. Electroencephalography and cerebrospinal fluid analysis revealed no relevant alterations. Ten of 19 patients (53%) presented neurological abnormalities including present or past neurological clinical history (8/19, 42%), abnormal neurological clinical examination (5/19, 26%), and abnormal SPECT or MR (8/19, 42% and 3/19, 16%, respectively). The most common changes in SPECT were cerebral hypoperfusion and heterogeneous distribution of blood flow. The most common abnormalities in MR were leukomalacia and diffuse alterations of white matter. There was a correlation between SPECT and MR (P<0.05). We conclude that SPECT and MR are complementary and useful exams in the evaluation of neurological involvement of lupus.Universidade Federal de São Paulo (UNIFESP) Departamento de Pediatria Divisão de Alergia, Imunologia Clínica e ReumatologiaUniversidade Federal de São Paulo (UNIFESP) Departamento de Diagnóstico por Imagem Divisão de Medicina NuclearUNIFESP, Depto. de Pediatria Divisão de Alergia, Imunologia Clínica e ReumatologiaUNIFESP, Depto. de Diagnóstico por Imagem Divisão de Medicina NuclearSciELO805-810engAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological ResearchSystemic lupus erythematosusCentral nervous systemSingle photon emission computed tomographyMagnetic resonanceNeurological clinical historyUse of single photon emission computed tomography and magnetic resonance to evaluate central nervous system involvement in patients with juvenile systemic lupus erythematosusinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALS0100-879X2002000700007.pdfapplication/pdf478089${dspace.ui.url}/bitstream/11600/1477/1/S0100-879X2002000700007.pdf8b573ede327764092afb0747c534e719MD51open accessTEXTS0100-879X2002000700007.pdf.txtS0100-879X2002000700007.pdf.txtExtracted texttext/plain17610${dspace.ui.url}/bitstream/11600/1477/21/S0100-879X2002000700007.pdf.txte4d5ca6664faaa624dd3c0ad766f6b18MD521open accessTHUMBNAILS0100-879X2002000700007.pdf.jpgS0100-879X2002000700007.pdf.jpgIM Thumbnailimage/jpeg5892${dspace.ui.url}/bitstream/11600/1477/23/S0100-879X2002000700007.pdf.jpg6861789995857a95ff591fa027f61896MD523open access11600/14772023-06-05 19:11:55.191open accessoai:repositorio.unifesp.br:11600/1477Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-06-05T22:11:55Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Use of single photon emission computed tomography and magnetic resonance to evaluate central nervous system involvement in patients with juvenile systemic lupus erythematosus |
title |
Use of single photon emission computed tomography and magnetic resonance to evaluate central nervous system involvement in patients with juvenile systemic lupus erythematosus |
spellingShingle |
Use of single photon emission computed tomography and magnetic resonance to evaluate central nervous system involvement in patients with juvenile systemic lupus erythematosus Prismich, Glaucia [UNIFESP] Systemic lupus erythematosus Central nervous system Single photon emission computed tomography Magnetic resonance Neurological clinical history |
title_short |
Use of single photon emission computed tomography and magnetic resonance to evaluate central nervous system involvement in patients with juvenile systemic lupus erythematosus |
title_full |
Use of single photon emission computed tomography and magnetic resonance to evaluate central nervous system involvement in patients with juvenile systemic lupus erythematosus |
title_fullStr |
Use of single photon emission computed tomography and magnetic resonance to evaluate central nervous system involvement in patients with juvenile systemic lupus erythematosus |
title_full_unstemmed |
Use of single photon emission computed tomography and magnetic resonance to evaluate central nervous system involvement in patients with juvenile systemic lupus erythematosus |
title_sort |
Use of single photon emission computed tomography and magnetic resonance to evaluate central nervous system involvement in patients with juvenile systemic lupus erythematosus |
author |
Prismich, Glaucia [UNIFESP] |
author_facet |
Prismich, Glaucia [UNIFESP] Hilário, Maria Odete Esteves [UNIFESP] Len, Claudio Arnaldo [UNIFESP] Terreri, Maria Teresa Ramos Ascensão [UNIFESP] Quaresma, Marina Rodrigues [UNIFESP] Alonso, Gilberto [UNIFESP] Sevillano, Marta Maite [UNIFESP] Lederman, Henrique Manoel [UNIFESP] |
author_role |
author |
author2 |
Hilário, Maria Odete Esteves [UNIFESP] Len, Claudio Arnaldo [UNIFESP] Terreri, Maria Teresa Ramos Ascensão [UNIFESP] Quaresma, Marina Rodrigues [UNIFESP] Alonso, Gilberto [UNIFESP] Sevillano, Marta Maite [UNIFESP] Lederman, Henrique Manoel [UNIFESP] |
author2_role |
author author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Prismich, Glaucia [UNIFESP] Hilário, Maria Odete Esteves [UNIFESP] Len, Claudio Arnaldo [UNIFESP] Terreri, Maria Teresa Ramos Ascensão [UNIFESP] Quaresma, Marina Rodrigues [UNIFESP] Alonso, Gilberto [UNIFESP] Sevillano, Marta Maite [UNIFESP] Lederman, Henrique Manoel [UNIFESP] |
dc.subject.eng.fl_str_mv |
Systemic lupus erythematosus Central nervous system Single photon emission computed tomography Magnetic resonance Neurological clinical history |
topic |
Systemic lupus erythematosus Central nervous system Single photon emission computed tomography Magnetic resonance Neurological clinical history |
description |
The objective of the present study was to identify the single photon emission computed tomography (SPECT) and magnetic resonance (MR) findings in juvenile systemic lupus erythematosus (JSLE) patients with CNS involvement and to try to correlate them with neurological clinical history data and neurological clinical examination. Nineteen patients with JSLE (16 girls and 3 boys, mean age at onset 9.2 years) were submitted to neurological examination, electroencephalography, cerebrospinal fluid analysis, SPECT and MR. All the evaluations were made separately within a period of 15 days. SPECT and MR findings were analyzed independently by two radiologists. Electroencephalography and cerebrospinal fluid analysis revealed no relevant alterations. Ten of 19 patients (53%) presented neurological abnormalities including present or past neurological clinical history (8/19, 42%), abnormal neurological clinical examination (5/19, 26%), and abnormal SPECT or MR (8/19, 42% and 3/19, 16%, respectively). The most common changes in SPECT were cerebral hypoperfusion and heterogeneous distribution of blood flow. The most common abnormalities in MR were leukomalacia and diffuse alterations of white matter. There was a correlation between SPECT and MR (P<0.05). We conclude that SPECT and MR are complementary and useful exams in the evaluation of neurological involvement of lupus. |
publishDate |
2002 |
dc.date.issued.fl_str_mv |
2002-07-01 |
dc.date.accessioned.fl_str_mv |
2015-06-14T13:29:45Z |
dc.date.available.fl_str_mv |
2015-06-14T13:29:45Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 35, n. 7, p. 805-810, 2002. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/1477 http://dx.doi.org/10.1590/S0100-879X2002000700007 |
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0100-879X |
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S0100-879X2002000700007.pdf |
dc.identifier.scielo.none.fl_str_mv |
S0100-879X2002000700007 |
dc.identifier.doi.none.fl_str_mv |
10.1590/S0100-879X2002000700007 |
dc.identifier.wos.none.fl_str_mv |
WOS:000177456600007 |
identifier_str_mv |
Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 35, n. 7, p. 805-810, 2002. 0100-879X S0100-879X2002000700007.pdf S0100-879X2002000700007 10.1590/S0100-879X2002000700007 WOS:000177456600007 |
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http://repositorio.unifesp.br/handle/11600/1477 http://dx.doi.org/10.1590/S0100-879X2002000700007 |
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