Autoantibodies in renal diseases-clinical significance and recent developments in serological detection
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/39100 http://dx.doi.org/10.3389/fimmu.2015.00221 |
Resumo: | Autoimmune dysfunctions are the bete noire in a range of debilitating nephropathies. Autoimmune-mediated damage to the kidneys can be triggered by autoantibodies directed against specific proteins or renal structures, for example, the phospholipase A2 receptor or the glomerular basement membrane, resulting in glomerular diseases such as primary membranous nephropathy or Goodpasture's disease. Moreover, secondary damage to the kidney can be part of the wide-reaching effects of systemic autoimmune diseases such as vasculitis or systemic lupus erythematosus (SLE) the latter counts lupus nephritis among its most severe manifestations. Systemic autoimmune diseases are characterized by non-organ-specific autoantibodies, directed for example against neutrophil cytoplasmic antigens in systemic vasculitis and against double-stranded DNA and nucleosomes in SLE. A large variety of innovative and highly specific and sensitive autoantibody tests have been developed in the last years that are available to identify autoimmune kidney diseases at an early stage. Thus, serological in vitro diagnostics allow for appropriate interventional therapy in order to prevent disease progression often resulting in need of dialysis and transplantation. |
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Kirsztajn, Gianna Mastroianni [UNIFESP]Hornig, NoraSchlumberger, WolfgangUniversidade Federal de São Paulo (UNIFESP)EUROIMMUN Med Labordiagnost AG2016-01-24T14:40:31Z2016-01-24T14:40:31Z2015-05-11Frontiers in Immunology. Lausanne: Frontiers Research Foundation, v. 6, 6 p., 2015.1664-3224http://repositorio.unifesp.br/handle/11600/39100http://dx.doi.org/10.3389/fimmu.2015.00221WOS000355321500001.pdf10.3389/fimmu.2015.00221WOS:000355321500001Autoimmune dysfunctions are the bete noire in a range of debilitating nephropathies. Autoimmune-mediated damage to the kidneys can be triggered by autoantibodies directed against specific proteins or renal structures, for example, the phospholipase A2 receptor or the glomerular basement membrane, resulting in glomerular diseases such as primary membranous nephropathy or Goodpasture's disease. Moreover, secondary damage to the kidney can be part of the wide-reaching effects of systemic autoimmune diseases such as vasculitis or systemic lupus erythematosus (SLE) the latter counts lupus nephritis among its most severe manifestations. Systemic autoimmune diseases are characterized by non-organ-specific autoantibodies, directed for example against neutrophil cytoplasmic antigens in systemic vasculitis and against double-stranded DNA and nucleosomes in SLE. A large variety of innovative and highly specific and sensitive autoantibody tests have been developed in the last years that are available to identify autoimmune kidney diseases at an early stage. Thus, serological in vitro diagnostics allow for appropriate interventional therapy in order to prevent disease progression often resulting in need of dialysis and transplantation.Universidade Federal de São Paulo, Dept Med, Div Nephrol, São Paulo, BrazilEUROIMMUN Med Labordiagnost AG, Inst Expt Immunol, D-23560 Lubeck, GermanyUniversidade Federal de São Paulo, Dept Med, Div Nephrol, São Paulo, BrazilWeb of Science6engFrontiers Research FoundationFrontiers in Immunologyautoantibodiesrenal autoimmune diseasesanti-PLA2Ranti-THSD7Aanti-nucleosomesanti-dsDNAANCAanti-PR3Autoantibodies in renal diseases-clinical significance and recent developments in serological detectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000355321500001.pdfapplication/pdf4470989${dspace.ui.url}/bitstream/11600/39100/1/WOS000355321500001.pdf526e00e43d8073ad34c4d62e773d34e2MD51open accessTEXTWOS000355321500001.pdf.txtWOS000355321500001.pdf.txtExtracted texttext/plain29963${dspace.ui.url}/bitstream/11600/39100/2/WOS000355321500001.pdf.txt1592c9cb2f91ca09765b1d0d264b6de2MD52open access11600/391002023-01-12 21:39:40.498open accessoai:repositorio.unifesp.br:11600/39100Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-01-13T00:39:40Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Autoantibodies in renal diseases-clinical significance and recent developments in serological detection |
title |
Autoantibodies in renal diseases-clinical significance and recent developments in serological detection |
spellingShingle |
Autoantibodies in renal diseases-clinical significance and recent developments in serological detection Kirsztajn, Gianna Mastroianni [UNIFESP] autoantibodies renal autoimmune diseases anti-PLA2R anti-THSD7A anti-nucleosomes anti-dsDNA ANCA anti-PR3 |
title_short |
Autoantibodies in renal diseases-clinical significance and recent developments in serological detection |
title_full |
Autoantibodies in renal diseases-clinical significance and recent developments in serological detection |
title_fullStr |
Autoantibodies in renal diseases-clinical significance and recent developments in serological detection |
title_full_unstemmed |
Autoantibodies in renal diseases-clinical significance and recent developments in serological detection |
title_sort |
Autoantibodies in renal diseases-clinical significance and recent developments in serological detection |
author |
Kirsztajn, Gianna Mastroianni [UNIFESP] |
author_facet |
Kirsztajn, Gianna Mastroianni [UNIFESP] Hornig, Nora Schlumberger, Wolfgang |
author_role |
author |
author2 |
Hornig, Nora Schlumberger, Wolfgang |
author2_role |
author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) EUROIMMUN Med Labordiagnost AG |
dc.contributor.author.fl_str_mv |
Kirsztajn, Gianna Mastroianni [UNIFESP] Hornig, Nora Schlumberger, Wolfgang |
dc.subject.eng.fl_str_mv |
autoantibodies renal autoimmune diseases anti-PLA2R anti-THSD7A anti-nucleosomes anti-dsDNA ANCA anti-PR3 |
topic |
autoantibodies renal autoimmune diseases anti-PLA2R anti-THSD7A anti-nucleosomes anti-dsDNA ANCA anti-PR3 |
description |
Autoimmune dysfunctions are the bete noire in a range of debilitating nephropathies. Autoimmune-mediated damage to the kidneys can be triggered by autoantibodies directed against specific proteins or renal structures, for example, the phospholipase A2 receptor or the glomerular basement membrane, resulting in glomerular diseases such as primary membranous nephropathy or Goodpasture's disease. Moreover, secondary damage to the kidney can be part of the wide-reaching effects of systemic autoimmune diseases such as vasculitis or systemic lupus erythematosus (SLE) the latter counts lupus nephritis among its most severe manifestations. Systemic autoimmune diseases are characterized by non-organ-specific autoantibodies, directed for example against neutrophil cytoplasmic antigens in systemic vasculitis and against double-stranded DNA and nucleosomes in SLE. A large variety of innovative and highly specific and sensitive autoantibody tests have been developed in the last years that are available to identify autoimmune kidney diseases at an early stage. Thus, serological in vitro diagnostics allow for appropriate interventional therapy in order to prevent disease progression often resulting in need of dialysis and transplantation. |
publishDate |
2015 |
dc.date.issued.fl_str_mv |
2015-05-11 |
dc.date.accessioned.fl_str_mv |
2016-01-24T14:40:31Z |
dc.date.available.fl_str_mv |
2016-01-24T14:40:31Z |
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article |
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dc.identifier.citation.fl_str_mv |
Frontiers in Immunology. Lausanne: Frontiers Research Foundation, v. 6, 6 p., 2015. |
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http://repositorio.unifesp.br/handle/11600/39100 http://dx.doi.org/10.3389/fimmu.2015.00221 |
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1664-3224 |
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WOS000355321500001.pdf |
dc.identifier.doi.none.fl_str_mv |
10.3389/fimmu.2015.00221 |
dc.identifier.wos.none.fl_str_mv |
WOS:000355321500001 |
identifier_str_mv |
Frontiers in Immunology. Lausanne: Frontiers Research Foundation, v. 6, 6 p., 2015. 1664-3224 WOS000355321500001.pdf 10.3389/fimmu.2015.00221 WOS:000355321500001 |
url |
http://repositorio.unifesp.br/handle/11600/39100 http://dx.doi.org/10.3389/fimmu.2015.00221 |
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eng |
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Frontiers Research Foundation |
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