Hippocampal ether-a-go-go1 potassium channels blockade: Effects in the startle reflex and prepulse inhibition
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://dx.doi.org/10.1016/j.neulet.2013.11.026 http://repositorio.unifesp.br/handle/11600/37326 |
Resumo: | Recently, our group described the ether-a-go-go1(Eag1) voltage-gated potassium (K+) channel (Kv10.1) expression in the dopaminergic cells indicating that these channels are part of the diversified group of ion channels related to dopaminergic neurons function. the increase of dopamine neurotransmission induces a reduction in the prepulse inhibition (PPI) of the acoustic startle reflex in rodents, which is a reliable index of sensorimotor gating deficits. the PPI response has been reported to be abnormally reduced in schizophrenia patients. the role of Eag1 K+ channels in the PPI reaction had not been revealed until now, albeit the singular distribution of Eag1 in the dentate gyrus of the hippocampus and the hippocampal regulation of the startle reflex and PPI. the aim of this work was to investigate if Eag1 blockade on hippocampus modifies the PPI-disruptive effects of apomorphine in Wistar rats. Bilateral injection of anti-Eag1 single-chain antibody into the dentate gyrus of hippocampus did not modify apomorphine-disruptive effects in the PPI response. However, Eag1 antibody completely restored the startle amplitude decrease revealed after dentate gyrus surgery. These potentially biological important phenomenon merits further investigation regarding the role of Eag1 K+ channels, mainly, on startle reflex modulation, since the physiological role of these channels remain obscure. (C) 2013 Elsevier Ireland Ltd. All rights reserved. |
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Hippocampal ether-a-go-go1 potassium channels blockade: Effects in the startle reflex and prepulse inhibitionDopaminePrepulse inhibitionSchizophreniaEag1Kv10.1Startle reflexRecently, our group described the ether-a-go-go1(Eag1) voltage-gated potassium (K+) channel (Kv10.1) expression in the dopaminergic cells indicating that these channels are part of the diversified group of ion channels related to dopaminergic neurons function. the increase of dopamine neurotransmission induces a reduction in the prepulse inhibition (PPI) of the acoustic startle reflex in rodents, which is a reliable index of sensorimotor gating deficits. the PPI response has been reported to be abnormally reduced in schizophrenia patients. the role of Eag1 K+ channels in the PPI reaction had not been revealed until now, albeit the singular distribution of Eag1 in the dentate gyrus of the hippocampus and the hippocampal regulation of the startle reflex and PPI. the aim of this work was to investigate if Eag1 blockade on hippocampus modifies the PPI-disruptive effects of apomorphine in Wistar rats. Bilateral injection of anti-Eag1 single-chain antibody into the dentate gyrus of hippocampus did not modify apomorphine-disruptive effects in the PPI response. However, Eag1 antibody completely restored the startle amplitude decrease revealed after dentate gyrus surgery. These potentially biological important phenomenon merits further investigation regarding the role of Eag1 K+ channels, mainly, on startle reflex modulation, since the physiological role of these channels remain obscure. (C) 2013 Elsevier Ireland Ltd. All rights reserved.Univ São Paulo, Dept Morphol Physiol & Basic Pathol, Dent Sch Ribeirao Preto, BR-14049904 São Paulo, BrazilUniversidade Federal de São Paulo UNIFESP, São Paulo, BrazilMax Planck Inst Expt Med, Dept Mol Biol Neuronal Signals, D-37075 Gottingen, GermanyUniversidade Federal de São Paulo UNIFESP, São Paulo, BrazilWeb of ScienceConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Elsevier B.V.Universidade de São Paulo (USP)Universidade Federal de São Paulo (UNIFESP)Max Planck Inst Expt MedIssy, Ana CarolinaFonseca, José Roberto Falco [UNIFESP]Pardo, Luis AngelStuehmer, WalterDel Bel, Eliane Aparecida2016-01-24T14:35:09Z2016-01-24T14:35:09Z2014-01-24info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion13-17application/pdfhttp://dx.doi.org/10.1016/j.neulet.2013.11.026Neuroscience Letters. Clare: Elsevier B.V., v. 559, p. 13-17, 2014.10.1016/j.neulet.2013.11.026WOS000331021900003.pdf0304-3940http://repositorio.unifesp.br/handle/11600/37326WOS:000331021900003engNeuroscience Lettersinfo:eu-repo/semantics/openAccesshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policyreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-31T18:33:32Zoai:repositorio.unifesp.br/:11600/37326Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-31T18:33:32Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Hippocampal ether-a-go-go1 potassium channels blockade: Effects in the startle reflex and prepulse inhibition |
title |
Hippocampal ether-a-go-go1 potassium channels blockade: Effects in the startle reflex and prepulse inhibition |
spellingShingle |
Hippocampal ether-a-go-go1 potassium channels blockade: Effects in the startle reflex and prepulse inhibition Issy, Ana Carolina Dopamine Prepulse inhibition Schizophrenia Eag1 Kv10.1 Startle reflex |
title_short |
Hippocampal ether-a-go-go1 potassium channels blockade: Effects in the startle reflex and prepulse inhibition |
title_full |
Hippocampal ether-a-go-go1 potassium channels blockade: Effects in the startle reflex and prepulse inhibition |
title_fullStr |
Hippocampal ether-a-go-go1 potassium channels blockade: Effects in the startle reflex and prepulse inhibition |
title_full_unstemmed |
Hippocampal ether-a-go-go1 potassium channels blockade: Effects in the startle reflex and prepulse inhibition |
title_sort |
Hippocampal ether-a-go-go1 potassium channels blockade: Effects in the startle reflex and prepulse inhibition |
author |
Issy, Ana Carolina |
author_facet |
Issy, Ana Carolina Fonseca, José Roberto Falco [UNIFESP] Pardo, Luis Angel Stuehmer, Walter Del Bel, Eliane Aparecida |
author_role |
author |
author2 |
Fonseca, José Roberto Falco [UNIFESP] Pardo, Luis Angel Stuehmer, Walter Del Bel, Eliane Aparecida |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Federal de São Paulo (UNIFESP) Max Planck Inst Expt Med |
dc.contributor.author.fl_str_mv |
Issy, Ana Carolina Fonseca, José Roberto Falco [UNIFESP] Pardo, Luis Angel Stuehmer, Walter Del Bel, Eliane Aparecida |
dc.subject.por.fl_str_mv |
Dopamine Prepulse inhibition Schizophrenia Eag1 Kv10.1 Startle reflex |
topic |
Dopamine Prepulse inhibition Schizophrenia Eag1 Kv10.1 Startle reflex |
description |
Recently, our group described the ether-a-go-go1(Eag1) voltage-gated potassium (K+) channel (Kv10.1) expression in the dopaminergic cells indicating that these channels are part of the diversified group of ion channels related to dopaminergic neurons function. the increase of dopamine neurotransmission induces a reduction in the prepulse inhibition (PPI) of the acoustic startle reflex in rodents, which is a reliable index of sensorimotor gating deficits. the PPI response has been reported to be abnormally reduced in schizophrenia patients. the role of Eag1 K+ channels in the PPI reaction had not been revealed until now, albeit the singular distribution of Eag1 in the dentate gyrus of the hippocampus and the hippocampal regulation of the startle reflex and PPI. the aim of this work was to investigate if Eag1 blockade on hippocampus modifies the PPI-disruptive effects of apomorphine in Wistar rats. Bilateral injection of anti-Eag1 single-chain antibody into the dentate gyrus of hippocampus did not modify apomorphine-disruptive effects in the PPI response. However, Eag1 antibody completely restored the startle amplitude decrease revealed after dentate gyrus surgery. These potentially biological important phenomenon merits further investigation regarding the role of Eag1 K+ channels, mainly, on startle reflex modulation, since the physiological role of these channels remain obscure. (C) 2013 Elsevier Ireland Ltd. All rights reserved. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-01-24 2016-01-24T14:35:09Z 2016-01-24T14:35:09Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.neulet.2013.11.026 Neuroscience Letters. Clare: Elsevier B.V., v. 559, p. 13-17, 2014. 10.1016/j.neulet.2013.11.026 WOS000331021900003.pdf 0304-3940 http://repositorio.unifesp.br/handle/11600/37326 WOS:000331021900003 |
url |
http://dx.doi.org/10.1016/j.neulet.2013.11.026 http://repositorio.unifesp.br/handle/11600/37326 |
identifier_str_mv |
Neuroscience Letters. Clare: Elsevier B.V., v. 559, p. 13-17, 2014. 10.1016/j.neulet.2013.11.026 WOS000331021900003.pdf 0304-3940 WOS:000331021900003 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Neuroscience Letters |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy |
dc.format.none.fl_str_mv |
13-17 application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier B.V. |
publisher.none.fl_str_mv |
Elsevier B.V. |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
_version_ |
1814268414944870400 |