Fluoxetina: indícios de uso inadequado
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://dx.doi.org/10.1590/S0047-20852009000200005 http://repositorio.unifesp.br/handle/11600/4761 |
Resumo: | OBJECTIVE: Investigate the use of fluoxetine in Santo André city, SP, by collecting and analyzing special prescriptions (SP) issued by physicians and filed in compounding pharmacies and drugstores of that city. METHODS: Special prescriptions were collected during August 2005 to July 2006 in 13 compounding pharmacies and 27 drugstores, in different regions of Santo André. Each prescription has been examined for the presence of fluoxetine, in combination or not with other active ingredients, and sex (a) patient was noted. RESULTS: We examined 39,782 SP; 16,124 of them were collected from compounding pharmacies and 23,658 from drugstores. Of these totals, 10,919 prescriptions contained fluoxetine as follows: 9,259 from the compounding pharmacies (84.8%) and only 1,660 (15.2%) from drugstores. Fluoxetine was manly prescribed for women (79.8%). In the vast majority of SP, fluoxetine was prescribed in combination with a large number of other active substances reaching more than ten others in almost half of the prescriptions. CONCLUSION: It is suggested that the large use of fluoxetine possibily aims to an aesthetic objective (to lose weight) and not as a therapeutic aim (treatment of depression). This work discusses the risk/benefit of this use which could be described as inappropriate, given the known adverse reactions of fluoxetine and its interference with the cytochrome P450 system. |
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Fluoxetina: indícios de uso inadequadoFluoxetine: indication of inadequate useFluoxetinemisusecompounding pharmacyweight lossantidepressantFluoxetinauso irracionalfarmácia magistralperda de pesoantidepressivoOBJECTIVE: Investigate the use of fluoxetine in Santo André city, SP, by collecting and analyzing special prescriptions (SP) issued by physicians and filed in compounding pharmacies and drugstores of that city. METHODS: Special prescriptions were collected during August 2005 to July 2006 in 13 compounding pharmacies and 27 drugstores, in different regions of Santo André. Each prescription has been examined for the presence of fluoxetine, in combination or not with other active ingredients, and sex (a) patient was noted. RESULTS: We examined 39,782 SP; 16,124 of them were collected from compounding pharmacies and 23,658 from drugstores. Of these totals, 10,919 prescriptions contained fluoxetine as follows: 9,259 from the compounding pharmacies (84.8%) and only 1,660 (15.2%) from drugstores. Fluoxetine was manly prescribed for women (79.8%). In the vast majority of SP, fluoxetine was prescribed in combination with a large number of other active substances reaching more than ten others in almost half of the prescriptions. CONCLUSION: It is suggested that the large use of fluoxetine possibily aims to an aesthetic objective (to lose weight) and not as a therapeutic aim (treatment of depression). This work discusses the risk/benefit of this use which could be described as inappropriate, given the known adverse reactions of fluoxetine and its interference with the cytochrome P450 system.OBJETIVO: Investigar o uso da fluoxetina na cidade de Santo André, SP, por meio de coleta e análise das receitas especiais (RE) prescritas por médicos e arquivadas nas farmácias e drogarias daquela cidade. MÉTODOS: Foram coletadas as receitas especiais retidas durante os meses de agosto do ano de 2005 a julho de 2006, em 13 farmácias de manipulação e em 27 drogarias em diferentes regiões de Santo André. Cada receita especial foi analisada em relação à presença de fluoxetina, em associação ou não a outros princípios ativos, e o sexo do(a) paciente foi anotado. RESULTADOS: Foram analisadas 39.782 RE - 16.124 coletadas das farmácias magistrais e 23.658 das drogarias. Desses totais, 10.919 prescrições continham fluoxetina - 9.259 provenientes das farmácias magistrais (84,8%) e apenas 1.660 (15,2%) das drogarias. As prescrições de fluoxetina eram predominantemente destinadas a mulheres (79,8%). Na imensa maioria das RE, a fluoxetina foi prescrita em associação com um grande número de outras substâncias ativas, inclusive anfetaminas anoréticas, chegando a mais de dez outras em quase a metade das prescrições. Esse tipo de prescrição múltipla, principalmente para mulheres, é comparado com as prescrições de fórmulas magistrais para emagrecer, muito utilizadas no Brasil. CONCLUSÃO: Os dados obtidos sugerem que a utilização de fluoxetina teria um fim estético (perda de peso), e não um fim terapêutico (tratamento de depressão). Discute-se a relação risco-benefício desse possível uso, que poderia ser classificado de inadequado dado as conhecidas reações adversas da fluoxetina e a sua interferência no sistema citocromo P450.Universidade Federal de São Paulo (UNIFESP) Centro Brasileiro de Informações sobre Drogas Psicotrópicas Departamento de PsicobiologiaPrefeitura Municipal de Santo André Secretaria da Saúde Departamento de Assistência à SaúdeUNIFESP, Centro Brasileiro de Informações sobre Drogas Psicotrópicas Depto. de PsicobiologiaSciELOInstituto de Psiquiatria da Universidade Federal do Rio de JaneiroUniversidade Federal de São Paulo (UNIFESP)Prefeitura Municipal de Santo André Secretaria da Saúde Departamento de Assistência à SaúdeCarlini, Elisaldo Araujo [UNIFESP]Noto, Ana Regina [UNIFESP]Nappo, Solange Aparecida [UNIFESP]Sanchez, Zila van der Meer [UNIFESP]Franco, Vera Lúcia da SilvaSilva, Luiz Carlos FrancoSantos, Vilmar Ezequiel dosAlves, Décio de Castro2015-06-14T13:38:57Z2015-06-14T13:38:57Z2009-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion97-100application/pdfhttp://dx.doi.org/10.1590/S0047-20852009000200005Jornal Brasileiro de Psiquiatria. Instituto de Psiquiatria da Universidade Federal do Rio de Janeiro, v. 58, n. 2, p. 97-100, 2009.10.1590/S0047-20852009000200005S0047-20852009000200005.pdf0047-2085S0047-20852009000200005http://repositorio.unifesp.br/handle/11600/4761porJornal Brasileiro de Psiquiatriainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-29T14:36:38Zoai:repositorio.unifesp.br/:11600/4761Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-29T14:36:38Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Fluoxetina: indícios de uso inadequado Fluoxetine: indication of inadequate use |
title |
Fluoxetina: indícios de uso inadequado |
spellingShingle |
Fluoxetina: indícios de uso inadequado Carlini, Elisaldo Araujo [UNIFESP] Fluoxetine misuse compounding pharmacy weight loss antidepressant Fluoxetina uso irracional farmácia magistral perda de peso antidepressivo |
title_short |
Fluoxetina: indícios de uso inadequado |
title_full |
Fluoxetina: indícios de uso inadequado |
title_fullStr |
Fluoxetina: indícios de uso inadequado |
title_full_unstemmed |
Fluoxetina: indícios de uso inadequado |
title_sort |
Fluoxetina: indícios de uso inadequado |
author |
Carlini, Elisaldo Araujo [UNIFESP] |
author_facet |
Carlini, Elisaldo Araujo [UNIFESP] Noto, Ana Regina [UNIFESP] Nappo, Solange Aparecida [UNIFESP] Sanchez, Zila van der Meer [UNIFESP] Franco, Vera Lúcia da Silva Silva, Luiz Carlos Franco Santos, Vilmar Ezequiel dos Alves, Décio de Castro |
author_role |
author |
author2 |
Noto, Ana Regina [UNIFESP] Nappo, Solange Aparecida [UNIFESP] Sanchez, Zila van der Meer [UNIFESP] Franco, Vera Lúcia da Silva Silva, Luiz Carlos Franco Santos, Vilmar Ezequiel dos Alves, Décio de Castro |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Prefeitura Municipal de Santo André Secretaria da Saúde Departamento de Assistência à Saúde |
dc.contributor.author.fl_str_mv |
Carlini, Elisaldo Araujo [UNIFESP] Noto, Ana Regina [UNIFESP] Nappo, Solange Aparecida [UNIFESP] Sanchez, Zila van der Meer [UNIFESP] Franco, Vera Lúcia da Silva Silva, Luiz Carlos Franco Santos, Vilmar Ezequiel dos Alves, Décio de Castro |
dc.subject.por.fl_str_mv |
Fluoxetine misuse compounding pharmacy weight loss antidepressant Fluoxetina uso irracional farmácia magistral perda de peso antidepressivo |
topic |
Fluoxetine misuse compounding pharmacy weight loss antidepressant Fluoxetina uso irracional farmácia magistral perda de peso antidepressivo |
description |
OBJECTIVE: Investigate the use of fluoxetine in Santo André city, SP, by collecting and analyzing special prescriptions (SP) issued by physicians and filed in compounding pharmacies and drugstores of that city. METHODS: Special prescriptions were collected during August 2005 to July 2006 in 13 compounding pharmacies and 27 drugstores, in different regions of Santo André. Each prescription has been examined for the presence of fluoxetine, in combination or not with other active ingredients, and sex (a) patient was noted. RESULTS: We examined 39,782 SP; 16,124 of them were collected from compounding pharmacies and 23,658 from drugstores. Of these totals, 10,919 prescriptions contained fluoxetine as follows: 9,259 from the compounding pharmacies (84.8%) and only 1,660 (15.2%) from drugstores. Fluoxetine was manly prescribed for women (79.8%). In the vast majority of SP, fluoxetine was prescribed in combination with a large number of other active substances reaching more than ten others in almost half of the prescriptions. CONCLUSION: It is suggested that the large use of fluoxetine possibily aims to an aesthetic objective (to lose weight) and not as a therapeutic aim (treatment of depression). This work discusses the risk/benefit of this use which could be described as inappropriate, given the known adverse reactions of fluoxetine and its interference with the cytochrome P450 system. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-01-01 2015-06-14T13:38:57Z 2015-06-14T13:38:57Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S0047-20852009000200005 Jornal Brasileiro de Psiquiatria. Instituto de Psiquiatria da Universidade Federal do Rio de Janeiro, v. 58, n. 2, p. 97-100, 2009. 10.1590/S0047-20852009000200005 S0047-20852009000200005.pdf 0047-2085 S0047-20852009000200005 http://repositorio.unifesp.br/handle/11600/4761 |
url |
http://dx.doi.org/10.1590/S0047-20852009000200005 http://repositorio.unifesp.br/handle/11600/4761 |
identifier_str_mv |
Jornal Brasileiro de Psiquiatria. Instituto de Psiquiatria da Universidade Federal do Rio de Janeiro, v. 58, n. 2, p. 97-100, 2009. 10.1590/S0047-20852009000200005 S0047-20852009000200005.pdf 0047-2085 S0047-20852009000200005 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
Jornal Brasileiro de Psiquiatria |
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info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
97-100 application/pdf |
dc.publisher.none.fl_str_mv |
Instituto de Psiquiatria da Universidade Federal do Rio de Janeiro |
publisher.none.fl_str_mv |
Instituto de Psiquiatria da Universidade Federal do Rio de Janeiro |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
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UNIFESP |
institution |
UNIFESP |
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Repositório Institucional da UNIFESP |
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Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
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1814268450553462784 |