Cancer/Testis Antigen MAGE-C1/CT7: New Target for Multiple Myeloma Therapy
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://dx.doi.org/10.1155/2012/257695 http://repositorio.unifesp.br/handle/11600/34367 |
Resumo: | Cancer/Testis Antigens (CTAs) are a promising class of tumor antigens that have a limited expression in somatic tissues (testis, ovary, fetal, and placental cells). Aberrant expression of CTAs in cancer cells may lead to abnormal chromosome segregation and aneuploidy. CTAs are regulated by epigenetic mechanisms (DNA methylation and acetylation of histones) and are attractive targets for immunotherapy in cancer because the gonads are immune privileged organs and anti-CTA immune response can be tumor-specific. Multiple myeloma (MM) is an incurable hematological malignancy, and several CTAs have been detected in many MM cell lines and patients. Among CTAs expressed in MM we must highlight the MAGE-C1/CT7 located on the X chromosome and expressed specificity in the malignant plasma cells. MAGE-C1/CT7 seems to be related to disease progression and functional studies suggests that this CTA might play a role in cell cycle and mainly in survival of malignant plasma cells, protecting myeloma cells against spontaneous as well as drug-induced apoptosis. |
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Cancer/Testis Antigen MAGE-C1/CT7: New Target for Multiple Myeloma TherapyCancer/Testis Antigens (CTAs) are a promising class of tumor antigens that have a limited expression in somatic tissues (testis, ovary, fetal, and placental cells). Aberrant expression of CTAs in cancer cells may lead to abnormal chromosome segregation and aneuploidy. CTAs are regulated by epigenetic mechanisms (DNA methylation and acetylation of histones) and are attractive targets for immunotherapy in cancer because the gonads are immune privileged organs and anti-CTA immune response can be tumor-specific. Multiple myeloma (MM) is an incurable hematological malignancy, and several CTAs have been detected in many MM cell lines and patients. Among CTAs expressed in MM we must highlight the MAGE-C1/CT7 located on the X chromosome and expressed specificity in the malignant plasma cells. MAGE-C1/CT7 seems to be related to disease progression and functional studies suggests that this CTA might play a role in cell cycle and mainly in survival of malignant plasma cells, protecting myeloma cells against spontaneous as well as drug-induced apoptosis.Universidade Federal de São Paulo, Disciplina Hematol & Hemoterapia, UNIFESP EPM, BR-04023900 Vila Clementino, SP, BrazilUNIFESP, Dept Ciencias Biol, BR-09972270 Diadema, SP, BrazilUniversidade Federal de São Paulo, Disciplina Hematol & Hemoterapia, UNIFESP EPM, BR-04023900 Vila Clementino, SP, BrazilUNIFESP, Dept Ciencias Biol, BR-09972270 Diadema, SP, BrazilWeb of ScienceHindawi Publishing CorporationUniversidade Federal de São Paulo (UNIFESP)Carvalho, Fabricio de [UNIFESP]Vettore, Andre L. [UNIFESP]Colleoni, Gisele W. B. [UNIFESP]2016-01-24T14:17:37Z2016-01-24T14:17:37Z2012-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion7application/pdfhttp://dx.doi.org/10.1155/2012/257695Clinical & Developmental Immunology. New York: Hindawi Publishing Corporation, 7 p., 2012.10.1155/2012/257695WOS000302578400001.pdf1740-2522http://repositorio.unifesp.br/handle/11600/34367WOS:000302578400001engClinical & Developmental Immunologyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-31T23:25:58Zoai:repositorio.unifesp.br/:11600/34367Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-31T23:25:58Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Cancer/Testis Antigen MAGE-C1/CT7: New Target for Multiple Myeloma Therapy |
title |
Cancer/Testis Antigen MAGE-C1/CT7: New Target for Multiple Myeloma Therapy |
spellingShingle |
Cancer/Testis Antigen MAGE-C1/CT7: New Target for Multiple Myeloma Therapy Carvalho, Fabricio de [UNIFESP] |
title_short |
Cancer/Testis Antigen MAGE-C1/CT7: New Target for Multiple Myeloma Therapy |
title_full |
Cancer/Testis Antigen MAGE-C1/CT7: New Target for Multiple Myeloma Therapy |
title_fullStr |
Cancer/Testis Antigen MAGE-C1/CT7: New Target for Multiple Myeloma Therapy |
title_full_unstemmed |
Cancer/Testis Antigen MAGE-C1/CT7: New Target for Multiple Myeloma Therapy |
title_sort |
Cancer/Testis Antigen MAGE-C1/CT7: New Target for Multiple Myeloma Therapy |
author |
Carvalho, Fabricio de [UNIFESP] |
author_facet |
Carvalho, Fabricio de [UNIFESP] Vettore, Andre L. [UNIFESP] Colleoni, Gisele W. B. [UNIFESP] |
author_role |
author |
author2 |
Vettore, Andre L. [UNIFESP] Colleoni, Gisele W. B. [UNIFESP] |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Carvalho, Fabricio de [UNIFESP] Vettore, Andre L. [UNIFESP] Colleoni, Gisele W. B. [UNIFESP] |
description |
Cancer/Testis Antigens (CTAs) are a promising class of tumor antigens that have a limited expression in somatic tissues (testis, ovary, fetal, and placental cells). Aberrant expression of CTAs in cancer cells may lead to abnormal chromosome segregation and aneuploidy. CTAs are regulated by epigenetic mechanisms (DNA methylation and acetylation of histones) and are attractive targets for immunotherapy in cancer because the gonads are immune privileged organs and anti-CTA immune response can be tumor-specific. Multiple myeloma (MM) is an incurable hematological malignancy, and several CTAs have been detected in many MM cell lines and patients. Among CTAs expressed in MM we must highlight the MAGE-C1/CT7 located on the X chromosome and expressed specificity in the malignant plasma cells. MAGE-C1/CT7 seems to be related to disease progression and functional studies suggests that this CTA might play a role in cell cycle and mainly in survival of malignant plasma cells, protecting myeloma cells against spontaneous as well as drug-induced apoptosis. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-01-01 2016-01-24T14:17:37Z 2016-01-24T14:17:37Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1155/2012/257695 Clinical & Developmental Immunology. New York: Hindawi Publishing Corporation, 7 p., 2012. 10.1155/2012/257695 WOS000302578400001.pdf 1740-2522 http://repositorio.unifesp.br/handle/11600/34367 WOS:000302578400001 |
url |
http://dx.doi.org/10.1155/2012/257695 http://repositorio.unifesp.br/handle/11600/34367 |
identifier_str_mv |
Clinical & Developmental Immunology. New York: Hindawi Publishing Corporation, 7 p., 2012. 10.1155/2012/257695 WOS000302578400001.pdf 1740-2522 WOS:000302578400001 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Clinical & Developmental Immunology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
7 application/pdf |
dc.publisher.none.fl_str_mv |
Hindawi Publishing Corporation |
publisher.none.fl_str_mv |
Hindawi Publishing Corporation |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
_version_ |
1814268451841114112 |