Neuropsychological predictors of response to randomized treatment in obsessive-compulsive disorder
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/35605 http://dx.doi.org/10.1016/j.pnpbp.2012.07.002 |
Resumo: | Objective: To identify neuropsychological predictors of treatment response to cognitive-behavioral therapy (CBT) and fluoxetine in treatment-naive adults with obsessive-compulsive disorder (OCD).Method: Thirty-eight adult outpatients with OCD underwent neuropsychological assessment, including tasks of intellectual function, executive functioning and visual and verbal memory, before randomization to a 12-week clinical trial of either CBT or fluoxetine. Neuropsychological measures were used to identify predictors of treatment response in OCD.Results: Neuropsychological measures that predicted a better treatment response to either CBT or fluoxetine were higher verbal IQ (Wechsler Abbreviated Scale of Intelligence) (p = 0.008); higher verbal memory on the California Verbal Learning Test (p = 0.710); shorter time to complete part D (Dots) (p<0.001), longer time to complete part W (Words) (p = 0.025) and less errors on part C (Colors) (p<0.001) in the Victoria Stroop Test (VST). Fewer perseverations on the California Verbal Learning Test, a measure of mental flexibility, predicted better response to CBT, but worse response to fluoxetine (p = 0.002).Conclusion: in general, OCD patients with better cognitive and executive abilities at baseline were more prone to respond to either CBT or fluoxetine. Our finding that neuropsychological measures of mental flexibility predicted response to treatment in opposite directions for CBT and fluoxetine suggests that OCD patients with different neuropsychological profiles may respond preferentially to one type of treatment versus the other. Further studies with larger samples of OCD patients are necessary to investigate the heuristic value of such findings in a clinical context. (C) 2012 Elsevier Inc. All rights reserved. |
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D'Alcante, Carina ChaubetDiniz, Juliana BeloFossaluza, VictorBatistuzzo, Marcelo CamargoLopes, Antonio CarlosShavitt, Roseli GedankeDeckersbach, ThiloMalloy-Diniz, LeandroMiguel, Euripedes ConstantinoHoexter, Marcelo Queiroz [UNIFESP]Universidade de São Paulo (USP)Harvard UnivUniversidade Federal de Minas Gerais (UFMG)Universidade Federal de São Paulo (UNIFESP)2016-01-24T14:28:08Z2016-01-24T14:28:08Z2012-12-03Progress in Neuro-psychopharmacology & Biological Psychiatry. Oxford: Pergamon-Elsevier B.V., v. 39, n. 2, p. 310-317, 2012.0278-5846http://repositorio.unifesp.br/handle/11600/35605http://dx.doi.org/10.1016/j.pnpbp.2012.07.002WOS000310943500014.pdf10.1016/j.pnpbp.2012.07.002WOS:000310943500014Objective: To identify neuropsychological predictors of treatment response to cognitive-behavioral therapy (CBT) and fluoxetine in treatment-naive adults with obsessive-compulsive disorder (OCD).Method: Thirty-eight adult outpatients with OCD underwent neuropsychological assessment, including tasks of intellectual function, executive functioning and visual and verbal memory, before randomization to a 12-week clinical trial of either CBT or fluoxetine. Neuropsychological measures were used to identify predictors of treatment response in OCD.Results: Neuropsychological measures that predicted a better treatment response to either CBT or fluoxetine were higher verbal IQ (Wechsler Abbreviated Scale of Intelligence) (p = 0.008); higher verbal memory on the California Verbal Learning Test (p = 0.710); shorter time to complete part D (Dots) (p<0.001), longer time to complete part W (Words) (p = 0.025) and less errors on part C (Colors) (p<0.001) in the Victoria Stroop Test (VST). Fewer perseverations on the California Verbal Learning Test, a measure of mental flexibility, predicted better response to CBT, but worse response to fluoxetine (p = 0.002).Conclusion: in general, OCD patients with better cognitive and executive abilities at baseline were more prone to respond to either CBT or fluoxetine. Our finding that neuropsychological measures of mental flexibility predicted response to treatment in opposite directions for CBT and fluoxetine suggests that OCD patients with different neuropsychological profiles may respond preferentially to one type of treatment versus the other. Further studies with larger samples of OCD patients are necessary to investigate the heuristic value of such findings in a clinical context. (C) 2012 Elsevier Inc. All rights reserved.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Univ São Paulo, Sch Med, Dept Psychiat, Obsess Compuls Disorder Spectrum Project Clin, BR-78505453 São Paulo, BrazilUniv São Paulo, Inst Math & Stat, BR-78505453 São Paulo, BrazilHarvard Univ, Sch Med, Dept Psychiat, Massachusetts Gen Hosp, Boston, MA 02115 USAUniv Fed Minas Gerais, Inst Biol Sci, Grad Program Neurosci, Belo Horizonte, MG, BrazilFed Univ São Paulo UNIFESP, Dept Psychiat, Interdisciplinary Lab Clin Neurosci LiNC, São Paulo, BrazilFed Univ São Paulo UNIFESP, Dept Psychiat, Interdisciplinary Lab Clin Neurosci LiNC, São Paulo, BrazilCNPq: 521369/96-7CNPq: 475919/2006-8CNPq: 481791/2004-3FAPESP: 05/55628-08FAPESP: 05/04206-6FAPESP: 06/61459-7FAPESP: 06/50273-0FAPESP: 06/58286-3Web of Science310-317engElsevier B.V.Progress in Neuro-psychopharmacology & Biological Psychiatryhttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policyinfo:eu-repo/semantics/openAccessCognitive-behavioral therapyNeuropsychologyObsessive-compulsive disorderSerotonin reuptake inhibitorsTreatment-naiveNeuropsychological predictors of response to randomized treatment in obsessive-compulsive disorderinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlereponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000310943500014.pdfapplication/pdf260422${dspace.ui.url}/bitstream/11600/35605/1/WOS000310943500014.pdf64747592c9ded2f6520d6ca896b30d44MD51open accessTEXTWOS000310943500014.pdf.txtWOS000310943500014.pdf.txtExtracted texttext/plain52302${dspace.ui.url}/bitstream/11600/35605/2/WOS000310943500014.pdf.txt4c2ba6d0109c97d7e061e0f2adec0749MD52open access11600/356052021-10-05 21:59:09.964open accessoai:repositorio.unifesp.br:11600/35605Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:26:37.911661Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Neuropsychological predictors of response to randomized treatment in obsessive-compulsive disorder |
title |
Neuropsychological predictors of response to randomized treatment in obsessive-compulsive disorder |
spellingShingle |
Neuropsychological predictors of response to randomized treatment in obsessive-compulsive disorder D'Alcante, Carina Chaubet Cognitive-behavioral therapy Neuropsychology Obsessive-compulsive disorder Serotonin reuptake inhibitors Treatment-naive |
title_short |
Neuropsychological predictors of response to randomized treatment in obsessive-compulsive disorder |
title_full |
Neuropsychological predictors of response to randomized treatment in obsessive-compulsive disorder |
title_fullStr |
Neuropsychological predictors of response to randomized treatment in obsessive-compulsive disorder |
title_full_unstemmed |
Neuropsychological predictors of response to randomized treatment in obsessive-compulsive disorder |
title_sort |
Neuropsychological predictors of response to randomized treatment in obsessive-compulsive disorder |
author |
D'Alcante, Carina Chaubet |
author_facet |
D'Alcante, Carina Chaubet Diniz, Juliana Belo Fossaluza, Victor Batistuzzo, Marcelo Camargo Lopes, Antonio Carlos Shavitt, Roseli Gedanke Deckersbach, Thilo Malloy-Diniz, Leandro Miguel, Euripedes Constantino Hoexter, Marcelo Queiroz [UNIFESP] |
author_role |
author |
author2 |
Diniz, Juliana Belo Fossaluza, Victor Batistuzzo, Marcelo Camargo Lopes, Antonio Carlos Shavitt, Roseli Gedanke Deckersbach, Thilo Malloy-Diniz, Leandro Miguel, Euripedes Constantino Hoexter, Marcelo Queiroz [UNIFESP] |
author2_role |
author author author author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade de São Paulo (USP) Harvard Univ Universidade Federal de Minas Gerais (UFMG) Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
D'Alcante, Carina Chaubet Diniz, Juliana Belo Fossaluza, Victor Batistuzzo, Marcelo Camargo Lopes, Antonio Carlos Shavitt, Roseli Gedanke Deckersbach, Thilo Malloy-Diniz, Leandro Miguel, Euripedes Constantino Hoexter, Marcelo Queiroz [UNIFESP] |
dc.subject.eng.fl_str_mv |
Cognitive-behavioral therapy Neuropsychology Obsessive-compulsive disorder Serotonin reuptake inhibitors Treatment-naive |
topic |
Cognitive-behavioral therapy Neuropsychology Obsessive-compulsive disorder Serotonin reuptake inhibitors Treatment-naive |
description |
Objective: To identify neuropsychological predictors of treatment response to cognitive-behavioral therapy (CBT) and fluoxetine in treatment-naive adults with obsessive-compulsive disorder (OCD).Method: Thirty-eight adult outpatients with OCD underwent neuropsychological assessment, including tasks of intellectual function, executive functioning and visual and verbal memory, before randomization to a 12-week clinical trial of either CBT or fluoxetine. Neuropsychological measures were used to identify predictors of treatment response in OCD.Results: Neuropsychological measures that predicted a better treatment response to either CBT or fluoxetine were higher verbal IQ (Wechsler Abbreviated Scale of Intelligence) (p = 0.008); higher verbal memory on the California Verbal Learning Test (p = 0.710); shorter time to complete part D (Dots) (p<0.001), longer time to complete part W (Words) (p = 0.025) and less errors on part C (Colors) (p<0.001) in the Victoria Stroop Test (VST). Fewer perseverations on the California Verbal Learning Test, a measure of mental flexibility, predicted better response to CBT, but worse response to fluoxetine (p = 0.002).Conclusion: in general, OCD patients with better cognitive and executive abilities at baseline were more prone to respond to either CBT or fluoxetine. Our finding that neuropsychological measures of mental flexibility predicted response to treatment in opposite directions for CBT and fluoxetine suggests that OCD patients with different neuropsychological profiles may respond preferentially to one type of treatment versus the other. Further studies with larger samples of OCD patients are necessary to investigate the heuristic value of such findings in a clinical context. (C) 2012 Elsevier Inc. All rights reserved. |
publishDate |
2012 |
dc.date.issued.fl_str_mv |
2012-12-03 |
dc.date.accessioned.fl_str_mv |
2016-01-24T14:28:08Z |
dc.date.available.fl_str_mv |
2016-01-24T14:28:08Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Progress in Neuro-psychopharmacology & Biological Psychiatry. Oxford: Pergamon-Elsevier B.V., v. 39, n. 2, p. 310-317, 2012. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/35605 http://dx.doi.org/10.1016/j.pnpbp.2012.07.002 |
dc.identifier.issn.none.fl_str_mv |
0278-5846 |
dc.identifier.file.none.fl_str_mv |
WOS000310943500014.pdf |
dc.identifier.doi.none.fl_str_mv |
10.1016/j.pnpbp.2012.07.002 |
dc.identifier.wos.none.fl_str_mv |
WOS:000310943500014 |
identifier_str_mv |
Progress in Neuro-psychopharmacology & Biological Psychiatry. Oxford: Pergamon-Elsevier B.V., v. 39, n. 2, p. 310-317, 2012. 0278-5846 WOS000310943500014.pdf 10.1016/j.pnpbp.2012.07.002 WOS:000310943500014 |
url |
http://repositorio.unifesp.br/handle/11600/35605 http://dx.doi.org/10.1016/j.pnpbp.2012.07.002 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Progress in Neuro-psychopharmacology & Biological Psychiatry |
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http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
310-317 |
dc.publisher.none.fl_str_mv |
Elsevier B.V. |
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Elsevier B.V. |
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