Fluoxetina: indícios de uso inadequado

Detalhes bibliográficos
Autor(a) principal: Carlini, Elisaldo Araujo [UNIFESP]
Data de Publicação: 2009
Outros Autores: Noto, Ana Regina [UNIFESP], Nappo, Solange Aparecida [UNIFESP], Sanchez, Zila van der Meer [UNIFESP], Franco, Vera Lúcia da Silva, Silva, Luiz Carlos Franco, Santos, Vilmar Ezequiel dos, Alves, Décio de Castro
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/S0047-20852009000200005
http://repositorio.unifesp.br/handle/11600/4761
Resumo: OBJECTIVE: Investigate the use of fluoxetine in Santo André city, SP, by collecting and analyzing special prescriptions (SP) issued by physicians and filed in compounding pharmacies and drugstores of that city. METHODS: Special prescriptions were collected during August 2005 to July 2006 in 13 compounding pharmacies and 27 drugstores, in different regions of Santo André. Each prescription has been examined for the presence of fluoxetine, in combination or not with other active ingredients, and sex (a) patient was noted. RESULTS: We examined 39,782 SP; 16,124 of them were collected from compounding pharmacies and 23,658 from drugstores. Of these totals, 10,919 prescriptions contained fluoxetine as follows: 9,259 from the compounding pharmacies (84.8%) and only 1,660 (15.2%) from drugstores. Fluoxetine was manly prescribed for women (79.8%). In the vast majority of SP, fluoxetine was prescribed in combination with a large number of other active substances reaching more than ten others in almost half of the prescriptions. CONCLUSION: It is suggested that the large use of fluoxetine possibily aims to an aesthetic objective (to lose weight) and not as a therapeutic aim (treatment of depression). This work discusses the risk/benefit of this use which could be described as inappropriate, given the known adverse reactions of fluoxetine and its interference with the cytochrome P450 system.
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spelling Fluoxetina: indícios de uso inadequadoFluoxetine: indication of inadequate useFluoxetinemisusecompounding pharmacyweight lossantidepressantFluoxetinauso irracionalfarmácia magistralperda de pesoantidepressivoOBJECTIVE: Investigate the use of fluoxetine in Santo André city, SP, by collecting and analyzing special prescriptions (SP) issued by physicians and filed in compounding pharmacies and drugstores of that city. METHODS: Special prescriptions were collected during August 2005 to July 2006 in 13 compounding pharmacies and 27 drugstores, in different regions of Santo André. Each prescription has been examined for the presence of fluoxetine, in combination or not with other active ingredients, and sex (a) patient was noted. RESULTS: We examined 39,782 SP; 16,124 of them were collected from compounding pharmacies and 23,658 from drugstores. Of these totals, 10,919 prescriptions contained fluoxetine as follows: 9,259 from the compounding pharmacies (84.8%) and only 1,660 (15.2%) from drugstores. Fluoxetine was manly prescribed for women (79.8%). In the vast majority of SP, fluoxetine was prescribed in combination with a large number of other active substances reaching more than ten others in almost half of the prescriptions. CONCLUSION: It is suggested that the large use of fluoxetine possibily aims to an aesthetic objective (to lose weight) and not as a therapeutic aim (treatment of depression). This work discusses the risk/benefit of this use which could be described as inappropriate, given the known adverse reactions of fluoxetine and its interference with the cytochrome P450 system.OBJETIVO: Investigar o uso da fluoxetina na cidade de Santo André, SP, por meio de coleta e análise das receitas especiais (RE) prescritas por médicos e arquivadas nas farmácias e drogarias daquela cidade. MÉTODOS: Foram coletadas as receitas especiais retidas durante os meses de agosto do ano de 2005 a julho de 2006, em 13 farmácias de manipulação e em 27 drogarias em diferentes regiões de Santo André. Cada receita especial foi analisada em relação à presença de fluoxetina, em associação ou não a outros princípios ativos, e o sexo do(a) paciente foi anotado. RESULTADOS: Foram analisadas 39.782 RE - 16.124 coletadas das farmácias magistrais e 23.658 das drogarias. Desses totais, 10.919 prescrições continham fluoxetina - 9.259 provenientes das farmácias magistrais (84,8%) e apenas 1.660 (15,2%) das drogarias. As prescrições de fluoxetina eram predominantemente destinadas a mulheres (79,8%). Na imensa maioria das RE, a fluoxetina foi prescrita em associação com um grande número de outras substâncias ativas, inclusive anfetaminas anoréticas, chegando a mais de dez outras em quase a metade das prescrições. Esse tipo de prescrição múltipla, principalmente para mulheres, é comparado com as prescrições de fórmulas magistrais para emagrecer, muito utilizadas no Brasil. CONCLUSÃO: Os dados obtidos sugerem que a utilização de fluoxetina teria um fim estético (perda de peso), e não um fim terapêutico (tratamento de depressão). Discute-se a relação risco-benefício desse possível uso, que poderia ser classificado de inadequado dado as conhecidas reações adversas da fluoxetina e a sua interferência no sistema citocromo P450.Universidade Federal de São Paulo (UNIFESP) Centro Brasileiro de Informações sobre Drogas Psicotrópicas Departamento de PsicobiologiaPrefeitura Municipal de Santo André Secretaria da Saúde Departamento de Assistência à SaúdeUNIFESP, Centro Brasileiro de Informações sobre Drogas Psicotrópicas Depto. de PsicobiologiaSciELOInstituto de Psiquiatria da Universidade Federal do Rio de JaneiroUniversidade Federal de São Paulo (UNIFESP)Prefeitura Municipal de Santo André Secretaria da Saúde Departamento de Assistência à SaúdeCarlini, Elisaldo Araujo [UNIFESP]Noto, Ana Regina [UNIFESP]Nappo, Solange Aparecida [UNIFESP]Sanchez, Zila van der Meer [UNIFESP]Franco, Vera Lúcia da SilvaSilva, Luiz Carlos FrancoSantos, Vilmar Ezequiel dosAlves, Décio de Castro2015-06-14T13:38:57Z2015-06-14T13:38:57Z2009-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion97-100application/pdfhttp://dx.doi.org/10.1590/S0047-20852009000200005Jornal Brasileiro de Psiquiatria. Instituto de Psiquiatria da Universidade Federal do Rio de Janeiro, v. 58, n. 2, p. 97-100, 2009.10.1590/S0047-20852009000200005S0047-20852009000200005.pdf0047-2085S0047-20852009000200005http://repositorio.unifesp.br/handle/11600/4761porJornal Brasileiro de Psiquiatriainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-29T14:36:38Zoai:repositorio.unifesp.br/:11600/4761Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-29T14:36:38Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Fluoxetina: indícios de uso inadequado
Fluoxetine: indication of inadequate use
title Fluoxetina: indícios de uso inadequado
spellingShingle Fluoxetina: indícios de uso inadequado
Carlini, Elisaldo Araujo [UNIFESP]
Fluoxetine
misuse
compounding pharmacy
weight loss
antidepressant
Fluoxetina
uso irracional
farmácia magistral
perda de peso
antidepressivo
title_short Fluoxetina: indícios de uso inadequado
title_full Fluoxetina: indícios de uso inadequado
title_fullStr Fluoxetina: indícios de uso inadequado
title_full_unstemmed Fluoxetina: indícios de uso inadequado
title_sort Fluoxetina: indícios de uso inadequado
author Carlini, Elisaldo Araujo [UNIFESP]
author_facet Carlini, Elisaldo Araujo [UNIFESP]
Noto, Ana Regina [UNIFESP]
Nappo, Solange Aparecida [UNIFESP]
Sanchez, Zila van der Meer [UNIFESP]
Franco, Vera Lúcia da Silva
Silva, Luiz Carlos Franco
Santos, Vilmar Ezequiel dos
Alves, Décio de Castro
author_role author
author2 Noto, Ana Regina [UNIFESP]
Nappo, Solange Aparecida [UNIFESP]
Sanchez, Zila van der Meer [UNIFESP]
Franco, Vera Lúcia da Silva
Silva, Luiz Carlos Franco
Santos, Vilmar Ezequiel dos
Alves, Décio de Castro
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
Prefeitura Municipal de Santo André Secretaria da Saúde Departamento de Assistência à Saúde
dc.contributor.author.fl_str_mv Carlini, Elisaldo Araujo [UNIFESP]
Noto, Ana Regina [UNIFESP]
Nappo, Solange Aparecida [UNIFESP]
Sanchez, Zila van der Meer [UNIFESP]
Franco, Vera Lúcia da Silva
Silva, Luiz Carlos Franco
Santos, Vilmar Ezequiel dos
Alves, Décio de Castro
dc.subject.por.fl_str_mv Fluoxetine
misuse
compounding pharmacy
weight loss
antidepressant
Fluoxetina
uso irracional
farmácia magistral
perda de peso
antidepressivo
topic Fluoxetine
misuse
compounding pharmacy
weight loss
antidepressant
Fluoxetina
uso irracional
farmácia magistral
perda de peso
antidepressivo
description OBJECTIVE: Investigate the use of fluoxetine in Santo André city, SP, by collecting and analyzing special prescriptions (SP) issued by physicians and filed in compounding pharmacies and drugstores of that city. METHODS: Special prescriptions were collected during August 2005 to July 2006 in 13 compounding pharmacies and 27 drugstores, in different regions of Santo André. Each prescription has been examined for the presence of fluoxetine, in combination or not with other active ingredients, and sex (a) patient was noted. RESULTS: We examined 39,782 SP; 16,124 of them were collected from compounding pharmacies and 23,658 from drugstores. Of these totals, 10,919 prescriptions contained fluoxetine as follows: 9,259 from the compounding pharmacies (84.8%) and only 1,660 (15.2%) from drugstores. Fluoxetine was manly prescribed for women (79.8%). In the vast majority of SP, fluoxetine was prescribed in combination with a large number of other active substances reaching more than ten others in almost half of the prescriptions. CONCLUSION: It is suggested that the large use of fluoxetine possibily aims to an aesthetic objective (to lose weight) and not as a therapeutic aim (treatment of depression). This work discusses the risk/benefit of this use which could be described as inappropriate, given the known adverse reactions of fluoxetine and its interference with the cytochrome P450 system.
publishDate 2009
dc.date.none.fl_str_mv 2009-01-01
2015-06-14T13:38:57Z
2015-06-14T13:38:57Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0047-20852009000200005
Jornal Brasileiro de Psiquiatria. Instituto de Psiquiatria da Universidade Federal do Rio de Janeiro, v. 58, n. 2, p. 97-100, 2009.
10.1590/S0047-20852009000200005
S0047-20852009000200005.pdf
0047-2085
S0047-20852009000200005
http://repositorio.unifesp.br/handle/11600/4761
url http://dx.doi.org/10.1590/S0047-20852009000200005
http://repositorio.unifesp.br/handle/11600/4761
identifier_str_mv Jornal Brasileiro de Psiquiatria. Instituto de Psiquiatria da Universidade Federal do Rio de Janeiro, v. 58, n. 2, p. 97-100, 2009.
10.1590/S0047-20852009000200005
S0047-20852009000200005.pdf
0047-2085
S0047-20852009000200005
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv Jornal Brasileiro de Psiquiatria
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 97-100
application/pdf
dc.publisher.none.fl_str_mv Instituto de Psiquiatria da Universidade Federal do Rio de Janeiro
publisher.none.fl_str_mv Instituto de Psiquiatria da Universidade Federal do Rio de Janeiro
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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