Autonomic processing of the cardiovascular reflexes in the nucleus tractus solitarii
Autor(a) principal: | |
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Data de Publicação: | 1997 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://dx.doi.org/10.1590/S0100-879X1997000400015 http://repositorio.unifesp.br/handle/11600/43119 |
Resumo: | The nucleus tractus solitarii (NTS) receives afferent projections from the arterial baroreceptors, carotid chemoreceptors and cardiopulmonary receptors and as a function of this information produces autonomic adjustments in order to maintain arterial blood pressure within a narrow range of variation. The activation of each of these cardiovascular afferents produces a specific autonomic response by the excitation of neuronal projections from the NTS to the ventrolateral areas of the medulla (nucleus ambiguus, caudal and rostral ventrolateral medulla). The neurotransmitters at the NTS level as well as the excitatory amino acid (EAA) receptors involved in the processing of the autonomic responses in the NTS, although extensively studied, remain to be completely elucidated, In the present review we discuss the role of the EAA L-glutamate and its different receptor subtypes in the processing of the cardiovascular reflexes in the NTS. The data presented in this review related to the neurotransmission in the NTS are based on experimental evidence obtained in our laboratory in unanesthetized rats. The two major conclusions of the present review are that a) the excitation of the cardiovagal component by cardiovascular reflex activation (chemo- and Bezold-Jarisch reflexes) or by L-glutamate microinjection into the NTS is mediated by N-methyl-D-aspartate (NMDA) receptors, and b) the sympatho-excitatory component of the chemoreflex and the presser response to L-glutamate microinjected into the NTS are not affected by an NMDA receptor antagonist, suggesting that the sympatho-excitatory component of these responses is mediated by non-NMDA receptors. |
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Repositório Institucional da UNIFESP |
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Autonomic processing of the cardiovascular reflexes in the nucleus tractus solitariiL-glutamateexcitatory amino acid receptorsNMDA receptorsbaroreflexchemoreflexBezold-Jarisch reflexAP-5kynureic acidThe nucleus tractus solitarii (NTS) receives afferent projections from the arterial baroreceptors, carotid chemoreceptors and cardiopulmonary receptors and as a function of this information produces autonomic adjustments in order to maintain arterial blood pressure within a narrow range of variation. The activation of each of these cardiovascular afferents produces a specific autonomic response by the excitation of neuronal projections from the NTS to the ventrolateral areas of the medulla (nucleus ambiguus, caudal and rostral ventrolateral medulla). The neurotransmitters at the NTS level as well as the excitatory amino acid (EAA) receptors involved in the processing of the autonomic responses in the NTS, although extensively studied, remain to be completely elucidated, In the present review we discuss the role of the EAA L-glutamate and its different receptor subtypes in the processing of the cardiovascular reflexes in the NTS. The data presented in this review related to the neurotransmission in the NTS are based on experimental evidence obtained in our laboratory in unanesthetized rats. The two major conclusions of the present review are that a) the excitation of the cardiovagal component by cardiovascular reflex activation (chemo- and Bezold-Jarisch reflexes) or by L-glutamate microinjection into the NTS is mediated by N-methyl-D-aspartate (NMDA) receptors, and b) the sympatho-excitatory component of the chemoreflex and the presser response to L-glutamate microinjected into the NTS are not affected by an NMDA receptor antagonist, suggesting that the sympatho-excitatory component of these responses is mediated by non-NMDA receptors.UNIV FED ESPIRITO SANTO,CTR BIOMED,DEPT CIENCIAS FISIOL,BR-29040090 VITORIA,ES,BRAZILUNIV FED OURO PRETO,DEPT CIENCIAS BIOL,BR-35400000 OURO PRETO,MG,BRAZILUNIV FED SAO PAULO,ESCOLA PAULISTA MED,DEPT FISIOL,BR-04023060 SAO PAULO,SP,BRAZILUNIV FED SAO PAULO,ESCOLA PAULISTA MED,DEPT FISIOL,BR-04023060 SAO PAULO,SP,BRAZILWeb of ScienceAssoc Bras Divulg CientificaUNIV FED ESPIRITO SANTOUNIV FED OURO PRETOUniversidade Federal de São Paulo (UNIFESP)Machado, B. H.Mauad, H.Chianca, D. A.Haibara, A. S.Colombari, Eduardo [UNIFESP]2018-06-15T16:24:00Z2018-06-15T16:24:00Z1997-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion533-543http://dx.doi.org/10.1590/S0100-879X1997000400015Brazilian Journal Of Medical And Biological Research. Sao Paulo: Assoc Bras Divulg Cientifica, v. 30, n. 4, p. 533-543, 1997.10.1590/S0100-879X1997000400015S0100-879X1997000400015.pdf0100-879XS0100-879X1997000400015http://repositorio.unifesp.br/handle/11600/43119WOS:A1997WT02000015engBrazilian Journal Of Medical And Biological Researchinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-05-02T13:57:04Zoai:repositorio.unifesp.br/:11600/43119Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-05-02T13:57:04Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Autonomic processing of the cardiovascular reflexes in the nucleus tractus solitarii |
title |
Autonomic processing of the cardiovascular reflexes in the nucleus tractus solitarii |
spellingShingle |
Autonomic processing of the cardiovascular reflexes in the nucleus tractus solitarii Machado, B. H. L-glutamate excitatory amino acid receptors NMDA receptors baroreflex chemoreflex Bezold-Jarisch reflex AP-5 kynureic acid |
title_short |
Autonomic processing of the cardiovascular reflexes in the nucleus tractus solitarii |
title_full |
Autonomic processing of the cardiovascular reflexes in the nucleus tractus solitarii |
title_fullStr |
Autonomic processing of the cardiovascular reflexes in the nucleus tractus solitarii |
title_full_unstemmed |
Autonomic processing of the cardiovascular reflexes in the nucleus tractus solitarii |
title_sort |
Autonomic processing of the cardiovascular reflexes in the nucleus tractus solitarii |
author |
Machado, B. H. |
author_facet |
Machado, B. H. Mauad, H. Chianca, D. A. Haibara, A. S. Colombari, Eduardo [UNIFESP] |
author_role |
author |
author2 |
Mauad, H. Chianca, D. A. Haibara, A. S. Colombari, Eduardo [UNIFESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
UNIV FED ESPIRITO SANTO UNIV FED OURO PRETO Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Machado, B. H. Mauad, H. Chianca, D. A. Haibara, A. S. Colombari, Eduardo [UNIFESP] |
dc.subject.por.fl_str_mv |
L-glutamate excitatory amino acid receptors NMDA receptors baroreflex chemoreflex Bezold-Jarisch reflex AP-5 kynureic acid |
topic |
L-glutamate excitatory amino acid receptors NMDA receptors baroreflex chemoreflex Bezold-Jarisch reflex AP-5 kynureic acid |
description |
The nucleus tractus solitarii (NTS) receives afferent projections from the arterial baroreceptors, carotid chemoreceptors and cardiopulmonary receptors and as a function of this information produces autonomic adjustments in order to maintain arterial blood pressure within a narrow range of variation. The activation of each of these cardiovascular afferents produces a specific autonomic response by the excitation of neuronal projections from the NTS to the ventrolateral areas of the medulla (nucleus ambiguus, caudal and rostral ventrolateral medulla). The neurotransmitters at the NTS level as well as the excitatory amino acid (EAA) receptors involved in the processing of the autonomic responses in the NTS, although extensively studied, remain to be completely elucidated, In the present review we discuss the role of the EAA L-glutamate and its different receptor subtypes in the processing of the cardiovascular reflexes in the NTS. The data presented in this review related to the neurotransmission in the NTS are based on experimental evidence obtained in our laboratory in unanesthetized rats. The two major conclusions of the present review are that a) the excitation of the cardiovagal component by cardiovascular reflex activation (chemo- and Bezold-Jarisch reflexes) or by L-glutamate microinjection into the NTS is mediated by N-methyl-D-aspartate (NMDA) receptors, and b) the sympatho-excitatory component of the chemoreflex and the presser response to L-glutamate microinjected into the NTS are not affected by an NMDA receptor antagonist, suggesting that the sympatho-excitatory component of these responses is mediated by non-NMDA receptors. |
publishDate |
1997 |
dc.date.none.fl_str_mv |
1997-04-01 2018-06-15T16:24:00Z 2018-06-15T16:24:00Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S0100-879X1997000400015 Brazilian Journal Of Medical And Biological Research. Sao Paulo: Assoc Bras Divulg Cientifica, v. 30, n. 4, p. 533-543, 1997. 10.1590/S0100-879X1997000400015 S0100-879X1997000400015.pdf 0100-879X S0100-879X1997000400015 http://repositorio.unifesp.br/handle/11600/43119 WOS:A1997WT02000015 |
url |
http://dx.doi.org/10.1590/S0100-879X1997000400015 http://repositorio.unifesp.br/handle/11600/43119 |
identifier_str_mv |
Brazilian Journal Of Medical And Biological Research. Sao Paulo: Assoc Bras Divulg Cientifica, v. 30, n. 4, p. 533-543, 1997. 10.1590/S0100-879X1997000400015 S0100-879X1997000400015.pdf 0100-879X S0100-879X1997000400015 WOS:A1997WT02000015 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Brazilian Journal Of Medical And Biological Research |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
533-543 |
dc.publisher.none.fl_str_mv |
Assoc Bras Divulg Cientifica |
publisher.none.fl_str_mv |
Assoc Bras Divulg Cientifica |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
_version_ |
1814268365366099968 |