N-Acetyltransferase 2 genetic polymorphisms and risk of colorectal cancer
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/33465 http://dx.doi.org/10.3748/wjg.v17.i6.760 |
Resumo: | AIM: To investigate the possible association between meat intake, cigarette smoking and N-acetyltransferase 2 (NAT2) genetic polymorphisms on colorectal cancer (CRC) risk.METHODS: Patients with CRC were matched for gender and age to healthy controls. Meat intake and cigarette smoking were assessed using a specific frequency questionnaire. DNA was extracted from peripheral blood and the genotypes of the polymorphism were assessed by polymerase chain reaction-restriction fragment length polymorphism. Five NAT2 alleles were studied (WT, M1, M2, M3 and M4) using specific digestion enzymes.RESULTS: A total of 147 patients with colorectal cancer (76 women and 90 men with colon cancer) and 212 controls were studied. the mean age of the two groups was 62 years. More than half the subjects (59.8% in the case group and 51.9% in the control group) were NAT2 slow acetylators. the odds ratio for colorectal cancer was 1.38 (95% CI: 0.90-2.12) in slow acetylators. Although the number of women was small (n = 76 in the case group), the cancer risk was found to be lower in intermediate (W/Mx) acetylators [odds ratio (OR): 0.55, 95% confidence interval (95% CI): 0.29-1.02]. This difference was not observed in men (OR: 0.56, 95% CI: 0.16-2.00). Among NAT2 fast acetylators (W/W or W/Mx), meat consumption more than 3 times a week increased the risk of colorectal cancer (OR: 2.05, 95% CI: 1.01-4.16). in contrast, cigarette smoking increased the risk of CRC among slow acetylators (OR: 1.97, 95% CI: 1.02-3.79).CONCLUSION: the risk of CRC was higher among fast acetylators who reported a higher meat intake. Slow NAT2 acetylation was associated with an increased risk of CRC. (C) 2011 Baishideng. All rights reserved. |
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Silva, Tiago Donizetti da [UNIFESP]Felipe, Aledson Vitor [UNIFESP]Lima, Jacqueline Miranda de [UNIFESP]Oshima, Celina Tizuko Fujiyama [UNIFESP]Forones, Nora Manoukian [UNIFESP]Universidade Federal de São Paulo (UNIFESP)2016-01-24T14:06:11Z2016-01-24T14:06:11Z2011-02-14World Journal of Gastroenterology. Beijing: Baishideng Publ Grp Co Ltd, v. 17, n. 6, p. 760-765, 2011.1007-9327http://repositorio.unifesp.br/handle/11600/33465http://dx.doi.org/10.3748/wjg.v17.i6.76010.3748/wjg.v17.i6.760WOS:000288058700010AIM: To investigate the possible association between meat intake, cigarette smoking and N-acetyltransferase 2 (NAT2) genetic polymorphisms on colorectal cancer (CRC) risk.METHODS: Patients with CRC were matched for gender and age to healthy controls. Meat intake and cigarette smoking were assessed using a specific frequency questionnaire. DNA was extracted from peripheral blood and the genotypes of the polymorphism were assessed by polymerase chain reaction-restriction fragment length polymorphism. Five NAT2 alleles were studied (WT, M1, M2, M3 and M4) using specific digestion enzymes.RESULTS: A total of 147 patients with colorectal cancer (76 women and 90 men with colon cancer) and 212 controls were studied. the mean age of the two groups was 62 years. More than half the subjects (59.8% in the case group and 51.9% in the control group) were NAT2 slow acetylators. the odds ratio for colorectal cancer was 1.38 (95% CI: 0.90-2.12) in slow acetylators. Although the number of women was small (n = 76 in the case group), the cancer risk was found to be lower in intermediate (W/Mx) acetylators [odds ratio (OR): 0.55, 95% confidence interval (95% CI): 0.29-1.02]. This difference was not observed in men (OR: 0.56, 95% CI: 0.16-2.00). Among NAT2 fast acetylators (W/W or W/Mx), meat consumption more than 3 times a week increased the risk of colorectal cancer (OR: 2.05, 95% CI: 1.01-4.16). in contrast, cigarette smoking increased the risk of CRC among slow acetylators (OR: 1.97, 95% CI: 1.02-3.79).CONCLUSION: the risk of CRC was higher among fast acetylators who reported a higher meat intake. Slow NAT2 acetylation was associated with an increased risk of CRC. (C) 2011 Baishideng. All rights reserved.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Universidade Federal de São Paulo, Div Gastroenterol, Oncol Grp, BR-04023900 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Pathol, BR-04023900 São Paulo, BrazilUniversidade Federal de São Paulo, Div Gastroenterol, Oncol Grp, BR-04023900 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Pathol, BR-04023900 São Paulo, BrazilWeb of Science760-765engBaishideng Publ Grp Co LtdWorld Journal of GastroenterologyN-acetyltransferase 2PolymorphismColorectal cancerN-Acetyltransferase 2 genetic polymorphisms and risk of colorectal cancerinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/334652022-06-02 09:34:43.773metadata only accessoai:repositorio.unifesp.br:11600/33465Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652022-06-02T12:34:43Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
N-Acetyltransferase 2 genetic polymorphisms and risk of colorectal cancer |
title |
N-Acetyltransferase 2 genetic polymorphisms and risk of colorectal cancer |
spellingShingle |
N-Acetyltransferase 2 genetic polymorphisms and risk of colorectal cancer Silva, Tiago Donizetti da [UNIFESP] N-acetyltransferase 2 Polymorphism Colorectal cancer |
title_short |
N-Acetyltransferase 2 genetic polymorphisms and risk of colorectal cancer |
title_full |
N-Acetyltransferase 2 genetic polymorphisms and risk of colorectal cancer |
title_fullStr |
N-Acetyltransferase 2 genetic polymorphisms and risk of colorectal cancer |
title_full_unstemmed |
N-Acetyltransferase 2 genetic polymorphisms and risk of colorectal cancer |
title_sort |
N-Acetyltransferase 2 genetic polymorphisms and risk of colorectal cancer |
author |
Silva, Tiago Donizetti da [UNIFESP] |
author_facet |
Silva, Tiago Donizetti da [UNIFESP] Felipe, Aledson Vitor [UNIFESP] Lima, Jacqueline Miranda de [UNIFESP] Oshima, Celina Tizuko Fujiyama [UNIFESP] Forones, Nora Manoukian [UNIFESP] |
author_role |
author |
author2 |
Felipe, Aledson Vitor [UNIFESP] Lima, Jacqueline Miranda de [UNIFESP] Oshima, Celina Tizuko Fujiyama [UNIFESP] Forones, Nora Manoukian [UNIFESP] |
author2_role |
author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Silva, Tiago Donizetti da [UNIFESP] Felipe, Aledson Vitor [UNIFESP] Lima, Jacqueline Miranda de [UNIFESP] Oshima, Celina Tizuko Fujiyama [UNIFESP] Forones, Nora Manoukian [UNIFESP] |
dc.subject.eng.fl_str_mv |
N-acetyltransferase 2 Polymorphism Colorectal cancer |
topic |
N-acetyltransferase 2 Polymorphism Colorectal cancer |
description |
AIM: To investigate the possible association between meat intake, cigarette smoking and N-acetyltransferase 2 (NAT2) genetic polymorphisms on colorectal cancer (CRC) risk.METHODS: Patients with CRC were matched for gender and age to healthy controls. Meat intake and cigarette smoking were assessed using a specific frequency questionnaire. DNA was extracted from peripheral blood and the genotypes of the polymorphism were assessed by polymerase chain reaction-restriction fragment length polymorphism. Five NAT2 alleles were studied (WT, M1, M2, M3 and M4) using specific digestion enzymes.RESULTS: A total of 147 patients with colorectal cancer (76 women and 90 men with colon cancer) and 212 controls were studied. the mean age of the two groups was 62 years. More than half the subjects (59.8% in the case group and 51.9% in the control group) were NAT2 slow acetylators. the odds ratio for colorectal cancer was 1.38 (95% CI: 0.90-2.12) in slow acetylators. Although the number of women was small (n = 76 in the case group), the cancer risk was found to be lower in intermediate (W/Mx) acetylators [odds ratio (OR): 0.55, 95% confidence interval (95% CI): 0.29-1.02]. This difference was not observed in men (OR: 0.56, 95% CI: 0.16-2.00). Among NAT2 fast acetylators (W/W or W/Mx), meat consumption more than 3 times a week increased the risk of colorectal cancer (OR: 2.05, 95% CI: 1.01-4.16). in contrast, cigarette smoking increased the risk of CRC among slow acetylators (OR: 1.97, 95% CI: 1.02-3.79).CONCLUSION: the risk of CRC was higher among fast acetylators who reported a higher meat intake. Slow NAT2 acetylation was associated with an increased risk of CRC. (C) 2011 Baishideng. All rights reserved. |
publishDate |
2011 |
dc.date.issued.fl_str_mv |
2011-02-14 |
dc.date.accessioned.fl_str_mv |
2016-01-24T14:06:11Z |
dc.date.available.fl_str_mv |
2016-01-24T14:06:11Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
World Journal of Gastroenterology. Beijing: Baishideng Publ Grp Co Ltd, v. 17, n. 6, p. 760-765, 2011. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/33465 http://dx.doi.org/10.3748/wjg.v17.i6.760 |
dc.identifier.issn.none.fl_str_mv |
1007-9327 |
dc.identifier.doi.none.fl_str_mv |
10.3748/wjg.v17.i6.760 |
dc.identifier.wos.none.fl_str_mv |
WOS:000288058700010 |
identifier_str_mv |
World Journal of Gastroenterology. Beijing: Baishideng Publ Grp Co Ltd, v. 17, n. 6, p. 760-765, 2011. 1007-9327 10.3748/wjg.v17.i6.760 WOS:000288058700010 |
url |
http://repositorio.unifesp.br/handle/11600/33465 http://dx.doi.org/10.3748/wjg.v17.i6.760 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
World Journal of Gastroenterology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
760-765 |
dc.publisher.none.fl_str_mv |
Baishideng Publ Grp Co Ltd |
publisher.none.fl_str_mv |
Baishideng Publ Grp Co Ltd |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
_version_ |
1802764137314385920 |