Asymmetric Macular Structural Damage Is Associated With Relative Afferent Pupillary Defects in Patients With Glaucoma
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | https://repositorio.unifesp.br/handle/11600/56098 http://dx.doi.org/10.1167/iovs.15-18079 |
Resumo: | PURPOSE. We examined the relationship between relative afferent pupillary defects (RAPDs) and macular structural damage measured by macular thickness and macular ganglion cell-inner plexiform layer (mGCIPL) thickness in patients with glaucoma. METHODS. A cross-sectional study was done of 106 glaucoma patients and 85 healthy individuals from the Diagnostic Innovations in Glaucoma Study. All subjects underwent standard automated perimetry (SAP) and optic nerve and macular imaging using Cirrus Spectral Domain Optical Coherence Tomography (SDOCT). Glaucoma was defined as repeatable abnormal SAP or progressive glaucomatous changes on stereo photographs. Pupil responses were assessed using an automated pupillometer, which records the magnitude of RAPD (RAPD score), with additional RAPD scores recorded for each of a series of colored stimuli (blue, red, green, and yellow). The relationship between RAPD score and intereye differences (right minus left eye) in circumpapillary retinal nerve fiber layer (cpRNFL) thickness, mGCIPL, macular thickness, and SAP mean deviation (MD), was examined using linear regression. RESULTS. There was fair correlation between RAPD score and asymmetric macular structural damage measured by intereye difference in mGCIPL thickness (R-2 = 0.285, P < 0.001). The relationship between RAPD score and intereye difference in macular thickness was weaker (R-2 = 0.167, P < 0.001). Intereye difference in cpRNFL thickness (R-2 = 0.350, P < 0.001) and SAP MD (R-2 = 0.594, P < 0.001) had stronger association with RAPD scores compared to intereye difference in mGCIPL and macular thickness. CONCLUSIONS. Objective assessment of pupillary responses using a pupillometer was associated with asymmetric macular structural damage in patients with glaucoma. |
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Gracitelli, Carolina Pelegrini Barbosa [UNIFESP]Tatham, Andrew J.Zangwill, Linda M.Weinreb, Robert N.Abe, Ricardo Y.Diniz-Filho, AlbertoParanhos Junior, Augusto [UNIFESP]Baig, SaifMedeiros, Felipe A.2020-07-22T13:23:13Z2020-07-22T13:23:13Z2016Investigative Ophthalmology & Visual Science. Rockville, v. 57, n. 4, p. 1738-1746, 2016.0146-0404https://repositorio.unifesp.br/handle/11600/56098http://dx.doi.org/10.1167/iovs.15-18079WOS000375926700028.pdf10.1167/iovs.15-18079WOS:000375926700028PURPOSE. We examined the relationship between relative afferent pupillary defects (RAPDs) and macular structural damage measured by macular thickness and macular ganglion cell-inner plexiform layer (mGCIPL) thickness in patients with glaucoma. METHODS. A cross-sectional study was done of 106 glaucoma patients and 85 healthy individuals from the Diagnostic Innovations in Glaucoma Study. All subjects underwent standard automated perimetry (SAP) and optic nerve and macular imaging using Cirrus Spectral Domain Optical Coherence Tomography (SDOCT). Glaucoma was defined as repeatable abnormal SAP or progressive glaucomatous changes on stereo photographs. Pupil responses were assessed using an automated pupillometer, which records the magnitude of RAPD (RAPD score), with additional RAPD scores recorded for each of a series of colored stimuli (blue, red, green, and yellow). The relationship between RAPD score and intereye differences (right minus left eye) in circumpapillary retinal nerve fiber layer (cpRNFL) thickness, mGCIPL, macular thickness, and SAP mean deviation (MD), was examined using linear regression. RESULTS. There was fair correlation between RAPD score and asymmetric macular structural damage measured by intereye difference in mGCIPL thickness (R-2 = 0.285, P < 0.001). The relationship between RAPD score and intereye difference in macular thickness was weaker (R-2 = 0.167, P < 0.001). Intereye difference in cpRNFL thickness (R-2 = 0.350, P < 0.001) and SAP MD (R-2 = 0.594, P < 0.001) had stronger association with RAPD scores compared to intereye difference in mGCIPL and macular thickness. CONCLUSIONS. Objective assessment of pupillary responses using a pupillometer was associated with asymmetric macular structural damage in patients with glaucoma.National Institutes of Health/National Eye InstituteResearch to Prevent Blindness (New York, NY, USA)AlconAllerganPfizerMerckSantenBrazilian National Research Council-CAPESUniv Calif San Diego, Hamilton Glaucoma Ctr, 9500 Gilman Dr, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Ophthalmol, La Jolla, CA 92093 USAUniv Fed Sao Paulo, Dept Ophthalmol, Sao Paulo, BrazilUniv Edinburgh, Princess Alexandra Eye Pavil, Edinburgh EH8 9YL, Midlothian, ScotlandUniv Edinburgh, Dept Ophthalmol, Edinburgh EH8 9YL, Midlothian, ScotlandUniv Fed Sao Paulo, Dept Ophthalmol, Sao Paulo, BrazilNIH/NEI: EY021818NIH/NEI: EY11008NIH/NEI: EY14267NIH/NEI: EY019869NIH/NEI: P30EY022589CAPES: 12309-13-3Web of Science1738-1746engAssoc Research Vision Ophthalmology IncInvestigative Ophthalmology & Visual Sciencepupillary responsepupillary reflexglaucomamaculastructural damageAsymmetric Macular Structural Damage Is Associated With Relative Afferent Pupillary Defects in Patients With Glaucomainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleRockville574info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000375926700028.pdfapplication/pdf1228082${dspace.ui.url}/bitstream/11600/56098/1/WOS000375926700028.pdf8078313b6da8959d9ca4f5e6279245c4MD51open accessTEXTWOS000375926700028.pdf.txtWOS000375926700028.pdf.txtExtracted texttext/plain40864${dspace.ui.url}/bitstream/11600/56098/2/WOS000375926700028.pdf.txtf15933b79f2d4c247e69336c84fe407cMD52open accessTHUMBNAILWOS000375926700028.pdf.jpgWOS000375926700028.pdf.jpgIM Thumbnailimage/jpeg7699${dspace.ui.url}/bitstream/11600/56098/4/WOS000375926700028.pdf.jpg8a788a7a43185499fa3af0e657eaf0dbMD54open access11600/560982022-08-01 01:15:36.003open accessoai:repositorio.unifesp.br:11600/56098Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652022-08-01T04:15:36Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Asymmetric Macular Structural Damage Is Associated With Relative Afferent Pupillary Defects in Patients With Glaucoma |
title |
Asymmetric Macular Structural Damage Is Associated With Relative Afferent Pupillary Defects in Patients With Glaucoma |
spellingShingle |
Asymmetric Macular Structural Damage Is Associated With Relative Afferent Pupillary Defects in Patients With Glaucoma Gracitelli, Carolina Pelegrini Barbosa [UNIFESP] pupillary response pupillary reflex glaucoma macula structural damage |
title_short |
Asymmetric Macular Structural Damage Is Associated With Relative Afferent Pupillary Defects in Patients With Glaucoma |
title_full |
Asymmetric Macular Structural Damage Is Associated With Relative Afferent Pupillary Defects in Patients With Glaucoma |
title_fullStr |
Asymmetric Macular Structural Damage Is Associated With Relative Afferent Pupillary Defects in Patients With Glaucoma |
title_full_unstemmed |
Asymmetric Macular Structural Damage Is Associated With Relative Afferent Pupillary Defects in Patients With Glaucoma |
title_sort |
Asymmetric Macular Structural Damage Is Associated With Relative Afferent Pupillary Defects in Patients With Glaucoma |
author |
Gracitelli, Carolina Pelegrini Barbosa [UNIFESP] |
author_facet |
Gracitelli, Carolina Pelegrini Barbosa [UNIFESP] Tatham, Andrew J. Zangwill, Linda M. Weinreb, Robert N. Abe, Ricardo Y. Diniz-Filho, Alberto Paranhos Junior, Augusto [UNIFESP] Baig, Saif Medeiros, Felipe A. |
author_role |
author |
author2 |
Tatham, Andrew J. Zangwill, Linda M. Weinreb, Robert N. Abe, Ricardo Y. Diniz-Filho, Alberto Paranhos Junior, Augusto [UNIFESP] Baig, Saif Medeiros, Felipe A. |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Gracitelli, Carolina Pelegrini Barbosa [UNIFESP] Tatham, Andrew J. Zangwill, Linda M. Weinreb, Robert N. Abe, Ricardo Y. Diniz-Filho, Alberto Paranhos Junior, Augusto [UNIFESP] Baig, Saif Medeiros, Felipe A. |
dc.subject.eng.fl_str_mv |
pupillary response pupillary reflex glaucoma macula structural damage |
topic |
pupillary response pupillary reflex glaucoma macula structural damage |
description |
PURPOSE. We examined the relationship between relative afferent pupillary defects (RAPDs) and macular structural damage measured by macular thickness and macular ganglion cell-inner plexiform layer (mGCIPL) thickness in patients with glaucoma. METHODS. A cross-sectional study was done of 106 glaucoma patients and 85 healthy individuals from the Diagnostic Innovations in Glaucoma Study. All subjects underwent standard automated perimetry (SAP) and optic nerve and macular imaging using Cirrus Spectral Domain Optical Coherence Tomography (SDOCT). Glaucoma was defined as repeatable abnormal SAP or progressive glaucomatous changes on stereo photographs. Pupil responses were assessed using an automated pupillometer, which records the magnitude of RAPD (RAPD score), with additional RAPD scores recorded for each of a series of colored stimuli (blue, red, green, and yellow). The relationship between RAPD score and intereye differences (right minus left eye) in circumpapillary retinal nerve fiber layer (cpRNFL) thickness, mGCIPL, macular thickness, and SAP mean deviation (MD), was examined using linear regression. RESULTS. There was fair correlation between RAPD score and asymmetric macular structural damage measured by intereye difference in mGCIPL thickness (R-2 = 0.285, P < 0.001). The relationship between RAPD score and intereye difference in macular thickness was weaker (R-2 = 0.167, P < 0.001). Intereye difference in cpRNFL thickness (R-2 = 0.350, P < 0.001) and SAP MD (R-2 = 0.594, P < 0.001) had stronger association with RAPD scores compared to intereye difference in mGCIPL and macular thickness. CONCLUSIONS. Objective assessment of pupillary responses using a pupillometer was associated with asymmetric macular structural damage in patients with glaucoma. |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016 |
dc.date.accessioned.fl_str_mv |
2020-07-22T13:23:13Z |
dc.date.available.fl_str_mv |
2020-07-22T13:23:13Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Investigative Ophthalmology & Visual Science. Rockville, v. 57, n. 4, p. 1738-1746, 2016. |
dc.identifier.uri.fl_str_mv |
https://repositorio.unifesp.br/handle/11600/56098 http://dx.doi.org/10.1167/iovs.15-18079 |
dc.identifier.issn.none.fl_str_mv |
0146-0404 |
dc.identifier.file.none.fl_str_mv |
WOS000375926700028.pdf |
dc.identifier.doi.none.fl_str_mv |
10.1167/iovs.15-18079 |
dc.identifier.wos.none.fl_str_mv |
WOS:000375926700028 |
identifier_str_mv |
Investigative Ophthalmology & Visual Science. Rockville, v. 57, n. 4, p. 1738-1746, 2016. 0146-0404 WOS000375926700028.pdf 10.1167/iovs.15-18079 WOS:000375926700028 |
url |
https://repositorio.unifesp.br/handle/11600/56098 http://dx.doi.org/10.1167/iovs.15-18079 |
dc.language.iso.fl_str_mv |
eng |
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eng |
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Investigative Ophthalmology & Visual Science |
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info:eu-repo/semantics/openAccess |
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openAccess |
dc.format.none.fl_str_mv |
1738-1746 |
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Rockville |
dc.publisher.none.fl_str_mv |
Assoc Research Vision Ophthalmology Inc |
publisher.none.fl_str_mv |
Assoc Research Vision Ophthalmology Inc |
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reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
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