Hippocampal ether-a-go-go1 potassium channels blockade: Effects in the startle reflex and prepulse inhibition

Detalhes bibliográficos
Autor(a) principal: Issy, Ana Carolina
Data de Publicação: 2014
Outros Autores: Fonseca, José Roberto Falco [UNIFESP], Pardo, Luis Angel, Stuehmer, Walter, Del Bel, Eliane Aparecida
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1016/j.neulet.2013.11.026
http://repositorio.unifesp.br/handle/11600/37326
Resumo: Recently, our group described the ether-a-go-go1(Eag1) voltage-gated potassium (K+) channel (Kv10.1) expression in the dopaminergic cells indicating that these channels are part of the diversified group of ion channels related to dopaminergic neurons function. the increase of dopamine neurotransmission induces a reduction in the prepulse inhibition (PPI) of the acoustic startle reflex in rodents, which is a reliable index of sensorimotor gating deficits. the PPI response has been reported to be abnormally reduced in schizophrenia patients. the role of Eag1 K+ channels in the PPI reaction had not been revealed until now, albeit the singular distribution of Eag1 in the dentate gyrus of the hippocampus and the hippocampal regulation of the startle reflex and PPI. the aim of this work was to investigate if Eag1 blockade on hippocampus modifies the PPI-disruptive effects of apomorphine in Wistar rats. Bilateral injection of anti-Eag1 single-chain antibody into the dentate gyrus of hippocampus did not modify apomorphine-disruptive effects in the PPI response. However, Eag1 antibody completely restored the startle amplitude decrease revealed after dentate gyrus surgery. These potentially biological important phenomenon merits further investigation regarding the role of Eag1 K+ channels, mainly, on startle reflex modulation, since the physiological role of these channels remain obscure. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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spelling Hippocampal ether-a-go-go1 potassium channels blockade: Effects in the startle reflex and prepulse inhibitionDopaminePrepulse inhibitionSchizophreniaEag1Kv10.1Startle reflexRecently, our group described the ether-a-go-go1(Eag1) voltage-gated potassium (K+) channel (Kv10.1) expression in the dopaminergic cells indicating that these channels are part of the diversified group of ion channels related to dopaminergic neurons function. the increase of dopamine neurotransmission induces a reduction in the prepulse inhibition (PPI) of the acoustic startle reflex in rodents, which is a reliable index of sensorimotor gating deficits. the PPI response has been reported to be abnormally reduced in schizophrenia patients. the role of Eag1 K+ channels in the PPI reaction had not been revealed until now, albeit the singular distribution of Eag1 in the dentate gyrus of the hippocampus and the hippocampal regulation of the startle reflex and PPI. the aim of this work was to investigate if Eag1 blockade on hippocampus modifies the PPI-disruptive effects of apomorphine in Wistar rats. Bilateral injection of anti-Eag1 single-chain antibody into the dentate gyrus of hippocampus did not modify apomorphine-disruptive effects in the PPI response. However, Eag1 antibody completely restored the startle amplitude decrease revealed after dentate gyrus surgery. These potentially biological important phenomenon merits further investigation regarding the role of Eag1 K+ channels, mainly, on startle reflex modulation, since the physiological role of these channels remain obscure. (C) 2013 Elsevier Ireland Ltd. All rights reserved.Univ São Paulo, Dept Morphol Physiol & Basic Pathol, Dent Sch Ribeirao Preto, BR-14049904 São Paulo, BrazilUniversidade Federal de São Paulo UNIFESP, São Paulo, BrazilMax Planck Inst Expt Med, Dept Mol Biol Neuronal Signals, D-37075 Gottingen, GermanyUniversidade Federal de São Paulo UNIFESP, São Paulo, BrazilWeb of ScienceConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Elsevier B.V.Universidade de São Paulo (USP)Universidade Federal de São Paulo (UNIFESP)Max Planck Inst Expt MedIssy, Ana CarolinaFonseca, José Roberto Falco [UNIFESP]Pardo, Luis AngelStuehmer, WalterDel Bel, Eliane Aparecida2016-01-24T14:35:09Z2016-01-24T14:35:09Z2014-01-24info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion13-17application/pdfhttp://dx.doi.org/10.1016/j.neulet.2013.11.026Neuroscience Letters. Clare: Elsevier B.V., v. 559, p. 13-17, 2014.10.1016/j.neulet.2013.11.026WOS000331021900003.pdf0304-3940http://repositorio.unifesp.br/handle/11600/37326WOS:000331021900003engNeuroscience Lettersinfo:eu-repo/semantics/openAccesshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policyreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-31T18:33:32Zoai:repositorio.unifesp.br/:11600/37326Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-31T18:33:32Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Hippocampal ether-a-go-go1 potassium channels blockade: Effects in the startle reflex and prepulse inhibition
title Hippocampal ether-a-go-go1 potassium channels blockade: Effects in the startle reflex and prepulse inhibition
spellingShingle Hippocampal ether-a-go-go1 potassium channels blockade: Effects in the startle reflex and prepulse inhibition
Issy, Ana Carolina
Dopamine
Prepulse inhibition
Schizophrenia
Eag1
Kv10.1
Startle reflex
title_short Hippocampal ether-a-go-go1 potassium channels blockade: Effects in the startle reflex and prepulse inhibition
title_full Hippocampal ether-a-go-go1 potassium channels blockade: Effects in the startle reflex and prepulse inhibition
title_fullStr Hippocampal ether-a-go-go1 potassium channels blockade: Effects in the startle reflex and prepulse inhibition
title_full_unstemmed Hippocampal ether-a-go-go1 potassium channels blockade: Effects in the startle reflex and prepulse inhibition
title_sort Hippocampal ether-a-go-go1 potassium channels blockade: Effects in the startle reflex and prepulse inhibition
author Issy, Ana Carolina
author_facet Issy, Ana Carolina
Fonseca, José Roberto Falco [UNIFESP]
Pardo, Luis Angel
Stuehmer, Walter
Del Bel, Eliane Aparecida
author_role author
author2 Fonseca, José Roberto Falco [UNIFESP]
Pardo, Luis Angel
Stuehmer, Walter
Del Bel, Eliane Aparecida
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Max Planck Inst Expt Med
dc.contributor.author.fl_str_mv Issy, Ana Carolina
Fonseca, José Roberto Falco [UNIFESP]
Pardo, Luis Angel
Stuehmer, Walter
Del Bel, Eliane Aparecida
dc.subject.por.fl_str_mv Dopamine
Prepulse inhibition
Schizophrenia
Eag1
Kv10.1
Startle reflex
topic Dopamine
Prepulse inhibition
Schizophrenia
Eag1
Kv10.1
Startle reflex
description Recently, our group described the ether-a-go-go1(Eag1) voltage-gated potassium (K+) channel (Kv10.1) expression in the dopaminergic cells indicating that these channels are part of the diversified group of ion channels related to dopaminergic neurons function. the increase of dopamine neurotransmission induces a reduction in the prepulse inhibition (PPI) of the acoustic startle reflex in rodents, which is a reliable index of sensorimotor gating deficits. the PPI response has been reported to be abnormally reduced in schizophrenia patients. the role of Eag1 K+ channels in the PPI reaction had not been revealed until now, albeit the singular distribution of Eag1 in the dentate gyrus of the hippocampus and the hippocampal regulation of the startle reflex and PPI. the aim of this work was to investigate if Eag1 blockade on hippocampus modifies the PPI-disruptive effects of apomorphine in Wistar rats. Bilateral injection of anti-Eag1 single-chain antibody into the dentate gyrus of hippocampus did not modify apomorphine-disruptive effects in the PPI response. However, Eag1 antibody completely restored the startle amplitude decrease revealed after dentate gyrus surgery. These potentially biological important phenomenon merits further investigation regarding the role of Eag1 K+ channels, mainly, on startle reflex modulation, since the physiological role of these channels remain obscure. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
publishDate 2014
dc.date.none.fl_str_mv 2014-01-24
2016-01-24T14:35:09Z
2016-01-24T14:35:09Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.neulet.2013.11.026
Neuroscience Letters. Clare: Elsevier B.V., v. 559, p. 13-17, 2014.
10.1016/j.neulet.2013.11.026
WOS000331021900003.pdf
0304-3940
http://repositorio.unifesp.br/handle/11600/37326
WOS:000331021900003
url http://dx.doi.org/10.1016/j.neulet.2013.11.026
http://repositorio.unifesp.br/handle/11600/37326
identifier_str_mv Neuroscience Letters. Clare: Elsevier B.V., v. 559, p. 13-17, 2014.
10.1016/j.neulet.2013.11.026
WOS000331021900003.pdf
0304-3940
WOS:000331021900003
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Neuroscience Letters
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
eu_rights_str_mv openAccess
rights_invalid_str_mv http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.format.none.fl_str_mv 13-17
application/pdf
dc.publisher.none.fl_str_mv Elsevier B.V.
publisher.none.fl_str_mv Elsevier B.V.
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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