Effects of neonatal ganglioside GM1 administration on memory in adult and old rats
Autor(a) principal: | |
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Data de Publicação: | 2000 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/26363 http://dx.doi.org/10.1034/j.1600-0773.2000.pto870304.x |
Resumo: | Numerous investigations have been reporting the involvement of GM1 ganglioside in central nervous system development and memory formation. the effects of neonatal treatment with GM1 ganglioside on the performance of adult rats in a plus-maze discriminative avoidance task and old rats in a step-down passive avoidance task were investigated. Rats were injected subcutaneously from day 3 to 15 after birth with 10 mg/kg GM1 or saline. GM1 treatment did not modify indicative landmarks of physical and motor development. Behavioural tasks were carried out when the animals were 4 (discriminative avoidance) or 24 (passive avoidance) months old. Discriminative avoidance conditioning was performed in a modified elevated plus-maze. During the training session, the animals received aversive stimulation (light and hot air blow) in one of the enclosed arms. Tests were performed 7, 14 and 21 days after conditioning (tests 1, 2 and 3), in the absence of the aversive stimulation. in all tests, GM1-treated animals spent less time in the aversive arm than in the non-aversive enclosed arm. Control animals, however, spent a shorter time in the aversive arm only in tests 1 and 2. Passive avoidance conditioning was performed in an acrylic box with a grid floor, that was partially covered by an inclined platform. Animals were placed on the platform and received a 0,5 mA foot shock when stepped down. A test was performed 48 hr later. Latency to step down presented by GM1-treated animals was significantly higher in the test session, whereas no significant increase in latency to step down was found for control animals. the results suggest a possible action of GM1 on the maturation of the central nervous system that persists during adulthood and ageing. |
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Silva, Regina H. [UNIFESP]Bergamo, Marcelo [UNIFESP]Frussa-Filho, Roberto [UNIFESP]Universidade Federal de São Paulo (UNIFESP)Univ Santo Amaro2016-01-24T12:31:09Z2016-01-24T12:31:09Z2000-09-01Pharmacology & Toxicology. Copenhagen: Munksgaard Int Publ Ltd, v. 87, n. 3, p. 120-125, 2000.0901-9928http://repositorio.unifesp.br/handle/11600/26363http://dx.doi.org/10.1034/j.1600-0773.2000.pto870304.x10.1034/j.1600-0773.2000.pto870304.xWOS:000089615100004Numerous investigations have been reporting the involvement of GM1 ganglioside in central nervous system development and memory formation. the effects of neonatal treatment with GM1 ganglioside on the performance of adult rats in a plus-maze discriminative avoidance task and old rats in a step-down passive avoidance task were investigated. Rats were injected subcutaneously from day 3 to 15 after birth with 10 mg/kg GM1 or saline. GM1 treatment did not modify indicative landmarks of physical and motor development. Behavioural tasks were carried out when the animals were 4 (discriminative avoidance) or 24 (passive avoidance) months old. Discriminative avoidance conditioning was performed in a modified elevated plus-maze. During the training session, the animals received aversive stimulation (light and hot air blow) in one of the enclosed arms. Tests were performed 7, 14 and 21 days after conditioning (tests 1, 2 and 3), in the absence of the aversive stimulation. in all tests, GM1-treated animals spent less time in the aversive arm than in the non-aversive enclosed arm. Control animals, however, spent a shorter time in the aversive arm only in tests 1 and 2. Passive avoidance conditioning was performed in an acrylic box with a grid floor, that was partially covered by an inclined platform. Animals were placed on the platform and received a 0,5 mA foot shock when stepped down. A test was performed 48 hr later. Latency to step down presented by GM1-treated animals was significantly higher in the test session, whereas no significant increase in latency to step down was found for control animals. the results suggest a possible action of GM1 on the maturation of the central nervous system that persists during adulthood and ageing.Universidade Federal de São Paulo, Dept Pharmacol, BR-04034970 São Paulo, SP, BrazilUniv Santo Amaro, Dept Pharmacol, Santo Amaro, BrazilUniversidade Federal de São Paulo, Dept Pharmacol, BR-04034970 São Paulo, SP, BrazilWeb of Science120-125engMunksgaard Int Publ LtdPharmacology & ToxicologyEffects of neonatal ganglioside GM1 administration on memory in adult and old ratsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/263632022-06-02 09:02:09.883metadata only accessoai:repositorio.unifesp.br:11600/26363Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652022-06-02T12:02:09Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Effects of neonatal ganglioside GM1 administration on memory in adult and old rats |
title |
Effects of neonatal ganglioside GM1 administration on memory in adult and old rats |
spellingShingle |
Effects of neonatal ganglioside GM1 administration on memory in adult and old rats Silva, Regina H. [UNIFESP] |
title_short |
Effects of neonatal ganglioside GM1 administration on memory in adult and old rats |
title_full |
Effects of neonatal ganglioside GM1 administration on memory in adult and old rats |
title_fullStr |
Effects of neonatal ganglioside GM1 administration on memory in adult and old rats |
title_full_unstemmed |
Effects of neonatal ganglioside GM1 administration on memory in adult and old rats |
title_sort |
Effects of neonatal ganglioside GM1 administration on memory in adult and old rats |
author |
Silva, Regina H. [UNIFESP] |
author_facet |
Silva, Regina H. [UNIFESP] Bergamo, Marcelo [UNIFESP] Frussa-Filho, Roberto [UNIFESP] |
author_role |
author |
author2 |
Bergamo, Marcelo [UNIFESP] Frussa-Filho, Roberto [UNIFESP] |
author2_role |
author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Univ Santo Amaro |
dc.contributor.author.fl_str_mv |
Silva, Regina H. [UNIFESP] Bergamo, Marcelo [UNIFESP] Frussa-Filho, Roberto [UNIFESP] |
description |
Numerous investigations have been reporting the involvement of GM1 ganglioside in central nervous system development and memory formation. the effects of neonatal treatment with GM1 ganglioside on the performance of adult rats in a plus-maze discriminative avoidance task and old rats in a step-down passive avoidance task were investigated. Rats were injected subcutaneously from day 3 to 15 after birth with 10 mg/kg GM1 or saline. GM1 treatment did not modify indicative landmarks of physical and motor development. Behavioural tasks were carried out when the animals were 4 (discriminative avoidance) or 24 (passive avoidance) months old. Discriminative avoidance conditioning was performed in a modified elevated plus-maze. During the training session, the animals received aversive stimulation (light and hot air blow) in one of the enclosed arms. Tests were performed 7, 14 and 21 days after conditioning (tests 1, 2 and 3), in the absence of the aversive stimulation. in all tests, GM1-treated animals spent less time in the aversive arm than in the non-aversive enclosed arm. Control animals, however, spent a shorter time in the aversive arm only in tests 1 and 2. Passive avoidance conditioning was performed in an acrylic box with a grid floor, that was partially covered by an inclined platform. Animals were placed on the platform and received a 0,5 mA foot shock when stepped down. A test was performed 48 hr later. Latency to step down presented by GM1-treated animals was significantly higher in the test session, whereas no significant increase in latency to step down was found for control animals. the results suggest a possible action of GM1 on the maturation of the central nervous system that persists during adulthood and ageing. |
publishDate |
2000 |
dc.date.issued.fl_str_mv |
2000-09-01 |
dc.date.accessioned.fl_str_mv |
2016-01-24T12:31:09Z |
dc.date.available.fl_str_mv |
2016-01-24T12:31:09Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Pharmacology & Toxicology. Copenhagen: Munksgaard Int Publ Ltd, v. 87, n. 3, p. 120-125, 2000. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/26363 http://dx.doi.org/10.1034/j.1600-0773.2000.pto870304.x |
dc.identifier.issn.none.fl_str_mv |
0901-9928 |
dc.identifier.doi.none.fl_str_mv |
10.1034/j.1600-0773.2000.pto870304.x |
dc.identifier.wos.none.fl_str_mv |
WOS:000089615100004 |
identifier_str_mv |
Pharmacology & Toxicology. Copenhagen: Munksgaard Int Publ Ltd, v. 87, n. 3, p. 120-125, 2000. 0901-9928 10.1034/j.1600-0773.2000.pto870304.x WOS:000089615100004 |
url |
http://repositorio.unifesp.br/handle/11600/26363 http://dx.doi.org/10.1034/j.1600-0773.2000.pto870304.x |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Pharmacology & Toxicology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
120-125 |
dc.publisher.none.fl_str_mv |
Munksgaard Int Publ Ltd |
publisher.none.fl_str_mv |
Munksgaard Int Publ Ltd |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
_version_ |
1802764127175704576 |