Bronchodilators accelerate the dynamics of muscle O-2 delivery and utilisation during exercise in COPD

Detalhes bibliográficos
Autor(a) principal: Berton, Danilo C. [UNIFESP]
Data de Publicação: 2010
Outros Autores: Barbosa, Priscila B. [UNIFESP], Takara, Luciana S. [UNIFESP], Chiappa, Gaspar R. [UNIFESP], Siqueira, Ana Cristina B. [UNIFESP], Bravo, Daniela M. [UNIFESP], Ferreira, Leonardo F., Neder, J. Alberto [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1136/thx.2009.120857
http://repositorio.unifesp.br/handle/11600/32650
Resumo: Background Expiratory flow limitation and lung hyperinflation promote cardiocirculatory perturbations that might impair O-2 delivery to locomotor muscles in patients with chronic obstructive pulmonary disease (COPD). the hypothesis that decreases in lung hyperinflation after the inhalation of bronchodilators would improve skeletal muscle oxygenation during exercise was tested.Methods Twelve non-or mildly hypoxaemic males (forced expiratory volume in 1 s (FEV1)=38.5+/-12.9% predicted; Pao(2)>60 mm Hg) underwent constant work rate cycle ergometer exercise tests (70-80% peak) to the limit of tolerance (Tlim) after inhaled bronchodilators (salbutamol plus ipratropium) or placebo. Muscle (de) oxygenation (similar to fractional O-2 extraction) was determined in the vastus lateralis by changes (Delta) in the deoxyhaemoglobin/myoglobin signal ([HHb]) from near-infrared spectroscopy, and cardiac output (QT) was monitored by impedance cardiography.Results Bronchodilators reduced lung hyperinflation and increased Tlim compared with placebo (454+/-131 s vs 321+/-140 s, respectively; p<0.05). On-exercise kinetics of QT and pulmonary O-2 uptake ((V) over doto(2)) were accelerated with active treatment; Delta[HHb] dynamics, however, were delayed by similar to 78% and the signal amplitude diminished by similar to 21% (p<0.01). Consequently, the ratio between (V) over doto(2) and Delta[HHb] dynamics decreased, suggesting improved microvascular O-2 delivery (tau-(V) over doto(2)/MRT-Delta [HHb]=4.48+/-1.57 s vs 2.08+/-1.15 s, p<0.05). of note, reductions in lung hyperinflation were related to faster QT kinetics and larger decrements in tau-(V) over doto(2)/MRT-Delta[HHb] (p<0.01).Conclusions Decreases in operating lung volumes after the inhalation of bronchodilators are associated with faster 'central' cardiovascular adjustments to high-intensity exercise with beneficial consequences on muscle oxygenation in patients with moderate to severe COPD.
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spelling Bronchodilators accelerate the dynamics of muscle O-2 delivery and utilisation during exercise in COPDBackground Expiratory flow limitation and lung hyperinflation promote cardiocirculatory perturbations that might impair O-2 delivery to locomotor muscles in patients with chronic obstructive pulmonary disease (COPD). the hypothesis that decreases in lung hyperinflation after the inhalation of bronchodilators would improve skeletal muscle oxygenation during exercise was tested.Methods Twelve non-or mildly hypoxaemic males (forced expiratory volume in 1 s (FEV1)=38.5+/-12.9% predicted; Pao(2)>60 mm Hg) underwent constant work rate cycle ergometer exercise tests (70-80% peak) to the limit of tolerance (Tlim) after inhaled bronchodilators (salbutamol plus ipratropium) or placebo. Muscle (de) oxygenation (similar to fractional O-2 extraction) was determined in the vastus lateralis by changes (Delta) in the deoxyhaemoglobin/myoglobin signal ([HHb]) from near-infrared spectroscopy, and cardiac output (QT) was monitored by impedance cardiography.Results Bronchodilators reduced lung hyperinflation and increased Tlim compared with placebo (454+/-131 s vs 321+/-140 s, respectively; p<0.05). On-exercise kinetics of QT and pulmonary O-2 uptake ((V) over doto(2)) were accelerated with active treatment; Delta[HHb] dynamics, however, were delayed by similar to 78% and the signal amplitude diminished by similar to 21% (p<0.01). Consequently, the ratio between (V) over doto(2) and Delta[HHb] dynamics decreased, suggesting improved microvascular O-2 delivery (tau-(V) over doto(2)/MRT-Delta [HHb]=4.48+/-1.57 s vs 2.08+/-1.15 s, p<0.05). of note, reductions in lung hyperinflation were related to faster QT kinetics and larger decrements in tau-(V) over doto(2)/MRT-Delta[HHb] (p<0.01).Conclusions Decreases in operating lung volumes after the inhalation of bronchodilators are associated with faster 'central' cardiovascular adjustments to high-intensity exercise with beneficial consequences on muscle oxygenation in patients with moderate to severe COPD.Fed Univ São Paulo UNIFESP, Dept Med, Pulm Funct & Clin Exercise Physiol Unit SEFICE, Div Resp Dis, BR-04020050 São Paulo, BrazilUniv Kentucky, Dept Physiol, Lexington, KY USAFed Univ São Paulo UNIFESP, Dept Med, Pulm Funct & Clin Exercise Physiol Unit SEFICE, Div Resp Dis, BR-04020050 São Paulo, BrazilWeb of ScienceCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)B M J Publishing GroupUniversidade Federal de São Paulo (UNIFESP)Univ KentuckyBerton, Danilo C. [UNIFESP]Barbosa, Priscila B. [UNIFESP]Takara, Luciana S. [UNIFESP]Chiappa, Gaspar R. [UNIFESP]Siqueira, Ana Cristina B. [UNIFESP]Bravo, Daniela M. [UNIFESP]Ferreira, Leonardo F.Neder, J. Alberto [UNIFESP]2016-01-24T13:59:49Z2016-01-24T13:59:49Z2010-07-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion588-593http://dx.doi.org/10.1136/thx.2009.120857Thorax. London: B M J Publishing Group, v. 65, n. 7, p. 588-593, 2010.10.1136/thx.2009.1208570040-6376http://repositorio.unifesp.br/handle/11600/32650WOS:000279806400008engThoraxinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2021-09-30T17:26:14Zoai:repositorio.unifesp.br/:11600/32650Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652021-09-30T17:26:14Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Bronchodilators accelerate the dynamics of muscle O-2 delivery and utilisation during exercise in COPD
title Bronchodilators accelerate the dynamics of muscle O-2 delivery and utilisation during exercise in COPD
spellingShingle Bronchodilators accelerate the dynamics of muscle O-2 delivery and utilisation during exercise in COPD
Berton, Danilo C. [UNIFESP]
title_short Bronchodilators accelerate the dynamics of muscle O-2 delivery and utilisation during exercise in COPD
title_full Bronchodilators accelerate the dynamics of muscle O-2 delivery and utilisation during exercise in COPD
title_fullStr Bronchodilators accelerate the dynamics of muscle O-2 delivery and utilisation during exercise in COPD
title_full_unstemmed Bronchodilators accelerate the dynamics of muscle O-2 delivery and utilisation during exercise in COPD
title_sort Bronchodilators accelerate the dynamics of muscle O-2 delivery and utilisation during exercise in COPD
author Berton, Danilo C. [UNIFESP]
author_facet Berton, Danilo C. [UNIFESP]
Barbosa, Priscila B. [UNIFESP]
Takara, Luciana S. [UNIFESP]
Chiappa, Gaspar R. [UNIFESP]
Siqueira, Ana Cristina B. [UNIFESP]
Bravo, Daniela M. [UNIFESP]
Ferreira, Leonardo F.
Neder, J. Alberto [UNIFESP]
author_role author
author2 Barbosa, Priscila B. [UNIFESP]
Takara, Luciana S. [UNIFESP]
Chiappa, Gaspar R. [UNIFESP]
Siqueira, Ana Cristina B. [UNIFESP]
Bravo, Daniela M. [UNIFESP]
Ferreira, Leonardo F.
Neder, J. Alberto [UNIFESP]
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
Univ Kentucky
dc.contributor.author.fl_str_mv Berton, Danilo C. [UNIFESP]
Barbosa, Priscila B. [UNIFESP]
Takara, Luciana S. [UNIFESP]
Chiappa, Gaspar R. [UNIFESP]
Siqueira, Ana Cristina B. [UNIFESP]
Bravo, Daniela M. [UNIFESP]
Ferreira, Leonardo F.
Neder, J. Alberto [UNIFESP]
description Background Expiratory flow limitation and lung hyperinflation promote cardiocirculatory perturbations that might impair O-2 delivery to locomotor muscles in patients with chronic obstructive pulmonary disease (COPD). the hypothesis that decreases in lung hyperinflation after the inhalation of bronchodilators would improve skeletal muscle oxygenation during exercise was tested.Methods Twelve non-or mildly hypoxaemic males (forced expiratory volume in 1 s (FEV1)=38.5+/-12.9% predicted; Pao(2)>60 mm Hg) underwent constant work rate cycle ergometer exercise tests (70-80% peak) to the limit of tolerance (Tlim) after inhaled bronchodilators (salbutamol plus ipratropium) or placebo. Muscle (de) oxygenation (similar to fractional O-2 extraction) was determined in the vastus lateralis by changes (Delta) in the deoxyhaemoglobin/myoglobin signal ([HHb]) from near-infrared spectroscopy, and cardiac output (QT) was monitored by impedance cardiography.Results Bronchodilators reduced lung hyperinflation and increased Tlim compared with placebo (454+/-131 s vs 321+/-140 s, respectively; p<0.05). On-exercise kinetics of QT and pulmonary O-2 uptake ((V) over doto(2)) were accelerated with active treatment; Delta[HHb] dynamics, however, were delayed by similar to 78% and the signal amplitude diminished by similar to 21% (p<0.01). Consequently, the ratio between (V) over doto(2) and Delta[HHb] dynamics decreased, suggesting improved microvascular O-2 delivery (tau-(V) over doto(2)/MRT-Delta [HHb]=4.48+/-1.57 s vs 2.08+/-1.15 s, p<0.05). of note, reductions in lung hyperinflation were related to faster QT kinetics and larger decrements in tau-(V) over doto(2)/MRT-Delta[HHb] (p<0.01).Conclusions Decreases in operating lung volumes after the inhalation of bronchodilators are associated with faster 'central' cardiovascular adjustments to high-intensity exercise with beneficial consequences on muscle oxygenation in patients with moderate to severe COPD.
publishDate 2010
dc.date.none.fl_str_mv 2010-07-01
2016-01-24T13:59:49Z
2016-01-24T13:59:49Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1136/thx.2009.120857
Thorax. London: B M J Publishing Group, v. 65, n. 7, p. 588-593, 2010.
10.1136/thx.2009.120857
0040-6376
http://repositorio.unifesp.br/handle/11600/32650
WOS:000279806400008
url http://dx.doi.org/10.1136/thx.2009.120857
http://repositorio.unifesp.br/handle/11600/32650
identifier_str_mv Thorax. London: B M J Publishing Group, v. 65, n. 7, p. 588-593, 2010.
10.1136/thx.2009.120857
0040-6376
WOS:000279806400008
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Thorax
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 588-593
dc.publisher.none.fl_str_mv B M J Publishing Group
publisher.none.fl_str_mv B M J Publishing Group
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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