The route of antimicrobial resistance from the hospital effluent to the environment: focus on the occurrence of KPC-producing Aeromonas spp. and Enterobacteriaceae in sewage
Autor(a) principal: | |
---|---|
Data de Publicação: | 2013 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/36224 http://dx.doi.org/10.1016/j.diagmicrobio.2013.02.001 |
Resumo: | We investigated the antimicrobial resistance profile and the occurrence of Klebsiella pneumoniae carbapenemase (KPC)-producing Gram-negative rods in sewage samples obtained from a Brazilian teaching hospital and from the wastewater treatment plant (WWTP) that receives it for treatment. We identified multidrug-resistant bacteria as well as KPC-2-producing Aeromonas spp. and several Enterobacteriaceae species, including Kluyvera spp., in the hospital effluent and in different sites of the WWTP. Most isolates showed the bla(KPC-2) gene harbored on a transposon that was carried by conjugative plasmids. the presence of KPC production among Aeromonas spp., Kluyvera spp., and other Enterobacteriaceae indicates the adaptability of such isolates to aquatic environments, not only in the hospital effluent but also throughout the WWTP. Although secondary treatment seems to decrease the amount of KPC producers in sewage, multidrug-resistant isolates are continually disposed in the urban river. Thus, sewage treatment regulations are urgently needed to decelerate the evolution of antimicrobial resistance beyond hospitals. (C) 2013 Elsevier Inc. All rights reserved. |
id |
UFSP_46709cdb825afb7e2e46ecfcaab8277a |
---|---|
oai_identifier_str |
oai:repositorio.unifesp.br:11600/36224 |
network_acronym_str |
UFSP |
network_name_str |
Repositório Institucional da UNIFESP |
repository_id_str |
3465 |
spelling |
Picão, Renata Cristina [UNIFESP]Cardoso, Juliana Pereira [UNIFESP]Campana, Eloiza Helena [UNIFESP]Nicoletti, Adriana Giannini [UNIFESP]Petrolini, Fernanda Villas Boas [UNIFESP]Assis, Diego Magno [UNIFESP]Juliano, Luiz [UNIFESP]Gales, Ana Cristina [UNIFESP]Universidade Federal de São Paulo (UNIFESP)Universidade Federal do Rio de Janeiro (UFRJ)Fundacao Parque Zool São Paulo2016-01-24T14:31:36Z2016-01-24T14:31:36Z2013-05-01Diagnostic Microbiology and Infectious Disease. New York: Elsevier B.V., v. 76, n. 1, p. 80-85, 2013.0732-8893http://repositorio.unifesp.br/handle/11600/36224http://dx.doi.org/10.1016/j.diagmicrobio.2013.02.001WOS000318325900016.pdf10.1016/j.diagmicrobio.2013.02.001WOS:000318325900016We investigated the antimicrobial resistance profile and the occurrence of Klebsiella pneumoniae carbapenemase (KPC)-producing Gram-negative rods in sewage samples obtained from a Brazilian teaching hospital and from the wastewater treatment plant (WWTP) that receives it for treatment. We identified multidrug-resistant bacteria as well as KPC-2-producing Aeromonas spp. and several Enterobacteriaceae species, including Kluyvera spp., in the hospital effluent and in different sites of the WWTP. Most isolates showed the bla(KPC-2) gene harbored on a transposon that was carried by conjugative plasmids. the presence of KPC production among Aeromonas spp., Kluyvera spp., and other Enterobacteriaceae indicates the adaptability of such isolates to aquatic environments, not only in the hospital effluent but also throughout the WWTP. Although secondary treatment seems to decrease the amount of KPC producers in sewage, multidrug-resistant isolates are continually disposed in the urban river. Thus, sewage treatment regulations are urgently needed to decelerate the evolution of antimicrobial resistance beyond hospitals. (C) 2013 Elsevier Inc. All rights reserved.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Sanofi-AventisThermo FisherbioMerieuxUniversidade Federal de São Paulo, Dept Med, Div Infectol, Lab ALERTA, São Paulo, BrazilUniv Fed Rio de Janeiro, Inst Microbiol Paulo de Goes, Rio de Janeiro, BrazilUniversidade Federal de São Paulo, Dept Biofis, São Paulo, BrazilFundacao Parque Zool São Paulo, Lab Microbiol Aplicada, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Med, Div Infectol, Lab ALERTA, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Biofis, São Paulo, BrazilFAPESP: 2009/11051-0CNPq: 307816/2009-5CNPq: 302981/2011-0Web of Science80-85engElsevier B.V.Diagnostic Microbiology and Infectious Diseasehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policyinfo:eu-repo/semantics/openAccessCarbapenemasesbla(KPC) disseminationWastewaterThe route of antimicrobial resistance from the hospital effluent to the environment: focus on the occurrence of KPC-producing Aeromonas spp. and Enterobacteriaceae in sewageinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlereponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000318325900016.pdfapplication/pdf572829${dspace.ui.url}/bitstream/11600/36224/1/WOS000318325900016.pdf371f26b60891a2f8c6d73d4e0cfa8ba9MD51open accessTEXTWOS000318325900016.pdf.txtWOS000318325900016.pdf.txtExtracted texttext/plain30078${dspace.ui.url}/bitstream/11600/36224/2/WOS000318325900016.pdf.txt8a3218bbdd387ddb1dd521568b5c193aMD52open access11600/362242022-07-08 10:51:07.281open accessoai:repositorio.unifesp.br:11600/36224Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:20:18.460780Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
The route of antimicrobial resistance from the hospital effluent to the environment: focus on the occurrence of KPC-producing Aeromonas spp. and Enterobacteriaceae in sewage |
title |
The route of antimicrobial resistance from the hospital effluent to the environment: focus on the occurrence of KPC-producing Aeromonas spp. and Enterobacteriaceae in sewage |
spellingShingle |
The route of antimicrobial resistance from the hospital effluent to the environment: focus on the occurrence of KPC-producing Aeromonas spp. and Enterobacteriaceae in sewage Picão, Renata Cristina [UNIFESP] Carbapenemases bla(KPC) dissemination Wastewater |
title_short |
The route of antimicrobial resistance from the hospital effluent to the environment: focus on the occurrence of KPC-producing Aeromonas spp. and Enterobacteriaceae in sewage |
title_full |
The route of antimicrobial resistance from the hospital effluent to the environment: focus on the occurrence of KPC-producing Aeromonas spp. and Enterobacteriaceae in sewage |
title_fullStr |
The route of antimicrobial resistance from the hospital effluent to the environment: focus on the occurrence of KPC-producing Aeromonas spp. and Enterobacteriaceae in sewage |
title_full_unstemmed |
The route of antimicrobial resistance from the hospital effluent to the environment: focus on the occurrence of KPC-producing Aeromonas spp. and Enterobacteriaceae in sewage |
title_sort |
The route of antimicrobial resistance from the hospital effluent to the environment: focus on the occurrence of KPC-producing Aeromonas spp. and Enterobacteriaceae in sewage |
author |
Picão, Renata Cristina [UNIFESP] |
author_facet |
Picão, Renata Cristina [UNIFESP] Cardoso, Juliana Pereira [UNIFESP] Campana, Eloiza Helena [UNIFESP] Nicoletti, Adriana Giannini [UNIFESP] Petrolini, Fernanda Villas Boas [UNIFESP] Assis, Diego Magno [UNIFESP] Juliano, Luiz [UNIFESP] Gales, Ana Cristina [UNIFESP] |
author_role |
author |
author2 |
Cardoso, Juliana Pereira [UNIFESP] Campana, Eloiza Helena [UNIFESP] Nicoletti, Adriana Giannini [UNIFESP] Petrolini, Fernanda Villas Boas [UNIFESP] Assis, Diego Magno [UNIFESP] Juliano, Luiz [UNIFESP] Gales, Ana Cristina [UNIFESP] |
author2_role |
author author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Universidade Federal do Rio de Janeiro (UFRJ) Fundacao Parque Zool São Paulo |
dc.contributor.author.fl_str_mv |
Picão, Renata Cristina [UNIFESP] Cardoso, Juliana Pereira [UNIFESP] Campana, Eloiza Helena [UNIFESP] Nicoletti, Adriana Giannini [UNIFESP] Petrolini, Fernanda Villas Boas [UNIFESP] Assis, Diego Magno [UNIFESP] Juliano, Luiz [UNIFESP] Gales, Ana Cristina [UNIFESP] |
dc.subject.eng.fl_str_mv |
Carbapenemases bla(KPC) dissemination Wastewater |
topic |
Carbapenemases bla(KPC) dissemination Wastewater |
description |
We investigated the antimicrobial resistance profile and the occurrence of Klebsiella pneumoniae carbapenemase (KPC)-producing Gram-negative rods in sewage samples obtained from a Brazilian teaching hospital and from the wastewater treatment plant (WWTP) that receives it for treatment. We identified multidrug-resistant bacteria as well as KPC-2-producing Aeromonas spp. and several Enterobacteriaceae species, including Kluyvera spp., in the hospital effluent and in different sites of the WWTP. Most isolates showed the bla(KPC-2) gene harbored on a transposon that was carried by conjugative plasmids. the presence of KPC production among Aeromonas spp., Kluyvera spp., and other Enterobacteriaceae indicates the adaptability of such isolates to aquatic environments, not only in the hospital effluent but also throughout the WWTP. Although secondary treatment seems to decrease the amount of KPC producers in sewage, multidrug-resistant isolates are continually disposed in the urban river. Thus, sewage treatment regulations are urgently needed to decelerate the evolution of antimicrobial resistance beyond hospitals. (C) 2013 Elsevier Inc. All rights reserved. |
publishDate |
2013 |
dc.date.issued.fl_str_mv |
2013-05-01 |
dc.date.accessioned.fl_str_mv |
2016-01-24T14:31:36Z |
dc.date.available.fl_str_mv |
2016-01-24T14:31:36Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Diagnostic Microbiology and Infectious Disease. New York: Elsevier B.V., v. 76, n. 1, p. 80-85, 2013. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/36224 http://dx.doi.org/10.1016/j.diagmicrobio.2013.02.001 |
dc.identifier.issn.none.fl_str_mv |
0732-8893 |
dc.identifier.file.none.fl_str_mv |
WOS000318325900016.pdf |
dc.identifier.doi.none.fl_str_mv |
10.1016/j.diagmicrobio.2013.02.001 |
dc.identifier.wos.none.fl_str_mv |
WOS:000318325900016 |
identifier_str_mv |
Diagnostic Microbiology and Infectious Disease. New York: Elsevier B.V., v. 76, n. 1, p. 80-85, 2013. 0732-8893 WOS000318325900016.pdf 10.1016/j.diagmicrobio.2013.02.001 WOS:000318325900016 |
url |
http://repositorio.unifesp.br/handle/11600/36224 http://dx.doi.org/10.1016/j.diagmicrobio.2013.02.001 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Diagnostic Microbiology and Infectious Disease |
dc.rights.driver.fl_str_mv |
http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
80-85 |
dc.publisher.none.fl_str_mv |
Elsevier B.V. |
publisher.none.fl_str_mv |
Elsevier B.V. |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
bitstream.url.fl_str_mv |
${dspace.ui.url}/bitstream/11600/36224/1/WOS000318325900016.pdf ${dspace.ui.url}/bitstream/11600/36224/2/WOS000318325900016.pdf.txt |
bitstream.checksum.fl_str_mv |
371f26b60891a2f8c6d73d4e0cfa8ba9 8a3218bbdd387ddb1dd521568b5c193a |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
_version_ |
1783460278164258816 |