Langmuir films containing ibuprofen and phospholipids
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/35978 http://dx.doi.org/10.1016/j.cplett.2012.12.064 |
Resumo: | This study shows the incorporation of ibuprofen, an anti-inflammatory drug, in Langmuir monolayers as cell membrane models. Significant effects were observed for dipalmitoyl phosphatidyl choline (DPPC) monolayers with relevant changes in the elasticity of the monolayer. Dipalmitoyl phosphatidyl glycerol (DPPG) monolayers were affected by small concentrations of ibuprofen, from 1 to 5 mol%. for both types of monolayer, ibuprofen could penetrate into the hydrophobic part of the monolayer, which was confirmed with polarization-modulated infrared reflection-absorption spectroscopy (PM-IRRAS). Brewster angle microscopy (BAM) images showed that ibuprofen prevents the formation of large domains of DPPC. the pharmacological action should occur primarily with penetration of ibuprofen via electrically neutral phospholipid headgroups of the membrane. (c) 2013 Elsevier B.V. All rights reserved. |
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Geraldo, Vananelia P. N.Pavinatto, Felippe J.Nobre, Thatyane M.Caseli, Luciano [UNIFESP]Oliveira, Osvaldo N.Universidade de São Paulo (USP)Universidade Federal de São Paulo (UNIFESP)2016-01-24T14:31:16Z2016-01-24T14:31:16Z2013-02-20Chemical Physics Letters. Amsterdam: Elsevier B.V., v. 559, p. 99-106, 2013.0009-2614http://repositorio.unifesp.br/handle/11600/35978http://dx.doi.org/10.1016/j.cplett.2012.12.064WOS000314728300018.pdf10.1016/j.cplett.2012.12.064WOS:000314728300018This study shows the incorporation of ibuprofen, an anti-inflammatory drug, in Langmuir monolayers as cell membrane models. Significant effects were observed for dipalmitoyl phosphatidyl choline (DPPC) monolayers with relevant changes in the elasticity of the monolayer. Dipalmitoyl phosphatidyl glycerol (DPPG) monolayers were affected by small concentrations of ibuprofen, from 1 to 5 mol%. for both types of monolayer, ibuprofen could penetrate into the hydrophobic part of the monolayer, which was confirmed with polarization-modulated infrared reflection-absorption spectroscopy (PM-IRRAS). Brewster angle microscopy (BAM) images showed that ibuprofen prevents the formation of large domains of DPPC. the pharmacological action should occur primarily with penetration of ibuprofen via electrically neutral phospholipid headgroups of the membrane. (c) 2013 Elsevier B.V. All rights reserved.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)rede nBioNet (Brazil)Univ São Paulo, Inst Fis Sao Carlos, BR-13560970 Sao Carlos, SP, BrazilUniversidade Federal de São Paulo, Inst Ciencias Ambientais Quim & Farmaceut, Diadema, SP, BrazilUniversidade Federal de São Paulo, Inst Ciencias Ambientais Quim & Farmaceut, Diadema, SP, BrazilWeb of Science99-106engElsevier B.V.Chemical Physics Lettershttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policyinfo:eu-repo/semantics/openAccessLangmuir films containing ibuprofen and phospholipidsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlereponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000314728300018.pdfapplication/pdf767524${dspace.ui.url}/bitstream/11600/35978/1/WOS000314728300018.pdf744b857cd89e2f826f4ad551a00e9142MD51open accessTEXTWOS000314728300018.pdf.txtWOS000314728300018.pdf.txtExtracted texttext/plain40523${dspace.ui.url}/bitstream/11600/35978/2/WOS000314728300018.pdf.txtb972134736ccb180ac6c47b611264e1cMD52open access11600/359782016-02-01 03:16:37.483open accessoai:repositorio.unifesp.br:11600/35978Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652016-02-01T05:16:37Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Langmuir films containing ibuprofen and phospholipids |
title |
Langmuir films containing ibuprofen and phospholipids |
spellingShingle |
Langmuir films containing ibuprofen and phospholipids Geraldo, Vananelia P. N. |
title_short |
Langmuir films containing ibuprofen and phospholipids |
title_full |
Langmuir films containing ibuprofen and phospholipids |
title_fullStr |
Langmuir films containing ibuprofen and phospholipids |
title_full_unstemmed |
Langmuir films containing ibuprofen and phospholipids |
title_sort |
Langmuir films containing ibuprofen and phospholipids |
author |
Geraldo, Vananelia P. N. |
author_facet |
Geraldo, Vananelia P. N. Pavinatto, Felippe J. Nobre, Thatyane M. Caseli, Luciano [UNIFESP] Oliveira, Osvaldo N. |
author_role |
author |
author2 |
Pavinatto, Felippe J. Nobre, Thatyane M. Caseli, Luciano [UNIFESP] Oliveira, Osvaldo N. |
author2_role |
author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Geraldo, Vananelia P. N. Pavinatto, Felippe J. Nobre, Thatyane M. Caseli, Luciano [UNIFESP] Oliveira, Osvaldo N. |
description |
This study shows the incorporation of ibuprofen, an anti-inflammatory drug, in Langmuir monolayers as cell membrane models. Significant effects were observed for dipalmitoyl phosphatidyl choline (DPPC) monolayers with relevant changes in the elasticity of the monolayer. Dipalmitoyl phosphatidyl glycerol (DPPG) monolayers were affected by small concentrations of ibuprofen, from 1 to 5 mol%. for both types of monolayer, ibuprofen could penetrate into the hydrophobic part of the monolayer, which was confirmed with polarization-modulated infrared reflection-absorption spectroscopy (PM-IRRAS). Brewster angle microscopy (BAM) images showed that ibuprofen prevents the formation of large domains of DPPC. the pharmacological action should occur primarily with penetration of ibuprofen via electrically neutral phospholipid headgroups of the membrane. (c) 2013 Elsevier B.V. All rights reserved. |
publishDate |
2013 |
dc.date.issued.fl_str_mv |
2013-02-20 |
dc.date.accessioned.fl_str_mv |
2016-01-24T14:31:16Z |
dc.date.available.fl_str_mv |
2016-01-24T14:31:16Z |
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info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Chemical Physics Letters. Amsterdam: Elsevier B.V., v. 559, p. 99-106, 2013. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/35978 http://dx.doi.org/10.1016/j.cplett.2012.12.064 |
dc.identifier.issn.none.fl_str_mv |
0009-2614 |
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WOS000314728300018.pdf |
dc.identifier.doi.none.fl_str_mv |
10.1016/j.cplett.2012.12.064 |
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WOS:000314728300018 |
identifier_str_mv |
Chemical Physics Letters. Amsterdam: Elsevier B.V., v. 559, p. 99-106, 2013. 0009-2614 WOS000314728300018.pdf 10.1016/j.cplett.2012.12.064 WOS:000314728300018 |
url |
http://repositorio.unifesp.br/handle/11600/35978 http://dx.doi.org/10.1016/j.cplett.2012.12.064 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
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Chemical Physics Letters |
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http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy info:eu-repo/semantics/openAccess |
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http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy |
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openAccess |
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99-106 |
dc.publisher.none.fl_str_mv |
Elsevier B.V. |
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Elsevier B.V. |
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