Aspectos clínicos e histológicos da úlcera duodenal em crianças e adolescentes

Detalhes bibliográficos
Autor(a) principal: Kawakami, Elisabete [UNIFESP]
Data de Publicação: 2004
Outros Autores: Machado, Rodrigo S. [UNIFESP], Fonseca, Jacqueline A. [UNIFESP], Patricio, Francy Reis da Silva [UNIFESP]
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/S0021-75572004000500013
http://repositorio.unifesp.br/handle/11600/2173
Resumo: OBJECTIVE: To evaluate clinical and histological features of duodenal ulcer in children and adolescents. METHODS: Forty-three children with duodenal ulcer were prospectively and consecutively evaluated in a 6-year period (7.2 patients per year). Evaluation included clinical questionnaire focused on dyspeptic symptoms, physical examination, and digestive endoscopy with gastric biopsies for histological examination and Helicobacter pylori detection. RESULTS: Diagnostic age ranged from 4 years and 8 months to 17 years and 4 months (mean age: 12 years and 4 months). Abdominal pain was the main symptom (39/43, 90.7%), which was epigastric in 31/39, periumbilical in 7/39, and nocturnal in 27/39. Other symptoms were loss of appetite (32/43, 74.4%), vomiting (30/43, 69.8%), postprandial fullness (23/43, 53.5%), weight loss (22/43, 51.2%), and abdominal tenderness (19/43, 44.2%). Upper gastrointestinal bleeding occurred in 19/43 (44.2%), whereas anemia occurred in (21/43, 48.8%). Helicobacter pylori infection was detected in 41/43 (95.3%). All infected patients presented acute chronic gastritis in antrum, with lymphomononuclear infiltrate predominance in 92% of them. Eradication of the bacterium occurred in 68.3%. Ulcer healing occurred in all eradicated patients and in 89% of non-eradicated patients. CONCLUSION: Duodenal ulcer was associated with chronic gastritis due to Helicobacter pylori in the majority of patients. Many complications occurred, especially upper digestive bleeding.
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spelling Aspectos clínicos e histológicos da úlcera duodenal em crianças e adolescentesClinical and histological features of duodenal ulcer in children and adolescentsPeptic ulcerdyspepsiaHelicobacter pyloriChildrenÚlcera pépticadispepsiagastriteHelicobacter pyloriOBJECTIVE: To evaluate clinical and histological features of duodenal ulcer in children and adolescents. METHODS: Forty-three children with duodenal ulcer were prospectively and consecutively evaluated in a 6-year period (7.2 patients per year). Evaluation included clinical questionnaire focused on dyspeptic symptoms, physical examination, and digestive endoscopy with gastric biopsies for histological examination and Helicobacter pylori detection. RESULTS: Diagnostic age ranged from 4 years and 8 months to 17 years and 4 months (mean age: 12 years and 4 months). Abdominal pain was the main symptom (39/43, 90.7%), which was epigastric in 31/39, periumbilical in 7/39, and nocturnal in 27/39. Other symptoms were loss of appetite (32/43, 74.4%), vomiting (30/43, 69.8%), postprandial fullness (23/43, 53.5%), weight loss (22/43, 51.2%), and abdominal tenderness (19/43, 44.2%). Upper gastrointestinal bleeding occurred in 19/43 (44.2%), whereas anemia occurred in (21/43, 48.8%). Helicobacter pylori infection was detected in 41/43 (95.3%). All infected patients presented acute chronic gastritis in antrum, with lymphomononuclear infiltrate predominance in 92% of them. Eradication of the bacterium occurred in 68.3%. Ulcer healing occurred in all eradicated patients and in 89% of non-eradicated patients. CONCLUSION: Duodenal ulcer was associated with chronic gastritis due to Helicobacter pylori in the majority of patients. Many complications occurred, especially upper digestive bleeding.OBJETIVO: Avaliar as características clínicas e histológicas de crianças e adolescentes com úlcera duodenal. MÉTODOS: Foram avaliadas prospectiva e consecutivamente 43 pacientes com úlcera duodenal ao longo de 6 anos (7,2 pacientes por ano). A avaliação consistiu de questionário clínico de sintomas dispépticos, exame físico e endoscopia digestiva com biópsias gástricas para exame histológico e detecção do Helicobacter pylori. RESULTADOS: A idade no diagnóstico variou de 4 anos e 8 meses a 17 anos e 4 meses (mediana = 12 anos e 4 meses). O sintoma mais freqüente foi dor abdominal (39/43, 90,7%): no epigástrio em 31/39, periumbilical em 7/39 e noturna em 27/39. Outros sintomas freqüentes foram: diminuição do apetite (32/43, 74,4%), vômitos (30/43, 69,8%), plenitude pós-prandial (23/43, 53,5%), perda de peso (22/43, 51,2%) e sensibilidade abdominal (19/43, 44,2%). Hemorragia digestiva alta ocorreu em 19/43 pacientes (44,2%), e anemia em 21/43 (48,8%). H. pylori foi detectado em 41/43 (95,3%), e todos esses pacientes apresentaram gastrite crônica ativa de antro, 92% deles com predomínio do infiltrado linfomononuclear. A erradicação da bactéria ocorreu em 68,3% dos pacientes infectados, mas houve cicatrização da lesão em 100% dos pacientes erradicados e em 89% dos não-erradicados. CONCLUSÃO: Úlcera duodenal foi associada à gastrite crônica por H. pylori na grande maioria dos pacientes. Houve grande freqüência de complicações, especialmente hemorragia digestiva alta.Universidade Federal de São Paulo (UNIFESP) Escola Paulista de MedicinaUNIFESP, EPMSciELOSociedade Brasileira de PediatriaUniversidade Federal de São Paulo (UNIFESP)Kawakami, Elisabete [UNIFESP]Machado, Rodrigo S. [UNIFESP]Fonseca, Jacqueline A. [UNIFESP]Patricio, Francy Reis da Silva [UNIFESP]2015-06-14T13:31:13Z2015-06-14T13:31:13Z2004-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion321-325application/pdfhttp://dx.doi.org/10.1590/S0021-75572004000500013Jornal de Pediatria. Sociedade Brasileira de Pediatria, v. 80, n. 4, p. 321-325, 2004.10.1590/S0021-75572004000500013S0021-75572004000500013.pdf0021-7557S0021-75572004000500013http://repositorio.unifesp.br/handle/11600/2173porJornal de Pediatriainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-10-14T10:59:59Zoai:repositorio.unifesp.br/:11600/2173Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-10-14T10:59:59Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Aspectos clínicos e histológicos da úlcera duodenal em crianças e adolescentes
Clinical and histological features of duodenal ulcer in children and adolescents
title Aspectos clínicos e histológicos da úlcera duodenal em crianças e adolescentes
spellingShingle Aspectos clínicos e histológicos da úlcera duodenal em crianças e adolescentes
Kawakami, Elisabete [UNIFESP]
Peptic ulcer
dyspepsia
Helicobacter pylori
Children
Úlcera péptica
dispepsia
gastrite
Helicobacter pylori
title_short Aspectos clínicos e histológicos da úlcera duodenal em crianças e adolescentes
title_full Aspectos clínicos e histológicos da úlcera duodenal em crianças e adolescentes
title_fullStr Aspectos clínicos e histológicos da úlcera duodenal em crianças e adolescentes
title_full_unstemmed Aspectos clínicos e histológicos da úlcera duodenal em crianças e adolescentes
title_sort Aspectos clínicos e histológicos da úlcera duodenal em crianças e adolescentes
author Kawakami, Elisabete [UNIFESP]
author_facet Kawakami, Elisabete [UNIFESP]
Machado, Rodrigo S. [UNIFESP]
Fonseca, Jacqueline A. [UNIFESP]
Patricio, Francy Reis da Silva [UNIFESP]
author_role author
author2 Machado, Rodrigo S. [UNIFESP]
Fonseca, Jacqueline A. [UNIFESP]
Patricio, Francy Reis da Silva [UNIFESP]
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Kawakami, Elisabete [UNIFESP]
Machado, Rodrigo S. [UNIFESP]
Fonseca, Jacqueline A. [UNIFESP]
Patricio, Francy Reis da Silva [UNIFESP]
dc.subject.por.fl_str_mv Peptic ulcer
dyspepsia
Helicobacter pylori
Children
Úlcera péptica
dispepsia
gastrite
Helicobacter pylori
topic Peptic ulcer
dyspepsia
Helicobacter pylori
Children
Úlcera péptica
dispepsia
gastrite
Helicobacter pylori
description OBJECTIVE: To evaluate clinical and histological features of duodenal ulcer in children and adolescents. METHODS: Forty-three children with duodenal ulcer were prospectively and consecutively evaluated in a 6-year period (7.2 patients per year). Evaluation included clinical questionnaire focused on dyspeptic symptoms, physical examination, and digestive endoscopy with gastric biopsies for histological examination and Helicobacter pylori detection. RESULTS: Diagnostic age ranged from 4 years and 8 months to 17 years and 4 months (mean age: 12 years and 4 months). Abdominal pain was the main symptom (39/43, 90.7%), which was epigastric in 31/39, periumbilical in 7/39, and nocturnal in 27/39. Other symptoms were loss of appetite (32/43, 74.4%), vomiting (30/43, 69.8%), postprandial fullness (23/43, 53.5%), weight loss (22/43, 51.2%), and abdominal tenderness (19/43, 44.2%). Upper gastrointestinal bleeding occurred in 19/43 (44.2%), whereas anemia occurred in (21/43, 48.8%). Helicobacter pylori infection was detected in 41/43 (95.3%). All infected patients presented acute chronic gastritis in antrum, with lymphomononuclear infiltrate predominance in 92% of them. Eradication of the bacterium occurred in 68.3%. Ulcer healing occurred in all eradicated patients and in 89% of non-eradicated patients. CONCLUSION: Duodenal ulcer was associated with chronic gastritis due to Helicobacter pylori in the majority of patients. Many complications occurred, especially upper digestive bleeding.
publishDate 2004
dc.date.none.fl_str_mv 2004-08-01
2015-06-14T13:31:13Z
2015-06-14T13:31:13Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0021-75572004000500013
Jornal de Pediatria. Sociedade Brasileira de Pediatria, v. 80, n. 4, p. 321-325, 2004.
10.1590/S0021-75572004000500013
S0021-75572004000500013.pdf
0021-7557
S0021-75572004000500013
http://repositorio.unifesp.br/handle/11600/2173
url http://dx.doi.org/10.1590/S0021-75572004000500013
http://repositorio.unifesp.br/handle/11600/2173
identifier_str_mv Jornal de Pediatria. Sociedade Brasileira de Pediatria, v. 80, n. 4, p. 321-325, 2004.
10.1590/S0021-75572004000500013
S0021-75572004000500013.pdf
0021-7557
S0021-75572004000500013
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv Jornal de Pediatria
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 321-325
application/pdf
dc.publisher.none.fl_str_mv Sociedade Brasileira de Pediatria
publisher.none.fl_str_mv Sociedade Brasileira de Pediatria
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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