Analysis of clinical characteristics and risk factors for mortality in human status epilepticus
Autor(a) principal: | |
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Data de Publicação: | 2003 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/27369 http://dx.doi.org/10.1016/S1059-1311(02)00324-2 |
Resumo: | Purpose: To analyse clinical data including aetiology, age, antecedents, classification and mortality in human status epilepticus (SE), and to assess prognostic factors for mortality.Methods: A prospective study was performed, including detailed analysis of clinical and laboratorial data of SE in individuals of any age. except neonates.Results: One hundred and eleven SE were included, with patients' age ranging from 3 months to 98 years. SE incidence peaked in the first year of life, and 59.4% of the individuals had previous epilepsy while 40.6% had not. the main underlying causes were noncompliance to treatment in the first group, and CNS infection, stroke and metabolic disturbances in the second group. Overall mortality was 19.8%. and deaths were correlated to aetiology and patient's age. Refractory SE affected 11.7% of the cases. Clinical types included focal, secondarily generalised and generalised SE. Clinical and clinicoelectrographic classifications were convergent, but EEG was essential for the diagnosis in 4.5% of the cases.Conclusions: Epileptic patients are at greater risk to develop SE, however, individuals with no prior history of epilepsy and acute neurological problems can also present SE. Aetiology varies with patient's age, and mortality is high and related to age and underlying causes. Clinical and clinicoelectrographic classifications are usually convergent, but in some cases the diagnosis of SE would not be established without the EEG. (C) 2003 BEA Trading Ltd. Published by Elsevier B.V. All rights reserved. |
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Garzon, Eliana [UNIFESP]Fernandes, Regina Maria FrançaSakamoto, Américo Ceiki [UNIFESP]Universidade Federal de São Paulo (UNIFESP)Universidade de São Paulo (USP)2016-01-24T12:34:00Z2016-01-24T12:34:00Z2003-09-01Seizure-european Journal of Epilepsy. London: W B Saunders Co Ltd, v. 12, n. 6, p. 337-345, 2003.1059-1311http://repositorio.unifesp.br/handle/11600/27369http://dx.doi.org/10.1016/S1059-1311(02)00324-2WOS000185039300003.pdf10.1016/S1059-1311(02)00324-2WOS:000185039300003Purpose: To analyse clinical data including aetiology, age, antecedents, classification and mortality in human status epilepticus (SE), and to assess prognostic factors for mortality.Methods: A prospective study was performed, including detailed analysis of clinical and laboratorial data of SE in individuals of any age. except neonates.Results: One hundred and eleven SE were included, with patients' age ranging from 3 months to 98 years. SE incidence peaked in the first year of life, and 59.4% of the individuals had previous epilepsy while 40.6% had not. the main underlying causes were noncompliance to treatment in the first group, and CNS infection, stroke and metabolic disturbances in the second group. Overall mortality was 19.8%. and deaths were correlated to aetiology and patient's age. Refractory SE affected 11.7% of the cases. Clinical types included focal, secondarily generalised and generalised SE. Clinical and clinicoelectrographic classifications were convergent, but EEG was essential for the diagnosis in 4.5% of the cases.Conclusions: Epileptic patients are at greater risk to develop SE, however, individuals with no prior history of epilepsy and acute neurological problems can also present SE. Aetiology varies with patient's age, and mortality is high and related to age and underlying causes. Clinical and clinicoelectrographic classifications are usually convergent, but in some cases the diagnosis of SE would not be established without the EEG. (C) 2003 BEA Trading Ltd. Published by Elsevier B.V. All rights reserved.Universidade Federal de São Paulo, Dept Neurol & Neurosurg, São Paulo, BrazilUniv São Paulo, Ribeirao Preto Sch Med, Dept Neurol Psychiat & Psychol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Neurol & Neurosurg, São Paulo, BrazilWeb of Science337-345engW B Saunders Co LtdSeizure-european Journal of Epilepsystatus epilepticusrefractory status epilepticusEpilepsyMortalityEEGAnalysis of clinical characteristics and risk factors for mortality in human status epilepticusinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000185039300003.pdfapplication/pdf217988${dspace.ui.url}/bitstream/11600/27369/1/WOS000185039300003.pdf64873408db00b2463e2b9643a8249fb1MD51open accessTEXTWOS000185039300003.pdf.txtWOS000185039300003.pdf.txtExtracted texttext/plain34816${dspace.ui.url}/bitstream/11600/27369/2/WOS000185039300003.pdf.txt7d1e1eb37cb1e352b94632497acb459eMD52open access11600/273692023-01-24 21:58:58.376open accessoai:repositorio.unifesp.br:11600/27369Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:44:02.660589Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Analysis of clinical characteristics and risk factors for mortality in human status epilepticus |
title |
Analysis of clinical characteristics and risk factors for mortality in human status epilepticus |
spellingShingle |
Analysis of clinical characteristics and risk factors for mortality in human status epilepticus Garzon, Eliana [UNIFESP] status epilepticus refractory status epilepticus Epilepsy Mortality EEG |
title_short |
Analysis of clinical characteristics and risk factors for mortality in human status epilepticus |
title_full |
Analysis of clinical characteristics and risk factors for mortality in human status epilepticus |
title_fullStr |
Analysis of clinical characteristics and risk factors for mortality in human status epilepticus |
title_full_unstemmed |
Analysis of clinical characteristics and risk factors for mortality in human status epilepticus |
title_sort |
Analysis of clinical characteristics and risk factors for mortality in human status epilepticus |
author |
Garzon, Eliana [UNIFESP] |
author_facet |
Garzon, Eliana [UNIFESP] Fernandes, Regina Maria França Sakamoto, Américo Ceiki [UNIFESP] |
author_role |
author |
author2 |
Fernandes, Regina Maria França Sakamoto, Américo Ceiki [UNIFESP] |
author2_role |
author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Garzon, Eliana [UNIFESP] Fernandes, Regina Maria França Sakamoto, Américo Ceiki [UNIFESP] |
dc.subject.eng.fl_str_mv |
status epilepticus refractory status epilepticus Epilepsy Mortality EEG |
topic |
status epilepticus refractory status epilepticus Epilepsy Mortality EEG |
description |
Purpose: To analyse clinical data including aetiology, age, antecedents, classification and mortality in human status epilepticus (SE), and to assess prognostic factors for mortality.Methods: A prospective study was performed, including detailed analysis of clinical and laboratorial data of SE in individuals of any age. except neonates.Results: One hundred and eleven SE were included, with patients' age ranging from 3 months to 98 years. SE incidence peaked in the first year of life, and 59.4% of the individuals had previous epilepsy while 40.6% had not. the main underlying causes were noncompliance to treatment in the first group, and CNS infection, stroke and metabolic disturbances in the second group. Overall mortality was 19.8%. and deaths were correlated to aetiology and patient's age. Refractory SE affected 11.7% of the cases. Clinical types included focal, secondarily generalised and generalised SE. Clinical and clinicoelectrographic classifications were convergent, but EEG was essential for the diagnosis in 4.5% of the cases.Conclusions: Epileptic patients are at greater risk to develop SE, however, individuals with no prior history of epilepsy and acute neurological problems can also present SE. Aetiology varies with patient's age, and mortality is high and related to age and underlying causes. Clinical and clinicoelectrographic classifications are usually convergent, but in some cases the diagnosis of SE would not be established without the EEG. (C) 2003 BEA Trading Ltd. Published by Elsevier B.V. All rights reserved. |
publishDate |
2003 |
dc.date.issued.fl_str_mv |
2003-09-01 |
dc.date.accessioned.fl_str_mv |
2016-01-24T12:34:00Z |
dc.date.available.fl_str_mv |
2016-01-24T12:34:00Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
Seizure-european Journal of Epilepsy. London: W B Saunders Co Ltd, v. 12, n. 6, p. 337-345, 2003. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/27369 http://dx.doi.org/10.1016/S1059-1311(02)00324-2 |
dc.identifier.issn.none.fl_str_mv |
1059-1311 |
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WOS000185039300003.pdf |
dc.identifier.doi.none.fl_str_mv |
10.1016/S1059-1311(02)00324-2 |
dc.identifier.wos.none.fl_str_mv |
WOS:000185039300003 |
identifier_str_mv |
Seizure-european Journal of Epilepsy. London: W B Saunders Co Ltd, v. 12, n. 6, p. 337-345, 2003. 1059-1311 WOS000185039300003.pdf 10.1016/S1059-1311(02)00324-2 WOS:000185039300003 |
url |
http://repositorio.unifesp.br/handle/11600/27369 http://dx.doi.org/10.1016/S1059-1311(02)00324-2 |
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eng |
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Seizure-european Journal of Epilepsy |
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openAccess |
dc.format.none.fl_str_mv |
337-345 |
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W B Saunders Co Ltd |
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W B Saunders Co Ltd |
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