Stability Study of Hypervalent Tellurium Compounds in Aqueous Solutions

• Autor(a) principal: Princival, Cleverson R.
• Data de Publicação: 2017
• Outros Autores: Archilha, Marcos V. L. R., Dos Santos, Alcindo A., Franco, Mauricio P., Braga, Ataualpa A. C., Rodrigues-Oliveira, Andre F., Correra, Thiago C., Cunha, Rodrigo L. O. R., Comasseto, Joao V. [UNIFESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://dx.doi.org/10.1021/acsomega.7b00628; http://repositorio.unifesp.br/handle/11600/51424

Hypervalent tellurium compounds (telluranes) are promising therapeutical agents with negligible toxicities for some diseases in animal models. The C-Te bond of organotellurium compounds is commonly considered unstable, disfavoring their applicability in biological studies. In this study, the stability of a set of telluranes composed of an inorganic derivative and noncharged and charged organic derivatives was monitored in aqueous media with H-1, C-13, and Te-125 NMR spectroscopy and high-resolution mass spectrometry. Organic telluranes were found to be remarkably resistant and stable to hydrolysis, whereas the inorganic tellurane AS101 is totally converted to the hydrolysis product, trichlorooxytellurate, [TeOCl3](-), which was also observed in the hydrolysis of TeCl4. The noteworthy stability of organotelluranes in aqueous media makes them prone to further structure-activity relationship studies and to be considered for broad biological investigations.