Could sudden cardiac death in epilepsy be related to the occurrence of thalamic dysfunction or anatomic change?

Detalhes bibliográficos
Autor(a) principal: Scorza, Fulvio Alexandre [UNIFESP]
Data de Publicação: 2009
Outros Autores: Calderazzo, Lineu [UNIFESP], Albuquerque, Marly de [UNIFESP], Arida, Ricardo Mario [UNIFESP], Almeida, Antonio-Carlos G. de, Cavalheiro, Esper Abrão [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/S0004-282X2009000100037
http://repositorio.unifesp.br/handle/11600/4945
Resumo: Sudden unexpected death in epilepsy (SUDEP) is the most important direct epilepsy-related cause of death in people with chronic epilepsy. Its physiopathology is still unknown; however, the most commonly suggested potential mechanisms involve cardiac or respiratory abnormalities. As the anatomical substrate of epileptic activity in the central nervous system (CNS) shows a direct relationship with cardiovascular alterations, this may suggests that patients with epilepsy associated with focal CNS lesions may be at particular risk of SUDEP. Currently, experimental and clinical data support an important role for thalamic nuclei in the behavioural manifestations, initiation and propagation of seizures. In view of the above findings, we purpose that SUDEP, at least in some cases, could be related to the occurrence of thalamic dysfunction or anatomic change.
id UFSP_3bf237c7793a7c19a6336eac1e63f3f1
oai_identifier_str oai:repositorio.unifesp.br/:11600/4945
network_acronym_str UFSP
network_name_str Repositório Institucional da UNIFESP
repository_id_str 3465
spelling Could sudden cardiac death in epilepsy be related to the occurrence of thalamic dysfunction or anatomic change?A morte súbita cardíaca em epilepsia poderia estar relacionada com a ocorrência de alterações anatômicas ou funcionais do tálamo?epilepsycardiovascular abnormalitiesheartthalamussudden unexpected death in epilepsyepilepsiaalterações cardiovascularescoraçãotálamomorte súbita e inesperada nas epilepsiasSudden unexpected death in epilepsy (SUDEP) is the most important direct epilepsy-related cause of death in people with chronic epilepsy. Its physiopathology is still unknown; however, the most commonly suggested potential mechanisms involve cardiac or respiratory abnormalities. As the anatomical substrate of epileptic activity in the central nervous system (CNS) shows a direct relationship with cardiovascular alterations, this may suggests that patients with epilepsy associated with focal CNS lesions may be at particular risk of SUDEP. Currently, experimental and clinical data support an important role for thalamic nuclei in the behavioural manifestations, initiation and propagation of seizures. In view of the above findings, we purpose that SUDEP, at least in some cases, could be related to the occurrence of thalamic dysfunction or anatomic change.A morte súbita e inesperada nas epilepsias (SUDEP) é a mais importante causa de morte em pacientes com epilepsia. A fisiopatologia da SUDEP ainda é desconhecida, no entanto, os prováveis mecanismos estão relacionados com alterações cardiovasculares ou respiratórias. Como o substrato anatômico da atividade epiléptica no sistema nervoso central (SNC) apresenta direta relação com alterações cardiovasculares, esse fato sugere que pacientes com epilepsia e lesões focais no SNC podem apresentar maior risco para SUDEP. Atualmente, dados experimentais e clínicos demonstram um importante papel dos núcleos talâmicos nas manifestações comportamentais, bem como no início e propagação das crises epilépticas. Sendo assim, nós acreditamos que a SUDEP, pelo menos em alguns casos, poderia estar relacionada com a ocorrência de alterações anatômicas ou disfunções talâmicas.Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Disciplina de Neurologia ExperimentalUNIFESP-EPM Departamento de FisiologiaUniversidade Federal de São João Del Rei Departamento de Engenharia BiomédicaUNIFESP, EPM, Disciplina de Neurologia ExperimentalUNIFESP, EPM Depto. de FisiologiaSciELOAcademia Brasileira de Neurologia - ABNEUROUniversidade Federal de São Paulo (UNIFESP)Universidade Federal de São João Del Rei Departamento de Engenharia BiomédicaScorza, Fulvio Alexandre [UNIFESP]Calderazzo, Lineu [UNIFESP]Albuquerque, Marly de [UNIFESP]Arida, Ricardo Mario [UNIFESP]Almeida, Antonio-Carlos G. deCavalheiro, Esper Abrão [UNIFESP]2015-06-14T13:39:07Z2015-06-14T13:39:07Z2009-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion139-143application/pdfhttp://dx.doi.org/10.1590/S0004-282X2009000100037Arquivos de Neuro-Psiquiatria. Academia Brasileira de Neurologia - ABNEURO, v. 67, n. 1, p. 139-143, 2009.10.1590/S0004-282X2009000100037S0004-282X2009000100037.pdf0004-282XS0004-282X2009000100037http://repositorio.unifesp.br/handle/11600/4945WOS:000264693900037engArquivos de Neuro-Psiquiatriainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-05T17:52:09Zoai:repositorio.unifesp.br/:11600/4945Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-05T17:52:09Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Could sudden cardiac death in epilepsy be related to the occurrence of thalamic dysfunction or anatomic change?
A morte súbita cardíaca em epilepsia poderia estar relacionada com a ocorrência de alterações anatômicas ou funcionais do tálamo?
title Could sudden cardiac death in epilepsy be related to the occurrence of thalamic dysfunction or anatomic change?
spellingShingle Could sudden cardiac death in epilepsy be related to the occurrence of thalamic dysfunction or anatomic change?
Scorza, Fulvio Alexandre [UNIFESP]
epilepsy
cardiovascular abnormalities
heart
thalamus
sudden unexpected death in epilepsy
epilepsia
alterações cardiovasculares
coração
tálamo
morte súbita e inesperada nas epilepsias
title_short Could sudden cardiac death in epilepsy be related to the occurrence of thalamic dysfunction or anatomic change?
title_full Could sudden cardiac death in epilepsy be related to the occurrence of thalamic dysfunction or anatomic change?
title_fullStr Could sudden cardiac death in epilepsy be related to the occurrence of thalamic dysfunction or anatomic change?
title_full_unstemmed Could sudden cardiac death in epilepsy be related to the occurrence of thalamic dysfunction or anatomic change?
title_sort Could sudden cardiac death in epilepsy be related to the occurrence of thalamic dysfunction or anatomic change?
author Scorza, Fulvio Alexandre [UNIFESP]
author_facet Scorza, Fulvio Alexandre [UNIFESP]
Calderazzo, Lineu [UNIFESP]
Albuquerque, Marly de [UNIFESP]
Arida, Ricardo Mario [UNIFESP]
Almeida, Antonio-Carlos G. de
Cavalheiro, Esper Abrão [UNIFESP]
author_role author
author2 Calderazzo, Lineu [UNIFESP]
Albuquerque, Marly de [UNIFESP]
Arida, Ricardo Mario [UNIFESP]
Almeida, Antonio-Carlos G. de
Cavalheiro, Esper Abrão [UNIFESP]
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
Universidade Federal de São João Del Rei Departamento de Engenharia Biomédica
dc.contributor.author.fl_str_mv Scorza, Fulvio Alexandre [UNIFESP]
Calderazzo, Lineu [UNIFESP]
Albuquerque, Marly de [UNIFESP]
Arida, Ricardo Mario [UNIFESP]
Almeida, Antonio-Carlos G. de
Cavalheiro, Esper Abrão [UNIFESP]
dc.subject.por.fl_str_mv epilepsy
cardiovascular abnormalities
heart
thalamus
sudden unexpected death in epilepsy
epilepsia
alterações cardiovasculares
coração
tálamo
morte súbita e inesperada nas epilepsias
topic epilepsy
cardiovascular abnormalities
heart
thalamus
sudden unexpected death in epilepsy
epilepsia
alterações cardiovasculares
coração
tálamo
morte súbita e inesperada nas epilepsias
description Sudden unexpected death in epilepsy (SUDEP) is the most important direct epilepsy-related cause of death in people with chronic epilepsy. Its physiopathology is still unknown; however, the most commonly suggested potential mechanisms involve cardiac or respiratory abnormalities. As the anatomical substrate of epileptic activity in the central nervous system (CNS) shows a direct relationship with cardiovascular alterations, this may suggests that patients with epilepsy associated with focal CNS lesions may be at particular risk of SUDEP. Currently, experimental and clinical data support an important role for thalamic nuclei in the behavioural manifestations, initiation and propagation of seizures. In view of the above findings, we purpose that SUDEP, at least in some cases, could be related to the occurrence of thalamic dysfunction or anatomic change.
publishDate 2009
dc.date.none.fl_str_mv 2009-03-01
2015-06-14T13:39:07Z
2015-06-14T13:39:07Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0004-282X2009000100037
Arquivos de Neuro-Psiquiatria. Academia Brasileira de Neurologia - ABNEURO, v. 67, n. 1, p. 139-143, 2009.
10.1590/S0004-282X2009000100037
S0004-282X2009000100037.pdf
0004-282X
S0004-282X2009000100037
http://repositorio.unifesp.br/handle/11600/4945
WOS:000264693900037
url http://dx.doi.org/10.1590/S0004-282X2009000100037
http://repositorio.unifesp.br/handle/11600/4945
identifier_str_mv Arquivos de Neuro-Psiquiatria. Academia Brasileira de Neurologia - ABNEURO, v. 67, n. 1, p. 139-143, 2009.
10.1590/S0004-282X2009000100037
S0004-282X2009000100037.pdf
0004-282X
S0004-282X2009000100037
WOS:000264693900037
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Arquivos de Neuro-Psiquiatria
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 139-143
application/pdf
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
_version_ 1814268359148044288

Registros relacionados