Tratamento de Diabetes e Hipertensão no Paciente Obeso
Autor(a) principal: | |
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Data de Publicação: | 2002 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://dx.doi.org/10.1590/S0004-27302002000200004 http://repositorio.unifesp.br/handle/11600/1399 |
Resumo: | Obesity is an independent risk factor for coronary heart disease and it is associated with insulin resistance, which contributes to the development of dyslipidemia, hypertension, and type 2 diabetes. The coexistence of hypertension and diabetes increases the risk for macrovascular and microvascular complications, predisposing patients to congestive heart failure, coronary heart disease, cerebral and peripheral vascular diseases, nephropathy, and retinopathy. In obese diabetic patients, body weight reduction, as well as metiformin therapy, increase insulin sensitivity and enhance blood pressure and glicemic control. Antihypertensive treatment in diabetic patients decreases cardiovascular mortality and delays the decline of the glomerular function. Pharmacological treatment should consider the effects of the antihypertensive agents on insulin sensitivity and lipid profile. Diuretics and b-blockers are reported to reduce insulin sensitivity, whereas calcium channel blockers are metabolically neutral and ACE inhibitors increase insulin sensitivity and confer additional renal and vascular protection to diabetic patients. Angiotensin II antagonists has shown similar effects. |
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Tratamento de Diabetes e Hipertensão no Paciente ObesoTreating Diabetes and Hypertension in the Obese PatientDiabetesHypertensionObesityDrug therapyDiabetesHipertensãoObesidadeTerapia medicamentosaObesity is an independent risk factor for coronary heart disease and it is associated with insulin resistance, which contributes to the development of dyslipidemia, hypertension, and type 2 diabetes. The coexistence of hypertension and diabetes increases the risk for macrovascular and microvascular complications, predisposing patients to congestive heart failure, coronary heart disease, cerebral and peripheral vascular diseases, nephropathy, and retinopathy. In obese diabetic patients, body weight reduction, as well as metiformin therapy, increase insulin sensitivity and enhance blood pressure and glicemic control. Antihypertensive treatment in diabetic patients decreases cardiovascular mortality and delays the decline of the glomerular function. Pharmacological treatment should consider the effects of the antihypertensive agents on insulin sensitivity and lipid profile. Diuretics and b-blockers are reported to reduce insulin sensitivity, whereas calcium channel blockers are metabolically neutral and ACE inhibitors increase insulin sensitivity and confer additional renal and vascular protection to diabetic patients. Angiotensin II antagonists has shown similar effects.A obesidade é um fator de risco independente para doença coronariana. A resistência à insulina associada à obesidade contribui para o desenvolvimento de dislipidemia, hipertensão arterial e diabetes tipo 2. A coexistência de hipertensão e diabetes aumenta o risco para complicações micro e macrovasculares, predispondo os indivíduos à insuficiência cardíaca congestiva, doença coronariana e cerebrovascular, insuficiência arterial periférica, nefropatia e retinopatia. Em pacientes diabéticos obesos a redução do peso, bem como o uso de metiformina, melhoram a sensibilidade à insulina, o controle da glicemia e da pressão arterial. O tratamento anti-hipertensivo em diabéticos reduz a mortalidade cardiovascular e retarda o declínio da função glomerular. Deve-se considerar os efeitos dos agentes anti-hipertensivos sobre a sensibilidade à insulina e o perfil lipídico. Diuréticos e b-bloqueadores podem reduzir a sensibilidade à insulina, enquanto bloqueadores de canais de cálcio são metabolicamente neutros e os iECA aumentam a sensibilidade à insulina, além de conferir proteção adicional cardiovascular e renal para diabéticos. O bloqueio da angiotensina II tem mostrado benefícios semelhantes.Universidade Federal de São Paulo (UNIFESP) Escola Paulista de MedicinaUNIFESP, EPMSciELOSociedade Brasileira de Endocrinologia e MetabologiaUniversidade Federal de São Paulo (UNIFESP)Faria, Alessandra Nunes [UNIFESP]Zanella, Maria Teresa [UNIFESP]Kohlmann Junior, Osvaldo [UNIFESP]Ribeiro, Artur B. [UNIFESP]2015-06-14T13:29:39Z2015-06-14T13:29:39Z2002-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion137-142application/pdfhttp://dx.doi.org/10.1590/S0004-27302002000200004Arquivos Brasileiros de Endocrinologia & Metabologia. Sociedade Brasileira de Endocrinologia e Metabologia, v. 46, n. 2, p. 137-142, 2002.10.1590/S0004-27302002000200004S0004-27302002000200004.pdf0004-2730S0004-27302002000200004http://repositorio.unifesp.br/handle/11600/1399porArquivos Brasileiros de Endocrinologia & Metabologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-05T14:23:47Zoai:repositorio.unifesp.br/:11600/1399Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-05T14:23:47Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Tratamento de Diabetes e Hipertensão no Paciente Obeso Treating Diabetes and Hypertension in the Obese Patient |
title |
Tratamento de Diabetes e Hipertensão no Paciente Obeso |
spellingShingle |
Tratamento de Diabetes e Hipertensão no Paciente Obeso Faria, Alessandra Nunes [UNIFESP] Diabetes Hypertension Obesity Drug therapy Diabetes Hipertensão Obesidade Terapia medicamentosa |
title_short |
Tratamento de Diabetes e Hipertensão no Paciente Obeso |
title_full |
Tratamento de Diabetes e Hipertensão no Paciente Obeso |
title_fullStr |
Tratamento de Diabetes e Hipertensão no Paciente Obeso |
title_full_unstemmed |
Tratamento de Diabetes e Hipertensão no Paciente Obeso |
title_sort |
Tratamento de Diabetes e Hipertensão no Paciente Obeso |
author |
Faria, Alessandra Nunes [UNIFESP] |
author_facet |
Faria, Alessandra Nunes [UNIFESP] Zanella, Maria Teresa [UNIFESP] Kohlmann Junior, Osvaldo [UNIFESP] Ribeiro, Artur B. [UNIFESP] |
author_role |
author |
author2 |
Zanella, Maria Teresa [UNIFESP] Kohlmann Junior, Osvaldo [UNIFESP] Ribeiro, Artur B. [UNIFESP] |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Faria, Alessandra Nunes [UNIFESP] Zanella, Maria Teresa [UNIFESP] Kohlmann Junior, Osvaldo [UNIFESP] Ribeiro, Artur B. [UNIFESP] |
dc.subject.por.fl_str_mv |
Diabetes Hypertension Obesity Drug therapy Diabetes Hipertensão Obesidade Terapia medicamentosa |
topic |
Diabetes Hypertension Obesity Drug therapy Diabetes Hipertensão Obesidade Terapia medicamentosa |
description |
Obesity is an independent risk factor for coronary heart disease and it is associated with insulin resistance, which contributes to the development of dyslipidemia, hypertension, and type 2 diabetes. The coexistence of hypertension and diabetes increases the risk for macrovascular and microvascular complications, predisposing patients to congestive heart failure, coronary heart disease, cerebral and peripheral vascular diseases, nephropathy, and retinopathy. In obese diabetic patients, body weight reduction, as well as metiformin therapy, increase insulin sensitivity and enhance blood pressure and glicemic control. Antihypertensive treatment in diabetic patients decreases cardiovascular mortality and delays the decline of the glomerular function. Pharmacological treatment should consider the effects of the antihypertensive agents on insulin sensitivity and lipid profile. Diuretics and b-blockers are reported to reduce insulin sensitivity, whereas calcium channel blockers are metabolically neutral and ACE inhibitors increase insulin sensitivity and confer additional renal and vascular protection to diabetic patients. Angiotensin II antagonists has shown similar effects. |
publishDate |
2002 |
dc.date.none.fl_str_mv |
2002-04-01 2015-06-14T13:29:39Z 2015-06-14T13:29:39Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S0004-27302002000200004 Arquivos Brasileiros de Endocrinologia & Metabologia. Sociedade Brasileira de Endocrinologia e Metabologia, v. 46, n. 2, p. 137-142, 2002. 10.1590/S0004-27302002000200004 S0004-27302002000200004.pdf 0004-2730 S0004-27302002000200004 http://repositorio.unifesp.br/handle/11600/1399 |
url |
http://dx.doi.org/10.1590/S0004-27302002000200004 http://repositorio.unifesp.br/handle/11600/1399 |
identifier_str_mv |
Arquivos Brasileiros de Endocrinologia & Metabologia. Sociedade Brasileira de Endocrinologia e Metabologia, v. 46, n. 2, p. 137-142, 2002. 10.1590/S0004-27302002000200004 S0004-27302002000200004.pdf 0004-2730 S0004-27302002000200004 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
Arquivos Brasileiros de Endocrinologia & Metabologia |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
137-142 application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Endocrinologia e Metabologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Endocrinologia e Metabologia |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
_version_ |
1814268376741052416 |