Sensibilização a alérgenos inalantes e alimentares em crianças brasileiras atópicas, pela determinação in vitro de IgE total e específica: Projeto Alergia (PROAL)

Detalhes bibliográficos
Autor(a) principal: Naspitz, Charles Kirov [UNIFESP]
Data de Publicação: 2004
Outros Autores: Solé, Dirceu [UNIFESP], Jacob, Cristina Miuki Abe [UNIFESP], Sarinho, Emanuel [UNIFESP], Soares, Francisco J. P. [UNIFESP], Dantas, Vera [UNIFESP], Mallozi, Marcia Carvalho [UNIFESP], Wandalsen, Neusa Falbo [UNIFESP], Borges, Wellington [UNIFESP], Rocha Filho, Wilson [UNIFESP], Grupo Proal
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.2223/JPED.1184
http://repositorio.unifesp.br/handle/11600/2126
Resumo: OBJECTIVE: To determine the frequency of sensitization to inhalant and food allergens in children seen at Brazilian allergy services. PATIENTS AND METHODS: Total and specific IgE serum levels to inhalant and food allergens (RAST, UniCAP® - Pharmacia) were measured in 457 children accompanied in pediatric allergy services and in 62 control children age matched. RAST equal or higher than class 1 was considered as positive (R+). RESULTS: Frequency of R+ was significantly higher among atopics (361/457, 79%) when compared to controls (16/62, 25.8%). There were no differences according to gender. The frequency of R+ to all allergens evaluated were higher among atopics when compared to controls. Significantly higher total IgE serum levels were observed among the atopics with R+ in comparison to those with R-. The frequency of R+ to main inhalant allergens were: D. pteronyssinus = 66.7% x 14.5% (p < 0.05), D. farinae = 64.5% x 17.8% (p < 0.05), B. tropicalis = 55.2% x 19.4% (p < 0.05), cockroach = 32.8% x 9.7% (p < 0.05), and cat = 12% x 8.1%. In relation to food allergens we observed: fish = 29.5% x 11.3% (p < 0.05), egg = 24.4% x 4.8% (p < 0.05), cow's milk = 23.1% x 3.2% (p < 0.05), wheat = 20% x 8.1% (p < 0.05), peanuts = 14% x 4.8% (p < 0.05), soy = 11.8% x 4.8% (p < 0.05), and corn = 10.6% x 4.8% (p < 0.05). With respect of age, food allergen sensitization predominates in young children whereas the inverse occurs with inhalant allergens. CONCLUSIONS: There was a predominant frequency of sensitization to inhalant allergens, mainly house dust mites in the evaluated patients. Food allergens were also responsible for a significant proportion of sensitization, mainly in infants.
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spelling Sensibilização a alérgenos inalantes e alimentares em crianças brasileiras atópicas, pela determinação in vitro de IgE total e específica: Projeto Alergia (PROAL)Sensitization to inhalant and food allergens in Brazilian atopic children by in vitro total and specific IgE assay: Allergy Project - PROALAllergyallergenIgEmitefoodAlergiaalérgenoIgEácaroalimentoOBJECTIVE: To determine the frequency of sensitization to inhalant and food allergens in children seen at Brazilian allergy services. PATIENTS AND METHODS: Total and specific IgE serum levels to inhalant and food allergens (RAST, UniCAP® - Pharmacia) were measured in 457 children accompanied in pediatric allergy services and in 62 control children age matched. RAST equal or higher than class 1 was considered as positive (R+). RESULTS: Frequency of R+ was significantly higher among atopics (361/457, 79%) when compared to controls (16/62, 25.8%). There were no differences according to gender. The frequency of R+ to all allergens evaluated were higher among atopics when compared to controls. Significantly higher total IgE serum levels were observed among the atopics with R+ in comparison to those with R-. The frequency of R+ to main inhalant allergens were: D. pteronyssinus = 66.7% x 14.5% (p < 0.05), D. farinae = 64.5% x 17.8% (p < 0.05), B. tropicalis = 55.2% x 19.4% (p < 0.05), cockroach = 32.8% x 9.7% (p < 0.05), and cat = 12% x 8.1%. In relation to food allergens we observed: fish = 29.5% x 11.3% (p < 0.05), egg = 24.4% x 4.8% (p < 0.05), cow's milk = 23.1% x 3.2% (p < 0.05), wheat = 20% x 8.1% (p < 0.05), peanuts = 14% x 4.8% (p < 0.05), soy = 11.8% x 4.8% (p < 0.05), and corn = 10.6% x 4.8% (p < 0.05). With respect of age, food allergen sensitization predominates in young children whereas the inverse occurs with inhalant allergens. CONCLUSIONS: There was a predominant frequency of sensitization to inhalant allergens, mainly house dust mites in the evaluated patients. Food allergens were also responsible for a significant proportion of sensitization, mainly in infants.OBJETIVO: Determinar a freqüência de sensibilização a alérgenos inalantes e alimentares em crianças atendidas em serviços brasileiros de alergia. PACIENTES E MÉTODOS: IgE sérica total e específica (RAST) a alérgenos inalantes e alimentares (UniCAP® - Pharmacia) foram determinados em 457 crianças acompanhadas em serviços de alergia pediátrica e em um grupo de controles (n = 62). Resultados classe igual ou maior que 1 foram considerados positivos (R+). RESULTADOS: A freqüência de R+ foi significantemente maior entre os atópicos (361/457, 79%) quando comparados aos controles (16/62, 25,8%). Não houve diferenças quanto ao sexo. A prevalência de R+ entre os atópicos foi significantemente maior para todos os alérgenos avaliados. Os níveis séricos de IgE total foram significantemente mais elevados entre os atópicos com R+ quando comparados aos com R-. Comparando-se atópicos e controles, a freqüência de R+ para os principais alérgenos inalantes foi como segue: D. pteronyssinus = 66,7 versus 14,5% (p < 0,05), D. farinae = 64,5 versus 17,8% (p < 0,05), B. tropicalis = 55,2 versus 19,4% (p < 0,05), barata = 32,8 versus 9,7% (p < 0,05) e gato = 12 versus 8,1%. Com os alimentos, observou-se: peixe = 29,5 versus 11,3% (p < 0,05), ovo = 24,4 versus 4,8% (p < 0,05), leite de vaca = 23,1 versus 3,2% (p < 0,05), trigo = 20 versus 8,1% (p < 0,05), amendoim = 14 versus 4,8% (p < 0,05), soja = 11,8 versus 4,8% (p < 0,05) e milho = 10,6 versus 4,8% (p < 0,05). Segundo a idade, os R+ aos alimentares predominaram entre as crianças mais jovens, e o inverso ocorreu com os inalantes. CONCLUSÕES: Nesta população, predominou a sensibilização aos aeroalérgenos, sobretudo aos ácaros domiciliares, e os alimentos foram importantes em crianças mais jovens.Universidade Federal de São Paulo (UNIFESP) Departamento de Pediatria Disciplina de Alergia e Imunologia Clínica e ReumatologiaUniversidade Federal de São Paulo (UNIFESP)Grupo PROALUNIFESP, Depto. de Pediatria Disciplina de Alergia e Imunologia Clínica e ReumatologiaUNIFESPSciELOSociedade Brasileira de PediatriaUniversidade Federal de São Paulo (UNIFESP)Grupo PROALNaspitz, Charles Kirov [UNIFESP]Solé, Dirceu [UNIFESP]Jacob, Cristina Miuki Abe [UNIFESP]Sarinho, Emanuel [UNIFESP]Soares, Francisco J. P. [UNIFESP]Dantas, Vera [UNIFESP]Mallozi, Marcia Carvalho [UNIFESP]Wandalsen, Neusa Falbo [UNIFESP]Borges, Wellington [UNIFESP]Rocha Filho, Wilson [UNIFESP]Grupo Proal2015-06-14T13:31:09Z2015-06-14T13:31:09Z2004-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion203-210application/pdfhttp://dx.doi.org/10.2223/JPED.1184Jornal de Pediatria. Sociedade Brasileira de Pediatria, v. 80, n. 3, p. 203-210, 2004.10.2223/JPED.1184S0021-75572004000400008.pdf0021-7557S0021-75572004000400008http://repositorio.unifesp.br/handle/11600/2126porJornal de Pediatriainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-29T12:46:27Zoai:repositorio.unifesp.br/:11600/2126Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-29T12:46:27Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Sensibilização a alérgenos inalantes e alimentares em crianças brasileiras atópicas, pela determinação in vitro de IgE total e específica: Projeto Alergia (PROAL)
Sensitization to inhalant and food allergens in Brazilian atopic children by in vitro total and specific IgE assay: Allergy Project - PROAL
title Sensibilização a alérgenos inalantes e alimentares em crianças brasileiras atópicas, pela determinação in vitro de IgE total e específica: Projeto Alergia (PROAL)
spellingShingle Sensibilização a alérgenos inalantes e alimentares em crianças brasileiras atópicas, pela determinação in vitro de IgE total e específica: Projeto Alergia (PROAL)
Naspitz, Charles Kirov [UNIFESP]
Allergy
allergen
IgE
mite
food
Alergia
alérgeno
IgE
ácaro
alimento
title_short Sensibilização a alérgenos inalantes e alimentares em crianças brasileiras atópicas, pela determinação in vitro de IgE total e específica: Projeto Alergia (PROAL)
title_full Sensibilização a alérgenos inalantes e alimentares em crianças brasileiras atópicas, pela determinação in vitro de IgE total e específica: Projeto Alergia (PROAL)
title_fullStr Sensibilização a alérgenos inalantes e alimentares em crianças brasileiras atópicas, pela determinação in vitro de IgE total e específica: Projeto Alergia (PROAL)
title_full_unstemmed Sensibilização a alérgenos inalantes e alimentares em crianças brasileiras atópicas, pela determinação in vitro de IgE total e específica: Projeto Alergia (PROAL)
title_sort Sensibilização a alérgenos inalantes e alimentares em crianças brasileiras atópicas, pela determinação in vitro de IgE total e específica: Projeto Alergia (PROAL)
author Naspitz, Charles Kirov [UNIFESP]
author_facet Naspitz, Charles Kirov [UNIFESP]
Solé, Dirceu [UNIFESP]
Jacob, Cristina Miuki Abe [UNIFESP]
Sarinho, Emanuel [UNIFESP]
Soares, Francisco J. P. [UNIFESP]
Dantas, Vera [UNIFESP]
Mallozi, Marcia Carvalho [UNIFESP]
Wandalsen, Neusa Falbo [UNIFESP]
Borges, Wellington [UNIFESP]
Rocha Filho, Wilson [UNIFESP]
Grupo Proal
author_role author
author2 Solé, Dirceu [UNIFESP]
Jacob, Cristina Miuki Abe [UNIFESP]
Sarinho, Emanuel [UNIFESP]
Soares, Francisco J. P. [UNIFESP]
Dantas, Vera [UNIFESP]
Mallozi, Marcia Carvalho [UNIFESP]
Wandalsen, Neusa Falbo [UNIFESP]
Borges, Wellington [UNIFESP]
Rocha Filho, Wilson [UNIFESP]
Grupo Proal
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
Grupo PROAL
dc.contributor.author.fl_str_mv Naspitz, Charles Kirov [UNIFESP]
Solé, Dirceu [UNIFESP]
Jacob, Cristina Miuki Abe [UNIFESP]
Sarinho, Emanuel [UNIFESP]
Soares, Francisco J. P. [UNIFESP]
Dantas, Vera [UNIFESP]
Mallozi, Marcia Carvalho [UNIFESP]
Wandalsen, Neusa Falbo [UNIFESP]
Borges, Wellington [UNIFESP]
Rocha Filho, Wilson [UNIFESP]
Grupo Proal
dc.subject.por.fl_str_mv Allergy
allergen
IgE
mite
food
Alergia
alérgeno
IgE
ácaro
alimento
topic Allergy
allergen
IgE
mite
food
Alergia
alérgeno
IgE
ácaro
alimento
description OBJECTIVE: To determine the frequency of sensitization to inhalant and food allergens in children seen at Brazilian allergy services. PATIENTS AND METHODS: Total and specific IgE serum levels to inhalant and food allergens (RAST, UniCAP® - Pharmacia) were measured in 457 children accompanied in pediatric allergy services and in 62 control children age matched. RAST equal or higher than class 1 was considered as positive (R+). RESULTS: Frequency of R+ was significantly higher among atopics (361/457, 79%) when compared to controls (16/62, 25.8%). There were no differences according to gender. The frequency of R+ to all allergens evaluated were higher among atopics when compared to controls. Significantly higher total IgE serum levels were observed among the atopics with R+ in comparison to those with R-. The frequency of R+ to main inhalant allergens were: D. pteronyssinus = 66.7% x 14.5% (p < 0.05), D. farinae = 64.5% x 17.8% (p < 0.05), B. tropicalis = 55.2% x 19.4% (p < 0.05), cockroach = 32.8% x 9.7% (p < 0.05), and cat = 12% x 8.1%. In relation to food allergens we observed: fish = 29.5% x 11.3% (p < 0.05), egg = 24.4% x 4.8% (p < 0.05), cow's milk = 23.1% x 3.2% (p < 0.05), wheat = 20% x 8.1% (p < 0.05), peanuts = 14% x 4.8% (p < 0.05), soy = 11.8% x 4.8% (p < 0.05), and corn = 10.6% x 4.8% (p < 0.05). With respect of age, food allergen sensitization predominates in young children whereas the inverse occurs with inhalant allergens. CONCLUSIONS: There was a predominant frequency of sensitization to inhalant allergens, mainly house dust mites in the evaluated patients. Food allergens were also responsible for a significant proportion of sensitization, mainly in infants.
publishDate 2004
dc.date.none.fl_str_mv 2004-06-01
2015-06-14T13:31:09Z
2015-06-14T13:31:09Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.2223/JPED.1184
Jornal de Pediatria. Sociedade Brasileira de Pediatria, v. 80, n. 3, p. 203-210, 2004.
10.2223/JPED.1184
S0021-75572004000400008.pdf
0021-7557
S0021-75572004000400008
http://repositorio.unifesp.br/handle/11600/2126
url http://dx.doi.org/10.2223/JPED.1184
http://repositorio.unifesp.br/handle/11600/2126
identifier_str_mv Jornal de Pediatria. Sociedade Brasileira de Pediatria, v. 80, n. 3, p. 203-210, 2004.
10.2223/JPED.1184
S0021-75572004000400008.pdf
0021-7557
S0021-75572004000400008
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv Jornal de Pediatria
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 203-210
application/pdf
dc.publisher.none.fl_str_mv Sociedade Brasileira de Pediatria
publisher.none.fl_str_mv Sociedade Brasileira de Pediatria
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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