Habitual exercise program protects murine intestinal, skeletal, and cardiac muscles against aging
Autor(a) principal: | |
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Data de Publicação: | 2005 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/28481 http://dx.doi.org/10.1152/japplphysiol.00417.2005 |
Resumo: | Aging and aerobic exercise are two conditions known to interfere with health and quality of life, most likely by inducing oxidative stress to the organism. We studied the effects of aging on the morphological and functional properties of skeletal, cardiac, and intestinal muscles and their corresponding oxidative status in C57BL/6 mice and investigated whether a lifelong moderate exercise program would exert a protective effect against some deleterious effects of aging. As expected, aged animals presented a significant reduction of physical performance, accompanied by a decrease of gastrocnemius cross-sectional area and cardiac hypertrophy. However, most interesting was that aging dramatically interfered with the intestinal structure, causing a significant thickening of the ileum muscular layer. Senescent intestinal myocytes displayed many mitochondria with disorganized cristae and the presence of cytosolic lamellar corpuscles. Lipid peroxidation of ileum and gastrocnemius muscle, but not of the heart, increased in aged mice, thus suggesting enhanced oxidative stress. With exception of the intestinal muscle responsiveness, animals submitted to a daily session of 60 min, 5 days/wk, at 13 up to 21 m/min of moderate running in treadmill during animal life span exhibited a reversion of all the observed aging effects on intestinal, skeletal, and heart muscles. the introduction of this lifelong exercise protocol prevented the enhancement of lipid peroxidation and sarcopenia and also preserved cellular and ultracellular structures of the ileum This is the first time that the protective effect of a lifelong regular aerobic physical activity against the deleterious effects of aging on intestinal muscle was demonstrated. |
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Rosa, Eloi F. [UNIFESP]Silva, Antonio C. [UNIFESP]Ihara, Silvia SM [UNIFESP]Mora, Oswaldo A. [UNIFESP]Aboulafia, Jeannine [UNIFESP]Nouailhetas, Viviane LA [UNIFESP]Universidade Federal de São Paulo (UNIFESP)2016-01-24T12:38:04Z2016-01-24T12:38:04Z2005-10-01Journal of Applied Physiology. Bethesda: Amer Physiological Soc, v. 99, n. 4, p. 1569-1575, 2005.8750-7587http://repositorio.unifesp.br/handle/11600/28481http://dx.doi.org/10.1152/japplphysiol.00417.200510.1152/japplphysiol.00417.2005WOS:000232276800046Aging and aerobic exercise are two conditions known to interfere with health and quality of life, most likely by inducing oxidative stress to the organism. We studied the effects of aging on the morphological and functional properties of skeletal, cardiac, and intestinal muscles and their corresponding oxidative status in C57BL/6 mice and investigated whether a lifelong moderate exercise program would exert a protective effect against some deleterious effects of aging. As expected, aged animals presented a significant reduction of physical performance, accompanied by a decrease of gastrocnemius cross-sectional area and cardiac hypertrophy. However, most interesting was that aging dramatically interfered with the intestinal structure, causing a significant thickening of the ileum muscular layer. Senescent intestinal myocytes displayed many mitochondria with disorganized cristae and the presence of cytosolic lamellar corpuscles. Lipid peroxidation of ileum and gastrocnemius muscle, but not of the heart, increased in aged mice, thus suggesting enhanced oxidative stress. With exception of the intestinal muscle responsiveness, animals submitted to a daily session of 60 min, 5 days/wk, at 13 up to 21 m/min of moderate running in treadmill during animal life span exhibited a reversion of all the observed aging effects on intestinal, skeletal, and heart muscles. the introduction of this lifelong exercise protocol prevented the enhancement of lipid peroxidation and sarcopenia and also preserved cellular and ultracellular structures of the ileum This is the first time that the protective effect of a lifelong regular aerobic physical activity against the deleterious effects of aging on intestinal muscle was demonstrated.Universidade Federal de São Paulo, Escola Paulista Med, Dept Biophys, BR-04023062 São Paulo, BrazilUniversidade Federal de São Paulo, Escola Paulista Med, Dept Physiol, BR-04023062 São Paulo, BrazilUniversidade Federal de São Paulo, Escola Paulista Med, Dept Pathol, BR-04023062 São Paulo, BrazilUniversidade Federal de São Paulo, Escola Paulista Med, Dept Morphol, BR-04023062 São Paulo, BrazilUniversidade Federal de São Paulo, Escola Paulista Med, Dept Biophys, BR-04023062 São Paulo, BrazilUniversidade Federal de São Paulo, Escola Paulista Med, Dept Physiol, BR-04023062 São Paulo, BrazilUniversidade Federal de São Paulo, Escola Paulista Med, Dept Pathol, BR-04023062 São Paulo, BrazilUniversidade Federal de São Paulo, Escola Paulista Med, Dept Morphol, BR-04023062 São Paulo, BrazilWeb of Science1569-1575engAmer Physiological SocJournal of Applied Physiologymoderate exerciseC57B/6 miceileumoxidative stressisometric contractile responseHabitual exercise program protects murine intestinal, skeletal, and cardiac muscles against aginginfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/284812023-01-12 21:39:40.719metadata only accessoai:repositorio.unifesp.br:11600/28481Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:09:23.314520Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Habitual exercise program protects murine intestinal, skeletal, and cardiac muscles against aging |
title |
Habitual exercise program protects murine intestinal, skeletal, and cardiac muscles against aging |
spellingShingle |
Habitual exercise program protects murine intestinal, skeletal, and cardiac muscles against aging Rosa, Eloi F. [UNIFESP] moderate exercise C57B/6 mice ileum oxidative stress isometric contractile response |
title_short |
Habitual exercise program protects murine intestinal, skeletal, and cardiac muscles against aging |
title_full |
Habitual exercise program protects murine intestinal, skeletal, and cardiac muscles against aging |
title_fullStr |
Habitual exercise program protects murine intestinal, skeletal, and cardiac muscles against aging |
title_full_unstemmed |
Habitual exercise program protects murine intestinal, skeletal, and cardiac muscles against aging |
title_sort |
Habitual exercise program protects murine intestinal, skeletal, and cardiac muscles against aging |
author |
Rosa, Eloi F. [UNIFESP] |
author_facet |
Rosa, Eloi F. [UNIFESP] Silva, Antonio C. [UNIFESP] Ihara, Silvia SM [UNIFESP] Mora, Oswaldo A. [UNIFESP] Aboulafia, Jeannine [UNIFESP] Nouailhetas, Viviane LA [UNIFESP] |
author_role |
author |
author2 |
Silva, Antonio C. [UNIFESP] Ihara, Silvia SM [UNIFESP] Mora, Oswaldo A. [UNIFESP] Aboulafia, Jeannine [UNIFESP] Nouailhetas, Viviane LA [UNIFESP] |
author2_role |
author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Rosa, Eloi F. [UNIFESP] Silva, Antonio C. [UNIFESP] Ihara, Silvia SM [UNIFESP] Mora, Oswaldo A. [UNIFESP] Aboulafia, Jeannine [UNIFESP] Nouailhetas, Viviane LA [UNIFESP] |
dc.subject.eng.fl_str_mv |
moderate exercise C57B/6 mice ileum oxidative stress isometric contractile response |
topic |
moderate exercise C57B/6 mice ileum oxidative stress isometric contractile response |
description |
Aging and aerobic exercise are two conditions known to interfere with health and quality of life, most likely by inducing oxidative stress to the organism. We studied the effects of aging on the morphological and functional properties of skeletal, cardiac, and intestinal muscles and their corresponding oxidative status in C57BL/6 mice and investigated whether a lifelong moderate exercise program would exert a protective effect against some deleterious effects of aging. As expected, aged animals presented a significant reduction of physical performance, accompanied by a decrease of gastrocnemius cross-sectional area and cardiac hypertrophy. However, most interesting was that aging dramatically interfered with the intestinal structure, causing a significant thickening of the ileum muscular layer. Senescent intestinal myocytes displayed many mitochondria with disorganized cristae and the presence of cytosolic lamellar corpuscles. Lipid peroxidation of ileum and gastrocnemius muscle, but not of the heart, increased in aged mice, thus suggesting enhanced oxidative stress. With exception of the intestinal muscle responsiveness, animals submitted to a daily session of 60 min, 5 days/wk, at 13 up to 21 m/min of moderate running in treadmill during animal life span exhibited a reversion of all the observed aging effects on intestinal, skeletal, and heart muscles. the introduction of this lifelong exercise protocol prevented the enhancement of lipid peroxidation and sarcopenia and also preserved cellular and ultracellular structures of the ileum This is the first time that the protective effect of a lifelong regular aerobic physical activity against the deleterious effects of aging on intestinal muscle was demonstrated. |
publishDate |
2005 |
dc.date.issued.fl_str_mv |
2005-10-01 |
dc.date.accessioned.fl_str_mv |
2016-01-24T12:38:04Z |
dc.date.available.fl_str_mv |
2016-01-24T12:38:04Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Journal of Applied Physiology. Bethesda: Amer Physiological Soc, v. 99, n. 4, p. 1569-1575, 2005. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/28481 http://dx.doi.org/10.1152/japplphysiol.00417.2005 |
dc.identifier.issn.none.fl_str_mv |
8750-7587 |
dc.identifier.doi.none.fl_str_mv |
10.1152/japplphysiol.00417.2005 |
dc.identifier.wos.none.fl_str_mv |
WOS:000232276800046 |
identifier_str_mv |
Journal of Applied Physiology. Bethesda: Amer Physiological Soc, v. 99, n. 4, p. 1569-1575, 2005. 8750-7587 10.1152/japplphysiol.00417.2005 WOS:000232276800046 |
url |
http://repositorio.unifesp.br/handle/11600/28481 http://dx.doi.org/10.1152/japplphysiol.00417.2005 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Journal of Applied Physiology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1569-1575 |
dc.publisher.none.fl_str_mv |
Amer Physiological Soc |
publisher.none.fl_str_mv |
Amer Physiological Soc |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
_version_ |
1783460256470269952 |