A routine electrocardiogram cannot be used to determine the size of myocardial infarction in the rat
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2005 |
| Outros Autores: | , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UNIFESP |
| dARK ID: | ark:/48912/001300000v31m |
| DOI: | 10.1590/S0100-879X2005000400016 |
| Texto Completo: | http://dx.doi.org/10.1590/S0100-879X2005000400016 http://repositorio.unifesp.br/handle/11600/2465 |
Resumo: | Nine lead electrocardiograms of non-infarcted (N = 61) and infarcted (N = 71) female Wistar rats (200-250 g) were analyzed in order to distinguish left ventricle myocardial infarction (MI) larger than 40% (LMI) from MI smaller than 40% (SMI). MI larger than 40% clearly caused a deviation of ÂQRS and ÂT from normal values of 270-360 degrees to 90-270 degrees. Infarcted rats showed Q wave in D1 larger than 1 mm with 94% sensitivity and 100% specificity. The sum of QRS positivity in V1, V2 and V6 lower than 10 mm identified MI with 82% sensitivity and 100% specificity. The data showed that MI can be easily and reliably diagnosed by electrocardiogram in the rat. However, contradicting what is frequently believed, when specificity and sensitivity were analyzed focusing on MI size, none of these current electrocardiographic indices of MI size adequately discriminates LMI from SMI. |
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A routine electrocardiogram cannot be used to determine the size of myocardial infarction in the ratMyocardial infarction sizeRatsElectrocardiogramEchocardiogramROC curveNine lead electrocardiograms of non-infarcted (N = 61) and infarcted (N = 71) female Wistar rats (200-250 g) were analyzed in order to distinguish left ventricle myocardial infarction (MI) larger than 40% (LMI) from MI smaller than 40% (SMI). MI larger than 40% clearly caused a deviation of ÂQRS and ÂT from normal values of 270-360 degrees to 90-270 degrees. Infarcted rats showed Q wave in D1 larger than 1 mm with 94% sensitivity and 100% specificity. The sum of QRS positivity in V1, V2 and V6 lower than 10 mm identified MI with 82% sensitivity and 100% specificity. The data showed that MI can be easily and reliably diagnosed by electrocardiogram in the rat. However, contradicting what is frequently believed, when specificity and sensitivity were analyzed focusing on MI size, none of these current electrocardiographic indices of MI size adequately discriminates LMI from SMI.Universidade Federal de São Paulo (UNIFESP) Laboratório de Fisiologia CardíacaUNIFESP, Laboratório de Fisiologia CardíacaSciELOAssociação Brasileira de Divulgação CientíficaUniversidade Federal de São Paulo (UNIFESP)Bonilha, Andre.Mateis Martins [UNIFESP]Saraiva, Roberto Magalhães [UNIFESP]Kanashiro-Takeuchi, Rosimeire Miyuki [UNIFESP]Portes, Leslie Andrews [UNIFESP]Antonio, Ednei Luiz [UNIFESP]Tucci, Paulo José Ferreira [UNIFESP]2015-06-14T13:31:31Z2015-06-14T13:31:31Z2005-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion615-619application/pdfhttp://dx.doi.org/10.1590/S0100-879X2005000400016Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 38, n. 4, p. 615-619, 2005.10.1590/S0100-879X2005000400016S0100-879X2005000400016.pdf0100-879XS0100-879X2005000400016http://repositorio.unifesp.br/handle/11600/2465WOS:000228962700016ark:/48912/001300000v31mengBrazilian Journal of Medical and Biological Researchinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-29T18:10:33Zoai:repositorio.unifesp.br/:11600/2465Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-12-11T20:38:36.607223Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
| dc.title.none.fl_str_mv |
A routine electrocardiogram cannot be used to determine the size of myocardial infarction in the rat |
| title |
A routine electrocardiogram cannot be used to determine the size of myocardial infarction in the rat |
| spellingShingle |
A routine electrocardiogram cannot be used to determine the size of myocardial infarction in the rat A routine electrocardiogram cannot be used to determine the size of myocardial infarction in the rat Bonilha, Andre.Mateis Martins [UNIFESP] Myocardial infarction size Rats Electrocardiogram Echocardiogram ROC curve Bonilha, Andre.Mateis Martins [UNIFESP] Myocardial infarction size Rats Electrocardiogram Echocardiogram ROC curve |
| title_short |
A routine electrocardiogram cannot be used to determine the size of myocardial infarction in the rat |
| title_full |
A routine electrocardiogram cannot be used to determine the size of myocardial infarction in the rat |
| title_fullStr |
A routine electrocardiogram cannot be used to determine the size of myocardial infarction in the rat A routine electrocardiogram cannot be used to determine the size of myocardial infarction in the rat |
| title_full_unstemmed |
A routine electrocardiogram cannot be used to determine the size of myocardial infarction in the rat A routine electrocardiogram cannot be used to determine the size of myocardial infarction in the rat |
| title_sort |
A routine electrocardiogram cannot be used to determine the size of myocardial infarction in the rat |
| author |
Bonilha, Andre.Mateis Martins [UNIFESP] |
| author_facet |
Bonilha, Andre.Mateis Martins [UNIFESP] Bonilha, Andre.Mateis Martins [UNIFESP] Saraiva, Roberto Magalhães [UNIFESP] Kanashiro-Takeuchi, Rosimeire Miyuki [UNIFESP] Portes, Leslie Andrews [UNIFESP] Antonio, Ednei Luiz [UNIFESP] Tucci, Paulo José Ferreira [UNIFESP] Saraiva, Roberto Magalhães [UNIFESP] Kanashiro-Takeuchi, Rosimeire Miyuki [UNIFESP] Portes, Leslie Andrews [UNIFESP] Antonio, Ednei Luiz [UNIFESP] Tucci, Paulo José Ferreira [UNIFESP] |
| author_role |
author |
| author2 |
Saraiva, Roberto Magalhães [UNIFESP] Kanashiro-Takeuchi, Rosimeire Miyuki [UNIFESP] Portes, Leslie Andrews [UNIFESP] Antonio, Ednei Luiz [UNIFESP] Tucci, Paulo José Ferreira [UNIFESP] |
| author2_role |
author author author author author |
| dc.contributor.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
| dc.contributor.author.fl_str_mv |
Bonilha, Andre.Mateis Martins [UNIFESP] Saraiva, Roberto Magalhães [UNIFESP] Kanashiro-Takeuchi, Rosimeire Miyuki [UNIFESP] Portes, Leslie Andrews [UNIFESP] Antonio, Ednei Luiz [UNIFESP] Tucci, Paulo José Ferreira [UNIFESP] |
| dc.subject.por.fl_str_mv |
Myocardial infarction size Rats Electrocardiogram Echocardiogram ROC curve |
| topic |
Myocardial infarction size Rats Electrocardiogram Echocardiogram ROC curve |
| description |
Nine lead electrocardiograms of non-infarcted (N = 61) and infarcted (N = 71) female Wistar rats (200-250 g) were analyzed in order to distinguish left ventricle myocardial infarction (MI) larger than 40% (LMI) from MI smaller than 40% (SMI). MI larger than 40% clearly caused a deviation of ÂQRS and ÂT from normal values of 270-360 degrees to 90-270 degrees. Infarcted rats showed Q wave in D1 larger than 1 mm with 94% sensitivity and 100% specificity. The sum of QRS positivity in V1, V2 and V6 lower than 10 mm identified MI with 82% sensitivity and 100% specificity. The data showed that MI can be easily and reliably diagnosed by electrocardiogram in the rat. However, contradicting what is frequently believed, when specificity and sensitivity were analyzed focusing on MI size, none of these current electrocardiographic indices of MI size adequately discriminates LMI from SMI. |
| publishDate |
2005 |
| dc.date.none.fl_str_mv |
2005-04-01 2015-06-14T13:31:31Z 2015-06-14T13:31:31Z |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S0100-879X2005000400016 Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 38, n. 4, p. 615-619, 2005. 10.1590/S0100-879X2005000400016 S0100-879X2005000400016.pdf 0100-879X S0100-879X2005000400016 http://repositorio.unifesp.br/handle/11600/2465 WOS:000228962700016 |
| dc.identifier.dark.fl_str_mv |
ark:/48912/001300000v31m |
| url |
http://dx.doi.org/10.1590/S0100-879X2005000400016 http://repositorio.unifesp.br/handle/11600/2465 |
| identifier_str_mv |
Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 38, n. 4, p. 615-619, 2005. 10.1590/S0100-879X2005000400016 S0100-879X2005000400016.pdf 0100-879X S0100-879X2005000400016 WOS:000228962700016 ark:/48912/001300000v31m |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Brazilian Journal of Medical and Biological Research |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
615-619 application/pdf |
| dc.publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
| publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
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reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
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Universidade Federal de São Paulo (UNIFESP) |
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UNIFESP |
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UNIFESP |
| reponame_str |
Repositório Institucional da UNIFESP |
| collection |
Repositório Institucional da UNIFESP |
| repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
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biblioteca.csp@unifesp.br |
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1822183975285686272 |
| dc.identifier.doi.none.fl_str_mv |
10.1590/S0100-879X2005000400016 |