Carotid sinus denervation ameliorates renovascular hypertension in adult Wistar rats
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UNIFESP |
| Texto Completo: | http://dx.doi.org/10.1113/JP272708 https://repositorio.unifesp.br/handle/11600/56846 |
Resumo: | The peripheral chemoreflex is known to be hyper-responsive in both spontaneously hypertensive (SHR) and Goldblatt hypertensive (two kidney one clip |
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Carotid sinus denervation ameliorates renovascular hypertension in adult Wistar ratscarotid sinus denervationchemoreceptor reflexrenovascular hypertensionThe peripheral chemoreflex is known to be hyper-responsive in both spontaneously hypertensive (SHR) and Goldblatt hypertensive (two kidney one clip2K1C) rats. We have previously shown that carotid sinus nerve denervation (CSD) reduces arterial blood pressure (ABP) in SHR. In the present study, we show that CSD ameliorates 2K1C hypertension and reveal the potential underlying mechanisms. Adult Wistar rats were instrumented to record ABP via telemetry, and then underwent CSD (n=9) or sham CSD (n=9) 5weeks after renal artery clipping, in comparison with normal Wistar rats (n=5). After 21days, renal function was assessed, and tissue was collected to assess sympathetic postganglionic intracellular calcium transients ([Ca2+](i)) and immune cell infiltrates. Hypertensive 2K1C rats showed a profound elevation in ABP (Wistar: 984mmHg vs. 2K1C: 1478mmHgP<0.001), coupled with impairments in renal function and baroreflex sensitivity, increased neuroinflammatory markers and enhanced [Ca2+](I) in stellate neurons (P<0.05). CSD reduced ABP in 2K1C+CSD rats and prevented the further progressive increase in ABP seen in 2K1C+sham CSD rats, with a between-group difference of 142mmHg by week 3 (P<0.01), which was accompanied by improvements in both baroreflex control and spectral indicators of cardiac sympatho-vagal balance. Furthermore, CSD improved protein and albuminuria, decreased [Ca2+](i) evoked responses from stellate neurons, and also reduced indicators of brainstem inflammation. In summary, CSD in 2K1C rats reduces the hypertensive burden and improves renal function. This may be mediated by improvements in autonomic balance, functional remodelling of post-ganglionic neurons and reduced inflammation. Our results suggest that the peripheral chemoreflex may be considered as a potential therapeutic target for controlling renovascular hypertension.Univ Bristol, Sch Physiol Pharmacol & Neurosci, Biomed Sci, Bristol, Avon, EnglandUniv Auckland, Dept Physiol, Fac Med & Hlth Sci, Auckland, New ZealandGeorge Washington Univ, Sch Med & Hlth Sci, Dept Pharmacol & Physiol, Washington, DC 20052 USAUniv Fed Sao Paulo, Cardiovasc Div, Escola Paulista Med, Dept Physiol, Sao Paulo, BrazilUniv Oxford, Burdon Sanderson Cardiac Sci Ctr, Dept Physiol Anat & Genet, Oxford OX1 2JD, EnglandCardiovascular Division ‐ Department of Physiology, Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), Sao Paulo, BrazilWeb of ScienceBritish Heart FoundationRoyal SocietyNational Institutes of Health (NIH)European Commission Research Executive Agency Marie Curie International Incoming FellowshipAmerican Heart AssociationBritish Heart Foundation: RG/12/6/29670NIH: 1R01AT008632-01NIH: R00 HL107675-03European Commission Research Executive Agency Marie Curie International Incoming Fellowship: MC-IIF - 276147American Heart Association: 15CSA24340001Wiley2020-07-31T12:47:29Z2020-07-31T12:47:29Z2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion6255-6266http://dx.doi.org/10.1113/JP272708Journal Of Physiology-London. Hoboken, v. 594, n. 21, p. 6255-6266, 2016.10.1113/JP2727080022-3751https://repositorio.unifesp.br/handle/11600/56846WOS:000387084200016engJournal Of Physiology-LondonHobokeninfo:eu-repo/semantics/openAccessPijacka, WiolettaMcBryde, Fiona D.Marvar, Paul J.Lincevicius, Gisele S. [UNIFESP]Abdala, Ana Paula Lima [UNIFESP]Woodward, LaviniaLi, DanPaterson, David J.Paton, Julian F. R.reponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2022-10-06T11:07:56Zoai:repositorio.unifesp.br/:11600/56846Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652022-10-06T11:07:56Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
| dc.title.none.fl_str_mv |
Carotid sinus denervation ameliorates renovascular hypertension in adult Wistar rats |
| title |
Carotid sinus denervation ameliorates renovascular hypertension in adult Wistar rats |
| spellingShingle |
Carotid sinus denervation ameliorates renovascular hypertension in adult Wistar rats Pijacka, Wioletta carotid sinus denervation chemoreceptor reflex renovascular hypertension |
| title_short |
Carotid sinus denervation ameliorates renovascular hypertension in adult Wistar rats |
| title_full |
Carotid sinus denervation ameliorates renovascular hypertension in adult Wistar rats |
| title_fullStr |
Carotid sinus denervation ameliorates renovascular hypertension in adult Wistar rats |
| title_full_unstemmed |
Carotid sinus denervation ameliorates renovascular hypertension in adult Wistar rats |
| title_sort |
Carotid sinus denervation ameliorates renovascular hypertension in adult Wistar rats |
| author |
Pijacka, Wioletta |
| author_facet |
Pijacka, Wioletta McBryde, Fiona D. Marvar, Paul J. Lincevicius, Gisele S. [UNIFESP] Abdala, Ana Paula Lima [UNIFESP] Woodward, Lavinia Li, Dan Paterson, David J. Paton, Julian F. R. |
| author_role |
author |
| author2 |
McBryde, Fiona D. Marvar, Paul J. Lincevicius, Gisele S. [UNIFESP] Abdala, Ana Paula Lima [UNIFESP] Woodward, Lavinia Li, Dan Paterson, David J. Paton, Julian F. R. |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Pijacka, Wioletta McBryde, Fiona D. Marvar, Paul J. Lincevicius, Gisele S. [UNIFESP] Abdala, Ana Paula Lima [UNIFESP] Woodward, Lavinia Li, Dan Paterson, David J. Paton, Julian F. R. |
| dc.subject.por.fl_str_mv |
carotid sinus denervation chemoreceptor reflex renovascular hypertension |
| topic |
carotid sinus denervation chemoreceptor reflex renovascular hypertension |
| description |
The peripheral chemoreflex is known to be hyper-responsive in both spontaneously hypertensive (SHR) and Goldblatt hypertensive (two kidney one clip |
| publishDate |
2016 |
| dc.date.none.fl_str_mv |
2016 2020-07-31T12:47:29Z 2020-07-31T12:47:29Z |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1113/JP272708 Journal Of Physiology-London. Hoboken, v. 594, n. 21, p. 6255-6266, 2016. 10.1113/JP272708 0022-3751 https://repositorio.unifesp.br/handle/11600/56846 WOS:000387084200016 |
| url |
http://dx.doi.org/10.1113/JP272708 https://repositorio.unifesp.br/handle/11600/56846 |
| identifier_str_mv |
Journal Of Physiology-London. Hoboken, v. 594, n. 21, p. 6255-6266, 2016. 10.1113/JP272708 0022-3751 WOS:000387084200016 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Journal Of Physiology-London |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
6255-6266 |
| dc.coverage.none.fl_str_mv |
Hoboken |
| dc.publisher.none.fl_str_mv |
Wiley |
| publisher.none.fl_str_mv |
Wiley |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
| instname_str |
Universidade Federal de São Paulo (UNIFESP) |
| instacron_str |
UNIFESP |
| institution |
UNIFESP |
| reponame_str |
Repositório Institucional da UNIFESP |
| collection |
Repositório Institucional da UNIFESP |
| repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
| repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
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1814268373677113344 |