Analysis of the inflammatory response in endovascular treatment of aortic aneurysms
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/29514 http://dx.doi.org/10.1016/j.ejcts.2006.11.053 |
Resumo: | Objective: the objective of this study is to evaluate the inflammatory response caused by endovascular stents in the treatment of aortic aneurysms. Methods: Twenty-five patients underwent endovascular stent treatment from March through December 2005. the evolution of mediators (sedimentation velocity, C reactive protein, interteukin-6, interleukin-8, tumor necrosis factor-alpha, intercellular adhesion molecule-1, L-selectin), inflammatory cells (leukocytes, lymphocytes, platelets), serum creatinine and body temperature within preoperative period and in the following postoperative periods - 1, 6, 24 and 48 h, 7 days, 1-3 months, was analyzed. in order to achieve statistic significance, Friedman test and Wilcoxon test were used, with index of significance of 5% (p < 0.05). Results: Peak values of sedimentation velocity, C reactive protein and interleukin-6 were observed at 7 days (p < 0.0001), 48 h (p < 0.0001) and 24 h (p < 0.0001), respectively. Tumor necrosis factor-alpha and interteukin-8 did not show statistically significant variability during the entire follow-up. in terms of intercellular adhesion molecule-1 and L-selectin, their expressive values were found in late phase of follow-up, although without statistical significance. Elevation of leukocytes count occurred in premature phase of follow-up (p < 0.0001), while lymphocyte and platelet count occurred in a late phase of follow-up (p < 0.0001). Serum levels of creatinine did not show significant variability during follow-up. the period between 24 and 48 h corresponded to major frequency for fever (p < 0.0001). Conclusion: Individual mediators analysis and inflammatory cells demonstrated variability of their values during postoperative follow-up. This could help in the analysis of the inflammatory response evolution caused by endovascular stent treatment for aortic aneurysms in premature and late phases after implantation of the vascular prosthesis. (c) 2007 European Association for Cardio-Thoracic Surgery. Published by Elsevier B.V. All rights reserved. |
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Gabriel, Edmo Atique [UNIFESP]Locali, Rafael FagionatoRomano, Carta CristinaDuarte, Alberto Jose da Silva [UNIFESP]Fonseca, José Honório de Almeida Palma da [UNIFESP]Buffolo, Enio [UNIFESP]Universidade Federal de São Paulo (UNIFESP)2016-01-24T12:41:53Z2016-01-24T12:41:53Z2007-03-01European Journal of Cardio-thoracic Surgery. Amsterdam: Elsevier B.V., v. 31, n. 3, p. 406-412, 2007.1010-7940http://repositorio.unifesp.br/handle/11600/29514http://dx.doi.org/10.1016/j.ejcts.2006.11.05310.1016/j.ejcts.2006.11.053WOS:000245794500017Objective: the objective of this study is to evaluate the inflammatory response caused by endovascular stents in the treatment of aortic aneurysms. Methods: Twenty-five patients underwent endovascular stent treatment from March through December 2005. the evolution of mediators (sedimentation velocity, C reactive protein, interteukin-6, interleukin-8, tumor necrosis factor-alpha, intercellular adhesion molecule-1, L-selectin), inflammatory cells (leukocytes, lymphocytes, platelets), serum creatinine and body temperature within preoperative period and in the following postoperative periods - 1, 6, 24 and 48 h, 7 days, 1-3 months, was analyzed. in order to achieve statistic significance, Friedman test and Wilcoxon test were used, with index of significance of 5% (p < 0.05). Results: Peak values of sedimentation velocity, C reactive protein and interleukin-6 were observed at 7 days (p < 0.0001), 48 h (p < 0.0001) and 24 h (p < 0.0001), respectively. Tumor necrosis factor-alpha and interteukin-8 did not show statistically significant variability during the entire follow-up. in terms of intercellular adhesion molecule-1 and L-selectin, their expressive values were found in late phase of follow-up, although without statistical significance. Elevation of leukocytes count occurred in premature phase of follow-up (p < 0.0001), while lymphocyte and platelet count occurred in a late phase of follow-up (p < 0.0001). Serum levels of creatinine did not show significant variability during follow-up. the period between 24 and 48 h corresponded to major frequency for fever (p < 0.0001). Conclusion: Individual mediators analysis and inflammatory cells demonstrated variability of their values during postoperative follow-up. This could help in the analysis of the inflammatory response evolution caused by endovascular stent treatment for aortic aneurysms in premature and late phases after implantation of the vascular prosthesis. (c) 2007 European Association for Cardio-Thoracic Surgery. Published by Elsevier B.V. All rights reserved.Universidade Federal de São Paulo, Heart Hosp São Paulo, Paulista Sch Med, Div Cardiovasc Surg,Trop Illnessess Inst, São Paulo, BrazilUniversidade Federal de São Paulo, Heart Hosp São Paulo, Paulista Sch Med, Div Cardiovasc Surg,Trop Illnessess Inst, São Paulo, BrazilWeb of Science406-412engElsevier B.V.European Journal of Cardio-thoracic Surgeryhttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policyinfo:eu-repo/semantics/openAccessaortic aneurysmvascular prosthesisinflammatory mediatorsAnalysis of the inflammatory response in endovascular treatment of aortic aneurysmsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlereponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/295142022-02-18 10:09:40.177metadata only accessoai:repositorio.unifesp.br:11600/29514Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:07:25.515456Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Analysis of the inflammatory response in endovascular treatment of aortic aneurysms |
title |
Analysis of the inflammatory response in endovascular treatment of aortic aneurysms |
spellingShingle |
Analysis of the inflammatory response in endovascular treatment of aortic aneurysms Gabriel, Edmo Atique [UNIFESP] aortic aneurysm vascular prosthesis inflammatory mediators |
title_short |
Analysis of the inflammatory response in endovascular treatment of aortic aneurysms |
title_full |
Analysis of the inflammatory response in endovascular treatment of aortic aneurysms |
title_fullStr |
Analysis of the inflammatory response in endovascular treatment of aortic aneurysms |
title_full_unstemmed |
Analysis of the inflammatory response in endovascular treatment of aortic aneurysms |
title_sort |
Analysis of the inflammatory response in endovascular treatment of aortic aneurysms |
author |
Gabriel, Edmo Atique [UNIFESP] |
author_facet |
Gabriel, Edmo Atique [UNIFESP] Locali, Rafael Fagionato Romano, Carta Cristina Duarte, Alberto Jose da Silva [UNIFESP] Fonseca, José Honório de Almeida Palma da [UNIFESP] Buffolo, Enio [UNIFESP] |
author_role |
author |
author2 |
Locali, Rafael Fagionato Romano, Carta Cristina Duarte, Alberto Jose da Silva [UNIFESP] Fonseca, José Honório de Almeida Palma da [UNIFESP] Buffolo, Enio [UNIFESP] |
author2_role |
author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Gabriel, Edmo Atique [UNIFESP] Locali, Rafael Fagionato Romano, Carta Cristina Duarte, Alberto Jose da Silva [UNIFESP] Fonseca, José Honório de Almeida Palma da [UNIFESP] Buffolo, Enio [UNIFESP] |
dc.subject.eng.fl_str_mv |
aortic aneurysm vascular prosthesis inflammatory mediators |
topic |
aortic aneurysm vascular prosthesis inflammatory mediators |
description |
Objective: the objective of this study is to evaluate the inflammatory response caused by endovascular stents in the treatment of aortic aneurysms. Methods: Twenty-five patients underwent endovascular stent treatment from March through December 2005. the evolution of mediators (sedimentation velocity, C reactive protein, interteukin-6, interleukin-8, tumor necrosis factor-alpha, intercellular adhesion molecule-1, L-selectin), inflammatory cells (leukocytes, lymphocytes, platelets), serum creatinine and body temperature within preoperative period and in the following postoperative periods - 1, 6, 24 and 48 h, 7 days, 1-3 months, was analyzed. in order to achieve statistic significance, Friedman test and Wilcoxon test were used, with index of significance of 5% (p < 0.05). Results: Peak values of sedimentation velocity, C reactive protein and interleukin-6 were observed at 7 days (p < 0.0001), 48 h (p < 0.0001) and 24 h (p < 0.0001), respectively. Tumor necrosis factor-alpha and interteukin-8 did not show statistically significant variability during the entire follow-up. in terms of intercellular adhesion molecule-1 and L-selectin, their expressive values were found in late phase of follow-up, although without statistical significance. Elevation of leukocytes count occurred in premature phase of follow-up (p < 0.0001), while lymphocyte and platelet count occurred in a late phase of follow-up (p < 0.0001). Serum levels of creatinine did not show significant variability during follow-up. the period between 24 and 48 h corresponded to major frequency for fever (p < 0.0001). Conclusion: Individual mediators analysis and inflammatory cells demonstrated variability of their values during postoperative follow-up. This could help in the analysis of the inflammatory response evolution caused by endovascular stent treatment for aortic aneurysms in premature and late phases after implantation of the vascular prosthesis. (c) 2007 European Association for Cardio-Thoracic Surgery. Published by Elsevier B.V. All rights reserved. |
publishDate |
2007 |
dc.date.issued.fl_str_mv |
2007-03-01 |
dc.date.accessioned.fl_str_mv |
2016-01-24T12:41:53Z |
dc.date.available.fl_str_mv |
2016-01-24T12:41:53Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
European Journal of Cardio-thoracic Surgery. Amsterdam: Elsevier B.V., v. 31, n. 3, p. 406-412, 2007. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/29514 http://dx.doi.org/10.1016/j.ejcts.2006.11.053 |
dc.identifier.issn.none.fl_str_mv |
1010-7940 |
dc.identifier.doi.none.fl_str_mv |
10.1016/j.ejcts.2006.11.053 |
dc.identifier.wos.none.fl_str_mv |
WOS:000245794500017 |
identifier_str_mv |
European Journal of Cardio-thoracic Surgery. Amsterdam: Elsevier B.V., v. 31, n. 3, p. 406-412, 2007. 1010-7940 10.1016/j.ejcts.2006.11.053 WOS:000245794500017 |
url |
http://repositorio.unifesp.br/handle/11600/29514 http://dx.doi.org/10.1016/j.ejcts.2006.11.053 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
European Journal of Cardio-thoracic Surgery |
dc.rights.driver.fl_str_mv |
http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
406-412 |
dc.publisher.none.fl_str_mv |
Elsevier B.V. |
publisher.none.fl_str_mv |
Elsevier B.V. |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
_version_ |
1783460252158525440 |