Influence of autonomic neuropathy upon left ventricular dysfunction in insulin-dependent diabetic patients
Autor(a) principal: | |
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Data de Publicação: | 2000 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/11600/43351 http://dx.doi.org/10.1002/clc.4960230513 |
Resumo: | Background: Diabetic cardiomyopathy is a well-defined complication of diabetes that occurs in the absence of ischemic, vascular, and hypertensive disease.Hypothesis: The study was undertaken to test the relationship among autonomic neuropathy (AN), 24-h blood pressure (BP) profile, and left ventricular function.Methods: Nineteen type-1 diabetic patients underwent autonomic tests and echocardiographic examination. Patients were divided according to the presence (AN+) or absence (AN-) of AN.Results: In the AN+ group (n = 8), the E/A ratio at echo was lower than in the AN- group (n = 11) (1.1 +/- 0.3 vs. 1.6 +/- 0.3; p < 0.005). Systolic and diastolic BP reductions during sleep were smaller in the AN+ than in the AN- group (6.6 +/- 6.6 vs. 13.0 +/- 4.3%; p < 0.03 for systolic and 12.8 +/- 6.8 vs. 20.0 +/- 4.0% for diastolic BP reduction; p < 0.03, respectively). Considering all patients, the EIA ratio correlated inversely with awake diastolic BP (r - 0.63; p = 0.005); sleep systolic BP (r - 0.48; p = 0.04), and sleep diastolic BP (r - 0.67; p = 0.002). The AN correlated with diastolic interventricular septum thickness (r 0.57; p = 0.01), sleep systolic BP (r 0.45; = 0.05), sleep diastolic BP (r 0.54; p = 0.02), and correlated inversely with systolic and diastolic sleep BP reduction (r - 0.49; p = 0.03 and r - 0.67; p = 0.002, respectively). Finally, E/A ratio and AN score correlated between themselves (r - 0.6; p = 0.005).Conclusion: Our results suggest that left ventricular diastolic dysfunction may be detected very early in type-1 diabetic patients with AN. Parasympathetic lesion and nocturnal elevations in BP could be the Link between AN and diastolic ventricular dysfunction. |
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Monteagudo, Patrícia Teófilo [UNIFESP]Moisés, Valdir Ambrósio [UNIFESP]Kohlmann Junior, Osvaldo [UNIFESP]Ribeiro, Artur Beltrame [UNIFESP]Lima, Valter Correia de [UNIFESP]Zanella, Maria Teresa [UNIFESP]Universidade Federal de São Paulo (UNIFESP)2018-06-15T16:52:46Z2018-06-15T16:52:46Z2000-05-01Clinical Cardiology. Mahwah: Clinical Cardiology Publ Co, v. 23, n. 5, p. 371-375, 2000.0160-9289http://repositorio.unifesp.br/11600/43351http://dx.doi.org/10.1002/clc.496023051310.1002/clc.4960230513WOS:000086771200011Background: Diabetic cardiomyopathy is a well-defined complication of diabetes that occurs in the absence of ischemic, vascular, and hypertensive disease.Hypothesis: The study was undertaken to test the relationship among autonomic neuropathy (AN), 24-h blood pressure (BP) profile, and left ventricular function.Methods: Nineteen type-1 diabetic patients underwent autonomic tests and echocardiographic examination. Patients were divided according to the presence (AN+) or absence (AN-) of AN.Results: In the AN+ group (n = 8), the E/A ratio at echo was lower than in the AN- group (n = 11) (1.1 +/- 0.3 vs. 1.6 +/- 0.3; p < 0.005). Systolic and diastolic BP reductions during sleep were smaller in the AN+ than in the AN- group (6.6 +/- 6.6 vs. 13.0 +/- 4.3%; p < 0.03 for systolic and 12.8 +/- 6.8 vs. 20.0 +/- 4.0% for diastolic BP reduction; p < 0.03, respectively). Considering all patients, the EIA ratio correlated inversely with awake diastolic BP (r - 0.63; p = 0.005); sleep systolic BP (r - 0.48; p = 0.04), and sleep diastolic BP (r - 0.67; p = 0.002). The AN correlated with diastolic interventricular septum thickness (r 0.57; p = 0.01), sleep systolic BP (r 0.45; = 0.05), sleep diastolic BP (r 0.54; p = 0.02), and correlated inversely with systolic and diastolic sleep BP reduction (r - 0.49; p = 0.03 and r - 0.67; p = 0.002, respectively). Finally, E/A ratio and AN score correlated between themselves (r - 0.6; p = 0.005).Conclusion: Our results suggest that left ventricular diastolic dysfunction may be detected very early in type-1 diabetic patients with AN. Parasympathetic lesion and nocturnal elevations in BP could be the Link between AN and diastolic ventricular dysfunction.UNIFESP, Escola Paulista Med, Dept Med, Div Endocrinol, BR-04024000 Sao Paulo, BrazilUNIFESP, Escola Paulista Med, Dept Med, Div Cardiol, BR-04024000 Sao Paulo, BrazilUNIFESP, Escola Paulista Med, Dept Med, Div Nephrol, BR-04024000 Sao Paulo, BrazilUNIFESP, Escola Paulista Med, Dept Med, Div Endocrinol, BR-04024000 Sao Paulo, BrazilUNIFESP, Escola Paulista Med, Dept Med, Div Cardiol, BR-04024000 Sao Paulo, BrazilUNIFESP, Escola Paulista Med, Dept Med, Div Nephrol, BR-04024000 Sao Paulo, BrazilWeb of Science371-375engClinical Cardiology Publ CoClinical Cardiologydiabetic cardiomyopathyautonomic neuropathyleft diastolic dysfunctiontype-1 diabetesinsulin-dependent diabetesInfluence of autonomic neuropathy upon left ventricular dysfunction in insulin-dependent diabetic patientsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/433512021-10-05 22:07:13.371metadata only accessoai:repositorio.unifesp.br:11600/43351Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652021-10-06T01:07:13Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Influence of autonomic neuropathy upon left ventricular dysfunction in insulin-dependent diabetic patients |
title |
Influence of autonomic neuropathy upon left ventricular dysfunction in insulin-dependent diabetic patients |
spellingShingle |
Influence of autonomic neuropathy upon left ventricular dysfunction in insulin-dependent diabetic patients Monteagudo, Patrícia Teófilo [UNIFESP] diabetic cardiomyopathy autonomic neuropathy left diastolic dysfunction type-1 diabetes insulin-dependent diabetes |
title_short |
Influence of autonomic neuropathy upon left ventricular dysfunction in insulin-dependent diabetic patients |
title_full |
Influence of autonomic neuropathy upon left ventricular dysfunction in insulin-dependent diabetic patients |
title_fullStr |
Influence of autonomic neuropathy upon left ventricular dysfunction in insulin-dependent diabetic patients |
title_full_unstemmed |
Influence of autonomic neuropathy upon left ventricular dysfunction in insulin-dependent diabetic patients |
title_sort |
Influence of autonomic neuropathy upon left ventricular dysfunction in insulin-dependent diabetic patients |
author |
Monteagudo, Patrícia Teófilo [UNIFESP] |
author_facet |
Monteagudo, Patrícia Teófilo [UNIFESP] Moisés, Valdir Ambrósio [UNIFESP] Kohlmann Junior, Osvaldo [UNIFESP] Ribeiro, Artur Beltrame [UNIFESP] Lima, Valter Correia de [UNIFESP] Zanella, Maria Teresa [UNIFESP] |
author_role |
author |
author2 |
Moisés, Valdir Ambrósio [UNIFESP] Kohlmann Junior, Osvaldo [UNIFESP] Ribeiro, Artur Beltrame [UNIFESP] Lima, Valter Correia de [UNIFESP] Zanella, Maria Teresa [UNIFESP] |
author2_role |
author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Monteagudo, Patrícia Teófilo [UNIFESP] Moisés, Valdir Ambrósio [UNIFESP] Kohlmann Junior, Osvaldo [UNIFESP] Ribeiro, Artur Beltrame [UNIFESP] Lima, Valter Correia de [UNIFESP] Zanella, Maria Teresa [UNIFESP] |
dc.subject.eng.fl_str_mv |
diabetic cardiomyopathy autonomic neuropathy left diastolic dysfunction type-1 diabetes insulin-dependent diabetes |
topic |
diabetic cardiomyopathy autonomic neuropathy left diastolic dysfunction type-1 diabetes insulin-dependent diabetes |
description |
Background: Diabetic cardiomyopathy is a well-defined complication of diabetes that occurs in the absence of ischemic, vascular, and hypertensive disease.Hypothesis: The study was undertaken to test the relationship among autonomic neuropathy (AN), 24-h blood pressure (BP) profile, and left ventricular function.Methods: Nineteen type-1 diabetic patients underwent autonomic tests and echocardiographic examination. Patients were divided according to the presence (AN+) or absence (AN-) of AN.Results: In the AN+ group (n = 8), the E/A ratio at echo was lower than in the AN- group (n = 11) (1.1 +/- 0.3 vs. 1.6 +/- 0.3; p < 0.005). Systolic and diastolic BP reductions during sleep were smaller in the AN+ than in the AN- group (6.6 +/- 6.6 vs. 13.0 +/- 4.3%; p < 0.03 for systolic and 12.8 +/- 6.8 vs. 20.0 +/- 4.0% for diastolic BP reduction; p < 0.03, respectively). Considering all patients, the EIA ratio correlated inversely with awake diastolic BP (r - 0.63; p = 0.005); sleep systolic BP (r - 0.48; p = 0.04), and sleep diastolic BP (r - 0.67; p = 0.002). The AN correlated with diastolic interventricular septum thickness (r 0.57; p = 0.01), sleep systolic BP (r 0.45; = 0.05), sleep diastolic BP (r 0.54; p = 0.02), and correlated inversely with systolic and diastolic sleep BP reduction (r - 0.49; p = 0.03 and r - 0.67; p = 0.002, respectively). Finally, E/A ratio and AN score correlated between themselves (r - 0.6; p = 0.005).Conclusion: Our results suggest that left ventricular diastolic dysfunction may be detected very early in type-1 diabetic patients with AN. Parasympathetic lesion and nocturnal elevations in BP could be the Link between AN and diastolic ventricular dysfunction. |
publishDate |
2000 |
dc.date.issued.fl_str_mv |
2000-05-01 |
dc.date.accessioned.fl_str_mv |
2018-06-15T16:52:46Z |
dc.date.available.fl_str_mv |
2018-06-15T16:52:46Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Clinical Cardiology. Mahwah: Clinical Cardiology Publ Co, v. 23, n. 5, p. 371-375, 2000. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/11600/43351 http://dx.doi.org/10.1002/clc.4960230513 |
dc.identifier.issn.none.fl_str_mv |
0160-9289 |
dc.identifier.doi.none.fl_str_mv |
10.1002/clc.4960230513 |
dc.identifier.wos.none.fl_str_mv |
WOS:000086771200011 |
identifier_str_mv |
Clinical Cardiology. Mahwah: Clinical Cardiology Publ Co, v. 23, n. 5, p. 371-375, 2000. 0160-9289 10.1002/clc.4960230513 WOS:000086771200011 |
url |
http://repositorio.unifesp.br/11600/43351 http://dx.doi.org/10.1002/clc.4960230513 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Clinical Cardiology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
371-375 |
dc.publisher.none.fl_str_mv |
Clinical Cardiology Publ Co |
publisher.none.fl_str_mv |
Clinical Cardiology Publ Co |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
_version_ |
1802764133467160576 |