The combination of atorvastatin and ethanol is not more hepatotoxic to rats than the administration of each drug alone
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/3590 http://dx.doi.org/10.1590/S0100-879X2007000300009 |
Resumo: | Animal studies and premarketing clinical trials have revealed hepatotoxicity of statins, primarily minor elevations in serum alanine aminotransferase levels. The combined chronic use of medicines and eventual ethanol abuse are common and may present a synergistic action regarding liver injury. Our objective was to study the effect of the chronic use of atorvastatin associated with acute ethanol administration on the liver in a rat model. One group of rats was treated daily for 5 days a week for 2 months with 0.8 mg/kg atorvastatin by gavage. At the end of the treatment the livers were perfused with 72 mM ethanol for 60 min. Control groups (at least 4 animals in each group) consisted of a group of 2-month-old male Wistar EPM-1 rats exposed to 10% ethanol (v/v) ad libitum replacing water for 2 months, followed by perfusion of the liver with 61 nM atorvastatin for 60 min, and a group of animals without chronic ethanol treatment whose livers were perfused with atorvastatin and/or ethanol. The combination of atorvastatin with ethanol did not increase the release of injury marker enzymes (alanine aminotransferase, aspartate aminotransferase, and lactic dehydrogenase) from the liver and no change in liver function markers (bromosulfophthalein clearance, and oxygen consumption) was observed. Our results suggest that the combination of atorvastatin with ethanol is not more hepatotoxic than the separate use of each substance. |
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Ito, Daniel Takeshi [UNIFESP]Molina, Hercilia Maris [UNIFESP]Andriolo, Adagmar [UNIFESP]Borges, Durval Rosa [UNIFESP]Universidade Federal de São Paulo (UNIFESP)2015-06-14T13:36:47Z2015-06-14T13:36:47Z2007-03-01Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 40, n. 3, p. 343-348, 2007.0100-879Xhttp://repositorio.unifesp.br/handle/11600/3590http://dx.doi.org/10.1590/S0100-879X2007000300009S0100-879X2007000300009.pdfS0100-879X200700030000910.1590/S0100-879X2007000300009WOS:000244667700009Animal studies and premarketing clinical trials have revealed hepatotoxicity of statins, primarily minor elevations in serum alanine aminotransferase levels. The combined chronic use of medicines and eventual ethanol abuse are common and may present a synergistic action regarding liver injury. Our objective was to study the effect of the chronic use of atorvastatin associated with acute ethanol administration on the liver in a rat model. One group of rats was treated daily for 5 days a week for 2 months with 0.8 mg/kg atorvastatin by gavage. At the end of the treatment the livers were perfused with 72 mM ethanol for 60 min. Control groups (at least 4 animals in each group) consisted of a group of 2-month-old male Wistar EPM-1 rats exposed to 10% ethanol (v/v) ad libitum replacing water for 2 months, followed by perfusion of the liver with 61 nM atorvastatin for 60 min, and a group of animals without chronic ethanol treatment whose livers were perfused with atorvastatin and/or ethanol. The combination of atorvastatin with ethanol did not increase the release of injury marker enzymes (alanine aminotransferase, aspartate aminotransferase, and lactic dehydrogenase) from the liver and no change in liver function markers (bromosulfophthalein clearance, and oxygen consumption) was observed. Our results suggest that the combination of atorvastatin with ethanol is not more hepatotoxic than the separate use of each substance.Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de BioquímicaUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de MedicinaUNIFESP, EPM, Depto. de BioquímicaUNIFESP, EPM, Depto. de MedicinaSciELO343-348engAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological ResearchAtorvastatinLiver injuryHepatotoxicAlcoholThe combination of atorvastatin and ethanol is not more hepatotoxic to rats than the administration of each drug aloneinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALS0100-879X2007000300009.pdfapplication/pdf474900${dspace.ui.url}/bitstream/11600/3590/1/S0100-879X2007000300009.pdfc000d958af479d506f412f4020e799a1MD51open accessTEXTS0100-879X2007000300009.pdf.txtS0100-879X2007000300009.pdf.txtExtracted texttext/plain21632${dspace.ui.url}/bitstream/11600/3590/2/S0100-879X2007000300009.pdf.txt57c84d2d2c2361139f11fbaf2737d36cMD52open access11600/35902021-09-29 14:52:14.624open accessoai:repositorio.unifesp.br:11600/3590Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652021-09-29T17:52:14Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
The combination of atorvastatin and ethanol is not more hepatotoxic to rats than the administration of each drug alone |
title |
The combination of atorvastatin and ethanol is not more hepatotoxic to rats than the administration of each drug alone |
spellingShingle |
The combination of atorvastatin and ethanol is not more hepatotoxic to rats than the administration of each drug alone Ito, Daniel Takeshi [UNIFESP] Atorvastatin Liver injury Hepatotoxic Alcohol |
title_short |
The combination of atorvastatin and ethanol is not more hepatotoxic to rats than the administration of each drug alone |
title_full |
The combination of atorvastatin and ethanol is not more hepatotoxic to rats than the administration of each drug alone |
title_fullStr |
The combination of atorvastatin and ethanol is not more hepatotoxic to rats than the administration of each drug alone |
title_full_unstemmed |
The combination of atorvastatin and ethanol is not more hepatotoxic to rats than the administration of each drug alone |
title_sort |
The combination of atorvastatin and ethanol is not more hepatotoxic to rats than the administration of each drug alone |
author |
Ito, Daniel Takeshi [UNIFESP] |
author_facet |
Ito, Daniel Takeshi [UNIFESP] Molina, Hercilia Maris [UNIFESP] Andriolo, Adagmar [UNIFESP] Borges, Durval Rosa [UNIFESP] |
author_role |
author |
author2 |
Molina, Hercilia Maris [UNIFESP] Andriolo, Adagmar [UNIFESP] Borges, Durval Rosa [UNIFESP] |
author2_role |
author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Ito, Daniel Takeshi [UNIFESP] Molina, Hercilia Maris [UNIFESP] Andriolo, Adagmar [UNIFESP] Borges, Durval Rosa [UNIFESP] |
dc.subject.eng.fl_str_mv |
Atorvastatin Liver injury Hepatotoxic Alcohol |
topic |
Atorvastatin Liver injury Hepatotoxic Alcohol |
description |
Animal studies and premarketing clinical trials have revealed hepatotoxicity of statins, primarily minor elevations in serum alanine aminotransferase levels. The combined chronic use of medicines and eventual ethanol abuse are common and may present a synergistic action regarding liver injury. Our objective was to study the effect of the chronic use of atorvastatin associated with acute ethanol administration on the liver in a rat model. One group of rats was treated daily for 5 days a week for 2 months with 0.8 mg/kg atorvastatin by gavage. At the end of the treatment the livers were perfused with 72 mM ethanol for 60 min. Control groups (at least 4 animals in each group) consisted of a group of 2-month-old male Wistar EPM-1 rats exposed to 10% ethanol (v/v) ad libitum replacing water for 2 months, followed by perfusion of the liver with 61 nM atorvastatin for 60 min, and a group of animals without chronic ethanol treatment whose livers were perfused with atorvastatin and/or ethanol. The combination of atorvastatin with ethanol did not increase the release of injury marker enzymes (alanine aminotransferase, aspartate aminotransferase, and lactic dehydrogenase) from the liver and no change in liver function markers (bromosulfophthalein clearance, and oxygen consumption) was observed. Our results suggest that the combination of atorvastatin with ethanol is not more hepatotoxic than the separate use of each substance. |
publishDate |
2007 |
dc.date.issued.fl_str_mv |
2007-03-01 |
dc.date.accessioned.fl_str_mv |
2015-06-14T13:36:47Z |
dc.date.available.fl_str_mv |
2015-06-14T13:36:47Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 40, n. 3, p. 343-348, 2007. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/3590 http://dx.doi.org/10.1590/S0100-879X2007000300009 |
dc.identifier.issn.none.fl_str_mv |
0100-879X |
dc.identifier.file.none.fl_str_mv |
S0100-879X2007000300009.pdf |
dc.identifier.scielo.none.fl_str_mv |
S0100-879X2007000300009 |
dc.identifier.doi.none.fl_str_mv |
10.1590/S0100-879X2007000300009 |
dc.identifier.wos.none.fl_str_mv |
WOS:000244667700009 |
identifier_str_mv |
Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 40, n. 3, p. 343-348, 2007. 0100-879X S0100-879X2007000300009.pdf S0100-879X2007000300009 10.1590/S0100-879X2007000300009 WOS:000244667700009 |
url |
http://repositorio.unifesp.br/handle/11600/3590 http://dx.doi.org/10.1590/S0100-879X2007000300009 |
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eng |
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eng |
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Brazilian Journal of Medical and Biological Research |
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info:eu-repo/semantics/openAccess |
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openAccess |
dc.format.none.fl_str_mv |
343-348 |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
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Associação Brasileira de Divulgação Científica |
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