Qualidade de vida dos pacientes com adenocarcinoma gástrico após tratamento cirúrgico com intenção curativa

• Autor(a) principal: Pinheiro, Rodrigo Nascimento [UNIFESP]
• Data de Publicação: 2018
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: https://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.jsf?popup=true&id_trabalho=6362535; https://repositorio.unifesp.br/handle/11600/52424
• topic: Quality of life; Gastric cancer; Gastrectomy; Stomach neoplasms; Gastric neoplasms; Stomach cancer; Qualidade de vida; Câncer gástrico; Gastrectomia; Neoplasias do estômago; Neoplasias gástricas; Câncer de estômago

Objective: To evaluate the quality of life (QoL) and identify the association among the FACT-GA and SF36 v2 scores of the QoL outcome with the sociodemographic, clinical and anatomopathological aspects of gastric adenocarcinoma patients underwent surgery with curative intent. Methods: It was made a cross-sectional study with medical charts analysis and application of questionnaires Medical Outcomes Study 36 - Item Short Form Health Survey (MOS-SF36) and Functional Assessment of Cancer Therapy – For Patients with Gastric Cancer (FACT-Ga), version 4. A total of 104 gastric adenocarcinoma patients were enrolled from three regions of Brazil. Inferential analyzes were used in the comparisons (Mann-Whitney or Kruskal-Wallis tests) and study of relationships among scores of QoL questionnaires and the variables gender, schooling, income, tumor site, type of surgery, histopathology (Lauren types), neoadjuvant and adjuvant therapies, age, postoperative time, staging, degree cell differentiation and lymphadenectomy (Spearman correlation coefficient). Results: The women presented worse quality of life (FACT-GASTRIC total score, p=0.049) and in the PWB (physical well-being; p=0.005), EWB (emotional well-being; p=0.007), GaCS (gastric cancer subscale; p=0.011), TOI (trial outcome index; p=0.030) and mental health (p=0.011). Patients with distal tumors had better quality of life scores (FACTGASTRIC total score; p = 0.018) and in the domains GaCS (p = 0.014), TOI (p = 0.020) compared to the proximal ones. Patients with cardia tumors, on the other hand, had better physical functioning scores compared to the proximal ones (p = 0.042). Patients submitted to partial gastrectomy show better total quality of life (FACT-GASTRIC total score, p = 0.011) and in the PWB (p = 0.033), GaCS (p = 0.006), TOI (p = 0.008) than total gastrectomy patients. Not using adjuvant therapy has worse scores on bodily pain than its use (p = 0.048). The higher the lymph node staging, the worse the total quality of life (total score FACT-GASTRIC, s= -0.200, p = 0.034) and the domains GaCS (s = -0.206, p = 0.037), TOI (s = -0.216; p = 0.028) and vitality (s= -0.215, p=0.029). The longer the time after treatment, the better the role-physical score (s=0.223; p=0.023).Conclusion: The type of treatment instituted, time of postoperative and socio-demographic and anatomical factors influence the QoL