Morpho/Proteomic Comparative between High Grade Pleomorphic Sarcoma and Metastasis Diagnosed in an Old Captive Common Hippo
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | https://repositorio.unifesp.br/handle/11600/54245 http://dx.doi.org/10.21577/0103-5053.20170149 |
Resumo: | Old age is a risk factor for cancer development in humans and animals, and studies have shown that tumors in animals are acceptable models for studying human cancers, considering the similarities between their factors. This work was conducted in a 53-year-old captive female common hippo (Hippopotamus amphibious) with a left leg tumor and metastatic mass. Histopathological and immunohistochemical analyses were carried out with a final diagnosis of a high grade pleomorphic sarcoma. A proteomic study using mass spectrometry was added in order to identify further aspects of the primary tumor and metastasis which could improve our understanding, and each tissue showed a proteomic profile indicative of its pathologic state with significant differences between healthy tissue, primary and metastatic tumors. Low levels of beta-actin in primary tumors were identified, and this may be associated with a possible consequence of cytoskeleton dynamic modification. In metastatic tissue, these dynamics may be affected by the presence of HSP chaperone 60. |
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Silva, Adriana R. [UNIFESP]de Lacerda, Jose T. J. G. [UNIFESP]Faria, Bernadete [UNIFESP]da Cunha, Isabela W.de Andrade, Vitor P.Assuncao, Nilson A. [UNIFESP]2020-07-08T13:09:51Z2020-07-08T13:09:51Z2018Journal Of The Brazilian Chemical Society. Sao Paulo, v. 29, n. 2, p. 363-370, 2018.0103-5053https://repositorio.unifesp.br/handle/11600/54245http://dx.doi.org/10.21577/0103-5053.20170149S0103-50532018000200363.pdfS0103-5053201800020036310.21577/0103-5053.20170149WOS:000416209700017Old age is a risk factor for cancer development in humans and animals, and studies have shown that tumors in animals are acceptable models for studying human cancers, considering the similarities between their factors. This work was conducted in a 53-year-old captive female common hippo (Hippopotamus amphibious) with a left leg tumor and metastatic mass. Histopathological and immunohistochemical analyses were carried out with a final diagnosis of a high grade pleomorphic sarcoma. A proteomic study using mass spectrometry was added in order to identify further aspects of the primary tumor and metastasis which could improve our understanding, and each tissue showed a proteomic profile indicative of its pathologic state with significant differences between healthy tissue, primary and metastatic tumors. Low levels of beta-actin in primary tumors were identified, and this may be associated with a possible consequence of cytoskeleton dynamic modification. In metastatic tissue, these dynamics may be affected by the presence of HSP chaperone 60.FAPESP: 2012/02514-9Univ Fed Sao Paulo, Inst Ciencias Ambientais Quim & Farmaceut, BR-04039032 Diadema, SP, BrazilUniv Fed Sao Paulo, Escola Paulista Med, BR-04023062 Sao Paulo, SP, BrazilAC Camargo Canc Ctr, Dept Patol, BR-01509010 Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Inst Ciencias Ambientais Quim & Farmaceut, BR-04039032 Diadema, SP, BrazilUniv Fed Sao Paulo, Escola Paulista Med, BR-04023062 Sao Paulo, SP, BrazilWeb of Science363-370engSoc Brasileira QuimicaJournal Of The Brazilian Chemical SocietyHippopotamus amphibioushigh grade pleomorphic sarcomacytoskeletonbeta-actinmass spectrometryMorpho/Proteomic Comparative between High Grade Pleomorphic Sarcoma and Metastasis Diagnosed in an Old Captive Common Hippoinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleSao Paulo292info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALS0103-50532018000200363.pdfapplication/pdf4591572${dspace.ui.url}/bitstream/11600/54245/1/S0103-50532018000200363.pdf129e29b31ae082aab1ab9902618b4204MD51open accessTEXTS0103-50532018000200363.pdf.txtS0103-50532018000200363.pdf.txtExtracted texttext/plain30836${dspace.ui.url}/bitstream/11600/54245/8/S0103-50532018000200363.pdf.txteaad937f65ad9ee7b14c538984dcc0e5MD58open accessTHUMBNAILS0103-50532018000200363.pdf.jpgS0103-50532018000200363.pdf.jpgIM Thumbnailimage/jpeg6666${dspace.ui.url}/bitstream/11600/54245/10/S0103-50532018000200363.pdf.jpg01f54e2d32c04025246d855110dc04d0MD510open access11600/542452023-06-05 19:28:23.014open accessoai:repositorio.unifesp.br:11600/54245Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-06-05T22:28:23Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Morpho/Proteomic Comparative between High Grade Pleomorphic Sarcoma and Metastasis Diagnosed in an Old Captive Common Hippo |
title |
Morpho/Proteomic Comparative between High Grade Pleomorphic Sarcoma and Metastasis Diagnosed in an Old Captive Common Hippo |
spellingShingle |
Morpho/Proteomic Comparative between High Grade Pleomorphic Sarcoma and Metastasis Diagnosed in an Old Captive Common Hippo Silva, Adriana R. [UNIFESP] Hippopotamus amphibious high grade pleomorphic sarcoma cytoskeleton beta-actin mass spectrometry |
title_short |
Morpho/Proteomic Comparative between High Grade Pleomorphic Sarcoma and Metastasis Diagnosed in an Old Captive Common Hippo |
title_full |
Morpho/Proteomic Comparative between High Grade Pleomorphic Sarcoma and Metastasis Diagnosed in an Old Captive Common Hippo |
title_fullStr |
Morpho/Proteomic Comparative between High Grade Pleomorphic Sarcoma and Metastasis Diagnosed in an Old Captive Common Hippo |
title_full_unstemmed |
Morpho/Proteomic Comparative between High Grade Pleomorphic Sarcoma and Metastasis Diagnosed in an Old Captive Common Hippo |
title_sort |
Morpho/Proteomic Comparative between High Grade Pleomorphic Sarcoma and Metastasis Diagnosed in an Old Captive Common Hippo |
author |
Silva, Adriana R. [UNIFESP] |
author_facet |
Silva, Adriana R. [UNIFESP] de Lacerda, Jose T. J. G. [UNIFESP] Faria, Bernadete [UNIFESP] da Cunha, Isabela W. de Andrade, Vitor P. Assuncao, Nilson A. [UNIFESP] |
author_role |
author |
author2 |
de Lacerda, Jose T. J. G. [UNIFESP] Faria, Bernadete [UNIFESP] da Cunha, Isabela W. de Andrade, Vitor P. Assuncao, Nilson A. [UNIFESP] |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Silva, Adriana R. [UNIFESP] de Lacerda, Jose T. J. G. [UNIFESP] Faria, Bernadete [UNIFESP] da Cunha, Isabela W. de Andrade, Vitor P. Assuncao, Nilson A. [UNIFESP] |
dc.subject.eng.fl_str_mv |
Hippopotamus amphibious high grade pleomorphic sarcoma cytoskeleton beta-actin mass spectrometry |
topic |
Hippopotamus amphibious high grade pleomorphic sarcoma cytoskeleton beta-actin mass spectrometry |
description |
Old age is a risk factor for cancer development in humans and animals, and studies have shown that tumors in animals are acceptable models for studying human cancers, considering the similarities between their factors. This work was conducted in a 53-year-old captive female common hippo (Hippopotamus amphibious) with a left leg tumor and metastatic mass. Histopathological and immunohistochemical analyses were carried out with a final diagnosis of a high grade pleomorphic sarcoma. A proteomic study using mass spectrometry was added in order to identify further aspects of the primary tumor and metastasis which could improve our understanding, and each tissue showed a proteomic profile indicative of its pathologic state with significant differences between healthy tissue, primary and metastatic tumors. Low levels of beta-actin in primary tumors were identified, and this may be associated with a possible consequence of cytoskeleton dynamic modification. In metastatic tissue, these dynamics may be affected by the presence of HSP chaperone 60. |
publishDate |
2018 |
dc.date.issued.fl_str_mv |
2018 |
dc.date.accessioned.fl_str_mv |
2020-07-08T13:09:51Z |
dc.date.available.fl_str_mv |
2020-07-08T13:09:51Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Journal Of The Brazilian Chemical Society. Sao Paulo, v. 29, n. 2, p. 363-370, 2018. |
dc.identifier.uri.fl_str_mv |
https://repositorio.unifesp.br/handle/11600/54245 http://dx.doi.org/10.21577/0103-5053.20170149 |
dc.identifier.issn.none.fl_str_mv |
0103-5053 |
dc.identifier.file.none.fl_str_mv |
S0103-50532018000200363.pdf |
dc.identifier.scielo.none.fl_str_mv |
S0103-50532018000200363 |
dc.identifier.doi.none.fl_str_mv |
10.21577/0103-5053.20170149 |
dc.identifier.wos.none.fl_str_mv |
WOS:000416209700017 |
identifier_str_mv |
Journal Of The Brazilian Chemical Society. Sao Paulo, v. 29, n. 2, p. 363-370, 2018. 0103-5053 S0103-50532018000200363.pdf S0103-50532018000200363 10.21577/0103-5053.20170149 WOS:000416209700017 |
url |
https://repositorio.unifesp.br/handle/11600/54245 http://dx.doi.org/10.21577/0103-5053.20170149 |
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eng |
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Journal Of The Brazilian Chemical Society |
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openAccess |
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363-370 |
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Sao Paulo |
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Soc Brasileira Quimica |
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Soc Brasileira Quimica |
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