Effects of chronic corticosterone and imipramine administration on panic and anxiety-related responses

Detalhes bibliográficos
Autor(a) principal: Diniz, Leila [UNIFESP]
Data de Publicação: 2011
Outros Autores: Reis, Bianca Beraldo dos [UNIFESP], Castro, Glaucia Monteiro de [UNIFESP], Medalha, Carla Christina [UNIFESP], Viana, Milena de Barros [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: https://dx.doi.org/10.1590/S0100-879X2011007500117
https://repositorio.unifesp.br/handle/11600/6628
Resumo: It is known that chronic high levels of corticosterone (CORT) enhance aversive responses such as avoidance and contextual freezing. In contrast, chronic CORT does not alter defensive behavior induced by the exposure to a predator odor. Since different defense-related responses have been associated with specific anxiety disorders found in clinical settings, the observation that chronic CORT alters some defensive behaviors but not others might be relevant to the understanding of the neurobiology of anxiety. In the present study, we investigated the effects of chronic CORT administration (through surgical implantation of a 21-day release 200 mg pellet) on avoidance acquisition and escape expression by male Wistar rats (200 g in weight at the beginning of the experiments, N = 6-10/group) tested in the elevated T-maze (ETM). These defensive behaviors have been associated with generalized anxiety and panic disorder, respectively. Since the tricyclic antidepressant imipramine is successfully used to treat both conditions, the effects of combined treatment with chronic imipramine (15 mg, ip) and CORT were also investigated. Results showed that chronic CORT facilitated avoidance performance, an anxiogenic-like effect (P < 0.05), without changing escape responses. Imipramine significantly reversed the anxiogenic effect of CORT (P < 0.05), although the drug did not exhibit anxiolytic effects by itself. Confirming previous observations, imipramine inhibited escape responses, a panicolytic-like effect. Unlike chronic CORT, imipramine also decreased locomotor activity in an open field. These data suggest that chronic CORT specifically altered ETM avoidance, a fact that should be relevant to a better understanding of the physiopathology of generalized anxiety and panic disorder.
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spelling Effects of chronic corticosterone and imipramine administration on panic and anxiety-related responsesCorticosteroneImipramineGeneralized anxiety disorderPanic disorderElevated T-mazeIt is known that chronic high levels of corticosterone (CORT) enhance aversive responses such as avoidance and contextual freezing. In contrast, chronic CORT does not alter defensive behavior induced by the exposure to a predator odor. Since different defense-related responses have been associated with specific anxiety disorders found in clinical settings, the observation that chronic CORT alters some defensive behaviors but not others might be relevant to the understanding of the neurobiology of anxiety. In the present study, we investigated the effects of chronic CORT administration (through surgical implantation of a 21-day release 200 mg pellet) on avoidance acquisition and escape expression by male Wistar rats (200 g in weight at the beginning of the experiments, N = 6-10/group) tested in the elevated T-maze (ETM). These defensive behaviors have been associated with generalized anxiety and panic disorder, respectively. Since the tricyclic antidepressant imipramine is successfully used to treat both conditions, the effects of combined treatment with chronic imipramine (15 mg, ip) and CORT were also investigated. Results showed that chronic CORT facilitated avoidance performance, an anxiogenic-like effect (P < 0.05), without changing escape responses. Imipramine significantly reversed the anxiogenic effect of CORT (P < 0.05), although the drug did not exhibit anxiolytic effects by itself. Confirming previous observations, imipramine inhibited escape responses, a panicolytic-like effect. Unlike chronic CORT, imipramine also decreased locomotor activity in an open field. These data suggest that chronic CORT specifically altered ETM avoidance, a fact that should be relevant to a better understanding of the physiopathology of generalized anxiety and panic disorder.Universidade Federal de São Paulo (UNIFESP) Departamento de PsiquiatriaUniversidade Federal de São Paulo (UNIFESP) Departamento de BiociênciasUNIFESP, Depto. de PsiquiatriaUNIFESP, Depto. de BiociênciasSciELOFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)FAPESP: 2008/58815-1FAPESP: 2009/50830-4Associação Brasileira de Divulgação CientíficaUniversidade Federal de São Paulo (UNIFESP)Diniz, Leila [UNIFESP]Reis, Bianca Beraldo dos [UNIFESP]Castro, Glaucia Monteiro de [UNIFESP]Medalha, Carla Christina [UNIFESP]Viana, Milena de Barros [UNIFESP]2015-06-14T13:43:16Z2015-06-14T13:43:16Z2011-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion1048-1053application/pdfhttps://dx.doi.org/10.1590/S0100-879X2011007500117Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 44, n. 10, p. 1048-1053, 2011.10.1590/S0100-879X2011007500117S0100-879X2011001000010.pdf0100-879XS0100-879X2011001000010https://repositorio.unifesp.br/handle/11600/6628WOS:000295721600010engBrazilian Journal of Medical and Biological Researchinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-05T23:33:31Zoai:repositorio.unifesp.br/:11600/6628Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-05T23:33:31Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Effects of chronic corticosterone and imipramine administration on panic and anxiety-related responses
title Effects of chronic corticosterone and imipramine administration on panic and anxiety-related responses
spellingShingle Effects of chronic corticosterone and imipramine administration on panic and anxiety-related responses
Diniz, Leila [UNIFESP]
Corticosterone
Imipramine
Generalized anxiety disorder
Panic disorder
Elevated T-maze
title_short Effects of chronic corticosterone and imipramine administration on panic and anxiety-related responses
title_full Effects of chronic corticosterone and imipramine administration on panic and anxiety-related responses
title_fullStr Effects of chronic corticosterone and imipramine administration on panic and anxiety-related responses
title_full_unstemmed Effects of chronic corticosterone and imipramine administration on panic and anxiety-related responses
title_sort Effects of chronic corticosterone and imipramine administration on panic and anxiety-related responses
author Diniz, Leila [UNIFESP]
author_facet Diniz, Leila [UNIFESP]
Reis, Bianca Beraldo dos [UNIFESP]
Castro, Glaucia Monteiro de [UNIFESP]
Medalha, Carla Christina [UNIFESP]
Viana, Milena de Barros [UNIFESP]
author_role author
author2 Reis, Bianca Beraldo dos [UNIFESP]
Castro, Glaucia Monteiro de [UNIFESP]
Medalha, Carla Christina [UNIFESP]
Viana, Milena de Barros [UNIFESP]
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Diniz, Leila [UNIFESP]
Reis, Bianca Beraldo dos [UNIFESP]
Castro, Glaucia Monteiro de [UNIFESP]
Medalha, Carla Christina [UNIFESP]
Viana, Milena de Barros [UNIFESP]
dc.subject.por.fl_str_mv Corticosterone
Imipramine
Generalized anxiety disorder
Panic disorder
Elevated T-maze
topic Corticosterone
Imipramine
Generalized anxiety disorder
Panic disorder
Elevated T-maze
description It is known that chronic high levels of corticosterone (CORT) enhance aversive responses such as avoidance and contextual freezing. In contrast, chronic CORT does not alter defensive behavior induced by the exposure to a predator odor. Since different defense-related responses have been associated with specific anxiety disorders found in clinical settings, the observation that chronic CORT alters some defensive behaviors but not others might be relevant to the understanding of the neurobiology of anxiety. In the present study, we investigated the effects of chronic CORT administration (through surgical implantation of a 21-day release 200 mg pellet) on avoidance acquisition and escape expression by male Wistar rats (200 g in weight at the beginning of the experiments, N = 6-10/group) tested in the elevated T-maze (ETM). These defensive behaviors have been associated with generalized anxiety and panic disorder, respectively. Since the tricyclic antidepressant imipramine is successfully used to treat both conditions, the effects of combined treatment with chronic imipramine (15 mg, ip) and CORT were also investigated. Results showed that chronic CORT facilitated avoidance performance, an anxiogenic-like effect (P < 0.05), without changing escape responses. Imipramine significantly reversed the anxiogenic effect of CORT (P < 0.05), although the drug did not exhibit anxiolytic effects by itself. Confirming previous observations, imipramine inhibited escape responses, a panicolytic-like effect. Unlike chronic CORT, imipramine also decreased locomotor activity in an open field. These data suggest that chronic CORT specifically altered ETM avoidance, a fact that should be relevant to a better understanding of the physiopathology of generalized anxiety and panic disorder.
publishDate 2011
dc.date.none.fl_str_mv 2011-10-01
2015-06-14T13:43:16Z
2015-06-14T13:43:16Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://dx.doi.org/10.1590/S0100-879X2011007500117
Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 44, n. 10, p. 1048-1053, 2011.
10.1590/S0100-879X2011007500117
S0100-879X2011001000010.pdf
0100-879X
S0100-879X2011001000010
https://repositorio.unifesp.br/handle/11600/6628
WOS:000295721600010
url https://dx.doi.org/10.1590/S0100-879X2011007500117
https://repositorio.unifesp.br/handle/11600/6628
identifier_str_mv Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 44, n. 10, p. 1048-1053, 2011.
10.1590/S0100-879X2011007500117
S0100-879X2011001000010.pdf
0100-879X
S0100-879X2011001000010
WOS:000295721600010
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Brazilian Journal of Medical and Biological Research
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1048-1053
application/pdf
dc.publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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