Effects of chronic corticosterone and imipramine administration on panic and anxiety-related responses
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | https://dx.doi.org/10.1590/S0100-879X2011007500117 https://repositorio.unifesp.br/handle/11600/6628 |
Resumo: | It is known that chronic high levels of corticosterone (CORT) enhance aversive responses such as avoidance and contextual freezing. In contrast, chronic CORT does not alter defensive behavior induced by the exposure to a predator odor. Since different defense-related responses have been associated with specific anxiety disorders found in clinical settings, the observation that chronic CORT alters some defensive behaviors but not others might be relevant to the understanding of the neurobiology of anxiety. In the present study, we investigated the effects of chronic CORT administration (through surgical implantation of a 21-day release 200 mg pellet) on avoidance acquisition and escape expression by male Wistar rats (200 g in weight at the beginning of the experiments, N = 6-10/group) tested in the elevated T-maze (ETM). These defensive behaviors have been associated with generalized anxiety and panic disorder, respectively. Since the tricyclic antidepressant imipramine is successfully used to treat both conditions, the effects of combined treatment with chronic imipramine (15 mg, ip) and CORT were also investigated. Results showed that chronic CORT facilitated avoidance performance, an anxiogenic-like effect (P < 0.05), without changing escape responses. Imipramine significantly reversed the anxiogenic effect of CORT (P < 0.05), although the drug did not exhibit anxiolytic effects by itself. Confirming previous observations, imipramine inhibited escape responses, a panicolytic-like effect. Unlike chronic CORT, imipramine also decreased locomotor activity in an open field. These data suggest that chronic CORT specifically altered ETM avoidance, a fact that should be relevant to a better understanding of the physiopathology of generalized anxiety and panic disorder. |
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Effects of chronic corticosterone and imipramine administration on panic and anxiety-related responsesCorticosteroneImipramineGeneralized anxiety disorderPanic disorderElevated T-mazeIt is known that chronic high levels of corticosterone (CORT) enhance aversive responses such as avoidance and contextual freezing. In contrast, chronic CORT does not alter defensive behavior induced by the exposure to a predator odor. Since different defense-related responses have been associated with specific anxiety disorders found in clinical settings, the observation that chronic CORT alters some defensive behaviors but not others might be relevant to the understanding of the neurobiology of anxiety. In the present study, we investigated the effects of chronic CORT administration (through surgical implantation of a 21-day release 200 mg pellet) on avoidance acquisition and escape expression by male Wistar rats (200 g in weight at the beginning of the experiments, N = 6-10/group) tested in the elevated T-maze (ETM). These defensive behaviors have been associated with generalized anxiety and panic disorder, respectively. Since the tricyclic antidepressant imipramine is successfully used to treat both conditions, the effects of combined treatment with chronic imipramine (15 mg, ip) and CORT were also investigated. Results showed that chronic CORT facilitated avoidance performance, an anxiogenic-like effect (P < 0.05), without changing escape responses. Imipramine significantly reversed the anxiogenic effect of CORT (P < 0.05), although the drug did not exhibit anxiolytic effects by itself. Confirming previous observations, imipramine inhibited escape responses, a panicolytic-like effect. Unlike chronic CORT, imipramine also decreased locomotor activity in an open field. These data suggest that chronic CORT specifically altered ETM avoidance, a fact that should be relevant to a better understanding of the physiopathology of generalized anxiety and panic disorder.Universidade Federal de São Paulo (UNIFESP) Departamento de PsiquiatriaUniversidade Federal de São Paulo (UNIFESP) Departamento de BiociênciasUNIFESP, Depto. de PsiquiatriaUNIFESP, Depto. de BiociênciasSciELOFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)FAPESP: 2008/58815-1FAPESP: 2009/50830-4Associação Brasileira de Divulgação CientíficaUniversidade Federal de São Paulo (UNIFESP)Diniz, Leila [UNIFESP]Reis, Bianca Beraldo dos [UNIFESP]Castro, Glaucia Monteiro de [UNIFESP]Medalha, Carla Christina [UNIFESP]Viana, Milena de Barros [UNIFESP]2015-06-14T13:43:16Z2015-06-14T13:43:16Z2011-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion1048-1053application/pdfhttps://dx.doi.org/10.1590/S0100-879X2011007500117Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 44, n. 10, p. 1048-1053, 2011.10.1590/S0100-879X2011007500117S0100-879X2011001000010.pdf0100-879XS0100-879X2011001000010https://repositorio.unifesp.br/handle/11600/6628WOS:000295721600010engBrazilian Journal of Medical and Biological Researchinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-05T23:33:31Zoai:repositorio.unifesp.br/:11600/6628Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-05T23:33:31Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Effects of chronic corticosterone and imipramine administration on panic and anxiety-related responses |
title |
Effects of chronic corticosterone and imipramine administration on panic and anxiety-related responses |
spellingShingle |
Effects of chronic corticosterone and imipramine administration on panic and anxiety-related responses Diniz, Leila [UNIFESP] Corticosterone Imipramine Generalized anxiety disorder Panic disorder Elevated T-maze |
title_short |
Effects of chronic corticosterone and imipramine administration on panic and anxiety-related responses |
title_full |
Effects of chronic corticosterone and imipramine administration on panic and anxiety-related responses |
title_fullStr |
Effects of chronic corticosterone and imipramine administration on panic and anxiety-related responses |
title_full_unstemmed |
Effects of chronic corticosterone and imipramine administration on panic and anxiety-related responses |
title_sort |
Effects of chronic corticosterone and imipramine administration on panic and anxiety-related responses |
author |
Diniz, Leila [UNIFESP] |
author_facet |
Diniz, Leila [UNIFESP] Reis, Bianca Beraldo dos [UNIFESP] Castro, Glaucia Monteiro de [UNIFESP] Medalha, Carla Christina [UNIFESP] Viana, Milena de Barros [UNIFESP] |
author_role |
author |
author2 |
Reis, Bianca Beraldo dos [UNIFESP] Castro, Glaucia Monteiro de [UNIFESP] Medalha, Carla Christina [UNIFESP] Viana, Milena de Barros [UNIFESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Diniz, Leila [UNIFESP] Reis, Bianca Beraldo dos [UNIFESP] Castro, Glaucia Monteiro de [UNIFESP] Medalha, Carla Christina [UNIFESP] Viana, Milena de Barros [UNIFESP] |
dc.subject.por.fl_str_mv |
Corticosterone Imipramine Generalized anxiety disorder Panic disorder Elevated T-maze |
topic |
Corticosterone Imipramine Generalized anxiety disorder Panic disorder Elevated T-maze |
description |
It is known that chronic high levels of corticosterone (CORT) enhance aversive responses such as avoidance and contextual freezing. In contrast, chronic CORT does not alter defensive behavior induced by the exposure to a predator odor. Since different defense-related responses have been associated with specific anxiety disorders found in clinical settings, the observation that chronic CORT alters some defensive behaviors but not others might be relevant to the understanding of the neurobiology of anxiety. In the present study, we investigated the effects of chronic CORT administration (through surgical implantation of a 21-day release 200 mg pellet) on avoidance acquisition and escape expression by male Wistar rats (200 g in weight at the beginning of the experiments, N = 6-10/group) tested in the elevated T-maze (ETM). These defensive behaviors have been associated with generalized anxiety and panic disorder, respectively. Since the tricyclic antidepressant imipramine is successfully used to treat both conditions, the effects of combined treatment with chronic imipramine (15 mg, ip) and CORT were also investigated. Results showed that chronic CORT facilitated avoidance performance, an anxiogenic-like effect (P < 0.05), without changing escape responses. Imipramine significantly reversed the anxiogenic effect of CORT (P < 0.05), although the drug did not exhibit anxiolytic effects by itself. Confirming previous observations, imipramine inhibited escape responses, a panicolytic-like effect. Unlike chronic CORT, imipramine also decreased locomotor activity in an open field. These data suggest that chronic CORT specifically altered ETM avoidance, a fact that should be relevant to a better understanding of the physiopathology of generalized anxiety and panic disorder. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-10-01 2015-06-14T13:43:16Z 2015-06-14T13:43:16Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://dx.doi.org/10.1590/S0100-879X2011007500117 Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 44, n. 10, p. 1048-1053, 2011. 10.1590/S0100-879X2011007500117 S0100-879X2011001000010.pdf 0100-879X S0100-879X2011001000010 https://repositorio.unifesp.br/handle/11600/6628 WOS:000295721600010 |
url |
https://dx.doi.org/10.1590/S0100-879X2011007500117 https://repositorio.unifesp.br/handle/11600/6628 |
identifier_str_mv |
Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 44, n. 10, p. 1048-1053, 2011. 10.1590/S0100-879X2011007500117 S0100-879X2011001000010.pdf 0100-879X S0100-879X2011001000010 WOS:000295721600010 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Brazilian Journal of Medical and Biological Research |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1048-1053 application/pdf |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
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1814268430804582400 |