Correlation and adaptation among functional and cognitive instruments for staging and monitoring Alzheimer?s disease in advanced stages
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2014 |
| Outros Autores: | , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UNIFESP |
| dARK ID: | ark:/48912/0013000008dqx |
| Texto Completo: | http://dx.doi.org/10.1590/0101-60830000041158 http://repositorio.unifesp.br/handle/11600/8364 |
Resumo: | Background: Although Alzheimer’s disease (AD) is the most prevalent form of dementia, little is known about cognitive and functional aspects in its advanced stages. Objective: This study aimed the adaptation and correlation among specific instruments for AD in advanced stages with regard to cognition objectively weighted, besides the comparison between static and ecological aspects of functional capacity. Method: 95 moderate, moderatly severe and severe AD patients (33 men and 62 women) underwent the scales CDR (Clinical for Dementia Rating), FAST (Functional Assessment Scale), MMSE (Mini-Mental State Exame), MMSEsev (Severe Mini-Mental State Examination), SIB-8 (Severe Impairment Battery) and TSI (Test for Severe Impairment), for the comparison with a golden-standard ecological scale the PADL (Performance Activities of Daily Living). Result: The evidence suggests an increasing and statistically significant linear correlation between the ecological functional scale and cognitive tests according to the stratification of AD stages once weighted by static functional scale. Discussion: The results indicate that for patients in advanced stages of AD, appropriate cognitive tests and performance-based functional scales are useful in more accurate assessment of disease staging and monitoring its progression. |
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Correlation and adaptation among functional and cognitive instruments for staging and monitoring Alzheimer?s disease in advanced stagesAdaptação e correlação entre instrumentos cognitivos e funcionais para o estadiamento e acompanhamento da doença de Alzheimer em fases avançadasAlzheimer?s diseasedementiacognitionfunctional capacityDoença de Alzheimerdemênciacogniçãocapacidade funcionalBackground: Although Alzheimer’s disease (AD) is the most prevalent form of dementia, little is known about cognitive and functional aspects in its advanced stages. Objective: This study aimed the adaptation and correlation among specific instruments for AD in advanced stages with regard to cognition objectively weighted, besides the comparison between static and ecological aspects of functional capacity. Method: 95 moderate, moderatly severe and severe AD patients (33 men and 62 women) underwent the scales CDR (Clinical for Dementia Rating), FAST (Functional Assessment Scale), MMSE (Mini-Mental State Exame), MMSEsev (Severe Mini-Mental State Examination), SIB-8 (Severe Impairment Battery) and TSI (Test for Severe Impairment), for the comparison with a golden-standard ecological scale the PADL (Performance Activities of Daily Living). Result: The evidence suggests an increasing and statistically significant linear correlation between the ecological functional scale and cognitive tests according to the stratification of AD stages once weighted by static functional scale. Discussion: The results indicate that for patients in advanced stages of AD, appropriate cognitive tests and performance-based functional scales are useful in more accurate assessment of disease staging and monitoring its progression.Contexto: Apesar de a doença de Alzheimer (DA) ser a forma de demência mais prevalente, pouco se sabe sobre aspectos cognitivos e funcionais em suas fases avançadas. Objetivo: Foi objetivo deste trabalho a adaptação e correlação entre instrumentos específicos para a DA em fases avançadas no que diz respeito à sua cognição objetivamente ponderada, além da comparação entre aspectos da capacidade funcional estática e ecológica. Método: Noventa e cinco pacientes (33 homens e 62 mulheres) com DA moderada, moderadamente grave e grave foram submetidos às escalas CDR (Clinical for Dementia Rating), FAST (Functional Assessment Scale), MEEM (Mini-Mental State Examination), MMSEsev (Severe Mini-Mental State Examination), SIB-8 (Severe Impairment Battery) e TSI (Test for Severe Impairment) para comparação com uma escala ecológica padrão-ouro, a PADL (Performance Activities of Daily Living). Resultado: As evidências encontradas sugerem uma correlação linear crescente e estatisticamente significativa entre a escala funcional ecológica e os testes cognitivos conforme a estratificação das fases da DA uma vez ponderadas pela escala funcional estática. Conclusão: Os resultados indicam que, para pacientes em fases avançadas da DA, testes cognitivos apropriados e escalas funcionais baseadas no desempenho são úteis na avaliação mais acurada do estadiamento da doença e acompanhamento de sua progressão.Universidade Federal de São Paulo (UNIFESP) Setor de Neurologia do Comportamento da Disciplina de Neurologia e Neurocirurgia Núcleo de Envelhecimento CerebralUNIFESP, Setor de Neurologia do Comportamento da Disciplina de Neurologia e Neurocirurgia Núcleo de Envelhecimento CerebralSciELOFaculdade de Medicina da Universidade de São PauloUniversidade Federal de São Paulo (UNIFESP)Wajman, José RobertoSchultz, Rodrigo RizekMarin, Sheilla de Medeiros Correia [UNIFESP]Bertolucci, Paulo Henrique Ferreira [UNIFESP]2015-06-14T13:47:05Z2015-06-14T13:47:05Z2014-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion5-8application/pdfhttp://dx.doi.org/10.1590/0101-60830000041158Archives of Clinical Psychiatry. Faculdade de Medicina da Universidade de São Paulo, v. 41, n. 1, p. 5-8, 2014.10.1590/0101-60830000041158S0101-60832014000100005.pdf0101-6083S0101-60832014000100005http://repositorio.unifesp.br/handle/11600/8364ark:/48912/0013000008dqxengArchives of Clinical Psychiatryinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-29T18:55:03Zoai:repositorio.unifesp.br/:11600/8364Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-12-11T20:05:01.896039Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
| dc.title.none.fl_str_mv |
Correlation and adaptation among functional and cognitive instruments for staging and monitoring Alzheimer?s disease in advanced stages Adaptação e correlação entre instrumentos cognitivos e funcionais para o estadiamento e acompanhamento da doença de Alzheimer em fases avançadas |
| title |
Correlation and adaptation among functional and cognitive instruments for staging and monitoring Alzheimer?s disease in advanced stages |
| spellingShingle |
Correlation and adaptation among functional and cognitive instruments for staging and monitoring Alzheimer?s disease in advanced stages Wajman, José Roberto Alzheimer?s disease dementia cognition functional capacity Doença de Alzheimer demência cognição capacidade funcional |
| title_short |
Correlation and adaptation among functional and cognitive instruments for staging and monitoring Alzheimer?s disease in advanced stages |
| title_full |
Correlation and adaptation among functional and cognitive instruments for staging and monitoring Alzheimer?s disease in advanced stages |
| title_fullStr |
Correlation and adaptation among functional and cognitive instruments for staging and monitoring Alzheimer?s disease in advanced stages |
| title_full_unstemmed |
Correlation and adaptation among functional and cognitive instruments for staging and monitoring Alzheimer?s disease in advanced stages |
| title_sort |
Correlation and adaptation among functional and cognitive instruments for staging and monitoring Alzheimer?s disease in advanced stages |
| author |
Wajman, José Roberto |
| author_facet |
Wajman, José Roberto Schultz, Rodrigo Rizek Marin, Sheilla de Medeiros Correia [UNIFESP] Bertolucci, Paulo Henrique Ferreira [UNIFESP] |
| author_role |
author |
| author2 |
Schultz, Rodrigo Rizek Marin, Sheilla de Medeiros Correia [UNIFESP] Bertolucci, Paulo Henrique Ferreira [UNIFESP] |
| author2_role |
author author author |
| dc.contributor.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
| dc.contributor.author.fl_str_mv |
Wajman, José Roberto Schultz, Rodrigo Rizek Marin, Sheilla de Medeiros Correia [UNIFESP] Bertolucci, Paulo Henrique Ferreira [UNIFESP] |
| dc.subject.por.fl_str_mv |
Alzheimer?s disease dementia cognition functional capacity Doença de Alzheimer demência cognição capacidade funcional |
| topic |
Alzheimer?s disease dementia cognition functional capacity Doença de Alzheimer demência cognição capacidade funcional |
| description |
Background: Although Alzheimer’s disease (AD) is the most prevalent form of dementia, little is known about cognitive and functional aspects in its advanced stages. Objective: This study aimed the adaptation and correlation among specific instruments for AD in advanced stages with regard to cognition objectively weighted, besides the comparison between static and ecological aspects of functional capacity. Method: 95 moderate, moderatly severe and severe AD patients (33 men and 62 women) underwent the scales CDR (Clinical for Dementia Rating), FAST (Functional Assessment Scale), MMSE (Mini-Mental State Exame), MMSEsev (Severe Mini-Mental State Examination), SIB-8 (Severe Impairment Battery) and TSI (Test for Severe Impairment), for the comparison with a golden-standard ecological scale the PADL (Performance Activities of Daily Living). Result: The evidence suggests an increasing and statistically significant linear correlation between the ecological functional scale and cognitive tests according to the stratification of AD stages once weighted by static functional scale. Discussion: The results indicate that for patients in advanced stages of AD, appropriate cognitive tests and performance-based functional scales are useful in more accurate assessment of disease staging and monitoring its progression. |
| publishDate |
2014 |
| dc.date.none.fl_str_mv |
2014-04-01 2015-06-14T13:47:05Z 2015-06-14T13:47:05Z |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/0101-60830000041158 Archives of Clinical Psychiatry. Faculdade de Medicina da Universidade de São Paulo, v. 41, n. 1, p. 5-8, 2014. 10.1590/0101-60830000041158 S0101-60832014000100005.pdf 0101-6083 S0101-60832014000100005 http://repositorio.unifesp.br/handle/11600/8364 |
| dc.identifier.dark.fl_str_mv |
ark:/48912/0013000008dqx |
| url |
http://dx.doi.org/10.1590/0101-60830000041158 http://repositorio.unifesp.br/handle/11600/8364 |
| identifier_str_mv |
Archives of Clinical Psychiatry. Faculdade de Medicina da Universidade de São Paulo, v. 41, n. 1, p. 5-8, 2014. 10.1590/0101-60830000041158 S0101-60832014000100005.pdf 0101-6083 S0101-60832014000100005 ark:/48912/0013000008dqx |
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eng |
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eng |
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Archives of Clinical Psychiatry |
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info:eu-repo/semantics/openAccess |
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openAccess |
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5-8 application/pdf |
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Faculdade de Medicina da Universidade de São Paulo |
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Faculdade de Medicina da Universidade de São Paulo |
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reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
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Universidade Federal de São Paulo (UNIFESP) |
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UNIFESP |
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Repositório Institucional da UNIFESP |
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Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
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