Autonomic processing of the cardiovascular reflexes in the nucleus tractus solitarii

Detalhes bibliográficos
Autor(a) principal: Machado, B. H.
Data de Publicação: 1997
Outros Autores: Mauad, H., Chianca, D. A., Haibara, A. S., Colombari, Eduardo [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/S0100-879X1997000400015
http://repositorio.unifesp.br/handle/11600/43119
Resumo: The nucleus tractus solitarii (NTS) receives afferent projections from the arterial baroreceptors, carotid chemoreceptors and cardiopulmonary receptors and as a function of this information produces autonomic adjustments in order to maintain arterial blood pressure within a narrow range of variation. The activation of each of these cardiovascular afferents produces a specific autonomic response by the excitation of neuronal projections from the NTS to the ventrolateral areas of the medulla (nucleus ambiguus, caudal and rostral ventrolateral medulla). The neurotransmitters at the NTS level as well as the excitatory amino acid (EAA) receptors involved in the processing of the autonomic responses in the NTS, although extensively studied, remain to be completely elucidated, In the present review we discuss the role of the EAA L-glutamate and its different receptor subtypes in the processing of the cardiovascular reflexes in the NTS. The data presented in this review related to the neurotransmission in the NTS are based on experimental evidence obtained in our laboratory in unanesthetized rats. The two major conclusions of the present review are that a) the excitation of the cardiovagal component by cardiovascular reflex activation (chemo- and Bezold-Jarisch reflexes) or by L-glutamate microinjection into the NTS is mediated by N-methyl-D-aspartate (NMDA) receptors, and b) the sympatho-excitatory component of the chemoreflex and the presser response to L-glutamate microinjected into the NTS are not affected by an NMDA receptor antagonist, suggesting that the sympatho-excitatory component of these responses is mediated by non-NMDA receptors.
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spelling Autonomic processing of the cardiovascular reflexes in the nucleus tractus solitariiL-glutamateexcitatory amino acid receptorsNMDA receptorsbaroreflexchemoreflexBezold-Jarisch reflexAP-5kynureic acidThe nucleus tractus solitarii (NTS) receives afferent projections from the arterial baroreceptors, carotid chemoreceptors and cardiopulmonary receptors and as a function of this information produces autonomic adjustments in order to maintain arterial blood pressure within a narrow range of variation. The activation of each of these cardiovascular afferents produces a specific autonomic response by the excitation of neuronal projections from the NTS to the ventrolateral areas of the medulla (nucleus ambiguus, caudal and rostral ventrolateral medulla). The neurotransmitters at the NTS level as well as the excitatory amino acid (EAA) receptors involved in the processing of the autonomic responses in the NTS, although extensively studied, remain to be completely elucidated, In the present review we discuss the role of the EAA L-glutamate and its different receptor subtypes in the processing of the cardiovascular reflexes in the NTS. The data presented in this review related to the neurotransmission in the NTS are based on experimental evidence obtained in our laboratory in unanesthetized rats. The two major conclusions of the present review are that a) the excitation of the cardiovagal component by cardiovascular reflex activation (chemo- and Bezold-Jarisch reflexes) or by L-glutamate microinjection into the NTS is mediated by N-methyl-D-aspartate (NMDA) receptors, and b) the sympatho-excitatory component of the chemoreflex and the presser response to L-glutamate microinjected into the NTS are not affected by an NMDA receptor antagonist, suggesting that the sympatho-excitatory component of these responses is mediated by non-NMDA receptors.UNIV FED ESPIRITO SANTO,CTR BIOMED,DEPT CIENCIAS FISIOL,BR-29040090 VITORIA,ES,BRAZILUNIV FED OURO PRETO,DEPT CIENCIAS BIOL,BR-35400000 OURO PRETO,MG,BRAZILUNIV FED SAO PAULO,ESCOLA PAULISTA MED,DEPT FISIOL,BR-04023060 SAO PAULO,SP,BRAZILUNIV FED SAO PAULO,ESCOLA PAULISTA MED,DEPT FISIOL,BR-04023060 SAO PAULO,SP,BRAZILWeb of ScienceAssoc Bras Divulg CientificaUNIV FED ESPIRITO SANTOUNIV FED OURO PRETOUniversidade Federal de São Paulo (UNIFESP)Machado, B. H.Mauad, H.Chianca, D. A.Haibara, A. S.Colombari, Eduardo [UNIFESP]2018-06-15T16:24:00Z2018-06-15T16:24:00Z1997-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion533-543http://dx.doi.org/10.1590/S0100-879X1997000400015Brazilian Journal Of Medical And Biological Research. Sao Paulo: Assoc Bras Divulg Cientifica, v. 30, n. 4, p. 533-543, 1997.10.1590/S0100-879X1997000400015S0100-879X1997000400015.pdf0100-879XS0100-879X1997000400015http://repositorio.unifesp.br/handle/11600/43119WOS:A1997WT02000015engBrazilian Journal Of Medical And Biological Researchinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-05-02T13:57:04Zoai:repositorio.unifesp.br/:11600/43119Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-05-02T13:57:04Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Autonomic processing of the cardiovascular reflexes in the nucleus tractus solitarii
title Autonomic processing of the cardiovascular reflexes in the nucleus tractus solitarii
spellingShingle Autonomic processing of the cardiovascular reflexes in the nucleus tractus solitarii
Machado, B. H.
L-glutamate
excitatory amino acid receptors
NMDA receptors
baroreflex
chemoreflex
Bezold-Jarisch reflex
AP-5
kynureic acid
title_short Autonomic processing of the cardiovascular reflexes in the nucleus tractus solitarii
title_full Autonomic processing of the cardiovascular reflexes in the nucleus tractus solitarii
title_fullStr Autonomic processing of the cardiovascular reflexes in the nucleus tractus solitarii
title_full_unstemmed Autonomic processing of the cardiovascular reflexes in the nucleus tractus solitarii
title_sort Autonomic processing of the cardiovascular reflexes in the nucleus tractus solitarii
author Machado, B. H.
author_facet Machado, B. H.
Mauad, H.
Chianca, D. A.
Haibara, A. S.
Colombari, Eduardo [UNIFESP]
author_role author
author2 Mauad, H.
Chianca, D. A.
Haibara, A. S.
Colombari, Eduardo [UNIFESP]
author2_role author
author
author
author
dc.contributor.none.fl_str_mv UNIV FED ESPIRITO SANTO
UNIV FED OURO PRETO
Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Machado, B. H.
Mauad, H.
Chianca, D. A.
Haibara, A. S.
Colombari, Eduardo [UNIFESP]
dc.subject.por.fl_str_mv L-glutamate
excitatory amino acid receptors
NMDA receptors
baroreflex
chemoreflex
Bezold-Jarisch reflex
AP-5
kynureic acid
topic L-glutamate
excitatory amino acid receptors
NMDA receptors
baroreflex
chemoreflex
Bezold-Jarisch reflex
AP-5
kynureic acid
description The nucleus tractus solitarii (NTS) receives afferent projections from the arterial baroreceptors, carotid chemoreceptors and cardiopulmonary receptors and as a function of this information produces autonomic adjustments in order to maintain arterial blood pressure within a narrow range of variation. The activation of each of these cardiovascular afferents produces a specific autonomic response by the excitation of neuronal projections from the NTS to the ventrolateral areas of the medulla (nucleus ambiguus, caudal and rostral ventrolateral medulla). The neurotransmitters at the NTS level as well as the excitatory amino acid (EAA) receptors involved in the processing of the autonomic responses in the NTS, although extensively studied, remain to be completely elucidated, In the present review we discuss the role of the EAA L-glutamate and its different receptor subtypes in the processing of the cardiovascular reflexes in the NTS. The data presented in this review related to the neurotransmission in the NTS are based on experimental evidence obtained in our laboratory in unanesthetized rats. The two major conclusions of the present review are that a) the excitation of the cardiovagal component by cardiovascular reflex activation (chemo- and Bezold-Jarisch reflexes) or by L-glutamate microinjection into the NTS is mediated by N-methyl-D-aspartate (NMDA) receptors, and b) the sympatho-excitatory component of the chemoreflex and the presser response to L-glutamate microinjected into the NTS are not affected by an NMDA receptor antagonist, suggesting that the sympatho-excitatory component of these responses is mediated by non-NMDA receptors.
publishDate 1997
dc.date.none.fl_str_mv 1997-04-01
2018-06-15T16:24:00Z
2018-06-15T16:24:00Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0100-879X1997000400015
Brazilian Journal Of Medical And Biological Research. Sao Paulo: Assoc Bras Divulg Cientifica, v. 30, n. 4, p. 533-543, 1997.
10.1590/S0100-879X1997000400015
S0100-879X1997000400015.pdf
0100-879X
S0100-879X1997000400015
http://repositorio.unifesp.br/handle/11600/43119
WOS:A1997WT02000015
url http://dx.doi.org/10.1590/S0100-879X1997000400015
http://repositorio.unifesp.br/handle/11600/43119
identifier_str_mv Brazilian Journal Of Medical And Biological Research. Sao Paulo: Assoc Bras Divulg Cientifica, v. 30, n. 4, p. 533-543, 1997.
10.1590/S0100-879X1997000400015
S0100-879X1997000400015.pdf
0100-879X
S0100-879X1997000400015
WOS:A1997WT02000015
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Brazilian Journal Of Medical And Biological Research
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 533-543
dc.publisher.none.fl_str_mv Assoc Bras Divulg Cientifica
publisher.none.fl_str_mv Assoc Bras Divulg Cientifica
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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