EULAR/PRINTO/PRES criteria for Henoch-Schonlein purpura, childhood polyarteritis nodosa, childhood Wegener granulomatosis and childhood Takayasu arteritis: Ankara 2008. Part II: Final classification criteria

• Autor(a) principal: Ozen, Seza
• Data de Publicação: 2010
• Outros Autores: Pistorio, Angela, Iusan, Silvia M., Bakkaloglu, Aysin, Herlin, Troels, Brik, Riva, Buoncompagni, Antonella, Lazar, Calin, Bilge, Ilmay, Uziel, Yosef, Rigante, Donato, Cantarini, Luca, Hilario, Maria Odete [UNIFESP], Silva, Clovis A., Alegria, Mauricio, Norambuena, Ximena, Belot, Alexandre, Berkun, Yackov, Estrella, Amparo Ibanez, Olivieri, Alma Nunzia, Alpigiani, Maria Giannina, Rumba, Ingrida, Sztajnbok, Flavio, Tambic-Bukovac, Lana, Breda, Luciana, Al-Mayouf, Sulaiman, Mihaylova, Dimitrina, Chasnyk, Vyacheslav, Sengler, Claudia, Klein-Gitelman, Maria, Djeddi, Djamal, Nuno, Laura, Pruunsild, Chris, Brunner, Jurgen, Kondi, Anuela, Pagava, Karaman, Pederzoli, Silvia, Martini, Alberto, Ruperto, Nicolino, PRINTO
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://repositorio.unifesp.br/handle/11600/32490; http://dx.doi.org/10.1136/ard.2009.116657

Objectives To validate the previously proposed classification criteria for Henoch-Schonlein purpura (HSP), childhood polyarteritis nodosa (c-PAN), c-Wegener granulomatosis (c-WG) and c-Takayasu arteritis (c-TA).Methods Step 1: retrospective/prospective webdata collection for children with HSP, c-PAN, c-WG and c-TA with age at diagnosis <= 18 years. Step 2: blinded classification by consensus panel of a representative sample of 280 cases. Step 3: statistical (sensitivity, specificity, area under the curve and.-agreement) and nominal group technique consensus evaluations.Results 827 patients with HSP, 150 with c-PAN, 60 with c-WG, 87 with c-TA and 52 with c-other were compared with each other. A patient was classified as HSP in the presence of purpura or petechiae (mandatory) with lower limb predominance plus one of four criteria: (1) abdominal pain; (2) histopathology (IgA); (3) arthritis or arthralgia; (4) renal involvement. Classification of c-PAN required a systemic inflammatory disease with evidence of necrotising vasculitis OR angiographic abnormalities of medium-/small-sized arteries (mandatory criterion) plus one of five criteria: (1) skin involvement; (2) myalgia/muscle tenderness; (3) hypertension; (4) peripheral neuropathy; (5) renal involvement. Classification of c-WG required three of six criteria: (1) histopathological evidence of granulomatous inflammation; (2) upper airway involvement; (3) laryngo-tracheo-bronchial involvement; (4) pulmonary involvement (x-ray/CT); (5) antineutrophilic cytoplasmic antibody positivity; (6) renal involvement. Classification of c-TA required typical angiographic abnormalities of the aorta or its main branches and pulmonary arteries (mandatory criterion) plus one of five criteria: (1) pulse deficit or claudication; (2) blood pressure discrepancy in any limb; (3) bruits; (4) hypertension; (5) elevated acute phase reactant.Conclusion European League Against Rheumatism/Paediatric Rheumatology International Trials Organisation/Paediatric Rheumatology European Society propose validated classification criteria for HSP, c-PAN, c-WG and c-TA with high sensitivity/specificity.