Autonomic and renal alterations in the offspring of sleep-restricted mothers during late pregnancy
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | https://repositorio.unifesp.br/handle/11600/49411 https://dx.doi.org/10.6061/clinics/2016(09)07 |
Resumo: | OBJECTIVES: Considering that changes in the maternal environment may result in changes in progeny, the aim of this study was to investigate the influence of sleep restriction during the last week of pregnancy on renal function and autonomic responses in male descendants at an adult age. METHODS: After confirmation of pregnancy, female Wistar rats were randomly assigned to either a control or a sleep restriction group. The sleep-restricted rats were subjected to sleep restriction using the multiple platforms method for over 20 hours per day between the 14 th and 20 th day of pregnancy. After delivery, the litters were limited to 6 offspring that were designated as offspring from control and offspring from sleep-restricted mothers. Indirect measurements of systolic blood pressure (BPi), renal plasma flow, glomerular filtration rate, glomerular area and number of glomeruli per field were evaluated at three months of age. Direct measurements of cardiovascular function (heart rate and mean arterial pressure), cardiac sympathetic tone, cardiac parasympathetic tone, and baroreflex sensitivity were evaluated at four months of age. RESULTS: The sleep-restricted offspring presented increases in BPi, glomerular filtration rate and glomerular area compared with the control offspring. The sleep-restricted offspring also showed higher basal heart rate, increased mean arterial pressure, increased sympathetic cardiac tone, decreased parasympathetic cardiac tone and reduced baroreflex sensitivity. CONCLUSIONS: Our data suggest that reductions in sleep during the last week of pregnancy lead to alterations in cardiovascular autonomic regulation and renal morpho-functional changes in offspring, triggering increases in blood pressure. |
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Raimundo, Joyce Regina Santos [UNIFESP]Bergamaschi, Cassia Toledo [UNIFESP]Palma, Beatriz Duarte [UNIFESP]Tufik, Sergio [UNIFESP]Gomes, Guiomar Nascimento [UNIFESP]Campos, Ruy Ribeiro [UNIFESP]2019-01-21T10:29:49Z2019-01-21T10:29:49Z2016Clinics. Sao paulo, v. 71, n. 9, p. 521-527, 2016.1807-5932https://repositorio.unifesp.br/handle/11600/49411https://dx.doi.org/10.6061/clinics/2016(09)07S1807-59322016000900521.pdfS1807-5932201600090052110.6061/clinics/2016(09)07WOS:000382872800007OBJECTIVES: Considering that changes in the maternal environment may result in changes in progeny, the aim of this study was to investigate the influence of sleep restriction during the last week of pregnancy on renal function and autonomic responses in male descendants at an adult age. METHODS: After confirmation of pregnancy, female Wistar rats were randomly assigned to either a control or a sleep restriction group. The sleep-restricted rats were subjected to sleep restriction using the multiple platforms method for over 20 hours per day between the 14 th and 20 th day of pregnancy. After delivery, the litters were limited to 6 offspring that were designated as offspring from control and offspring from sleep-restricted mothers. Indirect measurements of systolic blood pressure (BPi), renal plasma flow, glomerular filtration rate, glomerular area and number of glomeruli per field were evaluated at three months of age. Direct measurements of cardiovascular function (heart rate and mean arterial pressure), cardiac sympathetic tone, cardiac parasympathetic tone, and baroreflex sensitivity were evaluated at four months of age. RESULTS: The sleep-restricted offspring presented increases in BPi, glomerular filtration rate and glomerular area compared with the control offspring. The sleep-restricted offspring also showed higher basal heart rate, increased mean arterial pressure, increased sympathetic cardiac tone, decreased parasympathetic cardiac tone and reduced baroreflex sensitivity. CONCLUSIONS: Our data suggest that reductions in sleep during the last week of pregnancy lead to alterations in cardiovascular autonomic regulation and renal morpho-functional changes in offspring, triggering increases in blood pressure.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Escola Paulista de Medicina - UNIFESP, Departamento de Fisiologia, São Paulo/SP, BrazilEscola Paulista de Medicina - UNIFESP, Departamento de Psicobiologia, São Paulo/SP, BrazilCentro Universitário São Camilo, São Paulo/SP, BrazilEscola Paulista de Medicina - UNIFESP, Departamento de Fisiologia, São Paulo/SP, BrazilEscola Paulista de Medicina - UNIFESP, Departamento de Psicobiologia, São Paulo/SP, BrazilFAPESP: 2013-23622-7Web of Science521-527engAtha Comunicacao & EditoraClinicsPrenatal Exposure Delayed EffectsHypertensionKidney DiseaseSleep RestrictionBlood-PressureAngiotensin-IiHeart-RateAntenatal BetamethasoneCardiovascular-DiseaseEssential-HypertensionArterial-PressureDeprivationRatsStressAutonomic and renal alterations in the offspring of sleep-restricted mothers during late pregnancyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/494112021-09-30 17:28:02.191metadata only accessoai:repositorio.unifesp.br:11600/49411Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:24:49.556338Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Autonomic and renal alterations in the offspring of sleep-restricted mothers during late pregnancy |
title |
Autonomic and renal alterations in the offspring of sleep-restricted mothers during late pregnancy |
spellingShingle |
Autonomic and renal alterations in the offspring of sleep-restricted mothers during late pregnancy Raimundo, Joyce Regina Santos [UNIFESP] Prenatal Exposure Delayed Effects Hypertension Kidney Disease Sleep RestrictionBlood-Pressure Angiotensin-Ii Heart-Rate Antenatal Betamethasone Cardiovascular-Disease Essential-Hypertension Arterial-Pressure Deprivation Rats Stress |
title_short |
Autonomic and renal alterations in the offspring of sleep-restricted mothers during late pregnancy |
title_full |
Autonomic and renal alterations in the offspring of sleep-restricted mothers during late pregnancy |
title_fullStr |
Autonomic and renal alterations in the offspring of sleep-restricted mothers during late pregnancy |
title_full_unstemmed |
Autonomic and renal alterations in the offspring of sleep-restricted mothers during late pregnancy |
title_sort |
Autonomic and renal alterations in the offspring of sleep-restricted mothers during late pregnancy |
author |
Raimundo, Joyce Regina Santos [UNIFESP] |
author_facet |
Raimundo, Joyce Regina Santos [UNIFESP] Bergamaschi, Cassia Toledo [UNIFESP] Palma, Beatriz Duarte [UNIFESP] Tufik, Sergio [UNIFESP] Gomes, Guiomar Nascimento [UNIFESP] Campos, Ruy Ribeiro [UNIFESP] |
author_role |
author |
author2 |
Bergamaschi, Cassia Toledo [UNIFESP] Palma, Beatriz Duarte [UNIFESP] Tufik, Sergio [UNIFESP] Gomes, Guiomar Nascimento [UNIFESP] Campos, Ruy Ribeiro [UNIFESP] |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Raimundo, Joyce Regina Santos [UNIFESP] Bergamaschi, Cassia Toledo [UNIFESP] Palma, Beatriz Duarte [UNIFESP] Tufik, Sergio [UNIFESP] Gomes, Guiomar Nascimento [UNIFESP] Campos, Ruy Ribeiro [UNIFESP] |
dc.subject.eng.fl_str_mv |
Prenatal Exposure Delayed Effects Hypertension Kidney Disease Sleep RestrictionBlood-Pressure Angiotensin-Ii Heart-Rate Antenatal Betamethasone Cardiovascular-Disease Essential-Hypertension Arterial-Pressure Deprivation Rats Stress |
topic |
Prenatal Exposure Delayed Effects Hypertension Kidney Disease Sleep RestrictionBlood-Pressure Angiotensin-Ii Heart-Rate Antenatal Betamethasone Cardiovascular-Disease Essential-Hypertension Arterial-Pressure Deprivation Rats Stress |
description |
OBJECTIVES: Considering that changes in the maternal environment may result in changes in progeny, the aim of this study was to investigate the influence of sleep restriction during the last week of pregnancy on renal function and autonomic responses in male descendants at an adult age. METHODS: After confirmation of pregnancy, female Wistar rats were randomly assigned to either a control or a sleep restriction group. The sleep-restricted rats were subjected to sleep restriction using the multiple platforms method for over 20 hours per day between the 14 th and 20 th day of pregnancy. After delivery, the litters were limited to 6 offspring that were designated as offspring from control and offspring from sleep-restricted mothers. Indirect measurements of systolic blood pressure (BPi), renal plasma flow, glomerular filtration rate, glomerular area and number of glomeruli per field were evaluated at three months of age. Direct measurements of cardiovascular function (heart rate and mean arterial pressure), cardiac sympathetic tone, cardiac parasympathetic tone, and baroreflex sensitivity were evaluated at four months of age. RESULTS: The sleep-restricted offspring presented increases in BPi, glomerular filtration rate and glomerular area compared with the control offspring. The sleep-restricted offspring also showed higher basal heart rate, increased mean arterial pressure, increased sympathetic cardiac tone, decreased parasympathetic cardiac tone and reduced baroreflex sensitivity. CONCLUSIONS: Our data suggest that reductions in sleep during the last week of pregnancy lead to alterations in cardiovascular autonomic regulation and renal morpho-functional changes in offspring, triggering increases in blood pressure. |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016 |
dc.date.accessioned.fl_str_mv |
2019-01-21T10:29:49Z |
dc.date.available.fl_str_mv |
2019-01-21T10:29:49Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Clinics. Sao paulo, v. 71, n. 9, p. 521-527, 2016. |
dc.identifier.uri.fl_str_mv |
https://repositorio.unifesp.br/handle/11600/49411 https://dx.doi.org/10.6061/clinics/2016(09)07 |
dc.identifier.issn.none.fl_str_mv |
1807-5932 |
dc.identifier.file.none.fl_str_mv |
S1807-59322016000900521.pdf |
dc.identifier.scielo.none.fl_str_mv |
S1807-59322016000900521 |
dc.identifier.doi.none.fl_str_mv |
10.6061/clinics/2016(09)07 |
dc.identifier.wos.none.fl_str_mv |
WOS:000382872800007 |
identifier_str_mv |
Clinics. Sao paulo, v. 71, n. 9, p. 521-527, 2016. 1807-5932 S1807-59322016000900521.pdf S1807-59322016000900521 10.6061/clinics/2016(09)07 WOS:000382872800007 |
url |
https://repositorio.unifesp.br/handle/11600/49411 https://dx.doi.org/10.6061/clinics/2016(09)07 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Clinics |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
521-527 |
dc.publisher.none.fl_str_mv |
Atha Comunicacao & Editora |
publisher.none.fl_str_mv |
Atha Comunicacao & Editora |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
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1783460287795429376 |