A Naturally Occurring Antibody Fragment Neutralizes Infectivity of Diverse Infectious Agents

Detalhes bibliográficos
Autor(a) principal: Polonelli, Luciano
Data de Publicação: 2016
Outros Autores: Ciociola, Tecla, Elviri, Lisa, Zanello, Pier Paolo, Giovati, Laura, Arruda, Denise Costa [UNIFESP], Munoz, Julian E., Mortara, Renato Arruda [UNIFESP], Morace, Giulia, Borghi, Elisa, Galati, Serena, Marin, Oriano, Casoli, Claudio, Pilotti, Elisabetta, Ronzi, Paola, Travassos, Luiz Roberto [UNIFESP], Magliani, Walter, Conti, Stefania
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1038/srep35018
https://repositorio.unifesp.br/handle/11600/56907
Resumo: A phosphorylated peptide, named K40H, derived from the constant region of IgMs was detected in human serum by liquid chromatography coupled to high-resolution mass spectrometry. Synthetic K40H proved to exert a potent in vitro activity against fungal pathogens, and to inhibit HIV-1 replication in vitro and ex vivo. It also showed a therapeutic effect against an experimental infection by Candida albicans in the invertebrate model Galleria mellonella. K40H represents the proof of concept of the innate role that naturally occurring antibody fragments may exert against infectious agents, shedding a new light upon the posthumous role of antibodies and opening a new scenario on the multifaceted functionality of humoral immunity.
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spelling A Naturally Occurring Antibody Fragment Neutralizes Infectivity of Diverse Infectious AgentsA phosphorylated peptide, named K40H, derived from the constant region of IgMs was detected in human serum by liquid chromatography coupled to high-resolution mass spectrometry. Synthetic K40H proved to exert a potent in vitro activity against fungal pathogens, and to inhibit HIV-1 replication in vitro and ex vivo. It also showed a therapeutic effect against an experimental infection by Candida albicans in the invertebrate model Galleria mellonella. K40H represents the proof of concept of the innate role that naturally occurring antibody fragments may exert against infectious agents, shedding a new light upon the posthumous role of antibodies and opening a new scenario on the multifaceted functionality of humoral immunity.Univ Parma, Dept Biomed Biotechnol & Translat Sci, Microbiol & Virol Unit, Parma, ItalyUniv Parma, Dept Pharm, Parma, ItalyFed Univ Sao Paulo UNIFESP, Expt Oncol Unit, Sao Paulo, BrazilUniv Sao Paulo, Dept Microbiol, Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Microbiol Immunol & Parasitol, Sao Paulo, BrazilUniv Milan, Dept Hlth Sci, Milan, ItalyUniv Parma, Dept Life Sci, Parma, ItalyUniv Padua, Dept Biomed Sci, Padua, ItalyUniv Milan, L Sacco Dept Biomed & Clin Sci, Milan, ItalyCtr Med Res & Mol Diagnost, GEMIB Lab, Parma, ItalyExperimental Oncology Unit, Universidade Federal de São Paulo (UNIFESP), São Paulo, BrazilDepartment of Microbiology, Immunology and Parasitology, Universidade Federal de São Paulo (UNIFESP), São Paulo, BrazilWeb of ScienceNature Publishing Group2020-07-31T12:47:33Z2020-07-31T12:47:33Z2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion-application/pdfhttp://dx.doi.org/10.1038/srep35018Scientific Reports. London, v. 6, p. -, 2016.10.1038/srep35018WOS000385063800001.pdf2045-2322https://repositorio.unifesp.br/handle/11600/56907WOS:000385063800001engScientific ReportsLondoninfo:eu-repo/semantics/openAccessPolonelli, LucianoCiociola, TeclaElviri, LisaZanello, Pier PaoloGiovati, LauraArruda, Denise Costa [UNIFESP]Munoz, Julian E.Mortara, Renato Arruda [UNIFESP]Morace, GiuliaBorghi, ElisaGalati, SerenaMarin, OrianoCasoli, ClaudioPilotti, ElisabettaRonzi, PaolaTravassos, Luiz Roberto [UNIFESP]Magliani, WalterConti, Stefaniareponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-03T12:32:46Zoai:repositorio.unifesp.br/:11600/56907Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-03T12:32:46Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv A Naturally Occurring Antibody Fragment Neutralizes Infectivity of Diverse Infectious Agents
title A Naturally Occurring Antibody Fragment Neutralizes Infectivity of Diverse Infectious Agents
spellingShingle A Naturally Occurring Antibody Fragment Neutralizes Infectivity of Diverse Infectious Agents
Polonelli, Luciano
title_short A Naturally Occurring Antibody Fragment Neutralizes Infectivity of Diverse Infectious Agents
title_full A Naturally Occurring Antibody Fragment Neutralizes Infectivity of Diverse Infectious Agents
title_fullStr A Naturally Occurring Antibody Fragment Neutralizes Infectivity of Diverse Infectious Agents
title_full_unstemmed A Naturally Occurring Antibody Fragment Neutralizes Infectivity of Diverse Infectious Agents
title_sort A Naturally Occurring Antibody Fragment Neutralizes Infectivity of Diverse Infectious Agents
author Polonelli, Luciano
author_facet Polonelli, Luciano
Ciociola, Tecla
Elviri, Lisa
Zanello, Pier Paolo
Giovati, Laura
Arruda, Denise Costa [UNIFESP]
Munoz, Julian E.
Mortara, Renato Arruda [UNIFESP]
Morace, Giulia
Borghi, Elisa
Galati, Serena
Marin, Oriano
Casoli, Claudio
Pilotti, Elisabetta
Ronzi, Paola
Travassos, Luiz Roberto [UNIFESP]
Magliani, Walter
Conti, Stefania
author_role author
author2 Ciociola, Tecla
Elviri, Lisa
Zanello, Pier Paolo
Giovati, Laura
Arruda, Denise Costa [UNIFESP]
Munoz, Julian E.
Mortara, Renato Arruda [UNIFESP]
Morace, Giulia
Borghi, Elisa
Galati, Serena
Marin, Oriano
Casoli, Claudio
Pilotti, Elisabetta
Ronzi, Paola
Travassos, Luiz Roberto [UNIFESP]
Magliani, Walter
Conti, Stefania
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Polonelli, Luciano
Ciociola, Tecla
Elviri, Lisa
Zanello, Pier Paolo
Giovati, Laura
Arruda, Denise Costa [UNIFESP]
Munoz, Julian E.
Mortara, Renato Arruda [UNIFESP]
Morace, Giulia
Borghi, Elisa
Galati, Serena
Marin, Oriano
Casoli, Claudio
Pilotti, Elisabetta
Ronzi, Paola
Travassos, Luiz Roberto [UNIFESP]
Magliani, Walter
Conti, Stefania
description A phosphorylated peptide, named K40H, derived from the constant region of IgMs was detected in human serum by liquid chromatography coupled to high-resolution mass spectrometry. Synthetic K40H proved to exert a potent in vitro activity against fungal pathogens, and to inhibit HIV-1 replication in vitro and ex vivo. It also showed a therapeutic effect against an experimental infection by Candida albicans in the invertebrate model Galleria mellonella. K40H represents the proof of concept of the innate role that naturally occurring antibody fragments may exert against infectious agents, shedding a new light upon the posthumous role of antibodies and opening a new scenario on the multifaceted functionality of humoral immunity.
publishDate 2016
dc.date.none.fl_str_mv 2016
2020-07-31T12:47:33Z
2020-07-31T12:47:33Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1038/srep35018
Scientific Reports. London, v. 6, p. -, 2016.
10.1038/srep35018
WOS000385063800001.pdf
2045-2322
https://repositorio.unifesp.br/handle/11600/56907
WOS:000385063800001
url http://dx.doi.org/10.1038/srep35018
https://repositorio.unifesp.br/handle/11600/56907
identifier_str_mv Scientific Reports. London, v. 6, p. -, 2016.
10.1038/srep35018
WOS000385063800001.pdf
2045-2322
WOS:000385063800001
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Scientific Reports
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv -
application/pdf
dc.coverage.none.fl_str_mv London
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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