Astaxanthin Restrains Nitrative-Oxidative Peroxidation in Mitochondrial-Mimetic Liposomes: A Pre-Apoptosis Model
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | https://repositorio.unifesp.br/handle/11600/55696 http://dx.doi.org/10.3390/md16040126 |
Resumo: | Astaxanthin (ASTA) is a ketocarotenoid found in many marine organisms and that affords many benefits to human health. ASTA is particularly effective against radical-mediated lipid peroxidation, and recent findings hypothesize a "mitochondrial-targeted" action of ASTA in cells. Therefore, we examined the protective effects of ASTA against lipid peroxidation in zwitterionic phosphatidylcholine liposomes (PCLs) and anionic phosphatidylcholine: phosphatidylglycerol liposomes (PCPGLs), at different pHs (6.2 to 8.0), which were challenged by oxidizing/nitrating conditions that mimic the regular and preapoptotic redox environment of active mitochondria. Pre-apoptotic conditions were created by oxidized/nitr(osyl) ated cytochrome c and resulted in the highest levels of lipoperoxidation in both PCL and PCPGLs (pH 7.4). ASTA was less protective at acidic conditions, especially in anionic PCPGLs. Our data demonstrated the ability of ASTA to hamper oxidative and nitrative events that lead to cytochrome c-peroxidase apoptosis and lipid peroxidation, although its efficiency changes with pH and lipid composition of membranes. |
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Mano, Camila M.Guaratini, ThaisCardozo, Karina H. M.Colepicolo, PioBechara, Etelvino José Henriques [UNIFESP]Barros, Marcelo P.2020-07-20T16:31:05Z2020-07-20T16:31:05Z2018Marine Drugs. Basel, v. 16, n. 4, 2018.1660-3397https://repositorio.unifesp.br/handle/11600/55696http://dx.doi.org/10.3390/md16040126WOS000431068000028.pdf10.3390/md16040126WOS:000431068000028Astaxanthin (ASTA) is a ketocarotenoid found in many marine organisms and that affords many benefits to human health. ASTA is particularly effective against radical-mediated lipid peroxidation, and recent findings hypothesize a "mitochondrial-targeted" action of ASTA in cells. Therefore, we examined the protective effects of ASTA against lipid peroxidation in zwitterionic phosphatidylcholine liposomes (PCLs) and anionic phosphatidylcholine: phosphatidylglycerol liposomes (PCPGLs), at different pHs (6.2 to 8.0), which were challenged by oxidizing/nitrating conditions that mimic the regular and preapoptotic redox environment of active mitochondria. Pre-apoptotic conditions were created by oxidized/nitr(osyl) ated cytochrome c and resulted in the highest levels of lipoperoxidation in both PCL and PCPGLs (pH 7.4). ASTA was less protective at acidic conditions, especially in anionic PCPGLs. Our data demonstrated the ability of ASTA to hamper oxidative and nitrative events that lead to cytochrome c-peroxidase apoptosis and lipid peroxidation, although its efficiency changes with pH and lipid composition of membranes.Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESPBPE fellowship)Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (Bolsa Produtividade em Pesquisa, Nivel 2, CNPq, Brazil)Programa Iberoamericano de Ciencia y Tecnologia para el Desarollo (CYTEDRed iberoamericana para el estudio de nuevos carotenoides bioactivos como ingredientes de alimentos, Spain)Univ Sao Paulo IQUSP, Inst Quim, Dept Bioquim, BR-05508000 Sao Paulo, SP, BrazilUniv Cruzeiro Sul, ICAFE, BR-01506000 Sao Paulo, SP, BrazilSuperintendencia Policia Tecn Cient, BR-05507060 Sao Paulo, SP, BrazilLychnoflora Pesquisa & Dev Prod Nat LTDA, BR-14030090 Ribeirao Preto, SP, BrazilGrp Fleury, BR-04344070 Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Dept Ciencias Exatas & Terra, UNIFESP, BR-09972270 Diadema, SP, BrazilUniv Sao Paulo IQUSP, Inst Quim, Dept Quim Fundamental, BR-05508000 Sao Paulo, SP, BrazilCSIC, IATA, Dept Ciencia Alimentos, Calle Catedrat Agustin Escardino 7, Paterna 46980, SpainUniv Fed Sao Paulo, Dept Ciencias Exatas & Terra, UNIFESP, BR-09972270 Diadema, SP, BrazilFAPESP: 017/06032-2CNPq: 304663/2015-8RIENCBI: 112RT0445Web of Science-engMdpiMarine Drugsmitochondriamembranelipid peroxidationapoptosiscarotenoidantioxidantliposomeoxidative stressAstaxanthin Restrains Nitrative-Oxidative Peroxidation in Mitochondrial-Mimetic Liposomes: A Pre-Apoptosis Modelinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleBaselv. 164info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000431068000028.pdfapplication/pdf2432502${dspace.ui.url}/bitstream/11600/55696/1/WOS000431068000028.pdf6b3790259ad10dfbbb8fd24f04ce7a81MD51open accessTEXTWOS000431068000028.pdf.txtWOS000431068000028.pdf.txtExtracted texttext/plain49623${dspace.ui.url}/bitstream/11600/55696/8/WOS000431068000028.pdf.txt32992edbc8f60dd7e2368eff4c8e3511MD58open accessTHUMBNAILWOS000431068000028.pdf.jpgWOS000431068000028.pdf.jpgIM Thumbnailimage/jpeg6623${dspace.ui.url}/bitstream/11600/55696/10/WOS000431068000028.pdf.jpge29c720a562ff520e38a8a75eaebf4b5MD510open access11600/556962023-06-05 19:29:49.934open accessoai:repositorio.unifesp.br:11600/55696Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-06-05T22:29:49Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Astaxanthin Restrains Nitrative-Oxidative Peroxidation in Mitochondrial-Mimetic Liposomes: A Pre-Apoptosis Model |
title |
Astaxanthin Restrains Nitrative-Oxidative Peroxidation in Mitochondrial-Mimetic Liposomes: A Pre-Apoptosis Model |
spellingShingle |
Astaxanthin Restrains Nitrative-Oxidative Peroxidation in Mitochondrial-Mimetic Liposomes: A Pre-Apoptosis Model Mano, Camila M. mitochondria membrane lipid peroxidation apoptosis carotenoid antioxidant liposome oxidative stress |
title_short |
Astaxanthin Restrains Nitrative-Oxidative Peroxidation in Mitochondrial-Mimetic Liposomes: A Pre-Apoptosis Model |
title_full |
Astaxanthin Restrains Nitrative-Oxidative Peroxidation in Mitochondrial-Mimetic Liposomes: A Pre-Apoptosis Model |
title_fullStr |
Astaxanthin Restrains Nitrative-Oxidative Peroxidation in Mitochondrial-Mimetic Liposomes: A Pre-Apoptosis Model |
title_full_unstemmed |
Astaxanthin Restrains Nitrative-Oxidative Peroxidation in Mitochondrial-Mimetic Liposomes: A Pre-Apoptosis Model |
title_sort |
Astaxanthin Restrains Nitrative-Oxidative Peroxidation in Mitochondrial-Mimetic Liposomes: A Pre-Apoptosis Model |
author |
Mano, Camila M. |
author_facet |
Mano, Camila M. Guaratini, Thais Cardozo, Karina H. M. Colepicolo, Pio Bechara, Etelvino José Henriques [UNIFESP] Barros, Marcelo P. |
author_role |
author |
author2 |
Guaratini, Thais Cardozo, Karina H. M. Colepicolo, Pio Bechara, Etelvino José Henriques [UNIFESP] Barros, Marcelo P. |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Mano, Camila M. Guaratini, Thais Cardozo, Karina H. M. Colepicolo, Pio Bechara, Etelvino José Henriques [UNIFESP] Barros, Marcelo P. |
dc.subject.eng.fl_str_mv |
mitochondria membrane lipid peroxidation apoptosis carotenoid antioxidant liposome oxidative stress |
topic |
mitochondria membrane lipid peroxidation apoptosis carotenoid antioxidant liposome oxidative stress |
description |
Astaxanthin (ASTA) is a ketocarotenoid found in many marine organisms and that affords many benefits to human health. ASTA is particularly effective against radical-mediated lipid peroxidation, and recent findings hypothesize a "mitochondrial-targeted" action of ASTA in cells. Therefore, we examined the protective effects of ASTA against lipid peroxidation in zwitterionic phosphatidylcholine liposomes (PCLs) and anionic phosphatidylcholine: phosphatidylglycerol liposomes (PCPGLs), at different pHs (6.2 to 8.0), which were challenged by oxidizing/nitrating conditions that mimic the regular and preapoptotic redox environment of active mitochondria. Pre-apoptotic conditions were created by oxidized/nitr(osyl) ated cytochrome c and resulted in the highest levels of lipoperoxidation in both PCL and PCPGLs (pH 7.4). ASTA was less protective at acidic conditions, especially in anionic PCPGLs. Our data demonstrated the ability of ASTA to hamper oxidative and nitrative events that lead to cytochrome c-peroxidase apoptosis and lipid peroxidation, although its efficiency changes with pH and lipid composition of membranes. |
publishDate |
2018 |
dc.date.issued.fl_str_mv |
2018 |
dc.date.accessioned.fl_str_mv |
2020-07-20T16:31:05Z |
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2020-07-20T16:31:05Z |
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dc.identifier.citation.fl_str_mv |
Marine Drugs. Basel, v. 16, n. 4, 2018. |
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https://repositorio.unifesp.br/handle/11600/55696 http://dx.doi.org/10.3390/md16040126 |
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1660-3397 |
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WOS000431068000028.pdf |
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10.3390/md16040126 |
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Marine Drugs. Basel, v. 16, n. 4, 2018. 1660-3397 WOS000431068000028.pdf 10.3390/md16040126 WOS:000431068000028 |
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