Neuropatia autonômica cardiovascular diabética: fatores de risco, impacto clínico e diagnóstico precoce

• Autor(a) principal: Rolim, Luiz Clemente de Souza Pereira [UNIFESP]
• Data de Publicação: 2008
• Outros Autores: Sá, João Roberto de [UNIFESP], Chacra, Antonio Roberto [UNIFESP], Dib, Sergio Atala [UNIFESP]
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://dx.doi.org/10.1590/S0066-782X2008000400014; http://repositorio.unifesp.br/handle/11600/4352
• topic: Diabetes mellitus; cardiovascular diseases; autonomic nervous system; risk factors; mortality; heart rate variability; Diabete melito; doenças do sistema cardiovascular; doenças do sistema nervoso autônomo; fatores de risco; mortalidade; neuropatias diabéticas

Cardiovascular autonomic neuropathy (CAN) is one of the most clinically significant complications of diabetes mellitus (DM), but one of the least frequently diagnosed. In this review, we discuss the major risk factors for the development and progression of CAN in patients with DM, the natural history of autonomic neuropathy and its impact on cardiovascular disease in DM, as well as the tests for the early diagnosis and staging of CAN in the clinical practice. The bibliographic research was based on two databases: Medline and Tripdatabase, with the following descriptors: diabetic cardiovascular autonomic neuropathy and cardiovascular autonomic neuropathy and diabetes. We selected English and German articles, written between 1998 and 2007. In its initial stages (early and intermediate), CAN may be diagnosed and reversed. However, in advanced cases (severe stage), the only treatment that remains is a symptomatic one. CAN is associated with higher cardiovascular morbidity and mortality rates and poor quality of life in diabetic individuals.