Safety and efficacy of intracameral moxifloxacin injection for prophylaxis of endophthalmitis after phacoemulsification
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | https://www.scielo.br/scielo.php?pid=S0004-27492017000300165&script=sci_arttext https://repositorio.unifesp.br/handle/11600/54506 |
Resumo: | Purpose: To evaluate the safety and efficacy of 0.05 mL intracameral injection of moxifloxacin in patients who underwent phacoemulsification and intraocular lens (IOL) implant. Methods: Retrospective study comprising patients who underwent phacoemulsification and IOL implant between January 2009 and December 2013. Patients were divided into two groups. Group A followed standard endophthalmitis prevention protocol and group B followed the same protocol plus intracameral injection of 0.05 mL of moxifloxacin hydrochloride at 5.45 mg/mL, immediately after IOL implant. Results: Medical records from 7,195 eyes of 3,751 patients (median age: 67.8 +/- 8.96, range: 48-83 years, 53.8% female) were evaluated. Group A included 3,515 eyes of 1,838 patients and group B included 3,680 eyes of 1,913 patients. The incidence of endophthalmitis in group A was 0.22% (8: 3,515 eyes) and in group B was 0.03% (1: 3,680 eyes, p= 0.0198, Fischer's exact test). No toxicity or inflammation related to the use of moxifloxacin was observed. Conclusions: There was a 7.3-fold lower ratio of endophthalmitis in the group that received moxifloxacin intracameral injection. This study provides further evidence that moxifloxacin is an effective intracameral prophylactic antibiotic. |
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Safety and efficacy of intracameral moxifloxacin injection for prophylaxis of endophthalmitis after phacoemulsificationEndophthalmitisCataractPhacoemulsificationAnti-bacterial agentsInjectionsAntibiotic prophylaxisPurpose: To evaluate the safety and efficacy of 0.05 mL intracameral injection of moxifloxacin in patients who underwent phacoemulsification and intraocular lens (IOL) implant. Methods: Retrospective study comprising patients who underwent phacoemulsification and IOL implant between January 2009 and December 2013. Patients were divided into two groups. Group A followed standard endophthalmitis prevention protocol and group B followed the same protocol plus intracameral injection of 0.05 mL of moxifloxacin hydrochloride at 5.45 mg/mL, immediately after IOL implant. Results: Medical records from 7,195 eyes of 3,751 patients (median age: 67.8 +/- 8.96, range: 48-83 years, 53.8% female) were evaluated. Group A included 3,515 eyes of 1,838 patients and group B included 3,680 eyes of 1,913 patients. The incidence of endophthalmitis in group A was 0.22% (8: 3,515 eyes) and in group B was 0.03% (1: 3,680 eyes, p= 0.0198, Fischer's exact test). No toxicity or inflammation related to the use of moxifloxacin was observed. Conclusions: There was a 7.3-fold lower ratio of endophthalmitis in the group that received moxifloxacin intracameral injection. This study provides further evidence that moxifloxacin is an effective intracameral prophylactic antibiotic.Univ Fed Sao Paulo, Dept Ophthalmol & Visual Sci, Escola Paulista Med, Sao Paulo, SP, BrazilOftalmed, Brasilia, DF, BrazilUniv Fed Sao Paulo, Dept Ophthalmol & Visual Sci, Escola Paulista Med, Sao Paulo, SP, BrazilWeb of ScienceConsel Brasil Oftalmologia2020-07-13T11:53:16Z2020-07-13T11:53:16Z2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion165-167application/pdfhttps://www.scielo.br/scielo.php?pid=S0004-27492017000300165&script=sci_arttextArquivos Brasileiros De Oftalmologia. Sao Paulo, v. 80, n. 3, p. 165-167, 2017.10.5935/0004-2749.20170040S0004-27492017000300165.pdf0004-2749S0004-27492017000300165https://repositorio.unifesp.br/handle/11600/54506WOS:000408254100006engArquivos Brasileiros De OftalmologiaSao Pauloinfo:eu-repo/semantics/openAccessVieira, Ibraim Viana [UNIFESP]Boianovsky, CelsoSaraiva, Thais Jonesde Godoy, Rodolfo BregionLake, Jonathanreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-08T23:09:48Zoai:repositorio.unifesp.br/:11600/54506Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-08T23:09:48Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Safety and efficacy of intracameral moxifloxacin injection for prophylaxis of endophthalmitis after phacoemulsification |
title |
Safety and efficacy of intracameral moxifloxacin injection for prophylaxis of endophthalmitis after phacoemulsification |
spellingShingle |
Safety and efficacy of intracameral moxifloxacin injection for prophylaxis of endophthalmitis after phacoemulsification Vieira, Ibraim Viana [UNIFESP] Endophthalmitis Cataract Phacoemulsification Anti-bacterial agents Injections Antibiotic prophylaxis |
title_short |
Safety and efficacy of intracameral moxifloxacin injection for prophylaxis of endophthalmitis after phacoemulsification |
title_full |
Safety and efficacy of intracameral moxifloxacin injection for prophylaxis of endophthalmitis after phacoemulsification |
title_fullStr |
Safety and efficacy of intracameral moxifloxacin injection for prophylaxis of endophthalmitis after phacoemulsification |
title_full_unstemmed |
Safety and efficacy of intracameral moxifloxacin injection for prophylaxis of endophthalmitis after phacoemulsification |
title_sort |
Safety and efficacy of intracameral moxifloxacin injection for prophylaxis of endophthalmitis after phacoemulsification |
author |
Vieira, Ibraim Viana [UNIFESP] |
author_facet |
Vieira, Ibraim Viana [UNIFESP] Boianovsky, Celso Saraiva, Thais Jones de Godoy, Rodolfo Bregion Lake, Jonathan |
author_role |
author |
author2 |
Boianovsky, Celso Saraiva, Thais Jones de Godoy, Rodolfo Bregion Lake, Jonathan |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Vieira, Ibraim Viana [UNIFESP] Boianovsky, Celso Saraiva, Thais Jones de Godoy, Rodolfo Bregion Lake, Jonathan |
dc.subject.por.fl_str_mv |
Endophthalmitis Cataract Phacoemulsification Anti-bacterial agents Injections Antibiotic prophylaxis |
topic |
Endophthalmitis Cataract Phacoemulsification Anti-bacterial agents Injections Antibiotic prophylaxis |
description |
Purpose: To evaluate the safety and efficacy of 0.05 mL intracameral injection of moxifloxacin in patients who underwent phacoemulsification and intraocular lens (IOL) implant. Methods: Retrospective study comprising patients who underwent phacoemulsification and IOL implant between January 2009 and December 2013. Patients were divided into two groups. Group A followed standard endophthalmitis prevention protocol and group B followed the same protocol plus intracameral injection of 0.05 mL of moxifloxacin hydrochloride at 5.45 mg/mL, immediately after IOL implant. Results: Medical records from 7,195 eyes of 3,751 patients (median age: 67.8 +/- 8.96, range: 48-83 years, 53.8% female) were evaluated. Group A included 3,515 eyes of 1,838 patients and group B included 3,680 eyes of 1,913 patients. The incidence of endophthalmitis in group A was 0.22% (8: 3,515 eyes) and in group B was 0.03% (1: 3,680 eyes, p= 0.0198, Fischer's exact test). No toxicity or inflammation related to the use of moxifloxacin was observed. Conclusions: There was a 7.3-fold lower ratio of endophthalmitis in the group that received moxifloxacin intracameral injection. This study provides further evidence that moxifloxacin is an effective intracameral prophylactic antibiotic. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017 2020-07-13T11:53:16Z 2020-07-13T11:53:16Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.scielo.br/scielo.php?pid=S0004-27492017000300165&script=sci_arttext Arquivos Brasileiros De Oftalmologia. Sao Paulo, v. 80, n. 3, p. 165-167, 2017. 10.5935/0004-2749.20170040 S0004-27492017000300165.pdf 0004-2749 S0004-27492017000300165 https://repositorio.unifesp.br/handle/11600/54506 WOS:000408254100006 |
url |
https://www.scielo.br/scielo.php?pid=S0004-27492017000300165&script=sci_arttext https://repositorio.unifesp.br/handle/11600/54506 |
identifier_str_mv |
Arquivos Brasileiros De Oftalmologia. Sao Paulo, v. 80, n. 3, p. 165-167, 2017. 10.5935/0004-2749.20170040 S0004-27492017000300165.pdf 0004-2749 S0004-27492017000300165 WOS:000408254100006 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Arquivos Brasileiros De Oftalmologia |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
165-167 application/pdf |
dc.coverage.none.fl_str_mv |
Sao Paulo |
dc.publisher.none.fl_str_mv |
Consel Brasil Oftalmologia |
publisher.none.fl_str_mv |
Consel Brasil Oftalmologia |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
_version_ |
1814268367180136448 |