Tratamento de Diabetes e Hipertensão no Paciente Obeso

Detalhes bibliográficos
Autor(a) principal: Faria, Alessandra Nunes [UNIFESP]
Data de Publicação: 2002
Outros Autores: Zanella, Maria Teresa [UNIFESP], Kohlmann Junior, Osvaldo [UNIFESP], Ribeiro, Artur B. [UNIFESP]
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/S0004-27302002000200004
http://repositorio.unifesp.br/handle/11600/1399
Resumo: Obesity is an independent risk factor for coronary heart disease and it is associated with insulin resistance, which contributes to the development of dyslipidemia, hypertension, and type 2 diabetes. The coexistence of hypertension and diabetes increases the risk for macrovascular and microvascular complications, predisposing patients to congestive heart failure, coronary heart disease, cerebral and peripheral vascular diseases, nephropathy, and retinopathy. In obese diabetic patients, body weight reduction, as well as metiformin therapy, increase insulin sensitivity and enhance blood pressure and glicemic control. Antihypertensive treatment in diabetic patients decreases cardiovascular mortality and delays the decline of the glomerular function. Pharmacological treatment should consider the effects of the antihypertensive agents on insulin sensitivity and lipid profile. Diuretics and b-blockers are reported to reduce insulin sensitivity, whereas calcium channel blockers are metabolically neutral and ACE inhibitors increase insulin sensitivity and confer additional renal and vascular protection to diabetic patients. Angiotensin II antagonists has shown similar effects.
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spelling Tratamento de Diabetes e Hipertensão no Paciente ObesoTreating Diabetes and Hypertension in the Obese PatientDiabetesHypertensionObesityDrug therapyDiabetesHipertensãoObesidadeTerapia medicamentosaObesity is an independent risk factor for coronary heart disease and it is associated with insulin resistance, which contributes to the development of dyslipidemia, hypertension, and type 2 diabetes. The coexistence of hypertension and diabetes increases the risk for macrovascular and microvascular complications, predisposing patients to congestive heart failure, coronary heart disease, cerebral and peripheral vascular diseases, nephropathy, and retinopathy. In obese diabetic patients, body weight reduction, as well as metiformin therapy, increase insulin sensitivity and enhance blood pressure and glicemic control. Antihypertensive treatment in diabetic patients decreases cardiovascular mortality and delays the decline of the glomerular function. Pharmacological treatment should consider the effects of the antihypertensive agents on insulin sensitivity and lipid profile. Diuretics and b-blockers are reported to reduce insulin sensitivity, whereas calcium channel blockers are metabolically neutral and ACE inhibitors increase insulin sensitivity and confer additional renal and vascular protection to diabetic patients. Angiotensin II antagonists has shown similar effects.A obesidade é um fator de risco independente para doença coronariana. A resistência à insulina associada à obesidade contribui para o desenvolvimento de dislipidemia, hipertensão arterial e diabetes tipo 2. A coexistência de hipertensão e diabetes aumenta o risco para complicações micro e macrovasculares, predispondo os indivíduos à insuficiência cardíaca congestiva, doença coronariana e cerebrovascular, insuficiência arterial periférica, nefropatia e retinopatia. Em pacientes diabéticos obesos a redução do peso, bem como o uso de metiformina, melhoram a sensibilidade à insulina, o controle da glicemia e da pressão arterial. O tratamento anti-hipertensivo em diabéticos reduz a mortalidade cardiovascular e retarda o declínio da função glomerular. Deve-se considerar os efeitos dos agentes anti-hipertensivos sobre a sensibilidade à insulina e o perfil lipídico. Diuréticos e b-bloqueadores podem reduzir a sensibilidade à insulina, enquanto bloqueadores de canais de cálcio são metabolicamente neutros e os iECA aumentam a sensibilidade à insulina, além de conferir proteção adicional cardiovascular e renal para diabéticos. O bloqueio da angiotensina II tem mostrado benefícios semelhantes.Universidade Federal de São Paulo (UNIFESP) Escola Paulista de MedicinaUNIFESP, EPMSciELOSociedade Brasileira de Endocrinologia e MetabologiaUniversidade Federal de São Paulo (UNIFESP)Faria, Alessandra Nunes [UNIFESP]Zanella, Maria Teresa [UNIFESP]Kohlmann Junior, Osvaldo [UNIFESP]Ribeiro, Artur B. [UNIFESP]2015-06-14T13:29:39Z2015-06-14T13:29:39Z2002-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion137-142application/pdfhttp://dx.doi.org/10.1590/S0004-27302002000200004Arquivos Brasileiros de Endocrinologia & Metabologia. Sociedade Brasileira de Endocrinologia e Metabologia, v. 46, n. 2, p. 137-142, 2002.10.1590/S0004-27302002000200004S0004-27302002000200004.pdf0004-2730S0004-27302002000200004http://repositorio.unifesp.br/handle/11600/1399porArquivos Brasileiros de Endocrinologia & Metabologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-05T14:23:47Zoai:repositorio.unifesp.br/:11600/1399Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-05T14:23:47Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Tratamento de Diabetes e Hipertensão no Paciente Obeso
Treating Diabetes and Hypertension in the Obese Patient
title Tratamento de Diabetes e Hipertensão no Paciente Obeso
spellingShingle Tratamento de Diabetes e Hipertensão no Paciente Obeso
Faria, Alessandra Nunes [UNIFESP]
Diabetes
Hypertension
Obesity
Drug therapy
Diabetes
Hipertensão
Obesidade
Terapia medicamentosa
title_short Tratamento de Diabetes e Hipertensão no Paciente Obeso
title_full Tratamento de Diabetes e Hipertensão no Paciente Obeso
title_fullStr Tratamento de Diabetes e Hipertensão no Paciente Obeso
title_full_unstemmed Tratamento de Diabetes e Hipertensão no Paciente Obeso
title_sort Tratamento de Diabetes e Hipertensão no Paciente Obeso
author Faria, Alessandra Nunes [UNIFESP]
author_facet Faria, Alessandra Nunes [UNIFESP]
Zanella, Maria Teresa [UNIFESP]
Kohlmann Junior, Osvaldo [UNIFESP]
Ribeiro, Artur B. [UNIFESP]
author_role author
author2 Zanella, Maria Teresa [UNIFESP]
Kohlmann Junior, Osvaldo [UNIFESP]
Ribeiro, Artur B. [UNIFESP]
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Faria, Alessandra Nunes [UNIFESP]
Zanella, Maria Teresa [UNIFESP]
Kohlmann Junior, Osvaldo [UNIFESP]
Ribeiro, Artur B. [UNIFESP]
dc.subject.por.fl_str_mv Diabetes
Hypertension
Obesity
Drug therapy
Diabetes
Hipertensão
Obesidade
Terapia medicamentosa
topic Diabetes
Hypertension
Obesity
Drug therapy
Diabetes
Hipertensão
Obesidade
Terapia medicamentosa
description Obesity is an independent risk factor for coronary heart disease and it is associated with insulin resistance, which contributes to the development of dyslipidemia, hypertension, and type 2 diabetes. The coexistence of hypertension and diabetes increases the risk for macrovascular and microvascular complications, predisposing patients to congestive heart failure, coronary heart disease, cerebral and peripheral vascular diseases, nephropathy, and retinopathy. In obese diabetic patients, body weight reduction, as well as metiformin therapy, increase insulin sensitivity and enhance blood pressure and glicemic control. Antihypertensive treatment in diabetic patients decreases cardiovascular mortality and delays the decline of the glomerular function. Pharmacological treatment should consider the effects of the antihypertensive agents on insulin sensitivity and lipid profile. Diuretics and b-blockers are reported to reduce insulin sensitivity, whereas calcium channel blockers are metabolically neutral and ACE inhibitors increase insulin sensitivity and confer additional renal and vascular protection to diabetic patients. Angiotensin II antagonists has shown similar effects.
publishDate 2002
dc.date.none.fl_str_mv 2002-04-01
2015-06-14T13:29:39Z
2015-06-14T13:29:39Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0004-27302002000200004
Arquivos Brasileiros de Endocrinologia & Metabologia. Sociedade Brasileira de Endocrinologia e Metabologia, v. 46, n. 2, p. 137-142, 2002.
10.1590/S0004-27302002000200004
S0004-27302002000200004.pdf
0004-2730
S0004-27302002000200004
http://repositorio.unifesp.br/handle/11600/1399
url http://dx.doi.org/10.1590/S0004-27302002000200004
http://repositorio.unifesp.br/handle/11600/1399
identifier_str_mv Arquivos Brasileiros de Endocrinologia & Metabologia. Sociedade Brasileira de Endocrinologia e Metabologia, v. 46, n. 2, p. 137-142, 2002.
10.1590/S0004-27302002000200004
S0004-27302002000200004.pdf
0004-2730
S0004-27302002000200004
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv Arquivos Brasileiros de Endocrinologia & Metabologia
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 137-142
application/pdf
dc.publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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