Antimicrobial activity and spectrum of PPI-0903M (T-91825), a novel cephalosporin, tested against a worldwide collection of clinical strains

Detalhes bibliográficos
Autor(a) principal: Sader, Helio S. [UNIFESP]
Data de Publicação: 2005
Outros Autores: Fritsche, Thomas R., Kaniga, Kone, Ge, Yi Gong, Jones, Ronald N.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1128/AAC.49.8.3501-3512.2005
http://repositorio.unifesp.br/handle/11600/28393
Resumo: PPI-0903M is a novel N-phosphono-type cephalosporin active against oxacillin-resistant staphylococci and many other gram-positive organisms. This study evaluated the in vitro activity and spectrum of PPI-0903M against 1,478 recent clinical isolates collected from 80 medical centers (22 countries). PPI-0903M demonstrated broader in vitro activity against gram-positive bacteria, particularly against multidrug-resistant staphylococci and streptococci of current clinical concern, than currently available extended-spectrum cephalosporins while maintaining similar activity against gram-negative pathogens.
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spelling Antimicrobial activity and spectrum of PPI-0903M (T-91825), a novel cephalosporin, tested against a worldwide collection of clinical strainsPPI-0903M is a novel N-phosphono-type cephalosporin active against oxacillin-resistant staphylococci and many other gram-positive organisms. This study evaluated the in vitro activity and spectrum of PPI-0903M against 1,478 recent clinical isolates collected from 80 medical centers (22 countries). PPI-0903M demonstrated broader in vitro activity against gram-positive bacteria, particularly against multidrug-resistant staphylococci and streptococci of current clinical concern, than currently available extended-spectrum cephalosporins while maintaining similar activity against gram-negative pathogens.JMI Labs Inc, N Liberty, IA 52317 USAUniversidade Federal de São Paulo, São Paulo, BrazilPeninsula Pharmaceut, Alameda, CA USATufts Univ, Sch Med, Boston, MA 02111 USAUniversidade Federal de São Paulo, São Paulo, BrazilWeb of ScienceAmer Soc MicrobiologyJMI Labs IncUniversidade Federal de São Paulo (UNIFESP)Peninsula PharmaceutTufts UnivSader, Helio S. [UNIFESP]Fritsche, Thomas R.Kaniga, KoneGe, Yi GongJones, Ronald N.2016-01-24T12:37:58Z2016-01-24T12:37:58Z2005-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion3501-3512application/pdfhttp://dx.doi.org/10.1128/AAC.49.8.3501-3512.2005Antimicrobial Agents and Chemotherapy. Washington: Amer Soc Microbiology, v. 49, n. 8, p. 3501-3512, 2005.10.1128/AAC.49.8.3501-3512.2005WOS000230950700061.pdf0066-4804http://repositorio.unifesp.br/handle/11600/28393WOS:000230950700061engAntimicrobial Agents and Chemotherapyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-07T02:32:00Zoai:repositorio.unifesp.br/:11600/28393Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-07T02:32Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Antimicrobial activity and spectrum of PPI-0903M (T-91825), a novel cephalosporin, tested against a worldwide collection of clinical strains
title Antimicrobial activity and spectrum of PPI-0903M (T-91825), a novel cephalosporin, tested against a worldwide collection of clinical strains
spellingShingle Antimicrobial activity and spectrum of PPI-0903M (T-91825), a novel cephalosporin, tested against a worldwide collection of clinical strains
Sader, Helio S. [UNIFESP]
title_short Antimicrobial activity and spectrum of PPI-0903M (T-91825), a novel cephalosporin, tested against a worldwide collection of clinical strains
title_full Antimicrobial activity and spectrum of PPI-0903M (T-91825), a novel cephalosporin, tested against a worldwide collection of clinical strains
title_fullStr Antimicrobial activity and spectrum of PPI-0903M (T-91825), a novel cephalosporin, tested against a worldwide collection of clinical strains
title_full_unstemmed Antimicrobial activity and spectrum of PPI-0903M (T-91825), a novel cephalosporin, tested against a worldwide collection of clinical strains
title_sort Antimicrobial activity and spectrum of PPI-0903M (T-91825), a novel cephalosporin, tested against a worldwide collection of clinical strains
author Sader, Helio S. [UNIFESP]
author_facet Sader, Helio S. [UNIFESP]
Fritsche, Thomas R.
Kaniga, Kone
Ge, Yi Gong
Jones, Ronald N.
author_role author
author2 Fritsche, Thomas R.
Kaniga, Kone
Ge, Yi Gong
Jones, Ronald N.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv JMI Labs Inc
Universidade Federal de São Paulo (UNIFESP)
Peninsula Pharmaceut
Tufts Univ
dc.contributor.author.fl_str_mv Sader, Helio S. [UNIFESP]
Fritsche, Thomas R.
Kaniga, Kone
Ge, Yi Gong
Jones, Ronald N.
description PPI-0903M is a novel N-phosphono-type cephalosporin active against oxacillin-resistant staphylococci and many other gram-positive organisms. This study evaluated the in vitro activity and spectrum of PPI-0903M against 1,478 recent clinical isolates collected from 80 medical centers (22 countries). PPI-0903M demonstrated broader in vitro activity against gram-positive bacteria, particularly against multidrug-resistant staphylococci and streptococci of current clinical concern, than currently available extended-spectrum cephalosporins while maintaining similar activity against gram-negative pathogens.
publishDate 2005
dc.date.none.fl_str_mv 2005-08-01
2016-01-24T12:37:58Z
2016-01-24T12:37:58Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1128/AAC.49.8.3501-3512.2005
Antimicrobial Agents and Chemotherapy. Washington: Amer Soc Microbiology, v. 49, n. 8, p. 3501-3512, 2005.
10.1128/AAC.49.8.3501-3512.2005
WOS000230950700061.pdf
0066-4804
http://repositorio.unifesp.br/handle/11600/28393
WOS:000230950700061
url http://dx.doi.org/10.1128/AAC.49.8.3501-3512.2005
http://repositorio.unifesp.br/handle/11600/28393
identifier_str_mv Antimicrobial Agents and Chemotherapy. Washington: Amer Soc Microbiology, v. 49, n. 8, p. 3501-3512, 2005.
10.1128/AAC.49.8.3501-3512.2005
WOS000230950700061.pdf
0066-4804
WOS:000230950700061
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Antimicrobial Agents and Chemotherapy
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 3501-3512
application/pdf
dc.publisher.none.fl_str_mv Amer Soc Microbiology
publisher.none.fl_str_mv Amer Soc Microbiology
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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