Role of endogenous carbon monoxide in central regulation of arterial pressure

• Autor(a) principal: Johnson, Robert A. [UNIFESP]
• Data de Publicação: 1997
• Outros Autores: Colombari, Eduardo [UNIFESP], Colombari, Debora Simões de Almeida [UNIFESP], Lavesa, M., Talman, W. T., Nasjletti, A.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: https://doi.org/10.1161/01.HYP.30.4.962; http://repositorio.unifesp.br/handle/11600/43847
• topic: carbon monoxide; heme oxygenase; blood pressure; reflex, baroreceptor; solitary tract nucleus; hypertension

We investigated the contribution of neural mechanisms to the arterial pressure increase produced by zinc deuteroporphyrin 2,4-bis glycol (ZnDPBG), an inhibitor of endogenous carbon monoxide synthesis. The arterial baroreceptor reflex control of heart rate was examined in rats with and without ZnDPBG pretreatment (45 mu mol/kg IP) by analysis of the arterial pressure-heart rate relationship during infusions of phenylephrine or sodium nitroprusside to vary arterial pressure. ZnDPBG increased arterial pressure from 110+/-3 to 126+/-2 mm Hg without eliciting bradycardia. The maximum gain of the heart rate response to changes in arterial pressure was attenuated by ZnDPBG treatment (-1.9+/-0.3 versus -4.8+/-1.0 bpm/mm Hg). The possibility that ZnDPBG elevates arterial pressure by attenuating baroreceptor reflex function was addressed by comparing the presser response to ZnDPBG (45 mu mol/kg IP) in rats with and without sinoaortic denervation. The presser effect of ZnDPBG was similar in rats with and without arterial baroreceptor deafferentation, implying that the increase in pressure is nat simply the consequence of attenuated baroreceptor reflex function per se. The possibility that ZnDPBG increases arterial pressure via an effect on the nucleus tractus solitarii (NTS) also was investigated ZnDPBG (1 nmol in 100 nL) injected into the NTS of rats increased arterial pressure from 111+/-4 to 126+/-5 mm Hg, and this effect was reversed by an ipsilateral microinjection of carbon monoxide into the NTS. Accordingly, the pressor effect of ZnDPBG may rely on inhibition of carbon monoxide production in the NTS. This implies that carbon monoxide formed by brain heme oxygenase plays a role in the central regulation of arterial pressure.