Safety and efficacy of intracameral moxifloxacin injection for prophylaxis of endophthalmitis after phacoemulsification

Detalhes bibliográficos
Autor(a) principal: Vieira, Ibraim Viana [UNIFESP]
Data de Publicação: 2017
Outros Autores: Boianovsky, Celso, Saraiva, Thais Jones, de Godoy, Rodolfo Bregion, Lake, Jonathan
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: https://www.scielo.br/scielo.php?pid=S0004-27492017000300165&script=sci_arttext
https://repositorio.unifesp.br/handle/11600/54506
Resumo: Purpose: To evaluate the safety and efficacy of 0.05 mL intracameral injection of moxifloxacin in patients who underwent phacoemulsification and intraocular lens (IOL) implant. Methods: Retrospective study comprising patients who underwent phacoemulsification and IOL implant between January 2009 and December 2013. Patients were divided into two groups. Group A followed standard endophthalmitis prevention protocol and group B followed the same protocol plus intracameral injection of 0.05 mL of moxifloxacin hydrochloride at 5.45 mg/mL, immediately after IOL implant. Results: Medical records from 7,195 eyes of 3,751 patients (median age: 67.8 +/- 8.96, range: 48-83 years, 53.8% female) were evaluated. Group A included 3,515 eyes of 1,838 patients and group B included 3,680 eyes of 1,913 patients. The incidence of endophthalmitis in group A was 0.22% (8: 3,515 eyes) and in group B was 0.03% (1: 3,680 eyes, p= 0.0198, Fischer's exact test). No toxicity or inflammation related to the use of moxifloxacin was observed. Conclusions: There was a 7.3-fold lower ratio of endophthalmitis in the group that received moxifloxacin intracameral injection. This study provides further evidence that moxifloxacin is an effective intracameral prophylactic antibiotic.
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spelling Safety and efficacy of intracameral moxifloxacin injection for prophylaxis of endophthalmitis after phacoemulsificationEndophthalmitisCataractPhacoemulsificationAnti-bacterial agentsInjectionsAntibiotic prophylaxisPurpose: To evaluate the safety and efficacy of 0.05 mL intracameral injection of moxifloxacin in patients who underwent phacoemulsification and intraocular lens (IOL) implant. Methods: Retrospective study comprising patients who underwent phacoemulsification and IOL implant between January 2009 and December 2013. Patients were divided into two groups. Group A followed standard endophthalmitis prevention protocol and group B followed the same protocol plus intracameral injection of 0.05 mL of moxifloxacin hydrochloride at 5.45 mg/mL, immediately after IOL implant. Results: Medical records from 7,195 eyes of 3,751 patients (median age: 67.8 +/- 8.96, range: 48-83 years, 53.8% female) were evaluated. Group A included 3,515 eyes of 1,838 patients and group B included 3,680 eyes of 1,913 patients. The incidence of endophthalmitis in group A was 0.22% (8: 3,515 eyes) and in group B was 0.03% (1: 3,680 eyes, p= 0.0198, Fischer's exact test). No toxicity or inflammation related to the use of moxifloxacin was observed. Conclusions: There was a 7.3-fold lower ratio of endophthalmitis in the group that received moxifloxacin intracameral injection. This study provides further evidence that moxifloxacin is an effective intracameral prophylactic antibiotic.Univ Fed Sao Paulo, Dept Ophthalmol & Visual Sci, Escola Paulista Med, Sao Paulo, SP, BrazilOftalmed, Brasilia, DF, BrazilUniv Fed Sao Paulo, Dept Ophthalmol & Visual Sci, Escola Paulista Med, Sao Paulo, SP, BrazilWeb of ScienceConsel Brasil Oftalmologia2020-07-13T11:53:16Z2020-07-13T11:53:16Z2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion165-167application/pdfhttps://www.scielo.br/scielo.php?pid=S0004-27492017000300165&script=sci_arttextArquivos Brasileiros De Oftalmologia. Sao Paulo, v. 80, n. 3, p. 165-167, 2017.10.5935/0004-2749.20170040S0004-27492017000300165.pdf0004-2749S0004-27492017000300165https://repositorio.unifesp.br/handle/11600/54506WOS:000408254100006engArquivos Brasileiros De OftalmologiaSao Pauloinfo:eu-repo/semantics/openAccessVieira, Ibraim Viana [UNIFESP]Boianovsky, CelsoSaraiva, Thais Jonesde Godoy, Rodolfo BregionLake, Jonathanreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-08T23:09:48Zoai:repositorio.unifesp.br/:11600/54506Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-08T23:09:48Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Safety and efficacy of intracameral moxifloxacin injection for prophylaxis of endophthalmitis after phacoemulsification
title Safety and efficacy of intracameral moxifloxacin injection for prophylaxis of endophthalmitis after phacoemulsification
spellingShingle Safety and efficacy of intracameral moxifloxacin injection for prophylaxis of endophthalmitis after phacoemulsification
Vieira, Ibraim Viana [UNIFESP]
Endophthalmitis
Cataract
Phacoemulsification
Anti-bacterial agents
Injections
Antibiotic prophylaxis
title_short Safety and efficacy of intracameral moxifloxacin injection for prophylaxis of endophthalmitis after phacoemulsification
title_full Safety and efficacy of intracameral moxifloxacin injection for prophylaxis of endophthalmitis after phacoemulsification
title_fullStr Safety and efficacy of intracameral moxifloxacin injection for prophylaxis of endophthalmitis after phacoemulsification
title_full_unstemmed Safety and efficacy of intracameral moxifloxacin injection for prophylaxis of endophthalmitis after phacoemulsification
title_sort Safety and efficacy of intracameral moxifloxacin injection for prophylaxis of endophthalmitis after phacoemulsification
author Vieira, Ibraim Viana [UNIFESP]
author_facet Vieira, Ibraim Viana [UNIFESP]
Boianovsky, Celso
Saraiva, Thais Jones
de Godoy, Rodolfo Bregion
Lake, Jonathan
author_role author
author2 Boianovsky, Celso
Saraiva, Thais Jones
de Godoy, Rodolfo Bregion
Lake, Jonathan
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Vieira, Ibraim Viana [UNIFESP]
Boianovsky, Celso
Saraiva, Thais Jones
de Godoy, Rodolfo Bregion
Lake, Jonathan
dc.subject.por.fl_str_mv Endophthalmitis
Cataract
Phacoemulsification
Anti-bacterial agents
Injections
Antibiotic prophylaxis
topic Endophthalmitis
Cataract
Phacoemulsification
Anti-bacterial agents
Injections
Antibiotic prophylaxis
description Purpose: To evaluate the safety and efficacy of 0.05 mL intracameral injection of moxifloxacin in patients who underwent phacoemulsification and intraocular lens (IOL) implant. Methods: Retrospective study comprising patients who underwent phacoemulsification and IOL implant between January 2009 and December 2013. Patients were divided into two groups. Group A followed standard endophthalmitis prevention protocol and group B followed the same protocol plus intracameral injection of 0.05 mL of moxifloxacin hydrochloride at 5.45 mg/mL, immediately after IOL implant. Results: Medical records from 7,195 eyes of 3,751 patients (median age: 67.8 +/- 8.96, range: 48-83 years, 53.8% female) were evaluated. Group A included 3,515 eyes of 1,838 patients and group B included 3,680 eyes of 1,913 patients. The incidence of endophthalmitis in group A was 0.22% (8: 3,515 eyes) and in group B was 0.03% (1: 3,680 eyes, p= 0.0198, Fischer's exact test). No toxicity or inflammation related to the use of moxifloxacin was observed. Conclusions: There was a 7.3-fold lower ratio of endophthalmitis in the group that received moxifloxacin intracameral injection. This study provides further evidence that moxifloxacin is an effective intracameral prophylactic antibiotic.
publishDate 2017
dc.date.none.fl_str_mv 2017
2020-07-13T11:53:16Z
2020-07-13T11:53:16Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.scielo.br/scielo.php?pid=S0004-27492017000300165&script=sci_arttext
Arquivos Brasileiros De Oftalmologia. Sao Paulo, v. 80, n. 3, p. 165-167, 2017.
10.5935/0004-2749.20170040
S0004-27492017000300165.pdf
0004-2749
S0004-27492017000300165
https://repositorio.unifesp.br/handle/11600/54506
WOS:000408254100006
url https://www.scielo.br/scielo.php?pid=S0004-27492017000300165&script=sci_arttext
https://repositorio.unifesp.br/handle/11600/54506
identifier_str_mv Arquivos Brasileiros De Oftalmologia. Sao Paulo, v. 80, n. 3, p. 165-167, 2017.
10.5935/0004-2749.20170040
S0004-27492017000300165.pdf
0004-2749
S0004-27492017000300165
WOS:000408254100006
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Arquivos Brasileiros De Oftalmologia
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 165-167
application/pdf
dc.coverage.none.fl_str_mv Sao Paulo
dc.publisher.none.fl_str_mv Consel Brasil Oftalmologia
publisher.none.fl_str_mv Consel Brasil Oftalmologia
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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