Brazilian network for HIV Drug Resistance Surveillance (HIV-BresNet): a survey of treatment-naive individuals

• Autor(a) principal: Arruda, Monica B.
• Data de Publicação: 2018
• Outros Autores: Boullosa, Lidia T., Cardoso, Cynthia C., da Costa, Carolina M., Alves, Carlos R. B., de Lima, Shirlene T. S., Kaminski, Helena T., Aleixo, Agdemir W., Esposito, Ana O. P., Cavalcanti, Ana M. S., Riedel, Maristela, Couto-Fernandez, Jose C., Ferreira, Selma B., de Oliveira, Ivi C. M., Portal, Loreci E., Wolf, Hilda H. C., Fernandes, Sandra B., Pardini, Maria I. de M. C., Feiteiro, Manoel V. C., Tolentino, Fernanda M., Diaz, Ricardo Sobhie [UNIFESP], Lopes, Giselle I. S. L., Francisco, Roberta B. L., Veras, Nazle M. C., Pires, Ana F., Franchini, Miriam, Mesquita, Fabio, Tanuri, Amilcar
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNIFESP
• dARK ID: ark:/48912/001300000fzrp
• DOI: 10.1002/jia2.25032
• Texto Completo: http://dx.doi.org/10.1002/jia2.25032; https://repositorio.unifesp.br/handle/11600/55874
• topic: HIV; HIV drug resistance; pretreatment HIV drug resistance; primary antiretroviral resistance; antiretroviral resistance; HIV Drug Resistance Surveillance

Introduction: In Brazil, more than 487,450 individuals are currently undergoing antiretroviral treatment. In order to monitor the transmission of drug-resistant strains and HIV subtype distribution in the country, this work aimed to estimate its prevalence and to characterize the nationwide pretreatment drug resistance in individuals recently diagnosed with HIV between 2013 and 2015. Methods: The HIV threshold survey methodology (HIV-THS, WHO) targeting antiretroviral-naive individuals with recent HIV diagnosis was utilized, and subjects were selected from 51 highly populated cities in all five Brazilian macroregions. The HIV pol genotypic test was performed by genomic sequencing. Results: We analysed samples from 1568 antiretroviral-naive individuals recently diagnosed with HIV, and the overall transmitted drug resistance (TDR) prevalence was 9.5% (150 sequences). The regional prevalence of resistance according to Brazilian geographical regions was 9.4% in the northeast, 11.2% in the southeast, 6.8% in the central region, 10.2% in the north and 8.8% in the south. The inhibitor-specific TDR prevalence was 3.6% for nucleoside reverse transcriptase inhibitors (NRTIs), 5.8% for non-nucleoside reverse transcriptase inhibitors (NNRTIs) and 1.6% for protease inhibitors (PIs)