Impact of sex on hyperalgesia induced by sleep loss
Main Author: | |
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Publication Date: | 2011 |
Other Authors: | , , |
Format: | Article |
Language: | eng |
Source: | Repositório Institucional da UNIFESP |
Download full: | http://repositorio.unifesp.br/handle/11600/33183 http://dx.doi.org/10.1016/j.yhbeh.2010.11.003 |
Summary: | This study evaluated the impact of sex on the short term consequences of different periods of sleep deprivation and the effect of the respective sleep recovery periods on nociceptive responses. Male and female C57BL/6J mice were assigned to the following groups: paradoxical sleep deprived (PSD) for 72 h, sleep restricted (SR) for 15 days, exposed to respective recovery periods for 24 h, or untreated home-cage controls (CTRL). Mice were submitted to a noxious thermal stimulus to evaluate their nociceptive response after PSD, SR, or recovery periods. Blood was collected for hormonal analysis. the nociceptive response was significantly lower in PSD and SR mice compared to CTRL animals, regardless of the sex. However, SR females had a lower paw withdrawal threshold than males. Sleep recovery was able to restore normal nociceptive sensitivity after PSD in both sexes. the hyperalgesia induced by SR was not reversed by sleep rebound. in females, low concentrations of estradiol were found after SR, and these concentrations continued to decrease after 24 hours of sleep recovery. the PSD male mice exhibited higher concentrations of corticosterone than the CTRL and SR male mice. Corticosterone levels were not affected by SR. Our study revealed that PSD and SR induce hyperalgesia in mice. the SR groups showed marked changes in the nociceptive response, and the females were more sensitive to these alterations. This finding indicates that, although different periods of sleep deprivation change the nociceptive sensitivity in male and female mice, sex could influence hyperalgesia induced by chronic sleep loss. (C) 2010 Elsevier Inc. All rights reserved. |
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Araujo, Paula [UNIFESP]Mazaro-Costa, RenataTufik, Sergio [UNIFESP]Andersen, Monica Levy [UNIFESP]Universidade Federal de São Paulo (UNIFESP)Universidade Federal de Goiás (UFG)2016-01-24T14:05:50Z2016-01-24T14:05:50Z2011-01-01Hormones and Behavior. San Diego: Academic Press Inc Elsevier Science, v. 59, n. 1, p. 174-179, 2011.0018-506Xhttp://repositorio.unifesp.br/handle/11600/33183http://dx.doi.org/10.1016/j.yhbeh.2010.11.003WOS000286717600023.pdf10.1016/j.yhbeh.2010.11.003WOS:000286717600023This study evaluated the impact of sex on the short term consequences of different periods of sleep deprivation and the effect of the respective sleep recovery periods on nociceptive responses. Male and female C57BL/6J mice were assigned to the following groups: paradoxical sleep deprived (PSD) for 72 h, sleep restricted (SR) for 15 days, exposed to respective recovery periods for 24 h, or untreated home-cage controls (CTRL). Mice were submitted to a noxious thermal stimulus to evaluate their nociceptive response after PSD, SR, or recovery periods. Blood was collected for hormonal analysis. the nociceptive response was significantly lower in PSD and SR mice compared to CTRL animals, regardless of the sex. However, SR females had a lower paw withdrawal threshold than males. Sleep recovery was able to restore normal nociceptive sensitivity after PSD in both sexes. the hyperalgesia induced by SR was not reversed by sleep rebound. in females, low concentrations of estradiol were found after SR, and these concentrations continued to decrease after 24 hours of sleep recovery. the PSD male mice exhibited higher concentrations of corticosterone than the CTRL and SR male mice. Corticosterone levels were not affected by SR. Our study revealed that PSD and SR induce hyperalgesia in mice. the SR groups showed marked changes in the nociceptive response, and the females were more sensitive to these alterations. This finding indicates that, although different periods of sleep deprivation change the nociceptive sensitivity in male and female mice, sex could influence hyperalgesia induced by chronic sleep loss. (C) 2010 Elsevier Inc. All rights reserved.Associacao Fundo de Incentivo a Psicofarmacologia (AFIP)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Universidade Federal de São Paulo, Dept Psicobiol, BR-04024002 São Paulo, BrazilUniv Fed Goias, Dept Ciencias Fisiol, Goiania, Go, BrazilUniversidade Federal de São Paulo, Dept Psicobiol, BR-04024002 São Paulo, BrazilFAPESP: 98/14303-3FAPESP: 10/50130-0Web of Science174-179engElsevier B.V.Hormones and Behaviorhttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policyinfo:eu-repo/semantics/openAccessSleep deprivationHyperalgesiaSex differencesCorticosteroneEstradiolHormonesMiceImpact of sex on hyperalgesia induced by sleep lossinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlereponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000286717600023.pdfapplication/pdf522009${dspace.ui.url}/bitstream/11600/33183/1/WOS000286717600023.pdf17d5b0a7350bb090b1974ef1b7c2cf2cMD51open accessTEXTWOS000286717600023.pdf.txtWOS000286717600023.pdf.txtExtracted texttext/plain35737${dspace.ui.url}/bitstream/11600/33183/2/WOS000286717600023.pdf.txtc2d50104ceba09d8d6805c85a4354777MD52open access11600/331832023-02-15 11:39:40.319open accessoai:repositorio.unifesp.br:11600/33183Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:32:06.786787Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Impact of sex on hyperalgesia induced by sleep loss |
title |
Impact of sex on hyperalgesia induced by sleep loss |
spellingShingle |
Impact of sex on hyperalgesia induced by sleep loss Araujo, Paula [UNIFESP] Sleep deprivation Hyperalgesia Sex differences Corticosterone Estradiol Hormones Mice |
title_short |
Impact of sex on hyperalgesia induced by sleep loss |
title_full |
Impact of sex on hyperalgesia induced by sleep loss |
title_fullStr |
Impact of sex on hyperalgesia induced by sleep loss |
title_full_unstemmed |
Impact of sex on hyperalgesia induced by sleep loss |
title_sort |
Impact of sex on hyperalgesia induced by sleep loss |
author |
Araujo, Paula [UNIFESP] |
author_facet |
Araujo, Paula [UNIFESP] Mazaro-Costa, Renata Tufik, Sergio [UNIFESP] Andersen, Monica Levy [UNIFESP] |
author_role |
author |
author2 |
Mazaro-Costa, Renata Tufik, Sergio [UNIFESP] Andersen, Monica Levy [UNIFESP] |
author2_role |
author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Universidade Federal de Goiás (UFG) |
dc.contributor.author.fl_str_mv |
Araujo, Paula [UNIFESP] Mazaro-Costa, Renata Tufik, Sergio [UNIFESP] Andersen, Monica Levy [UNIFESP] |
dc.subject.eng.fl_str_mv |
Sleep deprivation Hyperalgesia Sex differences Corticosterone Estradiol Hormones Mice |
topic |
Sleep deprivation Hyperalgesia Sex differences Corticosterone Estradiol Hormones Mice |
description |
This study evaluated the impact of sex on the short term consequences of different periods of sleep deprivation and the effect of the respective sleep recovery periods on nociceptive responses. Male and female C57BL/6J mice were assigned to the following groups: paradoxical sleep deprived (PSD) for 72 h, sleep restricted (SR) for 15 days, exposed to respective recovery periods for 24 h, or untreated home-cage controls (CTRL). Mice were submitted to a noxious thermal stimulus to evaluate their nociceptive response after PSD, SR, or recovery periods. Blood was collected for hormonal analysis. the nociceptive response was significantly lower in PSD and SR mice compared to CTRL animals, regardless of the sex. However, SR females had a lower paw withdrawal threshold than males. Sleep recovery was able to restore normal nociceptive sensitivity after PSD in both sexes. the hyperalgesia induced by SR was not reversed by sleep rebound. in females, low concentrations of estradiol were found after SR, and these concentrations continued to decrease after 24 hours of sleep recovery. the PSD male mice exhibited higher concentrations of corticosterone than the CTRL and SR male mice. Corticosterone levels were not affected by SR. Our study revealed that PSD and SR induce hyperalgesia in mice. the SR groups showed marked changes in the nociceptive response, and the females were more sensitive to these alterations. This finding indicates that, although different periods of sleep deprivation change the nociceptive sensitivity in male and female mice, sex could influence hyperalgesia induced by chronic sleep loss. (C) 2010 Elsevier Inc. All rights reserved. |
publishDate |
2011 |
dc.date.issued.fl_str_mv |
2011-01-01 |
dc.date.accessioned.fl_str_mv |
2016-01-24T14:05:50Z |
dc.date.available.fl_str_mv |
2016-01-24T14:05:50Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Hormones and Behavior. San Diego: Academic Press Inc Elsevier Science, v. 59, n. 1, p. 174-179, 2011. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/33183 http://dx.doi.org/10.1016/j.yhbeh.2010.11.003 |
dc.identifier.issn.none.fl_str_mv |
0018-506X |
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WOS000286717600023.pdf |
dc.identifier.doi.none.fl_str_mv |
10.1016/j.yhbeh.2010.11.003 |
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WOS:000286717600023 |
identifier_str_mv |
Hormones and Behavior. San Diego: Academic Press Inc Elsevier Science, v. 59, n. 1, p. 174-179, 2011. 0018-506X WOS000286717600023.pdf 10.1016/j.yhbeh.2010.11.003 WOS:000286717600023 |
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http://repositorio.unifesp.br/handle/11600/33183 http://dx.doi.org/10.1016/j.yhbeh.2010.11.003 |
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eng |
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Hormones and Behavior |
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http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy |
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openAccess |
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174-179 |
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Elsevier B.V. |
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Elsevier B.V. |
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