Effects of different physical exercise programs on susceptibility to pilocarpine-induced seizures in female rats

Detalhes bibliográficos
Autor(a) principal: Campos, Diego Vannucci [UNIFESP]
Data de Publicação: 2016
Outros Autores: Lopim, Glauber Menezes [UNIFESP], Almeida, Vanessa Santos de [UNIFESP], Amado, Debora [UNIFESP], Arida, Ricardo Mario [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1016/j.yebeh.2016.08.011
https://repositorio.unifesp.br/handle/11600/56790
Resumo: In epilepsy, the most common serious neurological disorder worldwide, several investigations in both humans and animals have shown the effectiveness of physical exercise programs as a complementary therapy. Among the benefits demonstrated, regular exercise can decrease the number of seizures as well as improve cardiovascular and psychological health in people with epilepsy. While many studies in animals have been performed to show the beneficial effects of exercise, they exclusively used male animals. However, females are also worthy of investigation because of their cyclical hormonal fluctuations and possible pregnancy. Considering the few animal studies concerning seizure susceptibility and exercise programs in females, this study aimed to verify whether exercise programs can interfere with seizure susceptibility induced by pilocarpine in adult female Wistar rats. Animals were randomly divided into three groups: control, forced, and voluntary (animals kept in a cage with a wheel). After the final exercise session, animals received a pilocarpine hydrochloride (350 mg/kg i.p.
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spelling Effects of different physical exercise programs on susceptibility to pilocarpine-induced seizures in female ratsEpilepsySeizures susceptibilityPilocarpineExerciseFemale ratsIn epilepsy, the most common serious neurological disorder worldwide, several investigations in both humans and animals have shown the effectiveness of physical exercise programs as a complementary therapy. Among the benefits demonstrated, regular exercise can decrease the number of seizures as well as improve cardiovascular and psychological health in people with epilepsy. While many studies in animals have been performed to show the beneficial effects of exercise, they exclusively used male animals. However, females are also worthy of investigation because of their cyclical hormonal fluctuations and possible pregnancy. Considering the few animal studies concerning seizure susceptibility and exercise programs in females, this study aimed to verify whether exercise programs can interfere with seizure susceptibility induced by pilocarpine in adult female Wistar rats. Animals were randomly divided into three groups: control, forced, and voluntary (animals kept in a cage with a wheel). After the final exercise session, animals received a pilocarpine hydrochloride (350 mg/kg i.p.Sigma) injection to induce seizures. To measure the intensity of pilocarpine-induced motor signs, we used a scale similar to that developed by Racine (1972) in the kindling model. During a 4-h period of observation, we recorded latency for first motor signs, latency for reaching SE, number of animals that developed SE, and intensity of pilocarpine-induced motor signs. No difference was observed among groups in latency for first motor signs and in the number of animals that developed SE. Although the voluntary group presented more intense motor signs, an increased latency for developing SE was observed compared with that in forced and control groups. Our behavioral results are not enough to explain physiological and molecular pathways, but there are mechanisms described in literature which may allow us to propose possible explanations. Voluntary exercise increased latency to SE development. Further investigation is necessary to elucidate the pathways involved in these results, while more studies should be performed regarding gender specific differences. (C) 2016 Elsevier Inc. All rights reserved.Univ Fed Sao Paulo, UNIFESP, Dept Fisiol, Rua Botucatu 862,Ed Ciencias Biomed,5 Andar, BR-04023900 Sao Paulo, SP, BrazilUniv Fed Sao Paulo, UNIFESP, Dept Neurol & Neurocirurgia, Sao Paulo, SP, BrazilDepartamento de Fisiologia, Universidade Federal de São Paulo (UNIFESP), São Paulo, — SP, BrazilDepartamento de Neurologia e Neurocirurgia, Universidade Federal de São Paulo (UNIFESP), São Paulo, — SP, BrazilWeb of ScienceCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)FAPESP: 2015/19256-0CNPq: 300605/2013-0Academic Press Inc Elsevier Science2020-07-31T12:47:23Z2020-07-31T12:47:23Z2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion262-267http://dx.doi.org/10.1016/j.yebeh.2016.08.011Epilepsy & Behavior. San Diego, v. 64, p. 262-267, 2016.10.1016/j.yebeh.2016.08.0111525-5050https://repositorio.unifesp.br/handle/11600/56790WOS:000389734800045engEpilepsy & BehaviorSan Diegoinfo:eu-repo/semantics/openAccessCampos, Diego Vannucci [UNIFESP]Lopim, Glauber Menezes [UNIFESP]Almeida, Vanessa Santos de [UNIFESP]Amado, Debora [UNIFESP]Arida, Ricardo Mario [UNIFESP]reponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2021-09-30T17:31:41Zoai:repositorio.unifesp.br/:11600/56790Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652021-09-30T17:31:41Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Effects of different physical exercise programs on susceptibility to pilocarpine-induced seizures in female rats
title Effects of different physical exercise programs on susceptibility to pilocarpine-induced seizures in female rats
spellingShingle Effects of different physical exercise programs on susceptibility to pilocarpine-induced seizures in female rats
Campos, Diego Vannucci [UNIFESP]
Epilepsy
Seizures susceptibility
Pilocarpine
Exercise
Female rats
title_short Effects of different physical exercise programs on susceptibility to pilocarpine-induced seizures in female rats
title_full Effects of different physical exercise programs on susceptibility to pilocarpine-induced seizures in female rats
title_fullStr Effects of different physical exercise programs on susceptibility to pilocarpine-induced seizures in female rats
title_full_unstemmed Effects of different physical exercise programs on susceptibility to pilocarpine-induced seizures in female rats
title_sort Effects of different physical exercise programs on susceptibility to pilocarpine-induced seizures in female rats
author Campos, Diego Vannucci [UNIFESP]
author_facet Campos, Diego Vannucci [UNIFESP]
Lopim, Glauber Menezes [UNIFESP]
Almeida, Vanessa Santos de [UNIFESP]
Amado, Debora [UNIFESP]
Arida, Ricardo Mario [UNIFESP]
author_role author
author2 Lopim, Glauber Menezes [UNIFESP]
Almeida, Vanessa Santos de [UNIFESP]
Amado, Debora [UNIFESP]
Arida, Ricardo Mario [UNIFESP]
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Campos, Diego Vannucci [UNIFESP]
Lopim, Glauber Menezes [UNIFESP]
Almeida, Vanessa Santos de [UNIFESP]
Amado, Debora [UNIFESP]
Arida, Ricardo Mario [UNIFESP]
dc.subject.por.fl_str_mv Epilepsy
Seizures susceptibility
Pilocarpine
Exercise
Female rats
topic Epilepsy
Seizures susceptibility
Pilocarpine
Exercise
Female rats
description In epilepsy, the most common serious neurological disorder worldwide, several investigations in both humans and animals have shown the effectiveness of physical exercise programs as a complementary therapy. Among the benefits demonstrated, regular exercise can decrease the number of seizures as well as improve cardiovascular and psychological health in people with epilepsy. While many studies in animals have been performed to show the beneficial effects of exercise, they exclusively used male animals. However, females are also worthy of investigation because of their cyclical hormonal fluctuations and possible pregnancy. Considering the few animal studies concerning seizure susceptibility and exercise programs in females, this study aimed to verify whether exercise programs can interfere with seizure susceptibility induced by pilocarpine in adult female Wistar rats. Animals were randomly divided into three groups: control, forced, and voluntary (animals kept in a cage with a wheel). After the final exercise session, animals received a pilocarpine hydrochloride (350 mg/kg i.p.
publishDate 2016
dc.date.none.fl_str_mv 2016
2020-07-31T12:47:23Z
2020-07-31T12:47:23Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.yebeh.2016.08.011
Epilepsy & Behavior. San Diego, v. 64, p. 262-267, 2016.
10.1016/j.yebeh.2016.08.011
1525-5050
https://repositorio.unifesp.br/handle/11600/56790
WOS:000389734800045
url http://dx.doi.org/10.1016/j.yebeh.2016.08.011
https://repositorio.unifesp.br/handle/11600/56790
identifier_str_mv Epilepsy & Behavior. San Diego, v. 64, p. 262-267, 2016.
10.1016/j.yebeh.2016.08.011
1525-5050
WOS:000389734800045
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Epilepsy & Behavior
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 262-267
dc.coverage.none.fl_str_mv San Diego
dc.publisher.none.fl_str_mv Academic Press Inc Elsevier Science
publisher.none.fl_str_mv Academic Press Inc Elsevier Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
_version_ 1814268281115115520

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