Breakthrough Candidemia Due to Multidrug-Resistant Candida glabrata during Prophylaxis with a Low Dose of Micafungin

Detalhes bibliográficos
Autor(a) principal: Bizerra, Fernando Cesar [UNIFESP]
Data de Publicação: 2014
Outros Autores: Jimenez-Ortigosa, Cristina, Souza, Ana Carolina R. [UNIFESP], Breda, Giovanni Luis, Queiroz-Telles, Flavio, Perlin, David S., Colombo, Arnaldo L. [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1128/AAC.02189-13
http://repositorio.unifesp.br/handle/11600/37578
Resumo: We identified a case of breakthrough candidemia in a 25-year-old patient receiving micafungin prophylaxis (50 mg/day). Five Candida glabrata isolates were obtained from blood cultures and were classified as multidrug-resistant isolates, since all of them exhibited high MICs for echinocandin and azole drugs. A mutation (S663F) in hot spot 1 of the FKS2 gene was found in all five isolates. This mutation yielded a 1,3-beta-D-glucan synthase enzyme with highly reduced sensitivities to echinocandin drugs.
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spelling Breakthrough Candidemia Due to Multidrug-Resistant Candida glabrata during Prophylaxis with a Low Dose of MicafunginWe identified a case of breakthrough candidemia in a 25-year-old patient receiving micafungin prophylaxis (50 mg/day). Five Candida glabrata isolates were obtained from blood cultures and were classified as multidrug-resistant isolates, since all of them exhibited high MICs for echinocandin and azole drugs. A mutation (S663F) in hot spot 1 of the FKS2 gene was found in all five isolates. This mutation yielded a 1,3-beta-D-glucan synthase enzyme with highly reduced sensitivities to echinocandin drugs.Universidade Federal de São Paulo, Lab Especial Micol, Disciplina Infectol, São Paulo, BrazilUniv Fed Parana, Hosp Clin, BR-80060000 Curitiba, Parana, BrazilRutgers State Univ, New Jersey Med Sch, Publ Hlth Res Inst, Newark, NJ 07102 USAUniversidade Federal de São Paulo, Lab Especial Micol, Disciplina Infectol, São Paulo, BrazilWeb of ScienceFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)NIHPfizerMerckAstellasMSDUnited MedicalFAPESP: 2007/08575-1FAPESP: 2012/04767-1CNPq: 308011/2010-4FAPESP: 2012/04769-4FAPESP: 2010/17179-5NIH: AI069397Amer Soc MicrobiologyUniversidade Federal de São Paulo (UNIFESP)Univ Fed ParanaRutgers State UnivBizerra, Fernando Cesar [UNIFESP]Jimenez-Ortigosa, CristinaSouza, Ana Carolina R. [UNIFESP]Breda, Giovanni LuisQueiroz-Telles, FlavioPerlin, David S.Colombo, Arnaldo L. [UNIFESP]2016-01-24T14:35:29Z2016-01-24T14:35:29Z2014-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion2438-2440application/pdfhttp://dx.doi.org/10.1128/AAC.02189-13Antimicrobial Agents and Chemotherapy. Washington: Amer Soc Microbiology, v. 58, n. 4, p. 2438-2440, 2014.10.1128/AAC.02189-13WOS000333605600079.pdf0066-4804http://repositorio.unifesp.br/handle/11600/37578WOS:000333605600079engAntimicrobial Agents and Chemotherapyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-31T21:25:22Zoai:repositorio.unifesp.br/:11600/37578Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-31T21:25:22Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Breakthrough Candidemia Due to Multidrug-Resistant Candida glabrata during Prophylaxis with a Low Dose of Micafungin
title Breakthrough Candidemia Due to Multidrug-Resistant Candida glabrata during Prophylaxis with a Low Dose of Micafungin
spellingShingle Breakthrough Candidemia Due to Multidrug-Resistant Candida glabrata during Prophylaxis with a Low Dose of Micafungin
Bizerra, Fernando Cesar [UNIFESP]
title_short Breakthrough Candidemia Due to Multidrug-Resistant Candida glabrata during Prophylaxis with a Low Dose of Micafungin
title_full Breakthrough Candidemia Due to Multidrug-Resistant Candida glabrata during Prophylaxis with a Low Dose of Micafungin
title_fullStr Breakthrough Candidemia Due to Multidrug-Resistant Candida glabrata during Prophylaxis with a Low Dose of Micafungin
title_full_unstemmed Breakthrough Candidemia Due to Multidrug-Resistant Candida glabrata during Prophylaxis with a Low Dose of Micafungin
title_sort Breakthrough Candidemia Due to Multidrug-Resistant Candida glabrata during Prophylaxis with a Low Dose of Micafungin
author Bizerra, Fernando Cesar [UNIFESP]
author_facet Bizerra, Fernando Cesar [UNIFESP]
Jimenez-Ortigosa, Cristina
Souza, Ana Carolina R. [UNIFESP]
Breda, Giovanni Luis
Queiroz-Telles, Flavio
Perlin, David S.
Colombo, Arnaldo L. [UNIFESP]
author_role author
author2 Jimenez-Ortigosa, Cristina
Souza, Ana Carolina R. [UNIFESP]
Breda, Giovanni Luis
Queiroz-Telles, Flavio
Perlin, David S.
Colombo, Arnaldo L. [UNIFESP]
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
Univ Fed Parana
Rutgers State Univ
dc.contributor.author.fl_str_mv Bizerra, Fernando Cesar [UNIFESP]
Jimenez-Ortigosa, Cristina
Souza, Ana Carolina R. [UNIFESP]
Breda, Giovanni Luis
Queiroz-Telles, Flavio
Perlin, David S.
Colombo, Arnaldo L. [UNIFESP]
description We identified a case of breakthrough candidemia in a 25-year-old patient receiving micafungin prophylaxis (50 mg/day). Five Candida glabrata isolates were obtained from blood cultures and were classified as multidrug-resistant isolates, since all of them exhibited high MICs for echinocandin and azole drugs. A mutation (S663F) in hot spot 1 of the FKS2 gene was found in all five isolates. This mutation yielded a 1,3-beta-D-glucan synthase enzyme with highly reduced sensitivities to echinocandin drugs.
publishDate 2014
dc.date.none.fl_str_mv 2014-04-01
2016-01-24T14:35:29Z
2016-01-24T14:35:29Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1128/AAC.02189-13
Antimicrobial Agents and Chemotherapy. Washington: Amer Soc Microbiology, v. 58, n. 4, p. 2438-2440, 2014.
10.1128/AAC.02189-13
WOS000333605600079.pdf
0066-4804
http://repositorio.unifesp.br/handle/11600/37578
WOS:000333605600079
url http://dx.doi.org/10.1128/AAC.02189-13
http://repositorio.unifesp.br/handle/11600/37578
identifier_str_mv Antimicrobial Agents and Chemotherapy. Washington: Amer Soc Microbiology, v. 58, n. 4, p. 2438-2440, 2014.
10.1128/AAC.02189-13
WOS000333605600079.pdf
0066-4804
WOS:000333605600079
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Antimicrobial Agents and Chemotherapy
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 2438-2440
application/pdf
dc.publisher.none.fl_str_mv Amer Soc Microbiology
publisher.none.fl_str_mv Amer Soc Microbiology
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
_version_ 1814268432663707648

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